8SD0
 
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8S3X
 | | LIM Domain Kinase 2 (LIMK2) bound to compound 52 | | 分子名称: | 4-(5-cyclopropyl-7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl)-~{N}-[3-(3-methoxyphenyl)phenyl]-3,6-dihydro-2~{H}-pyridine-1-carboxamide, LIM domain kinase 2 | | 著者 | Mathea, S, Chatterjee, D, Preuss, F, Ple, K, Knapp, S. | | 登録日 | 2024-02-20 | | 公開日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | LIM Domain Kinase 2 (LIMK2) bound to compound 52
To Be Published
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5NC7
 | | ENAH EVH1 in complex with Ac-WPPPPTEDEL-NH2 | | 分子名称: | ActA-derived 10-mer Ac-FPPPPTEDEL-NH2 with acetylated (Ac) and amidated (NH2) termini. Phe is substitued by Trp to increase affinity for crystallization, Protein enabled homolog | | 著者 | Barone, M, Roske, Y. | | 登録日 | 2017-03-03 | | 公開日 | 2018-03-21 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Proc.Natl.Acad.Sci.USA, 117, 2020
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8SDW
 | | Crystal structure of the non-myristoylated mutant [L8K]Arf1 in complex with a GDP analogue | | 分子名称: | ADP-ribosylation factor 1, GUANOSINE-3'-MONOPHOSPHATE-5'-DIPHOSPHATE, MAGNESIUM ION | | 著者 | Rosenberg Jr, E.M, Randazzo, P.A, Esser, L, Xia, D. | | 登録日 | 2023-04-07 | | 公開日 | 2023-06-28 | | 最終更新日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Point mutations in Arf1 reveal cooperative effects of the N-terminal extension and myristate for GTPase-activating protein catalytic activity.
Plos One, 19, 2024
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8BT6
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5NXD
 | | LIM Domain Kinase 2 (LIMK2) In Complex With TH-300 | | 分子名称: | 1,2-ETHANEDIOL, 4-[(3-chlorophenyl)sulfamoyl]-~{N}-(phenylmethyl)-~{N}-propyl-benzamide, LIM domain kinase 2 | | 著者 | Mathea, S, Salah, E, Hanke, T, Newman, J.A, Oerum, S, Wang, D, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N, Knapp, S. | | 登録日 | 2017-05-10 | | 公開日 | 2017-05-24 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | LIM Domain Kinase 2 (LIMK2)In Complex With TH-300
To Be Published
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7TM3
 | | Structure of the rabbit 80S ribosome stalled on a 2-TMD Rhodopsin intermediate in complex with the multipass translocon | | 分子名称: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | 著者 | Kim, M.K, Lewis, A.J.O, Keenan, R.J, Hegde, R.S. | | 登録日 | 2022-01-19 | | 公開日 | 2022-10-19 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | | 主引用文献 | Mechanism of an intramembrane chaperone for multipass membrane proteins.
Nature, 611, 2022
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7TUT
 | | Structure of the rabbit 80S ribosome stalled on a 4-TMD Rhodopsin intermediate in complex with the multipass translocon | | 分子名称: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | 著者 | Kim, M.K, Lewis, A.J.O, Keenan, R.J, Hegde, R.S. | | 登録日 | 2022-02-03 | | 公開日 | 2022-10-19 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.88 Å) | | 主引用文献 | Mechanism of an intramembrane chaperone for multipass membrane proteins.
Nature, 611, 2022
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1OBY
 | | Crystal structure of the complex of PDZ2 of syntenin with a syndecan-4 peptide. | | 分子名称: | SULFATE ION, SYNDECAN-4, SYNTENIN 1 | | 著者 | Kang, B.S, Cooper, D.R, Devedjiev, Y, Derewenda, U, Derewenda, Z.S. | | 登録日 | 2003-01-31 | | 公開日 | 2003-07-11 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Molecular Roots of Degenerate Specificity in Syntenin'S Pdz2 Domain: Reassessment of the Pdz Recognition Paradigm
Structure, 11, 2003
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5OCG
 | | Discovery of small molecules binding to KRAS via high affinity antibody fragment competition method. | | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, GTPase KRas, ... | | 著者 | Cruz-Migoni, A, Ehebauer, M.T, Phillips, S.E.V, Quevedo, C.E, Rabbitts, T.H. | | 登録日 | 2017-06-30 | | 公開日 | 2018-08-22 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.
Nat Commun, 9, 2018
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7ZSC
 | | Crystal structure of the heterodimeric human C-P4H-II with truncated alpha subunit (C-P4H-II delta281) | | 分子名称: | Prolyl 4-hydroxylase subunit alpha-2, Protein disulfide-isomerase, SULFATE ION | | 著者 | Lebedev, A, Koski, M.K, Wierenga, R.K, Murthy, A.V, Sulu, R. | | 登録日 | 2022-05-06 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (3.85 Å) | | 主引用文献 | Crystal structure of the collagen prolyl 4-hydroxylase (C-P4H) catalytic domain complexed with PDI: Toward a model of the C-P4H alpha 2 beta 2 tetramer.
J.Biol.Chem., 298, 2022
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7VDT
 | | The motor-nucleosome module of human chromatin remodeling PBAF-nucleosome complex | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (207-MER), ... | | 著者 | Chen, Z.C, Chen, K.J, Yuan, J.J. | | 登録日 | 2021-09-07 | | 公開日 | 2022-05-18 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structure of human chromatin-remodelling PBAF complex bound to a nucleosome.
Nature, 605, 2022
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8T2U
 | | Cryo-EM Structures of Full-length Integrin alphaIIbbeta3 in Native Lipids complexed with Eptifibatide | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Adair, B, Xiong, J.P, Yeager, M, Arnaout, M.A. | | 登録日 | 2023-06-06 | | 公開日 | 2023-07-26 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Cryo-EM structures of full-length integrin alpha IIb beta 3 in native lipids.
Nat Commun, 14, 2023
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8T2V
 | | Cryo-EM Structures of Full-length Integrin alphaIIbbeta3 in Native Lipids | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Adair, B, Xiong, J.P, Yeager, M, Arnaout, M.A. | | 登録日 | 2023-06-06 | | 公開日 | 2023-07-26 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Cryo-EM structures of full-length integrin alpha IIb beta 3 in native lipids.
Nat Commun, 14, 2023
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6QI9
 | | Truncated human R2TP complex, structure 4 (ADP-empty) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2 | | 著者 | Munoz-Hernandez, H, Rodriguez, C.F, Llorca, O. | | 登録日 | 2019-01-18 | | 公開日 | 2019-05-15 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (4.63 Å) | | 主引用文献 | Structural mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cryo-EM.
Sci Adv, 5, 2019
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2NGR
 | | TRANSITION STATE COMPLEX FOR GTP HYDROLYSIS BY CDC42: COMPARISONS OF THE HIGH RESOLUTION STRUCTURES FOR CDC42 BOUND TO THE ACTIVE AND CATALYTICALLY COMPROMISED FORMS OF THE CDC42-GAP. | | 分子名称: | ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Nassar, N, Hoffman, G, Clardy, J, Cerione, R. | | 登録日 | 1998-07-31 | | 公開日 | 1999-01-06 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP.
Nat.Struct.Biol., 5, 1998
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1NTE
 | | CRYSTAL STRUCTURE ANALYSIS OF THE SECOND PDZ DOMAIN OF SYNTENIN | | 分子名称: | OXYGEN ATOM, Syntenin 1 | | 著者 | Kang, B.S, Cooper, D.R, Devedjiev, Y, Derewenda, U, Derewenda, Z.S. | | 登録日 | 2003-01-29 | | 公開日 | 2003-07-15 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | | 主引用文献 | Molecular roots of degenerate specificity in syntenin's PDZ2 domain: reassessment of the PDZ recognition paradigm.
Structure, 11, 2003
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1OBZ
 | | Crystal structure of the complex of the PDZ tandem of syntenin with an interleukin 5 receptor alpha peptide. | | 分子名称: | ACETATE ION, INTERLEUKIN 5 RECEPTOR ALPHA, SYNTENIN 1 | | 著者 | Kang, B.S, Cooper, D.R, Devedjiev, Y, Derewenda, U, Derewenda, Z.S. | | 登録日 | 2003-01-31 | | 公開日 | 2003-07-11 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Molecular Roots of Degenerate Specificity in Syntenin'S Pdz2 Domain: Reassessment of the Pdz Recognition Paradigm
Structure, 11, 2003
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1OBX
 | | Crystal structure of the complex of PDZ2 of syntenin with an interleukin 5 receptor alpha peptide. | | 分子名称: | COBALT (II) ION, INTERLEUKIN 5 RECEPTOR ALPHA, SULFATE ION, ... | | 著者 | Kang, B.S, Cooper, D.R, Devedjiev, Y, Derewenda, U, Derewenda, Z.S. | | 登録日 | 2003-01-31 | | 公開日 | 2003-07-10 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Molecular Roots of Degenerate Specificity in Syntenin'S Pdz2 Domain: Reassessment of the Pdz Recognition Paradigm
Structure, 11, 2003
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2KB0
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2NXQ
 | | Crystal structure of calcium binding protein 1 from Entamoeba histolytica: a novel arrangement of EF hand motifs | | 分子名称: | ACETATE ION, CALCIUM ION, Calcium-binding protein | | 著者 | Kumar, S, Padhan, N, Alam, N, Gourinath, S. | | 登録日 | 2006-11-18 | | 公開日 | 2007-08-21 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of calcium binding protein-1 from Entamoeba histolytica: A novel arrangement of EF hand motifs.
Proteins, 68, 2007
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4Q21
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2OYC
 | | Crystal structure of human pyridoxal phosphate phosphatase | | 分子名称: | Pyridoxal phosphate phosphatase, SODIUM ION, TUNGSTATE(VI)ION | | 著者 | Ramagopal, U.A, Freeman, J, Izuka, M, Toro, R, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | 登録日 | 2007-02-21 | | 公開日 | 2007-03-13 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Structural genomics of protein phosphatases.
J.Struct.Funct.Genom., 8, 2007
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2P69
 | | Crystal Structure of Human Pyridoxal Phosphate Phosphatase with PLP | | 分子名称: | CALCIUM ION, PYRIDOXAL-5'-PHOSPHATE, Pyridoxal phosphate phosphatase | | 著者 | Ramagopal, U.A, Freeman, J, Izuka, M, Toro, R, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | 登録日 | 2007-03-16 | | 公開日 | 2007-04-03 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structural genomics of protein phosphatases.
J.Struct.Funct.Genom., 8, 2007
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4QH7
 | | LC8 - Ana2 (159-168) Complex | | 分子名称: | Anastral spindle 2, Dynein light chain 1, cytoplasmic | | 著者 | Slevin, L.K, Romes, E.R, Slep, K.C. | | 登録日 | 2014-05-27 | | 公開日 | 2014-06-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.829 Å) | | 主引用文献 | The Mechanism of Dynein Light Chain LC8-mediated Oligomerization of the Ana2 Centriole Duplication Factor.
J.Biol.Chem., 289, 2014
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