PDB: 41454 件ウェブページステータス検索Chemie searchBIRD

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7JUV	Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor APS-9-95-1 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, MAGNESIUM ION, ... 著者 Khan, Z.M, Dar, A.C, Scopton, A.P. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.36 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JUT	Crystal Structure of KSR2:MEK1 in complex with ANP-PNP, and allosteric MEK inhibitor Selumetinib 分子名称: 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.09 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JUS	Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Cobimetinib 分子名称: Cobimetinib, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.99 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JV0	Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor PD0325901 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.63 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JUW	Crystal Structure of KSR1:MEK1 in complex with AMP-PNP 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.88 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JV1	Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor APS-9-95-1 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ... 著者 Khan, Z.M, Dar, A.C, Scopton, A.P. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.62 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JUZ	Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Selumetinib 分子名称: 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.21 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JUU	Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor PD0325901 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, MAGNESIUM ION, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.19 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JUY	Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Cobimetinib 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-10-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.096 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
1CBM	THE 1.8 ANGSTROM STRUCTURE OF CARBONMONOXY-BETA4 HEMOGLOBIN: ANALYSIS OF A HOMOTETRAMER WITH THE R QUATERNARY STRUCTURE OF LIGANDED ALPHA2BETA2 HEMOGLOBIN 分子名称: CARBON MONOXIDE, HEMOGLOBIN BETA 4 (CARBONMONOXY), PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Borgstahl, G.E.O, Arnone, A. 登録日 1993-02-18 公開日 1994-07-31 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 The 1.8 A structure of carbonmonoxy-beta 4 hemoglobin. Analysis of a homotetramer with the R quaternary structure of liganded alpha 2 beta 2 hemoglobin. J.Mol.Biol., 236, 1994
5FHT	HtrA2 protease mutant V226K 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, POTASSIUM ION, ... 著者 Golik, P, Dubin, G, Zurawa-Janicka, D, Lipinska, B, Jarzab, M, Wenta, T, Gieldon, A, Ciarkowski, A. 登録日 2015-12-22 公開日 2016-09-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Distinct 3D Architecture and Dynamics of the Human HtrA2(Omi) Protease and Its Mutated Variants. Plos One, 11, 2016
4NZB	NS9283 bound to Ls-AChBP 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl]benzonitrile, ACETATE ION, ... 著者 Olsen, J.A, Kastrup, J.S, Gajhede, M. 登録日 2013-12-11 公開日 2014-07-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Structural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at alpha 4 beta 2 nicotinic acetylcholine receptors. J.Biol.Chem., 289, 2014
7KCZ	CRYSTAL STRUCTURE OF RHESUS MACAQUE (MACACA MULATTA) IGG1 FC FRAGMENT- FC-GAMMA RECEPTOR III COMPLEX V158 MUTANT 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, IgG1 Fc, ... 著者 Tolbert, W.D, Pazgier, M. 登録日 2020-10-07 公開日 2021-10-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Decoding human-macaque interspecies differences in Fc-effector functions: The structural basis for CD16-dependent effector function in Rhesus macaques. Front Immunol, 13, 2022
1BOY	EXTRACELLULAR REGION OF HUMAN TISSUE FACTOR 分子名称: HUMAN TISSUE FACTOR 著者 Boys, C.W.G, Tuddenham, E.G.D, Harlos, K. 登録日 1996-01-11 公開日 1996-06-10 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of the extracellular region of human tissue factor. Nature, 370, 1994
6WX9	SOX2 bound to Importin-alpha 5 分子名称: Importin subunit alpha-5, Transcription factor SOX-2 著者 Bikshapathi, J, Stewart, M, Forwood, J.K, Aragao, D, Roman, N. 登録日 2020-05-10 公開日 2020-10-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural basis for nuclear import selectivity of pioneer transcription factor SOX2. Nat Commun, 12, 2021
7AX3	CryoEM structure of the super-constricted two-start dynamin 1 filament 分子名称: Dynamin-1, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER 著者 Liu, J.W, Zhang, P.J. 登録日 2020-11-09 公開日 2021-11-10 実験手法 ELECTRON MICROSCOPY (3.74 Å) 主引用文献 CryoEM structure of the super-constricted two-start dynamin 1 filament. Nat Commun, 12, 2021
6WX7	SOX2 bound to Importin-alpha 2 分子名称: Importin subunit alpha-1, Transcription factor SOX-2 著者 Bikshapathi, J, Stewart, M, Forwood, J.K, Aragao, D, Roman, N. 登録日 2020-05-09 公開日 2020-10-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural basis for nuclear import selectivity of pioneer transcription factor SOX2. Nat Commun, 12, 2021
6WX8	SOX2 bound to Importin-alpha 3 分子名称: Importin subunit alpha-3, SULFATE ION, Transcription factor SOX-2 著者 Bikshapathi, J, Stewart, M, Forwood, J.K, Aragao, D, Roman, N. 登録日 2020-05-10 公開日 2020-10-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for nuclear import selectivity of pioneer transcription factor SOX2. Nat Commun, 12, 2021
5HRR	HIV Integrase Catalytic Domain containing F185K + A124N + T125S mutations complexed with GSK0002 分子名称: (2S)-tert-butoxy[1-(3,4-difluorobenzyl)-6-methyl-4-(5-methyl-3,4-dihydro-2H-chromen-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]acetic acid, 1,2-ETHANEDIOL, CACODYLATE ION, ... 著者 Nolte, R.T. 登録日 2016-01-24 公開日 2016-12-14 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase. PLoS Biol., 14, 2016
4ODA	Crystal structure of the vaccinia virus DNA polymerase holoenzyme subunit D4 in complex with the A20 N-terminus 分子名称: DNA polymerase processivity factor component A20, GLYCEROL, SULFATE ION, ... 著者 Contesto-Richefeu, C, Tarbouriech, N, Brazzolotto, X, Burmeister, W.P, Iseni, F. 登録日 2014-01-10 公開日 2014-03-26 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of the vaccinia virus DNA polymerase holoenzyme subunit d4 in complex with the a20 N-terminal domain. Plos Pathog., 10, 2014
5HRP	HIV Integrase Catalytic Domain containing F185K + A124T mutations complexed with GSK0002 分子名称: (2S)-tert-butoxy[1-(3,4-difluorobenzyl)-6-methyl-4-(5-methyl-3,4-dihydro-2H-chromen-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]acetic acid, 1,2-ETHANEDIOL, CACODYLATE ION, ... 著者 Nolte, R.T. 登録日 2016-01-24 公開日 2016-12-14 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase. PLoS Biol., 14, 2016
5HOT	Structural Basis for Inhibitor-Induced Aggregation of HIV-1 Integrase 分子名称: (2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]ethanoic acid, Integrase 著者 Gupta, K, Turkki, V, Sherrill-Mix, S, Hwang, Y, Eilers, G, Taylor, L, McDanal, C, Wang, P, Temelkoff, D, Nolte, R, Velthuisen, E, Jeffrey, J, Van Duyne, G.D, Bushman, F.D. 登録日 2016-01-19 公開日 2016-12-14 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (4.4 Å) 主引用文献 Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase. PLoS Biol., 14, 2016
5HRS	HIV Integrase Catalytic Domain containing F185K + A124N + T125A mutations complexed with GSK0002 分子名称: (2S)-tert-butoxy[1-(3,4-difluorobenzyl)-6-methyl-4-(5-methyl-3,4-dihydro-2H-chromen-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]acetic acid, 1,2-ETHANEDIOL, CACODYLATE ION, ... 著者 Nolte, R.T. 登録日 2016-01-24 公開日 2016-12-14 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase. PLoS Biol., 14, 2016
5HRN	HIV Integrase Catalytic Domain containing F185K mutation complexed with GSK0002 分子名称: (2S)-tert-butoxy[1-(3,4-difluorobenzyl)-6-methyl-4-(5-methyl-3,4-dihydro-2H-chromen-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]acetic acid, 1,2-ETHANEDIOL, CACODYLATE ION, ... 著者 Nolte, R.T. 登録日 2016-01-23 公開日 2016-12-14 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase. PLoS Biol., 14, 2016
7DLV	shrimp dUTPase in complex with Stl 分子名称: CALCIUM ION, Orf20, SULFATE ION, ... 著者 Ma, Q, Wang, F. 登録日 2020-11-30 公開日 2021-12-01 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.525 Å) 主引用文献 Structural basis of staphylococcal Stl inhibition on a eukaryotic dUTPase. Int.J.Biol.Macromol., 184, 2021

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