PDB: 243531 件ウェブページステータス検索Chemie searchBIRD

---

7M33	The structure of Bacillus subtilis BmrCD in the inward-facing conformation bound to Hoechst-33342 and ATP 分子名称: 2'-(4-ETHOXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, ADENOSINE-5'-TRIPHOSPHATE, Probable multidrug resistance ABC transporter ATP-binding/permease protein YheH, ... 著者 Thaker, T.M, Tomasiak, T.M. 登録日 2021-03-18 公開日 2022-01-05 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.55 Å) 主引用文献 Asymmetric drug binding in an ATP-loaded inward-facing state of an ABC transporter. Nat.Chem.Biol., 18, 2022
5IHS	Structure of CHU_2103 from Cytophaga hutchinsonii 分子名称: Endoglucanase, glycoside hydrolase family 5 protein 著者 Silvaggi, N.R, Han, L. 登録日 2016-02-29 公開日 2016-06-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Periplasmic Cytophaga hutchinsonii Endoglucanases Are Required for Use of Crystalline Cellulose as the Sole Source of Carbon and Energy. Appl.Environ.Microbiol., 82, 2016
7LLY	Oxyntomodulin-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein 分子名称: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Wootten, D, Sexton, P.M, Belousoff, M.J, Danev, R, Zhang, X, Khoshouei, M, Venugopal, H. 登録日 2021-02-04 公開日 2022-01-12 最終更新日 2025-05-21 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation. Nat Commun, 13, 2022
1RZJ	HIV-1 HXBC2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY 17B, HEAVY CHAIN, ... 著者 Huang, C.C, Venturi, M, Majeed, S, Moore, M.J, Phogat, S, Zhang, M.-Y, Dimitrov, D.S, Hendrickson, W.A, Robinson, J, Sodroski, J, Wyatt, R, Choe, H, Farzan, M, Kwong, P.D. 登録日 2003-12-24 公開日 2004-02-03 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120 Proc.Natl.Acad.Sci.USA, 101, 2004
5IRS	crystal structure of the proteasomal Rpn13 PRU-domain 分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Proteasomal ubiquitin receptor ADRM1 著者 Chen, X, Shi, K, Walters, K, Aihara, H. 登録日 2016-03-14 公開日 2016-07-20 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.796 Å) 主引用文献 Structures of Rpn1 T1:Rad23 and hRpn13:hPLIC2 Reveal Distinct Binding Mechanisms between Substrate Receptors and Shuttle Factors of the Proteasome. Structure, 24, 2016
5IRX	Structure of TRPV1 in complex with DkTx and RTX, determined in lipid nanodisc 分子名称: (2S)-2-(acetyloxy)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}propyl pentanoate, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, ... 著者 Gao, Y, Cao, E, Julius, D, Cheng, Y. 登録日 2016-03-14 公開日 2016-05-25 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (2.95 Å) 主引用文献 TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action. Nature, 534, 2016
5II3	The X-ray structure of the adduct formed in the reaction between hen egg white lysozyme and compound 3, a platin(II) compound containing a O, S bidentate ligand 分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, Lysozyme C, ... 著者 Ferraro, G, Merlino, A. 登録日 2016-03-01 公開日 2016-12-07 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Platinum(ii) O,S complexes as potential metallodrugs against Cisplatin resistance. Dalton Trans, 45, 2016
7LTZ	Bruton's tyrosine kinase in complex with compound 51 分子名称: 1-~{tert}-butyl-~{N}-[(5~{R})-8-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-2-(oxetan-3-yl)-1,3,4,5-tetrahydro-2-benzazepin-5-yl]-1,2,3-triazole-4-carboxamide, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ACETATE ION, ... 著者 Metrick, C.M, Marcotte, D.J. 登録日 2021-02-20 公開日 2022-01-12 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis. J.Med.Chem., 65, 2022
5VEF	PAK4 kinase domain in complex with fasudil 分子名称: 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, ACETATE ION, Serine/threonine-protein kinase PAK 4 著者 Zhang, E.Y, Ha, B.H, Boggon, T.J. 登録日 2017-04-04 公開日 2017-10-18 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.752 Å) 主引用文献 PAK4 crystal structures suggest unusual kinase conformational movements. Biochim. Biophys. Acta, 1866, 2018
7LLL	Exendin-4-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein 分子名称: Exendin-4, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Wootten, D, Sexton, P.M, Belousoff, M.J, Danev, R, Zhang, X, Khoshouei, M, Venugopal, H. 登録日 2021-02-04 公開日 2022-01-12 最終更新日 2025-06-04 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation. Nat Commun, 13, 2022
5VIO	Crystal structure of ASK1 kinase domain with a potent inhibitor (analog 13) 分子名称: 4-methoxy-N~1~-methyl-N~3~-{6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-yl}benzene-1,3-dicarboxamide, Mitogen-activated protein kinase kinase kinase 5 著者 Jasti, J, Chang, J, Kurumbail, R. 登録日 2017-04-17 公開日 2018-01-17 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.84 Å) 主引用文献 Rational approach to highly potent and selective apoptosis signal-regulating kinase 1 (ASK1) inhibitors. Eur J Med Chem, 145, 2017
7LL5	High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to PN5-150. 分子名称: 1,2-ETHANEDIOL, Tyrosine-protein kinase JAK2, {1-(ethylsulfonyl)-3-[4-(2-{[4-(1-methylpiperidin-4-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile 著者 Karim, M.R, Schonbrunn, E. 登録日 2021-02-03 公開日 2022-01-12 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to PN5-150. To Be Published
5ISE	Crystal structure of mouse CARM1 in complex with inhibitor SA0649 分子名称: 1,2-DIMETHOXYETHANE, 1,2-ETHANEDIOL, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, ... 著者 Cura, V, Marechal, N, Mailliot, J, Troffer-Charlier, N, Hassenboehler, P, Wurtz, J.M, Bonnefond, L, Cavarelli, J. 登録日 2016-03-15 公開日 2017-03-15 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of mouse CARM1 in complex with SAH at 1.8 Angstroms resolution To Be Published
7LSQ	The Crystal Structure of Q108K:K40E:T53A:R58W:Q38F:Q4F:Y19W Mutant of HCRBPII Bound with LizFluor Chromophore Showing Excited State Intermolecular Proton Transfer 分子名称: 4-{5-[(2E)-but-2-en-2-yl]thiophen-2-yl}-N,N-dimethylaniline, ACETATE ION, Retinol-binding protein 2 著者 Ghanbarpour, A, Geiger, J. 登録日 2021-02-18 公開日 2022-01-12 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.67130542 Å) 主引用文献 Design of Large Stokes Shift Fluorescent Proteins Based on Excited State Proton Transfer of an Engineered Photobase. J.Am.Chem.Soc., 143, 2021
5VJC	TOG-tubulin binding specificity promotes microtubule dynamics and mitotic spindle formation 分子名称: Protein mini spindles 著者 Byrnes, A.E, Slep, K.C. 登録日 2017-04-19 公開日 2017-05-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 TOG-tubulin binding specificity promotes microtubule dynamics and mitotic spindle formation. J. Cell Biol., 216, 2017
5IIR	NMR Structures Show Unwinding of the GCN4p Coiled Coil Superhelix Accompanying Disruption of Ion Pairs at Acidic pH 分子名称: General control protein GCN4 著者 Brady, M.R, Kaplan, A.R, Alexandrescu, A.T. 登録日 2016-03-01 公開日 2017-03-15 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Nuclear Magnetic Resonance Structures of GCN4p Are Largely Conserved When Ion Pairs Are Disrupted at Acidic pH but Show a Relaxation of the Coiled Coil Superhelix. Biochemistry, 56, 2017
7M1E	Structural and functional studies about scorpine showed the presence of blocking channel and cytolytic activities as well as two different structural domains 分子名称: Scorpine 著者 del Rio, J.F, Lopez, A.E, Titaux, G. 登録日 2021-03-12 公開日 2022-01-19 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural and functional studies of scorpine: A channel blocker and cytolytic peptide. Toxicon, 222, 2022
5VFB	1.36 Angstrom Resolution Crystal Structure of Malate Synthase G from Pseudomonas aeruginosa in Complex with Glycolic Acid. 分子名称: CHLORIDE ION, GLYCOLIC ACID, Malate synthase G, ... 著者 Minasov, G, Shuvalova, L, Dubrovska, I, Kiryukhina, O, Grimshaw, S, Kwon, K, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2017-04-07 公開日 2017-04-19 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.36 Å) 主引用文献 1.36 Angstrom Resolution Crystal Structure of Malate Synthase G from Pseudomonas aeruginosa in Complex with Glycolic Acid. To Be Published
7LII	Thermotoga maritima Encapsulin Nanocompartment Pore Mutant S7D 分子名称: Maritimacin, RIBOFLAVIN 著者 Andreas, M.P, Adamson, L, Tasneem, N, Close, W, Giessen, T, Lau, Y.H. 登録日 2021-01-27 公開日 2022-02-09 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.55 Å) 主引用文献 Pore structure controls stability and molecular flux in engineered protein cages. Sci Adv, 8, 2022
5VFZ	Integrase from mycobacterium phage Brujita 分子名称: ACETATE ION, GLYCEROL, Gp33, ... 著者 VanDemark, A.P, Lunt, B, Hatfull, G.F. 登録日 2017-04-10 公開日 2018-04-18 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.847 Å) 主引用文献 Integrase from mycobacterium phage Brujita To Be Published
5IK3	Crystal structure of anti-gliadin 1002-1E03 Fab fragment 分子名称: 1E03 Fab fragment heavy chain, 1E03 Fab fragment light chain, SULFATE ION 著者 Snir, O, Chen, X, Gidoni, M, du Pre, M.F, Zhao, Y, Steinsbo, O, Lundin, K.E, Yaari, G, Sollid, L.M. 登録日 2016-03-03 公開日 2017-03-15 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Stereotyped antibody responses target posttranslationally modified gluten in celiac disease. JCI Insight, 2, 2017
7LIL	Thermotoga maritima Encapsulin Nanocompartment Pore Mutant SE3 分子名称: Maritimacin, RIBOFLAVIN 著者 Andreas, M.P, Adamson, L, Tasneem, N, Close, W, Giessen, T, Lau, Y.H. 登録日 2021-01-27 公開日 2022-02-09 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (2.84 Å) 主引用文献 Pore structure controls stability and molecular flux in engineered protein cages. Sci Adv, 8, 2022
5VG7	Crystal Structure of the R503Q missense variant of human PGM1 分子名称: GLYCEROL, MAGNESIUM ION, Phosphoglucomutase-1, ... 著者 Stiers, K.M, Beamer, L.J. 登録日 2017-04-10 公開日 2018-06-20 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.95000327 Å) 主引用文献 A Hotspot for Disease-Associated Variants of Human PGM1 Is Associated with Impaired Ligand Binding and Loop Dynamics. Structure, 26, 2018
1SFG	BINDING OF HEXA-N-ACETYLCHITOHEXAOSE: A POWDER DIFFRACTION STUDY 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LYSOZYME 著者 Von Dreele, R.B. 登録日 2004-02-19 公開日 2004-03-02 最終更新日 2024-10-30 実験手法 POWDER DIFFRACTION 主引用文献 Binding of N-acetylglucosamine oligosaccharides to hen egg-white lysozyme: a powder diffraction study. Acta Crystallogr.,Sect.D, 61, 2005
5IKE	Crystal structure of mutant-D97N of peptidyl-tRNA hydrolase from Vibrio cholerae 分子名称: Peptidyl-tRNA hydrolase 著者 Shahid, S, Kabra, A, Pal, R.K, Arora, A. 登録日 2016-03-03 公開日 2017-03-08 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Unraveling the stereochemical and dynamic aspects of the catalytic site of bacterial peptidyl-tRNA hydrolase. RNA, 23, 2017

<244245246247248249250251252253254255256257258259>