PDB: 10530 件ウェブページステータス検索Chemie searchBIRD

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2YKB	Tricyclic series of Hsp90 inhibitors 分子名称: HEAT SHOCK PROTEIN HSP 90-ALPHA, N-[4-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-9H-FLUOREN-9-YL]-SUCCINAMIDE 著者 Dupuy, A, Vallee, F. 登録日 2011-05-26 公開日 2011-10-19 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-C]Pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone. J.Med.Chem., 54, 2011
2YKC	Tricyclic series of Hsp90 inhibitors 分子名称: HEAT SHOCK PROTEIN HSP 90-ALPHA, N-[4-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-9H-FLUOREN-9-YL-ISONICOTINAMIDE 著者 Dupuy, A, Vallee, F. 登録日 2011-05-26 公開日 2011-10-19 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-C]Pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone. J.Med.Chem., 54, 2011
2YEG	HSP90 inhibitors and drugs from fragment and virtual screening 分子名称: 6-METHYLSULFANYL-9H-PURINE, HEAT SHOCK PROTEIN HSP 90-ALPHA 著者 Roughley, S.D, Hubbard, R.E, Baker, L.M. 登録日 2011-03-25 公開日 2011-06-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 How Well Can Fragments Explore Accessed Chemical Space? a Case Study from Heat Shock Protein 90. J.Med.Chem., 54, 2011
2YKJ	Tricyclic series of Hsp90 inhibitors 分子名称: 2-AMINO-N-[4-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)--9H-FLUOREN-9-YL]-ISONICOTINAMIDE, HEAT SHOCK PROTEIN HSP 90-ALPHA 著者 Dupuy, A, Vallee, F. 登録日 2011-05-27 公開日 2011-10-19 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-C]Pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone. J.Med.Chem., 54, 2011
2YEE	HSP90 inhibitors and drugs from fragment and virtual screening 分子名称: 9-ETHYL-9H-PURIN-6-YLAMINE, HEAT SHOCK PROTEIN HSP 90-ALPHA, SULFATE ION 著者 Roughley, S.D, Hubbard, R.E, Baker, L.M. 登録日 2011-03-25 公開日 2011-06-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 How Well Can Fragments Explore Accessed Chemical Space? a Case Study from Heat Shock Protein 90. J.Med.Chem., 54, 2011
1MEM	Crystal structure of Cathepsin K complexed with a potent vinyl sulfone inhibitor 分子名称: Cathepsin K, N-{(1R)-3-phenyl-1-[2-(phenylsulfonyl)ethyl]propyl}-N~2~-(piperazin-1-ylcarbonyl)-L-leucinamide 著者 Mcgrath, M.E. 登録日 1997-01-08 公開日 1998-01-14 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of human cathepsin K complexed with a potent inhibitor. Nat.Struct.Biol., 4, 1997
7RPV	Crystal structure of affinity-enhancing and catalytically inactive ACE2 in complex with SARS-CoV-2 RBD 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike protein S1, ... 著者 Chen, Y, Tolbert, D.W, Pazgier, M. 登録日 2021-08-04 公開日 2021-12-15 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.54 Å) 主引用文献 Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities. Biorxiv, 2021
4BC1	Structure of mouse acetylcholinesterase inhibited by CBDP (30-min soak): cresyl-saligenin-phosphoserine adduct 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE, CHLORIDE ION, ... 著者 Carletti, E, Colletier, J.-P, Schopfer, L.M, Santoni, G, Masson, P, Lockridge, O, Nachon, F, Weik, M. 登録日 2012-09-30 公開日 2013-02-06 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Inhibition Pathways of the Potent Organophosphate Cbdp with Cholinesterases Revealed by X-Ray Crystallographic Snapshots and Mass Spectrometry Chem.Res.Toxicol., 26, 2013
2YEA	HSP90 inhibitors and drugs from fragment and virtual screening 分子名称: 5-(HYDROXYMETHYL)-2-METHOXYPHENOL, HEAT SHOCK PROTEIN HSP 90-ALPHA 著者 Roughley, S.D, Hubbard, R.E, Baker, L.M. 登録日 2011-03-25 公開日 2011-06-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 How Well Can Fragments Explore Accessed Chemical Space? a Case Study from Heat Shock Protein 90. J.Med.Chem., 54, 2011
2YE2	HSP90 inhibitors and drugs from fragment and virtual screening 分子名称: HEAT SHOCK PROTEIN HSP 90-ALPHA, METHYL 2-(3,5-DIHYDROXYPHENYL)ETHANOATE, SULFATE ION 著者 Roughley, S.D, Hubbard, R.E, Baker, L.M. 登録日 2011-03-25 公開日 2011-06-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 How Well Can Fragments Explore Accessed Chemical Space? a Case Study from Heat Shock Protein 90. J.Med.Chem., 54, 2011
2YED	HSP90 inhibitors and drugs from fragment and virtual screening 分子名称: ADENINE, CHLORIDE ION, HEAT SHOCK PROTEIN HSP 90-ALPHA 著者 Roughley, S.D, Hubbard, R.E, Baker, L.M. 登録日 2011-03-25 公開日 2011-06-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 How Well Can Fragments Explore Accessed Chemical Space? a Case Study from Heat Shock Protein 90. J.Med.Chem., 54, 2011
2YE8	HSP90 inhibitors and drugs from fragment and virtual screening 分子名称: HEAT SHOCK PROTEIN HSP 90-ALPHA, MAGNESIUM ION, METHYL 3-ISOXAZOL-5-YL-5-METHYL-1H-PYRAZOLE-4-CARBOXYLATE 著者 Roughley, S.D, Hubbard, R.E, Baker, L.M. 登録日 2011-03-25 公開日 2011-06-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 How Well Can Fragments Explore Accessed Chemical Space? a Case Study from Heat Shock Protein 90. J.Med.Chem., 54, 2011
2YE7	HSP90 inhibitors and drugs from fragment and virtual screening 分子名称: 2-[(3,5-DIMETHYL-1H-PYRAZOL-4-YL)SULFANYL]-5-METHYLSULFANYL-1,3,4-THIADIAZOLE, HEAT SHOCK PROTEIN HSP 90-ALPHA 著者 Roughley, S.D, Hubbard, R.E, Baker, L.M. 登録日 2011-03-25 公開日 2011-06-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 How Well Can Fragments Explore Accessed Chemical Space? a Case Study from Heat Shock Protein 90. J.Med.Chem., 54, 2011
2YEI	HSP90 inhibitors and drugs from fragment and virtual screening 分子名称: HEAT SHOCK PROTEIN HSP 90-ALPHA, METHYL 2-(3,5-DIHYDROXYPHENYL)ETHANOATE, METHYL 5-ISOXAZOL-5-YL-3-METHYL-1H-PYRAZOLE-4-CARBOXYLATE 著者 Roughley, S.D, Hubbard, R.E, Baker, L.M. 登録日 2011-03-25 公開日 2011-06-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 How Well Can Fragments Explore Accessed Chemical Space? a Case Study from Heat Shock Protein 90. J.Med.Chem., 54, 2011
2YE9	HSP90 inhibitors and drugs from fragment and virtual screening 分子名称: HEAT SHOCK PROTEIN HSP 90-ALPHA, N-[4-HYDROXY-3-(2-HYDROXYNAPHTHALEN-1-YL)PHENYL]THIOPHENE-2-SULFONAMIDE 著者 Roughley, S.D, Hubbard, R.E, Baker, L.M. 登録日 2011-03-25 公開日 2011-06-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 How Well Can Fragments Explore Accessed Chemical Space? a Case Study from Heat Shock Protein 90. J.Med.Chem., 54, 2011
2YKE	Tricyclic series of Hsp90 inhibitors 分子名称: HEAT SHOCK PROTEIN HSP 90-ALPHA, N-[(4R)-4-(3H-imidazo[4,5-c]pyridin-2-yl)-4H-fluoren-9-yl]quinoline-5-carboxamide 著者 Dupuy, A, Vallee, F. 登録日 2011-05-26 公開日 2011-10-19 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.43 Å) 主引用文献 Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-C]Pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone. J.Med.Chem., 54, 2011
2YJX	Tricyclic series of Hsp90 inhibitors 分子名称: 1-(3H-imidazo[4,5-c]pyridin-2-yl)-3,4-dihydropyrido[2,1-a]isoindol-6(2H)-one, HEAT SHOCK PROTEIN HSP 90-ALPHA 著者 Dupuy, A, Vallee, F. 登録日 2011-05-24 公開日 2011-10-19 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-C]Pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone. J.Med.Chem., 54, 2011
2YEH	HSP90 inhibitors and drugs from fragment and virtual screening 分子名称: HEAT SHOCK PROTEIN HSP 90-ALPHA, N-(3-METHOXYPROPYL)-9H-PURIN-6-AMINE, SULFATE ION 著者 Roughley, S.D, Hubbard, R.E, Baker, L.M. 登録日 2011-03-25 公開日 2011-06-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 How Well Can Fragments Explore Accessed Chemical Space? a Case Study from Heat Shock Protein 90. J.Med.Chem., 54, 2011
4BC0	Structure of mouse acetylcholinesterase inhibited by CBDP (12-h soak) : Cresyl-phosphoserine adduct 分子名称: (2-methylphenyl) dihydrogen phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE, ... 著者 Carletti, E, Colletier, J.-P, Schopfer, L.M, Santoni, G, Masson, P, Lockridge, O, Nachon, F, Weik, M. 登録日 2012-09-30 公開日 2013-02-06 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Inhibition Pathways of the Potent Organophosphate Cbdp with Cholinesterases Revealed by X-Ray Crystallographic Snapshots and Mass Spectrometry Chem.Res.Toxicol., 26, 2013
2YE4	HSP90 inhibitors and drugs from fragment and virtual screening 分子名称: 1-(2,4-DIHYDROXY-PHENYL)-PROPAN-1-ONE, HEAT SHOCK PROTEIN HSP 90-ALPHA 著者 Roughley, S.D, Hubbard, R.E, Baker, L.M. 登録日 2011-03-25 公開日 2011-06-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 How Well Can Fragments Explore Accessed Chemical Space? a Case Study from Heat Shock Protein 90. J.Med.Chem., 54, 2011
2YEC	HSP90 inhibitors and drugs from fragment and virtual screening 分子名称: 3-METHYL-1H-INDAZOL-6-OL, HEAT SHOCK PROTEIN HSP 90-ALPHA, SULFATE ION 著者 Roughley, S.D, Hubbard, R.E, Baker, L.M. 登録日 2011-03-25 公開日 2011-06-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 How Well Can Fragments Explore Accessed Chemical Space? a Case Study from Heat Shock Protein 90. J.Med.Chem., 54, 2011
2YEF	HSP90 inhibitors and drugs from fragment and virtual screening 分子名称: HEAT SHOCK PROTEIN HSP 90-ALPHA, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Roughley, S.D, Hubbard, R.E, Baker, L.M. 登録日 2011-03-25 公開日 2011-06-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 How Well Can Fragments Explore Accessed Chemical Space? a Case Study from Heat Shock Protein 90. J.Med.Chem., 54, 2011
2YEB	HSP90 inhibitors and drugs from fragment and virtual screening 分子名称: 1H-INDAZOL-6-OL, CHLORIDE ION, HEAT SHOCK PROTEIN HSP 90-ALPHA 著者 Roughley, S.D, Hubbard, R.E, Baker, L.M. 登録日 2011-03-25 公開日 2011-06-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 How Well Can Fragments Explore Accessed Chemical Space? a Case Study from Heat Shock Protein 90. J.Med.Chem., 54, 2011
4V8W	Structure and conformational variability of the Mycobacterium tuberculosis fatty acid synthase multienzyme complex 分子名称: FLAVIN MONONUCLEOTIDE, TYPE-I FATTY ACID SYNTHASE 著者 Ciccarelli, L, Connell, S.R, Enderle, M, Mills, D.J, Vonck, J, Grininger, M. 登録日 2013-04-18 公開日 2014-07-09 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (17.5 Å) 主引用文献 Structure and Conformational Variability of the Mycobacterium Tuberculosis Fatty Acid Synthase Multienzyme Complex. Structure, 21, 2013
5VGJ	Crystal Structure of the Human Fab VRC38.01, an HIV-1 V1V2-Directed Neutralizing Antibody Isolated from Donor N90, bound to a scaffolded WITO V1V2 domain 分子名称: 1FD6-V1V2-WITO, 2-acetamido-2-deoxy-beta-D-glucopyranose, VRC38.01 Fab Heavy Chain, ... 著者 Gorman, J, Li, J, Kwong, P.D. 登録日 2017-04-11 公開日 2017-05-31 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.456 Å) 主引用文献 Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop. Immunity, 46, 2017

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