PDB: 219886 件ウェブページステータス検索Chemie searchBIRD

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6VL6	De novo designed tetrahedral nanoparticle T33_dn2 presenting BG505 SOSIP trimers 分子名称: T33_dn2A, T33_dn2B 著者 Ward, A.B, Antanasijevic, A. 登録日 2020-01-22 公開日 2020-08-12 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations. NPJ Vaccines, 5, 2020
4ZT4	Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitorN-(3,5-dichlorobenzyl)-2,2-difluoro-N'-(1H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine (Chem 1708) 分子名称: DIMETHYL SULFOXIDE, GLYCEROL, METHIONINE, ... 著者 Koh, C.-Y, Hol, W.G.J. 登録日 2015-05-14 公開日 2016-05-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors. Acs Infect Dis., 2, 2016
5DLX	FIRST DOMAIN OF HUMAN BROMODOMAIN BRD4 IN COMPLEX WITH INHIBITOR N-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-1-{3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl}piperidine-4-carboxamide 分子名称: Bromodomain-containing protein 4, N-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-1-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidine-4-carboxamide 著者 Raux, B, Rebuffet, E, Betzi, S, Morelli, X. 登録日 2015-09-07 公開日 2016-06-01 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Protein-Protein Interaction Inhibition (2P2I)-Oriented Chemical Library Accelerates Hit Discovery. Acs Chem.Biol., 11, 2016
3I0C	Crystal structure of GTB C80S/C196S unliganded 分子名称: ABO glycosyltransferase 著者 Schuman, B, Persson, M, Landry, R.C, Polakowski, R, Weadge, J.T, Seto, N.O.L, Borisova, S, Palcic, M.M, Evans, S.V. 登録日 2009-06-25 公開日 2010-08-11 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Cysteine-to-serine mutants dramatically reorder the active site of human ABO(H) blood group B glycosyltransferase without affecting activity: structural insights into cooperative substrate binding J.Mol.Biol., 402, 2010
3I0H	Crystal structure of GTB C80S/C196S/C209S unliganded 分子名称: ABO glycosyltransferase 著者 Schuman, B, Persson, M, Landry, R.C, Polakowski, R, Weadge, J.T, Seto, N.O.L, Borisova, S, Palcic, M.M, Evans, S.V. 登録日 2009-06-25 公開日 2010-08-11 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Cysteine-to-serine mutants dramatically reorder the active site of human ABO(H) blood group B glycosyltransferase without affecting activity: structural insights into cooperative substrate binding J.Mol.Biol., 402, 2010
5F7T	TRIM5 B-box2 and coiled-coil chimera 分子名称: Tripartite motif-containing protein 5,Serine--tRNA ligase,Tripartite motif-containing protein 5, ZINC ION 著者 Wagner, J.M, Doss, G, Pornillos, O. 登録日 2015-12-08 公開日 2016-06-15 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.292 Å) 主引用文献 Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5 alpha. Elife, 5, 2016
5TU9	Crystal structure of Staphylococcus epidermidis Aap G58-spacer-G513 (variant G5-spacer-consensus G5) 分子名称: Accumulation associated protein Aap G58-spacer-G513 (variant G5-spacer-consensus G5) 著者 Shelton, C.L, Conrady, D.G, Herr, A.B. 登録日 2016-11-05 公開日 2016-12-21 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Functional consequences of B-repeat sequence variation in the staphylococcal biofilm protein Aap: deciphering the assembly code. Biochem. J., 474, 2017
5DD3	Crystal structures in an anti-HIV antibody lineage from immunization of Rhesus macaques 分子名称: ANTI-HIV ANTIBODY DH570.4 FAB HEAVY CHAIN, ANTI-HIV ANTIBODY DH570.4 FAB LIGHT CHAIN 著者 Nicely, N.I, Pemble IV, C.W, Haynes, B.F. 登録日 2015-08-24 公開日 2016-05-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.797 Å) 主引用文献 Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages. Sci Transl Med, 8, 2016
3OIF	Crystal Structure of Enoyl-ACP Reductases I (FabI) from B. subtilis (complex with NAD and TCL) 分子名称: Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRICLOSAN 著者 Kim, K.-H, Ha, B.H, Kim, S.J, Hong, S.K, Hwang, K.Y, Kim, E.E. 登録日 2010-08-19 公開日 2011-01-05 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structures of Enoyl-ACP Reductases I (FabI) and III (FabL) from B. subtilis J.Mol.Biol., 406, 2011
5DD5	Crystal structures in an anti-HIV antibody lineage from immunization of Rhesus macaques 分子名称: ANTI-HIV ANTIBODY DH570.9 FAB HEAVY CHAIN 著者 Nicely, N.I, Pemble IV, C.W, Haynes, B.F. 登録日 2015-08-24 公開日 2016-05-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages. Sci Transl Med, 8, 2016
5V5M	Crystal structure of HLA-B*5701 complex with HIV-1 gag derived peptide TW10 分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, B-57 alpha chain, ... 著者 Li, X, Wang, J.-H. 登録日 2017-03-14 公開日 2017-06-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.878 Å) 主引用文献 Crystal structure of HLA-B*5801 with a TW10 HIV Gag epitope reveals a novel mode of peptide presentation. Cell. Mol. Immunol., 14, 2017
6TH4	Tubulin-inhibitor complex 分子名称: 1,2,3,9-tetramethoxy-6-methylidene-5~{H}-cyclohepta[a]naphthalen-8-one, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Varela, P.F, Gigant, B. 登録日 2019-11-18 公開日 2021-12-01 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.121 Å) 主引用文献 B-nor-methylene Colchicinoid PT-100 Selectively Induces Apoptosis in Multidrug-Resistant Human Cancer Cells via an Intrinsic Pathway in a Caspase-Independent Manner Acs Omega, 7, 2022
5V5L	Crystal structure of HLA-B*5801 complex with HIV-1 gag derived peptide TW10 分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, B-58 alpha chain, ... 著者 Li, X, Wang, J.-H. 登録日 2017-03-14 公開日 2017-06-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.002 Å) 主引用文献 Crystal structure of HLA-B*5801 with a TW10 HIV Gag epitope reveals a novel mode of peptide presentation. Cell. Mol. Immunol., 14, 2017
5TU8	Crystal structure of Staphylococcus epidermidis Aap G58-spacer-G513* (variant G5-spacer-variant G5) 分子名称: Aap G58-spacer-G513* (variant G5-spacer-variant G5) 著者 Shelton, C.L, Conrady, D.G, Herr, A.B. 登録日 2016-11-05 公開日 2016-12-21 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Functional consequences of B-repeat sequence variation in the staphylococcal biofilm protein Aap: deciphering the assembly code. Biochem. J., 474, 2017
2L4M	Solution structure of the Zbeta domain of human DAI and its binding modes to B- and Z-DNA 分子名称: Uncharacterized protein 著者 Kim, K, Khayrutdinov, B.I, Jeon, Y.H, Kim, K.K. 登録日 2010-10-08 公開日 2011-04-13 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Solution structure of the Zbeta domain of human DNA-dependent activator of IFN-regulatory factors and its binding modes to B- and Z-DNA Proc.Natl.Acad.Sci.USA, 2011
3I0L	Crystal structure of GTB C80S/C196S/C209S + DA + UDP-Gal 分子名称: ABO glycosyltransferase, URIDINE-5'-DIPHOSPHATE, alpha-L-fucopyranose-(1-2)-hexyl beta-D-galactopyranoside, ... 著者 Schuman, B, Persson, M, Landry, R.C, Polakowski, R, Weadge, J.T, Seto, N.O.L, Borisova, S, Palcic, M.M, Evans, S.V. 登録日 2009-06-25 公開日 2010-08-11 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Cysteine-to-serine mutants dramatically reorder the active site of human ABO(H) blood group B glycosyltransferase without affecting activity: structural insights into cooperative substrate binding J.Mol.Biol., 402, 2010
4ZT6	Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor N-[(4R)-6,8-dichloro-3,4-dihydro-2H-chromen-4-yl]-N'-(5-fluoro-1H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine (Chem 1709) 分子名称: DIMETHYL SULFOXIDE, METHIONINE, Methionyl-tRNA synthetase, ... 著者 Koh, C.-Y, Hol, W.G.J. 登録日 2015-05-14 公開日 2016-05-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors. Acs Infect Dis., 2, 2016
4N5H	Crystal structure of ESTERASE B from Lactobacillus Rhamnosis (HN001) 分子名称: CALCIUM ION, CHLORIDE ION, Esterase/lipase, ... 著者 Bennett, M.D, Holland, R, Loo, T.S, Smith, C.A, Norris, G.E, Delabre, M.-L, Anderson, B.F. 登録日 2013-10-09 公開日 2014-10-15 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Crystal structure of ESTERASE B from Lactobacillus Rhamnosis (HN001) TO BE PUBLISHED
3RLL	Crystal structure of the T877A androgen receptor ligand binding domain in complex with (S)-N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanonaphthalen-1-yloxy)-2-hydroxy-2-methylpropanamide 分子名称: (2S)-3-[(4-cyanonaphthalen-1-yl)oxy]-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide, Androgen receptor 著者 Bohl, C.E, Duke, C.B, Jones, A, Dalton, J.T, Miller, D.D. 登録日 2011-04-19 公開日 2011-05-04 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Unexpected binding orientation of bulky-B-ring anti-androgens and implications for future drug targets. J.Med.Chem., 54, 2011
3RLJ	Crystal structure of the androgen receptor ligand binding domain in complex with SARM S-22 分子名称: (2S)-3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide, Androgen receptor 著者 Bohl, C.E, Duke, C.B, Jones, A, Dalton, J.T, Miller, D.D. 登録日 2011-04-19 公開日 2011-05-04 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Unexpected binding orientation of bulky-B-ring anti-androgens and implications for future drug targets. J.Med.Chem., 54, 2011
6QS1	Crystal structure of human Angiotensin-1 converting enzyme N-domain in complex with BPPb 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Cozier, G.E, Acharya, K.R. 登録日 2019-02-20 公開日 2019-05-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis for the C-domain-selective angiotensin-converting enzyme inhibition by bradykinin-potentiating peptide b (BPPb). Biochem.J., 476, 2019
6DQA	Linked KDM5A JMJ Domain Bound to Inhibitor N70 i.e.[2-((3-aminophenyl)(2-(piperidin-1-yl)ethoxy)methyl)thieno[3,2-b]pyridine-7-carboxylic acid] 分子名称: 1,2-ETHANEDIOL, 2-{(R)-(3-aminophenyl)[2-(piperidin-1-yl)ethoxy]methyl}thieno[3,2-b]pyridine-7-carboxylic acid, GLYCEROL, ... 著者 Horton, J.R, Cheng, X. 登録日 2018-06-10 公開日 2018-11-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.888 Å) 主引用文献 Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A. J. Med. Chem., 61, 2018
6GRS	Paired immunoglobulin-like receptor B (PirB) or Leukocyte immunoglobulin-like receptor subfamily B member 3 (LILRB3) full extracellular domain 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Paired immunoglobulin-like receptor B 著者 Vlieg, H.C, Huizinga, E.G, Janssen, B.J.C. 登録日 2018-06-12 公開日 2019-02-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Structure and flexibility of the extracellular region of the PirB receptor. J.Biol.Chem., 294, 2019
3IDP	B-Raf V600E kinase domain in complex with an aminoisoquinoline inhibitor 分子名称: B-Raf proto-oncogene serine/threonine-protein kinase, N~1~-(4-chlorophenyl)-6-methyl-N~5~-[3-(7H-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine 著者 Whittington, D.A, Epstein, L.F. 登録日 2009-07-21 公開日 2009-10-06 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Selective inhibitors of the mutant B-raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline. J.Med.Chem., 52, 2009
2KL5	Solution NMR Structure of protein yutD from B.subtilis, Northeast Structural Genomics Consortium Target SR232 分子名称: Uncharacterized protein yutD 著者 Liu, G, Hamilton, K, Xiao, R, Ciccosanti, C, Ho, C.J, Everett, J, Nair, R, Acton, T, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) 登録日 2009-06-30 公開日 2009-07-14 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Solution NMR Structure of protein yutD from B.subtilis, Northeast Structural Genomics Consortium Target Target SR232 To be Published

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