2NMM
| Crystal structure of human phosphohistidine phosphatase. Northeast Structural Genomics Consortium target HR1409 | 分子名称: | 14 kDa phosphohistidine phosphatase, SULFATE ION | 著者 | Kuzin, A.P, Abashidze, M, Forouhar, F, Seetharaman, J, Kent, C, Fang, Y, Cunningham, K, Conover, K, Ma, L.C, Xiao, R, Acton, T, Montelione, G, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2006-10-22 | 公開日 | 2007-01-23 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structure of human phosphohistidine phosphatase. Northeast Structural Genomics Consortium target HR1409 To be Published
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4FF8
| Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (Sky) | 分子名称: | 4-(cyclopentylamino)-2-[(2-methoxybenzyl)amino]-N-[3-(2-oxopyrrolidin-1-yl)propyl]pyrimidine-5-carboxamide, Tyrosine-protein kinase receptor TYRO3 | 著者 | Ohren, J.F, Powell, N.A, Kohrt, J, Perrin, L.A. | 登録日 | 2012-05-31 | 公開日 | 2013-03-13 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase. Bioorg.Med.Chem.Lett., 23, 2013
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4V3G
| Crystal structure of CymA from Klebsiella oxytoca | 分子名称: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, CYMA PROTEIN | 著者 | van den Berg, B, Bhamidimarri, S.P, Kleinekathoefer, U, Winterhalter, M. | 登録日 | 2014-10-18 | 公開日 | 2015-06-03 | 最終更新日 | 2018-02-21 | 実験手法 | X-RAY DIFFRACTION (2.513 Å) | 主引用文献 | Outer-membrane translocation of bulky small molecules by passive diffusion. Proc. Natl. Acad. Sci. U.S.A., 112, 2015
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3EDU
| Crystal structure of the ankyrin-binding domain of human erythroid spectrin | 分子名称: | Spectrin beta chain, erythrocyte | 著者 | Simonovic, M, Stabach, P, Simonovic, I, Steitz, T.A, Morrow, J.S. | 登録日 | 2008-09-03 | 公開日 | 2009-02-10 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The structure of the ankyrin-binding site of {beta}-spectrin reveals how tandem spectrin-repeats generate unique ligand-binding properties Blood, 113, 2009
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4MHG
| Crystal structure of ETV6 bound to a specific DNA sequence | 分子名称: | Complementary Specific 14 bp DNA, Specific 14 bp DNA, Transcription factor ETV6 | 著者 | Chan, A.C, De, S, Coyne III, H.J, Okon, M, Murphy, M.E, Graves, B.J, McIntosh, L.P. | 登録日 | 2013-08-29 | 公開日 | 2014-01-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.199 Å) | 主引用文献 | Steric Mechanism of Auto-Inhibitory Regulation of Specific and Non-Specific DNA Binding by the ETS Transcriptional Repressor ETV6. J.Mol.Biol., 426, 2014
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1K83
| Crystal Structure of Yeast RNA Polymerase II Complexed with the Inhibitor Alpha Amanitin | 分子名称: | ALPHA AMANITIN, DNA-DIRECTED RNA POLYMERASE II 13.6KD POLYPEPTIDE, DNA-DIRECTED RNA POLYMERASE II 14.2KD POLYPEPTIDE, ... | 著者 | Bushnell, D.A, Cramer, P, Kornberg, R.D. | 登録日 | 2001-10-22 | 公開日 | 2002-02-13 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural Basis of Transcription: Alpha-Amanitin-RNA Polymerase II Cocrystal at 2.8 A Resolution. Proc.Natl.Acad.Sci.USA, 99, 2002
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2W0A
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2W0B
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4W9K
| pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-((S)-2-acetamido-3-phenylpropanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 14) | 分子名称: | N-acetyl-L-phenylalanyl-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... | 著者 | Gadd, M.S, Galdeano, C, van Molle, I, Ciulli, A. | 登録日 | 2014-08-27 | 公開日 | 2014-09-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem., 57, 2014
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4V3H
| Crystal structure of CymA from Klebsiella oxytoca | 分子名称: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, CYMA PROTEIN, NITRATE ION | 著者 | van den Berg, B, Bhamidimarri, S.P, Kleinekathoefer, U, Winterhalter, M. | 登録日 | 2014-10-18 | 公開日 | 2015-06-03 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Outer-membrane translocation of bulky small molecules by passive diffusion. Proc. Natl. Acad. Sci. U.S.A., 112, 2015
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1Y1W
| Complete RNA Polymerase II elongation complex | 分子名称: | 5'-D(*AP*AP*GP*TP*AP*CP*T)-3', 5'-D(P*AP*GP*TP*AP*CP*TP*TP*AP*CP*GP*CP*CP*TP*GP*GP*TP*CP*AP*T)-3', 5'-R(*AP*AP*GP*AP*CP*CP*AP*GP*GP*C)-3', ... | 著者 | Cramer, P, Kettenberger, H, Armache, K.-J. | 登録日 | 2004-11-19 | 公開日 | 2005-01-04 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (4 Å) | 主引用文献 | Complete RNA Polymerase II Elongation Complex Structure and Its Interactions with NTP and TFIIS Mol.Cell, 16, 2004
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1Y1V
| Refined RNA Polymerase II-TFIIS complex | 分子名称: | DNA-directed RNA polymerase II 13.6 kDa polypeptide, DNA-directed RNA polymerase II 140 kDa polypeptide, DNA-directed RNA polymerase II 19 kDa polypeptide, ... | 著者 | Kettenberger, H, Armache, K.-J, Cramer, P. | 登録日 | 2004-11-19 | 公開日 | 2004-12-28 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS. Mol.Cell, 16, 2004
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5VOY
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7SUK
| Structure of Bfr2-Lcp5 Complex Observed in the Small Subunit Processome Isolated from R2TP-depleted Yeast Cells | 分子名称: | 18S pre-rRNA, 40S ribosomal protein S11-A, 40S ribosomal protein S13, ... | 著者 | Rai, J, Zhao, Y, Li, H. | 登録日 | 2021-11-17 | 公開日 | 2022-07-06 | 最終更新日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (3.99 Å) | 主引用文献 | Artificial intelligence-assisted cryoEM structure of Bfr2-Lcp5 complex observed in the yeast small subunit processome. Commun Biol, 5, 2022
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5M32
| Human 26S proteasome in complex with Oprozomib | 分子名称: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... | 著者 | Haselbach, D, Schrader, J, Lambrecht, F, Henneberg, F, Chari, A, Stark, H. | 登録日 | 2016-10-14 | 公開日 | 2017-07-05 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs. Nat Commun, 8, 2017
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5W0C
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1Y5C
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1YIJ
| Crystal Structure Of Telithromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui | 分子名称: | 23S Ribosomal RNA, 50S RIBOSOMAL PROTEIN L10E, 50S RIBOSOMAL PROTEIN L11P, ... | 著者 | Tu, D, Blaha, G, Moore, P.B, Steitz, T.A. | 登録日 | 2005-01-12 | 公開日 | 2005-04-26 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. Cell(Cambridge,Mass.), 121, 2005
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6ZIY
| Respiratory complex I from Thermus thermophilus, NADH dataset, major state | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ... | 著者 | Kaszuba, K, Tambalo, M, Gallagher, G.T, Sazanov, L.A. | 登録日 | 2020-06-26 | 公開日 | 2020-09-02 | 実験手法 | ELECTRON MICROSCOPY (4.25 Å) | 主引用文献 | Key role of quinone in the mechanism of respiratory complex I. Nat Commun, 11, 2020
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6ZJL
| Respiratory complex I from Thermus thermophilus, NAD+ dataset, major state | 分子名称: | FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, IRON/SULFUR CLUSTER, ... | 著者 | Kaszuba, K, Tambalo, M, Gallagher, G.T, Sazanov, L.A. | 登録日 | 2020-06-29 | 公開日 | 2020-09-02 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Key role of quinone in the mechanism of respiratory complex I. Nat Commun, 11, 2020
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7O6Y
| Cryo-EM structure of respiratory complex I under turnover | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Parey, K, Vonck, J. | 登録日 | 2021-04-12 | 公開日 | 2021-11-10 | 最終更新日 | 2021-12-01 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | High-resolution structure and dynamics of mitochondrial complex I-Insights into the proton pumping mechanism. Sci Adv, 7, 2021
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4DNK
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4LOP
| Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form) | 分子名称: | 1,2-ETHANEDIOL, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, L(+)-TARTARIC ACID, ... | 著者 | Chaikuad, A, DeNicola, G.F, Krojer, T, Allerston, C.K, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Marber, M.S, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2013-07-13 | 公開日 | 2013-08-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.049 Å) | 主引用文献 | Mechanism and consequence of the autoactivation of p38 alpha mitogen-activated protein kinase promoted by TAB1. Nat.Struct.Mol.Biol., 20, 2013
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6ZJN
| Respiratory complex I from Thermus thermophilus, NADH dataset, minor state | 分子名称: | FE2/S2 (INORGANIC) CLUSTER, IRON/SULFUR CLUSTER, NADH-quinone oxidoreductase subunit 1, ... | 著者 | Kaszuba, K, Tambalo, M, Gallagher, G.T, Sazanov, L.A. | 登録日 | 2020-06-29 | 公開日 | 2020-09-02 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | 主引用文献 | Key role of quinone in the mechanism of respiratory complex I. Nat Commun, 11, 2020
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6ZJY
| Respiratory complex I from Thermus thermophilus, NAD+ dataset, minor state | 分子名称: | FE2/S2 (INORGANIC) CLUSTER, IRON/SULFUR CLUSTER, NADH-quinone oxidoreductase subunit 1, ... | 著者 | Kaszuba, K, Tambalo, M, Gallagher, G.T, Sazanov, L.A. | 登録日 | 2020-06-29 | 公開日 | 2020-09-02 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (5.5 Å) | 主引用文献 | Key role of quinone in the mechanism of respiratory complex I. Nat Commun, 11, 2020
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