PDB: 367 件ウェブページステータス検索Chemie searchBIRD

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3L2V	Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with manganese and MK0518 (Raltegravir) 分子名称: 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*TP*GP*TP*A)-3', 5'-D(*TP*AP*CP*AP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3', AMMONIUM ION, ... 著者 Hare, S, Gupta, S.S, Cherepanov, P. 登録日 2009-12-15 公開日 2010-02-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Retroviral intasome assembly and inhibition of DNA strand transfer Nature, 464, 2010
3L3U	Crystal structure of the HIV-1 integrase core domain to 1.4A 分子名称: POL polyprotein, SULFATE ION 著者 Wielens, J, Chalmers, D.K, Scanlon, M.J, Parker, M.W. 登録日 2009-12-17 公開日 2010-03-31 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site. Febs Lett., 584, 2010
3L3V	Structure of HIV-1 integrase core domain in complex with sucrose 分子名称: CADMIUM ION, POL polyprotein, SULFATE ION, ... 著者 Wielens, J, Chalmers, D.K, Scanlon, M.J, Parker, M.W. 登録日 2009-12-18 公開日 2010-03-31 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site Febs Lett., 584, 2010
3LPT	HIV integrase 分子名称: (6-chloro-2-oxo-4-phenyl-1,2-dihydroquinolin-3-yl)acetic acid, 2-[3-[3-(2-hydroxyethoxy)propoxy]propoxy]ethanol, CALCIUM ION, ... 著者 Nicolet, S, Christ, F, Voet, A, Marchand, A, Strelkov, S.V, de Maeyer, M, Chaltin, P, Debyzer, Z. 登録日 2010-02-05 公開日 2010-05-12 最終更新日 2021-11-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication. Nat.Chem.Biol., 6, 2010
3LPU	HIV integrase 分子名称: (2S)-2-(6-chloro-2-methyl-4-phenylquinolin-3-yl)pentanoic acid, 2-[3-[3-(2-hydroxyethoxy)propoxy]propoxy]ethanol, CALCIUM ION, ... 著者 Nicolet, S, Christ, F, Voet, A, Marchand, A, Strelkov, S.V, de Maeyer, M, Chaltin, P, Debyzer, Z. 登録日 2010-02-06 公開日 2010-05-12 最終更新日 2021-11-10 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication. Nat.Chem.Biol., 6, 2010
2X6N	Human foamy virus integrase - catalytic core. Manganese-bound structure. 分子名称: INTEGRASE, MANGANESE (II) ION 著者 Rety, S, Delelis, O, Rezabkova, L, Dubanchet, B, Silhan, J, Lewit-Bentley, A. 登録日 2010-02-18 公開日 2010-08-11 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Structural Studies of the Catalytic Core of the Primate Foamy Virus (Pfv-1) Integrase Acta Crystallogr.,Sect.F, 66, 2010
2X6S	Human foamy virus integrase - catalytic core. Magnesium-bound structure. 分子名称: INTEGRASE, MAGNESIUM ION 著者 Rety, S, Delelis, O, Rezabkova, L, Dubanchet, B, Silhan, J, Lewit-Bentley, A. 登録日 2010-02-19 公開日 2010-08-11 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Structural Studies of the Catalytic Core of the Primate Foamy Virus (Pfv-1) Integrase Acta Crystallogr.,Sect.F, 66, 2010
2X74	Human foamy virus integrase - catalytic core. 分子名称: INTEGRASE 著者 Rety, S, Delelis, O, Rezabkova, L, Dubanchet, B, Legrand, P, Silhan, J, Lewit-Bentley, A. 登録日 2010-02-23 公開日 2010-08-11 最終更新日 2012-04-18 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Structural Studies of the Catalytic Core of the Primate Foamy Virus (Pfv-1) Integrase Acta Crystallogr.,Sect.F, 66, 2010
2X78	Human foamy virus integrase - catalytic core. 分子名称: INTEGRASE 著者 Rety, S, Delelis, O, Rezabkova, L, Dubanchet, B, Legrand, P, Silhan, J, Lewit-Bentley, A. 登録日 2010-02-24 公開日 2010-08-11 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Studies of the Catalytic Core of the Primate Foamy Virus (Pfv-1) Integrase Acta Crystallogr.,Sect.F, 66, 2010
3NF6	Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design 分子名称: 1,2-ETHANEDIOL, 5-[(2-oxo-2,3-dihydro-1H-indol-1-yl)methyl]-1,3-benzodioxole-4-carboxylic acid, ACETIC ACID, ... 著者 Peat, T.S, Newman, J, Deadman, J.J, Rhodes, D. 登録日 2010-06-09 公開日 2011-04-27 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design ANTIVIR.CHEM.CHEMOTHER., 21, 2011
3NF7	Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design 分子名称: 1,2-ETHANEDIOL, 5-[(5-chloro-2-oxo-2,3-dihydro-1H-indol-1-yl)methyl]-1,3-benzodioxole-4-carboxylic acid, ACETIC ACID, ... 著者 Peat, T.S, Newman, J, Deadman, J.J, Rhodes, D. 登録日 2010-06-09 公開日 2011-04-27 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design ANTIVIR.CHEM.CHEMOTHER., 21, 2011
3NF8	Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design 分子名称: 6-[(5-chloro-2-oxo-2,3-dihydro-1H-indol-1-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxylic acid, ACETIC ACID, Integrase, ... 著者 Peat, T.S, Newman, J, Deadman, J.J, Rhodes, D. 登録日 2010-06-09 公開日 2011-04-27 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design ANTIVIR.CHEM.CHEMOTHER., 21, 2011
3NF9	Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design 分子名称: 1,2-ETHANEDIOL, 5-[(6-chloro-2-oxo-2,3-dihydro-1H-indol-1-yl)methyl]-1,3-benzodioxole-4-carboxylic acid, ACETIC ACID, ... 著者 Peat, T.S, Newman, J, Deadman, J.J, Rhodes, D. 登録日 2010-06-10 公開日 2011-04-27 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design ANTIVIR.CHEM.CHEMOTHER., 21, 2011
3NFA	Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design 分子名称: 6-[(5-bromo-2,3-dioxo-2,3-dihydro-1H-indol-1-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxylic acid, ACETIC ACID, Integrase, ... 著者 Peat, T.S, Newman, J, Deadman, J.J, Rhodes, D. 登録日 2010-06-10 公開日 2011-04-27 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design ANTIVIR.CHEM.CHEMOTHER., 21, 2011
3O4N	Crystal structure of the Rous Associated Virus Integrase catalytic domain in MES buffer pH 6.0 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ZINC ION, integrase 著者 Ballandras, A, Robert, X, Gouet, P. 登録日 2010-07-27 公開日 2011-08-31 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A crystal structure of the catalytic core domain of an avian sarcoma and leukemia virus integrase suggests an alternate dimeric assembly. Plos One, 6, 2011
3O4Q	Crystal structure of the Rous Associated Virus Integrase catalytic domain A182T in citrate buffer pH 6.2 分子名称: CITRATE ANION, integrase 著者 Ballandras, A, Robert, X, Gouet, P. 登録日 2010-07-27 公開日 2011-08-31 最終更新日 2021-10-06 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 A crystal structure of the catalytic core domain of an avian sarcoma and leukemia virus integrase suggests an alternate dimeric assembly. Plos One, 6, 2011
3OS1	PFV target capture complex (TCC) at 2.97 A resolution 分子名称: DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*CP*CP*CP*GP*AP*GP*GP*CP*AP*CP*GP*TP*GP*CP*TP*AP*GP*CP*AP*CP*GP*TP*GP*CP*CP*TP*CP*GP*GP*G)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*(2DA))-3'), ... 著者 Maertens, G.N, Hare, S, Cherepanov, P. 登録日 2010-09-08 公開日 2010-11-17 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.97 Å) 主引用文献 The mechanism of retroviral integration from X-ray structures of its key intermediates Nature, 468, 2010
3OS2	PFV target capture complex (TCC) at 3.32 A resolution 分子名称: DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*CP*CP*CP*GP*AP*GP*GP*CP*AP*CP*GP*TP*GP*CP*TP*AP*GP*CP*AP*CP*GP*TP*GP*CP*CP*TP*CP*GP*GP*G)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), ... 著者 Maertens, G.N, Hare, S, Cherepanov, P. 登録日 2010-09-08 公開日 2010-11-17 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.32 Å) 主引用文献 The mechanism of retroviral integration from X-ray structures of its key intermediates Nature, 468, 2010
3OS0	PFV strand transfer complex (STC) at 2.81 A resolution 分子名称: DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*CP*CP*CP*GP*AP*G*GP*CP*AP*CP*GP*TP*G)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), ... 著者 Maertens, G.N, Hare, S, Cherepanov, P. 登録日 2010-09-08 公開日 2010-11-17 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 The mechanism of retroviral integration from X-ray structures of its key intermediates Nature, 468, 2010
3OVN	Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase 分子名称: 1-methyl-3-(thiophen-2-yl)-1H-pyrazol-5-amine, CADMIUM ION, POL polyprotein, ... 著者 Wielens, J, Chalmers, D.K, Headey, S.J, Deadman, J.J, Rhodes, D.K, Parker, M.W, Scanlon, M.J. 登録日 2010-09-16 公開日 2011-03-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1 Chemmedchem, 6, 2011
3AO1	Fragment-based approach to the design of ligands targeting a novel site in HIV-1 integrase 分子名称: 1,3-benzodioxol-5-ol, CADMIUM ION, POL polyprotein, ... 著者 Wielens, J, Parker, M.W, Chalmers, D.K, Scanlon, M.J. 登録日 2010-09-17 公開日 2011-03-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1 Chemmedchem, 6, 2011
3AO2	Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase 分子名称: (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 3-(7-bromo-1,3-benzodioxol-5-yl)-1-methyl-1H-pyrazol-5-amine, ... 著者 Wielens, J, Chalmers, D.K, Headey, S.J, Parker, M.W, Scanlon, M.J. 登録日 2010-09-20 公開日 2011-03-16 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1 Chemmedchem, 6, 2011
3AO4	Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase 分子名称: 3-(1,3-benzodioxol-5-yl)-1-methyl-1H-pyrazol-5-amine, CADMIUM ION, CHLORIDE ION, ... 著者 Wielens, J, Headey, S.J, Parker, M.W, Chalmers, D.K, Scanlon, M.J. 登録日 2010-09-20 公開日 2011-03-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1 Chemmedchem, 6, 2011
3AO3	Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase 分子名称: 3-(1,3-benzodioxol-5-yl)-1-methyl-1H-pyrazole-5-carboxylic acid, CADMIUM ION, CHLORIDE ION, ... 著者 Wielens, J, Headey, S.J, Parker, M.W, Chalmers, D.K, Scanlon, M.J. 登録日 2010-09-20 公開日 2011-03-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1 Chemmedchem, 6, 2011
3AO5	Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase 分子名称: 5-(7-bromo-1,3-benzodioxol-5-yl)-1-methyl-1H-pyrazol-3-amine, CADMIUM ION, CHLORIDE ION, ... 著者 Wielens, J, Headey, S.J, Parker, M.W, Chalmers, D.K, Scanlon, M.J. 登録日 2010-09-21 公開日 2011-03-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1 Chemmedchem, 6, 2011

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