PDB: 222415 件ウェブページステータス検索Chemie searchBIRD

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4MW9	Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(3-ethynylbenzyl)amino]propyl}-3-thiophen-3-ylurea (Chem 1478) 分子名称: 1-{3-[(3-ethynylbenzyl)amino]propyl}-3-thiophen-3-ylurea, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Koh, C.Y, Kim, J.E, Wetzel, A.B, de van der Schueren, W.J, Shibata, S, Liu, J, Zhang, Z, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J. 登録日 2013-09-24 公開日 2014-04-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness. Plos Negl Trop Dis, 8, 2014
4EGA	Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor Chem 1320 分子名称: 2-({3-[(3,5-dibromo-2-methoxybenzyl)amino]propyl}amino)quinolin-4(1H)-one, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Koh, C.Y, Kim, J.E, Shibata, S, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J. 登録日 2012-03-30 公開日 2012-09-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.698 Å) 主引用文献 Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection. Structure, 20, 2012
4EGQ	Crystal structure of D-alanine-D-alanine ligase B from Burkholderia pseudomallei 分子名称: D-alanine--D-alanine ligase 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2012-03-31 公開日 2012-04-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of D-alanine-D-alanine ligase B from Burkholderia pseudomallei To be Published
4EI5	Crystal Structure of XV19 TCR in complex with CD1d-sulfatide C24:1 分子名称: (15Z)-N-((1S,2R,3E)-2-HYDROXY-1-{[(3-O-SULFO-BETA-D-GALACTOPYRANOSYL)OXY]METHYL}HEPTADEC-3-ENYL)TETRACOS-15-ENAMIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Patel, O, Gras, S, Rossjohn, J. 登録日 2012-04-04 公開日 2012-07-25 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor. Nat.Immunol., 13, 2012
4EHP	Crystal Structure of human vinculin head domain (residues 1-252) in complex with alpha-catenin (residues 277-382) 分子名称: ACETATE ION, Catenin alpha-1, Vinculin 著者 Izard, T, Rangarajan, E.S. 登録日 2012-04-03 公開日 2012-04-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.66 Å) 主引用文献 alpha-Catenin unfurls upon binding to vinculin J.Biol.Chem., 287, 2012
4MWB	Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-(3-{[(2,5-dichlorothiophen-3-yl)methyl]amino}propyl)-3-thiophen-3-ylurea (Chem 1509) 分子名称: 1-(3-{[(2,5-dichlorothiophen-3-yl)methyl]amino}propyl)-3-thiophen-3-ylurea, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Koh, C.Y, Kim, J.E, Wetzel, A.B, de van der Schueren, W.J, Shibata, S, Liu, J, Zhang, Z, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J. 登録日 2013-09-24 公開日 2014-04-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.313 Å) 主引用文献 Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness. Plos Negl Trop Dis, 8, 2014
4N20	Crystal structure of Protein Arginine Deiminase 2 (0 mM Ca2+) 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, CALCIUM ION, ... 著者 Slade, D.J, Zhang, X, Fang, P, Dreyton, C.J, Zhang, Y, Gross, M.L, Guo, M, Coonrod, S.A, Thompson, P.R. 登録日 2013-10-04 公開日 2015-02-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.657 Å) 主引用文献 Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design. Acs Chem.Biol., 10, 2015
4ERY	X-ray structure of WDR5-MLL3 Win motif peptide binary complex 分子名称: Histone-lysine N-methyltransferase MLL3, WD repeat-containing protein 5 著者 Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S. 登録日 2012-04-21 公開日 2012-05-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases. J.Biol.Chem., 287, 2012
4ES9	Crystal Structure of the adhesin domain of Epf from Streptococcus pyogenes in P21 分子名称: Epf 著者 Linke, C, Siemens, N, Kreikemeyer, B, Baker, E.N. 登録日 2012-04-23 公開日 2012-09-19 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The Extracellular Protein Factor Epf from Streptococcus pyogenes Is a Cell Surface Adhesin That Binds to Cells through an N-terminal Domain Containing a Carbohydrate-binding Module. J.Biol.Chem., 287, 2012
4N5K	Crystal structure of hemagglutinin from an H7N9 influenza virus in complex with LSTa 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1, Hemagglutinin HA2, ... 著者 Xu, R, Wilson, I.A. 登録日 2013-10-10 公開日 2013-12-18 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.7053 Å) 主引用文献 Preferential recognition of avian-like receptors in human influenza A H7N9 viruses. Science, 342, 2013
4N7O	Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of half-liganded human haemoglobin with phosphate at 2.5 A resolution. 分子名称: Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Sugiyama, K, Shibayama, N, Park, S.Y. 登録日 2013-10-16 公開日 2014-04-02 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.502 Å) 主引用文献 Capturing the hemoglobin allosteric transition in a single crystal form J.Am.Chem.Soc., 136, 2014
4EVB	Crystal Structure HP-NAP from strain YS39 zinc soaked (20mM) 分子名称: 1,2-ETHANEDIOL, Neutrophil-activating protein, SULFATE ION, ... 著者 Yokoyama, H, Tsuruta, O, Akao, N, Fujii, S. 登録日 2012-04-26 公開日 2012-06-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of Helicobacter pylori neutrophil-activating protein with a di-nuclear ferroxidase center in a zinc or cadmium-bound form Biochem.Biophys.Res.Commun., 422, 2012
4KJN	Crystal structure of Staphylococcal nuclease variant Delta+PHS V23T/V66A/V99T at cryogenic temperature 分子名称: CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease 著者 Caro, J.A, Schlessman, J.L, Heroux, A, Garcia-Moreno E, B. 登録日 2013-05-03 公開日 2013-05-15 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Cavities in proteins To be Published
4KLX	Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in an open conformation. 分子名称: 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Dihydrofolate reductase 著者 Dias, M.V.B, Tyrakis, P, Blundell, T.L. 登録日 2013-05-07 公開日 2013-12-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.23 Å) 主引用文献 Mycobacterium tuberculosis Dihydrofolate Reductase Reveals Two Conformational States and a Possible Low Affinity Mechanism to Antifolate Drugs. Structure, 22, 2014
4KMD	Crystal structure of Sufud60-Gli1p 分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, GLYCEROL, Sufu, ... 著者 Zhang, Y, Qi, X, Zhang, Z, Wu, G. 登録日 2013-05-08 公開日 2013-11-20 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci. Nat Commun, 4, 2013
4KD4	Crystal structure of Staphylococcal nuclease variant V23L/L25V/V66I/I72V at cryogenic temperature 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, CALCIUM ION, PHOSPHATE ION, ... 著者 Caro, J.A, Flores, E, Schlessman, J.L, Heroux, A, Garcia-Moreno E, B. 登録日 2013-04-24 公開日 2013-05-08 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Pressure effects in proteins To be Published
4E93	Crystal structure of human Feline Sarcoma Viral Oncogene Homologue (v-FES)in complex with TAE684 分子名称: 5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PHENYL]-N'-(2-PROPAN-2-YLSULFONYLPHENYL)PYRIMIDINE-2,4-DIAMINE, Tyrosine-protein kinase Fes/Fps 著者 Filippakopoulos, P, Salah, E, Miduturu, C.V, Fedorov, O, Cooper, C, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Gray, N.S, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2012-03-20 公開日 2012-04-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Small-Molecule Inhibitors of the c-Fes Protein-Tyrosine Kinase. Chem.Biol., 19, 2012
4KFM	Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with the beta-gamma G protein subunits 分子名称: DODECYL-BETA-D-MALTOSIDE, G protein-activated inward rectifier potassium channel 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Whorton, M.R, MacKinnon, R. 登録日 2013-04-27 公開日 2013-06-12 最終更新日 2013-09-11 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 X-ray structure of the mammalian GIRK2-beta gamma G-protein complex. Nature, 498, 2013
4KRE	Structure of Human Argonaute-1 bound to endogenous Sf9 RNA 分子名称: Protein argonaute-1, RNA (5'-R(P*AP*AP*UP*AP*UP*UP*AP*AP*A*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 著者 Faehnle, C.R, Elkayam, E, Joshua-Tor, L. 登録日 2013-05-16 公開日 2013-06-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.754 Å) 主引用文献 The making of a slicer: activation of human argonaute-1. Cell Rep, 3, 2013
4KHM	HCV NS5B GT1A with GSK5852 分子名称: HCV Polymerase, SULFATE ION, [4-({[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl](methylsulfonyl)amino}methyl)-2-fluorophenyl]boronic acid 著者 Williams, S.P, Kahler, K.M, Shotwell, J.B. 登録日 2013-04-30 公開日 2013-05-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase. J.Med.Chem., 57, 2014
4EDU	The MBT repeats of human SCML2 in a complex with histone H2A peptide 分子名称: Histone H2A.J peptide, Sex comb on midleg-like protein 2 著者 Nady, N, Amaya, M.F, Tempel, W, Ravichandran, M, Arrowsmith, C.H. 登録日 2012-03-27 公開日 2012-09-19 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 Histone recognition by human malignant brain tumor domains. J.Mol.Biol., 423, 2012
4K59	Crystal Structure of Pseudomonas Aeruginosa RsmF 分子名称: RNA BINDING PROTEIN RsmF 著者 Betts, L, Walton, W.G, Redinbo, M.R. 登録日 2013-04-14 公開日 2013-08-28 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 An unusual CsrA family member operates in series with RsmA to amplify posttranscriptional responses in Pseudomonas aeruginosa. Proc.Natl.Acad.Sci.USA, 110, 2013
4KMO	Crystal Structure of the Vps33-Vps16 HOPS subcomplex from Chaetomium thermophilum 分子名称: Putative vacuolar protein sorting-associated protein, SULFATE ION, Small conjugating protein ligase-like protein 著者 Baker, R.W, Jeffrey, P.D, Hughson, F.M. 登録日 2013-05-08 公開日 2013-06-26 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structures of the Sec1/Munc18 (SM) Protein Vps33, Alone and Bound to the Homotypic Fusion and Vacuolar Protein Sorting (HOPS) Subunit Vps16* Plos One, 8, 2013
4KNE	Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with cycloguanil 分子名称: 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine, 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, Dihydrofolate reductase 著者 Dias, M.V.B, Tyrakis, P, Blundell, T.L. 登録日 2013-05-09 公開日 2013-12-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Mycobacterium tuberculosis Dihydrofolate Reductase Reveals Two Conformational States and a Possible Low Affinity Mechanism to Antifolate Drugs. Structure, 22, 2014
4KNM	Crystal structure of human carbonic anhydrase isozyme XIII with 2-Chloro-4-{[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetyl}benzenesulfonamide 分子名称: 2-chloro-4-{[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetyl}benzenesulfonamide, Carbonic anhydrase 13, TRIETHYLENE GLYCOL, ... 著者 Smirnov, A, Manakova, E, Grazulis, S. 登録日 2013-05-10 公開日 2013-11-06 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII Bioorg.Med.Chem., 21, 2013

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