PDB: 1183 件ウェブページステータス検索Chemie searchBIRD

---

5ZY8	Crystal structure of C terminal truncated HadBC (3R-Hydroxyacyl-ACP Dehydratase) complex from Mycobacterium tuberculosis 分子名称: 3-hydroxyacyl-ACP dehydratase, UPF0336 protein Rv0637 著者 Singh, B.K, Biswas, R, Bhattacharyya, S, Basak, A, Das, A.K. 登録日 2018-05-23 公開日 2019-06-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.899 Å) 主引用文献 The C-terminal end of mycobacterial HadBC regulates AcpM interaction during the FAS-II pathway: a structural perspective. Febs J., 2022
5FDQ	Murine COX-2 S530T mutant 分子名称: 2-[(2~{R})-2-(hydroxymethyloxy)propoxy]ethanol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Lucido, M.J, Orlando, B.J, Malkowski, M.G. 登録日 2015-12-16 公開日 2016-03-16 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry. Biochemistry, 55, 2016
3KXO	An orally active inhibitor bound at the active site of HPGDS 分子名称: 6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamide, GLUTATHIONE, Glutathione-requiring prostaglandin D synthase, ... 著者 Kiefer, J.R, Day, J.E, Thorarensen, A. 登録日 2009-12-03 公開日 2010-09-01 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery of an oral potent selective inhibitor of hematopoietic prostaglandin D synthase TO BE PUBLISHED
2N50	Novel Structural Components Contribute to the High Thermal Stability of Acyl Carrier Protein from Enterococcus faecalis 分子名称: Acyl carrier protein 著者 Park, Y, Jung, M, Song, H, Jeong, K, Kim, Y. 登録日 2015-07-02 公開日 2015-12-09 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Novel Structural Components Contribute to the High Thermal Stability of Acyl Carrier Protein from Enterococcus faecalis. J. Biol. Chem., 291, 2016
5F1A	The Crystal Structure of Salicylate Bound to Human Cyclooxygenase-2 分子名称: 1,2-ETHANEDIOL, 2-HYDROXYBENZOIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Lucido, M.J, Orlando, B.J, Malkowski, M.G. 登録日 2015-11-30 公開日 2016-03-16 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry. Biochemistry, 55, 2016
2PNO	Crystal structure of human leukotriene C4 synthase 分子名称: DODECYL-BETA-D-MALTOSIDE, GLUTATHIONE, Leukotriene C4 synthase 著者 Ago, H, Kanaoka, Y, Irikura, D, Lam, B.K, Shimamura, T, Austen, K.F, Miyano, M. 登録日 2007-04-24 公開日 2007-08-07 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis Nature, 448, 2007
3MWE	Truncated Human ATP-Citrate Lyase with Tartrate Bound 分子名称: ATP-citrate synthase, L(+)-TARTARIC ACID, MAGNESIUM ION 著者 Fraser, M.E, Sun, T. 登録日 2010-05-05 公開日 2010-06-16 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Identification of the citrate-binding site of human ATP-citrate lyase using X-ray crystallography. J.Biol.Chem., 285, 2010
8COU	Pa.FabF-C164Q in complex with 3-acetamido-4-methoxybenzoic acid 分子名称: 3-acetamido-4-methoxy-benzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, ... 著者 Georgiou, C, Brenk, R. 登録日 2023-02-28 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8COV	Pa.FabF-C164Q in complex with 6-chloro-2-methyl-1H-indole-5-carboxylic acid 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, 6-chloranyl-2-methyl-1~{H}-indole-5-carboxylic acid, DIMETHYL SULFOXIDE, ... 著者 Georgiou, C, Brenk, R, Espeland, L.O. 登録日 2023-02-28 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8CN4	Pa.FabF-C164Q in complex with 5-acetamido-2-chlorobenzoic acid 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, 5-acetamido-2-chloranyl-benzoic acid, DIMETHYL SULFOXIDE, ... 著者 Georgiou, C, Brenk, R. 登録日 2023-02-21 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
7EQI	ChlB3 [Aceyltransferase] 分子名称: ChlB3 著者 Saeed, A.U, Zheng, J. 登録日 2021-05-02 公開日 2021-06-09 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural Insight of KSIII ( beta-Ketoacyl-ACP Synthase)-like Acyltransferase ChlB3 in the Biosynthesis of Chlorothricin. Molecules, 27, 2022
8PFZ	Pseudomonas aeruginosa FabF C164A mutant in complex with(S)-2-(1H-pyrazole-3-carboxamido)butanoic acid 分子名称: (2~{S})-2-(1~{H}-pyrazol-3-ylcarbonylamino)butanoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2, CHLORIDE ION, ... 著者 Georgiou, C, Brenk, R, Yadrykhinsky, V, Espeland, L.O. 登録日 2023-06-17 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
7K73	Structure of Enoyl-[acyl-carrier-protein] reductase [NADH] from Mycobacterium fortuitum bound to NAD 分子名称: 1,2-ETHANEDIOL, ACETATE ION, Enoyl-[acyl-carrier-protein] reductase [NADH], ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2020-09-22 公開日 2020-10-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 In Vitro and In Vivo Efficacy of NITD-916 against Mycobacterium fortuitum. Antimicrob.Agents Chemother., 2023
4KRC	Crystal Structure of Pho85-Pcl10-ATP-gamma-S Complex 分子名称: Cyclin-dependent protein kinase PHO85, MAGNESIUM ION, PHO85 cyclin-10, ... 著者 Quiocho, F.A, Zheng, F. 登録日 2013-05-16 公開日 2013-09-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.597 Å) 主引用文献 New Structural Insights into Phosphorylation-free Mechanism for Full Cyclin-dependent Kinase (CDK)-Cyclin Activity and Substrate Recognition. J.Biol.Chem., 288, 2013
2E4J	Solution Structure of mouse Lipocalin-type Prostaglandin D Synthase 分子名称: Prostaglandin-H2 D-isomerase 著者 Shimamoto, S, Ohkubo, T. 登録日 2006-12-11 公開日 2007-08-21 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution Structure of mouse Lipocalin-type Prostaglandin D Synthase to be published
4CL6	Crystal Structure of 3-hydroxydecanoyl-Acyl Carrier Protein Dehydratase (FabA) from Pseudomonas aeruginosa in complex with N-(4- Chlorobenzyl)-3-(2-furyl)-1H-1,2,4-triazol-5-amine 分子名称: 3-HYDROXYDECANOYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE, N-(4-chlorobenzyl)-5-(furan-2-yl)-1H-1,2,4-triazol-3-amine 著者 Moynie, L, McMahon, S.A, Duthie, F.G, Naismith, J.H. 登録日 2014-01-13 公開日 2015-01-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 A Substrate Mimic Allows High Throughput Assay of the Faba Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas Aeruginosa Faba. J.Mol.Biol., 428, 2016
5OJO	Sirtuin 5 from Danio rerio in complex with 3-hydroxy-3-methylglutaryl-CPS1 peptide 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Carbamoyl-phosphate synthase [ammonia], ... 著者 Pannek, M, Steegborn, C. 登録日 2017-07-22 公開日 2017-11-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features. Nat Commun, 8, 2017
1KLP	The Solution Structure of Acyl Carrier Protein from Mycobacterium tuberculosis 分子名称: MEROMYCOLATE EXTENSION ACYL CARRIER PROTEIN 著者 Wong, H.C, Liu, G, Zhang, Y.-M, Rock, C.O, Zheng, J. 登録日 2001-12-12 公開日 2002-06-07 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 The solution structure of acyl carrier protein from Mycobacterium tuberculosis. J.Biol.Chem., 277, 2002
3Q7D	Structure of (R)-naproxen bound to mCOX-2. 分子名称: (2R)-2-(6-methoxynaphthalen-2-yl)propanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... 著者 Duggan, K.C, Hermanson, D.J, Musee, J, Prusakiewicz, J.J, Scheib, J, Carter, B.D, Banerjee, S, Marnett, L.J. 登録日 2011-01-04 公開日 2011-11-09 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 (R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2. Nat.Chem.Biol., 7, 2011
4EFI	Crystal Structure of 3-oxoacyl-(Acyl-carrier protein) Synthase from Burkholderia Xenovorans LB400 分子名称: 3-oxoacyl-(Acyl-carrier protein) synthase, CHLORIDE ION, FORMIC ACID, ... 著者 Seattle Structural Genomics Center for Infectious Disease, Craig, T.K, Abendroth, J, Staker, B, Stewart, L, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2012-03-29 公開日 2012-04-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One, 8, 2013
3RR3	Structure of (R)-flurbiprofen bound to mCOX-2 分子名称: (2R)-2-(3-fluoro-4-phenyl-phenyl)propanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Duggan, K.C, Hermanson, D.J, Musee, J, Prusakiewicz, J.J, Scheib, J, Carter, B.D, Banerjee, S, Oates, J.A, Marnett, L.J. 登録日 2011-04-28 公開日 2011-11-09 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.842 Å) 主引用文献 (R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2. Nat.Chem.Biol., 7, 2011
3MDL	X-ray crystal structure of 1-arachidonoyl glycerol bound to the cyclooxygenase channel of cyclooxygenase-2 分子名称: (2S)-2,3-dihydroxypropyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Vecchio, A.J, Malkowski, M.G. 登録日 2010-03-30 公開日 2011-04-13 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The structural basis of endocannabinoid oxygenation by cyclooxygenase-2. J.Biol.Chem., 286, 2011
2Z6I	Crystal Structure of S. pneumoniae Enoyl-Acyl Carrier Protein Reductase (FabK) 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, FLAVIN MONONUCLEOTIDE, ... 著者 Saito, J, Yamada, M, Watanabe, T, Takeuchi, Y. 登録日 2007-08-01 公開日 2008-04-01 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of enoyl-acyl carrier protein reductase (FabK) from Streptococcus pneumoniae reveals the binding mode of an inhibitor. Protein Sci., 17, 2008
5USR	Crystal structure of human NFS1-ISD11 in complex with E. coli acyl-carrier protein at 3.09 angstroms 分子名称: Acyl carrier protein, Cysteine desulfurase, mitochondrial, ... 著者 Cory, S.A, Barondeau, D.P. 登録日 2017-02-13 公開日 2017-06-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3.09 Å) 主引用文献 Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6ET2	Crystal structure of PqsBC (C129A) mutant from Pseudomonas aeruginosa (crystal form 3) 分子名称: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, PqsB, PqsC 著者 Witzgall, F, Blankenfeldt, W. 登録日 2017-10-25 公開日 2018-07-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The Alkylquinolone Repertoire of Pseudomonas aeruginosa is Linked to Structural Flexibility of the FabH-like 2-Heptyl-3-hydroxy-4(1H)-quinolone (PQS) Biosynthesis Enzyme PqsBC. Chembiochem, 19, 2018

<22232425262728293031323334353637>