PDB: 1334 件ウェブページステータス検索Chemie searchBIRD

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4DZ7	hCA II in complex with novel sulfonamide inhibitors Set D 分子名称: Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ZINC ION, ... 著者 Aggarwal, M, McKenna, R. 登録日 2012-02-29 公開日 2013-03-27 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.491 Å) 主引用文献 hCA II in complex with novel sulfonamide inhibitors Set D To be Published
4FRC	Carbonic Anhydrase II in complex with N'-sulfamoylpyrrolidine-1-carboximidamide 分子名称: Carbonic anhydrase 2, DIMETHYL SULFOXIDE, MERCURIBENZOIC ACID, ... 著者 Di Pizio, A, Heine, A, Klebe, G. 登録日 2012-06-26 公開日 2013-07-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (0.98 Å) 主引用文献 High resolution crystal structures of Carbonic Anhydrase II in complex with novel sulfamide binders To be Published
1ZGF	carbonic anhydrase II in complex with trichloromethiazide as sulfonamide inhibitor 分子名称: (4-CARBOXYPHENYL)(CHLORO)MERCURY, 6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE, Carbonic anhydrase II, ... 著者 Honndorf, V.S, Heine, A, Klebe, G, Supuran, C.T. 登録日 2005-04-21 公開日 2006-05-23 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 carbonic anhydrase II in complex with trichloromethiazide as sulfonamide inhibitor To be Published
4GL1	Structure of H64A/N62L/N67L Human Carbonic Anhydrase II triple mutant 分子名称: Carbonic anhydrase 2, ZINC ION 著者 West, D.M. 登録日 2012-08-13 公開日 2013-09-04 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Hydrophobicity and low pKa impact catalytic efficiency of Human Carbonic Anhydrases To be Published
4E49	Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors 分子名称: Carbonic anhydrase 2, MERCURIBENZOIC ACID, RESORCINOL, ... 著者 Cohen, S.M, Martin, D.P. 登録日 2012-03-12 公開日 2012-06-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors Chem.Commun.(Camb.), 48, 2012
4E5Q	Human Carbonic Anhydrase II in complex with cyanate 分子名称: Carbonic anhydrase 2, ZINC ION, cyanic acid 著者 West, D, McKenna, R. 登録日 2012-03-14 公開日 2013-03-27 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.7024 Å) 主引用文献 Human carbonic anhydrase II-cyanate inhibitor complex: putting the debate to rest. Acta Crystallogr F Struct Biol Commun, 70, 2014
1YDB	STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II 分子名称: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... 著者 Nair, S.K, Christianson, D.W. 登録日 1994-12-22 公開日 1995-02-14 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural basis of inhibitor affinity to variants of human carbonic anhydrase II. Biochemistry, 34, 1995
4FIK	Human carbonic anhydrase II H64A complexed with thioxolone hydrolysis products 分子名称: 2,4-dihydroxybenzenesulfenic acid, 4,4'-disulfanediyldibenzene-1,3-diol, 4-MERCAPTOBENZENE-1,3-DIOL, ... 著者 Sippel, K.H, Genis, C, Govindasamy, L, Agbandje-McKenna, M, Tripp, B.C, McKenna, R. 登録日 2012-06-08 公開日 2012-06-27 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Synchrotron Radiation Provides a Plausible Explanation for the Generation of a Free Radical Adduct of Thioxolone in Mutant Carbonic Anhydrase II. J Phys Chem Lett, 1, 2010
4E4A	Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors 分子名称: 2-sulfanylbenzoic acid, Carbonic anhydrase 2, MERCURIBENZOIC ACID, ... 著者 Cohen, S.M, Martin, D.P. 登録日 2012-03-12 公開日 2012-06-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors Chem.Commun.(Camb.), 48, 2012
1ZSA	CARBONIC ANHYDRASE II MUTANT E117Q, APO FORM 分子名称: CARBONIC ANHYDRASE II 著者 Lesburg, C.A, Christianson, D.W. 登録日 1996-01-09 公開日 1996-07-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II. Biochemistry, 35, 1996
1ZSB	CARBONIC ANHYDRASE II MUTANT E117Q, TRANSITION STATE ANALOGUE ACETAZOLAMIDE 分子名称: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, CARBONIC ANHYDRASE II, ZINC ION 著者 Lesburg, C.A, Christianson, D.W. 登録日 1996-01-09 公開日 1996-07-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II. Biochemistry, 35, 1996
1ZSC	CARBONIC ANHYDRASE II MUTANT E117Q, HOLO FORM 分子名称: CARBONIC ANHYDRASE II, ZINC ION 著者 Lesburg, C.A, Christianson, D.W. 登録日 1996-01-09 公開日 1996-07-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II. Biochemistry, 35, 1996
4HEY	Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure 分子名称: 4-METHYLIMIDAZOLE, Carbonic anhydrase 2, ZINC ION 著者 Aggarwal, M, McKenna, R. 登録日 2012-10-04 公開日 2013-10-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles. IUCrJ, 1, 2014
4HEW	Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure 分子名称: 2-METHYLIMIDAZOLE, Carbonic anhydrase 2, ZINC ION 著者 Aggarwal, M, McKenna, R. 登録日 2012-10-04 公開日 2013-10-23 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.6984 Å) 主引用文献 Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles. IUCrJ, 1, 2014
4HBA	Structural and Catalytic Characterization of a Thermal and Acid Stable Variant of Human Carbonic Anhydrase II Containing an Engineered Disulfide Bond 分子名称: Carbonic anhydrase 2, GLYCEROL, ZINC ION 著者 Boone, C.D, Habibzadegan, A, McKenna, R. 登録日 2012-09-27 公開日 2013-07-31 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.762 Å) 主引用文献 Structural and catalytic characterization of a thermally stable and acid-stable variant of human carbonic anhydrase II containing an engineered disulfide bond. Acta Crystallogr.,Sect.D, 69, 2013
4ETQ	Vaccinia virus D8L IMV envelope protein in complex with Fab of murine IgG2a LA5 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ... 著者 Matho, M.H, Zajonc, D.M. 登録日 2012-04-24 公開日 2012-06-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural and Biochemical Characterization of the Vaccinia Virus Envelope Protein D8 and Its Recognition by the Antibody LA5. J.Virol., 86, 2012
2AW1	Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor Celecoxib 分子名称: 4-(5-METHYL-3-PHENYLISOXAZOL-4-YL)BENZENESULFONAMIDE, 4-(HYDROXYMERCURY)BENZOIC ACID, Carbonic anhydrase II, ... 著者 Di Fiore, A, Pedone, C, D'Ambrosio, K, Scozzafava, A, De Simone, G, Supuran, C.T. 登録日 2005-08-31 公開日 2006-07-04 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II Bioorg.Med.Chem.Lett., 16, 2006
4FL7	The crystal structure of human carbonic anhydrase II in complex with N-(Hydroxy)-benzamide 分子名称: BENZHYDROXAMIC ACID, Carbonic anhydrase 2, GLYCEROL, ... 著者 Di Fiore, A, De Simone, G. 登録日 2012-06-14 公開日 2012-08-15 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors. Chem.Commun.(Camb.), 48, 2012
4FPT	Carbonic Anhydrase II in complex with ethyl (2Z,4R)-2-(sulfamoylimino)-1,3-thiazolidine-4-carboxylate 分子名称: Carbonic anhydrase 2, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Di Pizio, A, Heine, A, Klebe, G. 登録日 2012-06-22 公開日 2013-07-03 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (0.98 Å) 主引用文献 High resolution crystal structures of Carbonic Anhydrase II in complex with novel sulfamide binders To be Published
4HF3	Activity Enhancers of H64A Variant of Human Carbonic Anhydrase II Possess Multiple Binding Sites within and around the Enzyme Structure 分子名称: Carbonic anhydrase 2, IMIDAZOLE, ZINC ION 著者 Aggarwal, M, McKenna, R. 登録日 2012-10-04 公開日 2013-10-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.1476 Å) 主引用文献 Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles. IUCrJ, 1, 2014
1ZNC	HUMAN CARBONIC ANHYDRASE IV 分子名称: CARBONIC ANHYDRASE IV, SULFATE ION, ZINC ION 著者 Stams, T, Christianson, D.W. 登録日 1996-09-17 公開日 1997-09-17 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A resolution. Proc.Natl.Acad.Sci.USA, 93, 1996
1ZFQ	carbonic anhydrase II in complex with ethoxzolamidphenole as sulfonamide inhibitor 分子名称: (4-CARBOXYPHENYL)(CHLORO)MERCURY, 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE, Carbonic anhydrase II, ... 著者 Honndorf, V.S, Heine, A, Klebe, G, Supuran, C.T. 登録日 2005-04-20 公開日 2006-05-23 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 carbonic anhydrase II in complex with ethoxzolamidphenole as sulfonamide inhibitor To be Published
4E9O	Vaccinia D8L ectodomain structure 分子名称: IMV membrane protein, IODIDE ION 著者 Matho, M.H, Zajonc, D.M. 登録日 2012-03-21 公開日 2012-06-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Structural and Biochemical Characterization of the Vaccinia Virus Envelope Protein D8 and Its Recognition by the Antibody LA5. J.Virol., 86, 2012
1Z97	Human Carbonic Anhydrase III: Structural and Kinetic Study of Catalysis and Proton Transfer. 分子名称: Carbonic anhydrase III, ZINC ION 著者 Duda, D.M, Tu, C, Fisher, S.Z, An, H, Yoshioka, C, Govindasamy, L, Laipis, P.J, Agbandje-McKenna, M, Silverman, D.N, McKenna, R. 登録日 2005-03-31 公開日 2005-08-09 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Human Carbonic Anhydrase III: Structural and Kinetic Study of Catalysis and Proton Transfer Biochemistry, 44, 2005
1ZFK	carbonic anhydrase II in complex with N-4-sulfonamidphenyl-N'-4-methylbenzosulfonylurease as sulfonamide inhibitor 分子名称: (4-CARBOXYPHENYL)(CHLORO)MERCURY, Carbonic anhydrase II, GLYCEROL, ... 著者 Honndorf, V.S, Heine, A, Klebe, G, Supuran, C.T. 登録日 2005-04-20 公開日 2006-05-23 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 carbonic anhydrase II in complex with N-4-sulfonamidphenyl-N'-4-methylbenzosulfonylurease as sulfonamide inhibitor To be Published

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