PDB: 10619 件ウェブページステータス検索Chemie searchBIRD

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8QDY	Crystal structure of human MAT2a bound to S-Adenosylmethionine and Compound 8 分子名称: 3-cyclopropyl-4-(4-methoxyphenyl)-1~{H}-pyrazolo[4,3-c]pyridine, S-ADENOSYLMETHIONINE, S-adenosylmethionine synthase isoform type-2 著者 Schimpl, M. 登録日 2023-08-30 公開日 2024-03-20 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (1.19 Å) 主引用文献 Development of a Series of Pyrrolopyridone MAT2A Inhibitors. J.Med.Chem., 67, 2024
8PV2	Chaetomium thermophilum pre-60S State 10 - pre-5S rotation with Ytm1-Erb1 分子名称: 26S rRNA, 5.8S rRNA, 5S rRNA, ... 著者 Thoms, M, Cheng, J, Denk, T, Berninghausen, O, Beckmann, R. 登録日 2023-07-17 公開日 2023-11-15 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (2.63 Å) 主引用文献 Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation. Embo Rep., 24, 2023
8PUW	Chaetomium thermophilum Las1-Grc3-complex 分子名称: Las1, Polynucleotide 5'-hydroxyl-kinase GRC3 著者 Thoms, M, Cheng, J, Denk, T, Berninghausen, O, Beckmann, R. 登録日 2023-07-17 公開日 2023-11-15 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.01 Å) 主引用文献 Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation. Embo Rep., 24, 2023
8PV3	Chaetomium thermophilum pre-60S State 9 - pre-5S rotation - immature H68/H69 - composite structure 分子名称: 26S rRNA, 5.8S rRNA, 5S rRNA, ... 著者 Thoms, M, Cheng, J, Denk, T, Berninghausen, O, Beckmann, R. 登録日 2023-07-17 公開日 2023-11-15 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation. Embo Rep., 24, 2023
8PTW	Chaetomium thermophilum Rix1-complex 分子名称: Pre-rRNA-processing protein IPI3, Pre-rRNA-processing protein RIX1 著者 Thoms, M, Cheng, J, Denk, T, Berninghausen, O, Beckmann, R. 登録日 2023-07-15 公開日 2023-11-15 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (2.91 Å) 主引用文献 Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation. Embo Rep., 24, 2023
8PV7	Chaetomium thermophilum pre-60S State 1 - pre-5S rotation (Arx1/Nog2 state) - Composite structure 分子名称: 26S rRNA, 5.8S rRNA, 5S rRNA, ... 著者 Thoms, M, Cheng, J, Denk, T, Berninghausen, O, Beckmann, R. 登録日 2023-07-17 公開日 2023-11-15 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (2.12 Å) 主引用文献 Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation. Embo Rep., 24, 2023
8PV1	Chaetomium thermophilum pre-60S State 6 - pre-5S rotation - L1 intermediate - composite structure 分子名称: 26S rRNA, 5.8S rRNA, 5S rRNA, ... 著者 Thoms, M, Cheng, J, Denk, T, Berninghausen, O, Beckmann, R. 登録日 2023-07-17 公開日 2023-11-15 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (2.56 Å) 主引用文献 Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation. Embo Rep., 24, 2023
8PV4	Chaetomium thermophilum pre-60S State 2 - pre-5S rotation with Rix1 complex - composite structure 分子名称: 26S rRNA, 5.8S rRNA, 5S rRNA, ... 著者 Thoms, M, Cheng, J, Denk, T, Berninghausen, O, Beckmann, R. 登録日 2023-07-17 公開日 2023-11-15 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation. Embo Rep., 24, 2023
8PV5	Chaetomium thermophilum pre-60S State 8 - pre-5S rotation without Foot - composite structure 分子名称: 26S rRNA, 5.8S rRNA, 5S rRNA, ... 著者 Thoms, M, Cheng, J, Denk, T, Berninghausen, O, Beckmann, R. 登録日 2023-07-17 公開日 2023-11-15 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (2.86 Å) 主引用文献 Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation. Embo Rep., 24, 2023
8PV6	Chaetomium thermophilum pre-60S State 3 - post-5S rotation with Rix1 complex with Foot - composite structure 分子名称: 26S rRNA, 5.8S rRNA, 5S rRNA, ... 著者 Thoms, M, Cheng, J, Denk, T, Berninghausen, O, Beckmann, R. 登録日 2023-07-17 公開日 2023-11-15 最終更新日 2023-12-20 実験手法 ELECTRON MICROSCOPY (2.94 Å) 主引用文献 Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation. Embo Rep., 24, 2023
8OUU	Crystal structure of D1228V c-MET bound by compound 29 分子名称: 1,2-ETHANEDIOL, 5-(3-ethynyl-5-fluoranyl-1H-indazol-7-yl)-1-[(1S)-1-phenylethyl]pyrimidine-2,4-dione, FORMIC ACID, ... 著者 Collie, G.W. 登録日 2023-04-24 公開日 2023-07-05 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor. J.Med.Chem., 66, 2023
8OUV	Crystal structure of D1228V c-MET bound by compound 15 分子名称: 5-(1H-indazol-7-yl)-1-[(1S)-1-phenylethyl]pyrimidine-2,4-dione, CHLORIDE ION, Hepatocyte growth factor receptor 著者 Collie, G.W. 登録日 2023-04-24 公開日 2023-07-05 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.783 Å) 主引用文献 Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor. J.Med.Chem., 66, 2023
8OVZ	Crystal structure of D1228V c-MET bound by compound 16 分子名称: 1-[(1S)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl]-5-(1H-indazol-7-yl)pyrimidine-2,4-dione, Hepatocyte growth factor receptor, IODIDE ION 著者 Collie, G.W. 登録日 2023-04-26 公開日 2023-07-05 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.206 Å) 主引用文献 Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor. J.Med.Chem., 66, 2023
8OW3	Crystal structure of wild-type c-MET bound by compound 2 分子名称: 5-[3,5-bis(fluoranyl)phenyl]-1-[(1S)-1-phenylethyl]pyrimidine-2,4-dione, Hepatocyte growth factor receptor 著者 Collie, G.W. 登録日 2023-04-26 公開日 2023-07-05 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor. J.Med.Chem., 66, 2023
8OV7	Crystal structure of D1228V c-MET bound by compound 10 分子名称: 5-[3,5-bis(fluoranyl)phenyl]-1-[(1S)-1-[3-(1H-imidazol-5-yl)phenyl]ethyl]pyrimidine-2,4-dione, Hepatocyte growth factor receptor 著者 Collie, G.W. 登録日 2023-04-25 公開日 2023-07-05 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor. J.Med.Chem., 66, 2023
8OOG	Crystal structure of human MAT2a with S-Adenosylmethionine and a fragment bound in a novel pocket 分子名称: 6-oxidanyl-1,3-benzoxathiol-2-one, DIMETHYL SULFOXIDE, S-ADENOSYLMETHIONINE, ... 著者 Schimpl, M. 登録日 2023-04-05 公開日 2023-07-12 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.384 Å) 主引用文献 Combining structural and coevolution information to unveil allosteric sites. Chem Sci, 14, 2023
8QE0	Crystal structure of human MAT2a bound to S-Adenosylmethionine and Compound 12 分子名称: 4-[4-[bis(fluoranyl)methoxy]phenyl]-3-cyclopropyl-2~{H}-pyrazolo[4,3-b]pyridin-5-one, S-ADENOSYLMETHIONINE, S-adenosylmethionine synthase isoform type-2 著者 Schimpl, M. 登録日 2023-08-30 公開日 2024-03-20 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (1.12 Å) 主引用文献 Development of a Series of Pyrrolopyridone MAT2A Inhibitors. J.Med.Chem., 67, 2024
8QE2	Crystal structure of human MAT2a bound to S-Adenosylmethionine and Compound 21 分子名称: 4-[4-[bis(fluoranyl)methoxy]phenyl]-3-cyclopropyl-6-(2-methylindazol-5-yl)-2~{H}-pyrazolo[4,3-b]pyridin-5-one, S-ADENOSYLMETHIONINE, S-adenosylmethionine synthase isoform type-2 著者 Schimpl, M. 登録日 2023-08-30 公開日 2024-03-20 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (1.109 Å) 主引用文献 Development of a Series of Pyrrolopyridone MAT2A Inhibitors. J.Med.Chem., 67, 2024
8QE3	Crystal structure of human MAT2a bound to S-Adenosylmethionine and Compound 31 分子名称: 3-cyclopropyl-6-(2-methylindazol-5-yl)-4-(6-methylpyridin-3-yl)-2~{H}-pyrazolo[4,3-b]pyridin-5-one, S-ADENOSYLMETHIONINE, S-adenosylmethionine synthase isoform type-2 著者 Schimpl, M. 登録日 2023-08-30 公開日 2024-03-20 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (1.089 Å) 主引用文献 Development of a Series of Pyrrolopyridone MAT2A Inhibitors. J.Med.Chem., 67, 2024
8QE1	Crystal structure of human MAT2a bound to S-Adenosylmethionine and Compound 15 分子名称: 4-[4-[bis(fluoranyl)methoxy]phenyl]-3-cyclopropyl-6-(4-methoxyphenyl)-2~{H}-pyrazolo[4,3-b]pyridin-5-one, S-ADENOSYLMETHIONINE, S-adenosylmethionine synthase isoform type-2 著者 Schimpl, M. 登録日 2023-08-30 公開日 2024-03-20 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (1.095 Å) 主引用文献 Development of a Series of Pyrrolopyridone MAT2A Inhibitors. J.Med.Chem., 67, 2024
8QDZ	Crystal structure of human MAT2a bound to S-Adenosylmethionine and Compound 11 分子名称: 3-cyclopropyl-4-(4-methoxyphenyl)-5-oxidanyl-pyrazolo[4,3-c]pyridine, S-ADENOSYLMETHIONINE, S-adenosylmethionine synthase isoform type-2 著者 Schimpl, M. 登録日 2023-08-30 公開日 2024-03-20 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (1.16 Å) 主引用文献 Development of a Series of Pyrrolopyridone MAT2A Inhibitors. J.Med.Chem., 67, 2024
8ROX	Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to compound furan 12 分子名称: 5-[[3,4-bis(chloranyl)-1~{H}-indol-7-yl]sulfamoyl]-~{N},~{N},3-trimethyl-furan-2-carboxamide;ethane, DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, ... 著者 Shilliday, F, Lucas, S.C.C, Richter, M, Michaelides, I.N, Fusani, L. 登録日 2024-01-12 公開日 2024-04-03 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders. J.Med.Chem., 67, 2024
8R4V	Structure of Salt-inducible kinase 3 in complex with inhibitor 分子名称: 1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-[6-[[4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]urea, Serine/threonine-protein kinase SIK3 著者 Kack, H, Oster, L. 登録日 2023-11-14 公開日 2024-03-27 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The structures of salt-inducible kinase 3 in complex with inhibitors reveal determinants for binding and selectivity. J.Biol.Chem., 300, 2024
8PO0	Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 12 bound to EGFRinsNPG 分子名称: 1-[3-[7-methoxy-4-[3-(3-methoxyphenyl)-1~{H}-pyrazol-4-yl]quinazolin-6-yl]oxyazetidin-1-yl]propan-1-one, Epidermal growth factor receptor 著者 Hargreaves, D. 登録日 2023-07-03 公開日 2024-06-05 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.523 Å) 主引用文献 Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J.Med.Chem., 67, 2024
8PO1	Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 22 bound to EGFRinsNPG [V948R] 分子名称: 2-methyl-5-[[3-[1-[(3~{S},5~{R})-5-methyl-1-propanoyl-pyrrolidin-3-yl]-4-pyridin-4-yl-pyrazol-3-yl]phenoxy]methyl]-3~{H}-isoindol-1-one, Epidermal growth factor receptor, IODIDE ION 著者 Hargreaves, D. 登録日 2023-07-03 公開日 2024-06-05 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J.Med.Chem., 67, 2024

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