PDB: 2718 件ウェブページステータス検索Chemie searchBIRD

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3BD7	Glycogen Phosphorylase complex with 1(-D-glucopyranosyl) thymine 分子名称: 1-beta-D-glucopyranosyl-5-methylpyrimidine-2,4(1H,3H)-dione, Glycogen phosphorylase, muscle form, ... 著者 Sovantzis, D.A, Hadjiloi, T, Hayes, J.M, Zographos, S.E, Chrysina, E.D, Oikonomakos, N.G. 登録日 2007-11-14 公開日 2008-11-18 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 D-Glucopyranosyl pyrimidine nucleoside binding to muscle glycogen phosphorylase b To be Published
1U0F	Crystal structure of mouse phosphoglucose isomerase in complex with glucose 6-phosphate 分子名称: 6-O-phosphono-alpha-D-glucopyranose, BETA-MERCAPTOETHANOL, GLUCOSE-6-PHOSPHATE, ... 著者 Solomons, J.T.G, Zimmerly, E.M, Burns, S, Krishnamurthy, N, Swan, M.K, Krings, S, Muirhead, H, Chirgwin, J, Davies, C. 登録日 2004-07-13 公開日 2004-11-02 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 The crystal structure of mouse phosphoglucose isomerase at 1.6A resolution and its complex with glucose 6-phosphate reveals the catalytic mechanism of sugar ring opening. J.Mol.Biol., 342, 2004
1UBV	STRUCTURE OF FARNESYL PYROPHOSPHATE SYNTHETASE 分子名称: FARNESYL DIPHOSPHATE SYNTHASE 著者 Tarshis, L.C, Proteau, P, Poulter, C.D, Sacchettini, J.C. 登録日 1996-10-14 公開日 1997-03-12 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Regulation of product chain length by isoprenyl diphosphate synthases. Proc.Natl.Acad.Sci.USA, 93, 1996
1UBW	STRUCTURE OF FARNESYL PYROPHOSPHATE SYNTHETASE 分子名称: FARNESYL DIPHOSPHATE SYNTHASE, GERANYL DIPHOSPHATE, MAGNESIUM ION 著者 Tarshis, L.C, Proteau, P, Poulter, C.D, Sacchettini, J.C. 登録日 1996-10-14 公開日 1997-03-12 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Regulation of product chain length by isoprenyl diphosphate synthases. Proc.Natl.Acad.Sci.USA, 93, 1996
1UBX	STRUCTURE OF FARNESYL PYROPHOSPHATE SYNTHETASE 分子名称: FARNESYL DIPHOSPHATE, FARNESYL DIPHOSPHATE SYNTHASE, MAGNESIUM ION 著者 Tarshis, L.C, Proteau, P, Poulter, C.D, Sacchettini, J.C. 登録日 1996-10-14 公開日 1997-03-12 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Regulation of product chain length by isoprenyl diphosphate synthases. Proc.Natl.Acad.Sci.USA, 93, 1996
1UBY	STRUCTURE OF FARNESYL PYROPHOSPHATE SYNTHETASE 分子名称: DIMETHYLALLYL DIPHOSPHATE, FARNESYL DIPHOSPHATE SYNTHASE, MAGNESIUM ION 著者 Tarshis, L.C, Proteau, P, Poulter, C.D, Sacchettini, J.C. 登録日 1996-10-14 公開日 1997-03-12 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Regulation of product chain length by isoprenyl diphosphate synthases. Proc.Natl.Acad.Sci.USA, 93, 1996
1VG7	Crystal Structure Of Octaprenyl Pyrophosphate Synthase From Hyperthermophilic Thermotoga Maritima F132A/L128A/I123A/D62A mutant 分子名称: octoprenyl-diphosphate synthase 著者 Guo, R.T, Kuo, C.J, Ko, T.P, Chou, C.C, Liang, P.H, Wang, A.H.-J. 登録日 2004-04-23 公開日 2004-05-18 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 A molecular ruler for chain elongation catalyzed by octaprenyl pyrophosphate synthase and its structure-based engineering to produce unprecedented long chain trans-prenyl products Biochemistry, 43, 2004
1VPP	COMPLEX BETWEEN VEGF AND A RECEPTOR BLOCKING PEPTIDE 分子名称: PROTEIN (PEPTIDE V108), PROTEIN (VASCULAR ENDOTHELIAL GROWTH FACTOR) 著者 Wiesmann, C, Christinger, H.W, Cochran, A.G, Cunningham, B.C, Fairbrother, W.J, Keenan, C.J, Meng, G, de Vos, A.M. 登録日 1998-10-09 公開日 1999-02-23 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of the complex between VEGF and a receptor-blocking peptide. Biochemistry, 37, 1998
1VG3	Crystal Structure Of Octaprenyl Pyrophosphate Synthase From Hyperthermophilic Thermotoga Maritima A76Y/S77F mutant 分子名称: SULFATE ION, octoprenyl-diphosphate synthase 著者 Guo, R.T, Kuo, C.J, Ko, T.P, Chou, C.C, Liang, P.H, Wang, A.H.-J. 登録日 2004-04-23 公開日 2004-05-18 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 A molecular ruler for chain elongation catalyzed by octaprenyl pyrophosphate synthase and its structure-based engineering to produce unprecedented long chain trans-prenyl products Biochemistry, 43, 2004
3CEJ	Human glycogen phosphorylase (tense state) in complex with the allosteric inhibitor AVE2865 分子名称: 1-{2-[3-(2-Chloro-4,5-difluoro-benzoyl)-ureido]-4-fluoro-phenyl}-piperidine-4-carboxylic acid, Glycogen phosphorylase, liver form, ... 著者 Wendt, K.U, Dreyer, M.K, Anderka, O, Klabunde, T, Loenze, P, Defossa, E, Schmoll, D. 登録日 2008-02-29 公開日 2008-05-27 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Thermodynamic characterization of allosteric glycogen phosphorylase inhibitors. Biochemistry, 47, 2008
1VPF	STRUCTURE OF HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR 分子名称: VASCULAR ENDOTHELIAL GROWTH FACTOR 著者 Muller, Y.A, De Vos, A.M. 登録日 1997-04-08 公開日 1998-04-08 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site. Proc.Natl.Acad.Sci.USA, 94, 1997
3CUV	Tracking structure activity relationships of glycogen phosphorylase inhibitors: synthesis, kinetic and crystallographic evaluation of analogues of N-(-D-glucopyranosyl)-N'-oxamides 分子名称: DIMETHYL SULFOXIDE, Glycogen phosphorylase, muscle form, ... 著者 Kyritsi, C, Chrysina, E.D, Leonidas, D.D, Zographos, S.E, Oikonomakos, N.G. 登録日 2008-04-17 公開日 2009-04-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Tracking structure activity relationships of glycogen phosphorylase inhibitors: synthesis, kinetic and crystallographic evaluation of analogues of N-(-D-glucopyranosyl)-N'-oxamides To be Published
1VG2	Crystal Structure Of Octaprenyl Pyrophosphate Synthase From Hyperthermophilic Thermotoga Maritima A76Y mutant 分子名称: octoprenyl-diphosphate synthase 著者 Guo, R.T, Kuo, C.J, Ko, T.P, Chou, C.C, Liang, P.H, Wang, A.H.-J. 登録日 2004-04-23 公開日 2004-05-18 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 A molecular ruler for chain elongation catalyzed by octaprenyl pyrophosphate synthase and its structure-based engineering to produce unprecedented long chain trans-prenyl products Biochemistry, 43, 2004
3CC9	Crystal structure of Plasmodium vivax putative polyprenyl pyrophosphate synthase in complex with geranylgeranyl diphosphate 分子名称: GERANYLGERANYL DIPHOSPHATE, Putative farnesyl pyrophosphate synthase, SODIUM ION 著者 Wernimont, A.K, Dunford, J, Lew, J, Zhao, Y, Kozieradzki, I, Cossar, D, Schapira, M, Bochkarev, A, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Hui, R, Artz, J.D, Structural Genomics Consortium (SGC) 登録日 2008-02-25 公開日 2008-03-25 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of Plasmodium vivax putative polyprenyl pyrophosphate synthase in complex with geranylgeranyl diphosphate. To be Published
3BCU	Glucogen Phosphorylase complex with thymidine 分子名称: Glycogen phosphorylase, muscle form, THYMIDINE 著者 Sovantzis, D.A, Hadjiloi, T, Hayes, J.M, Zographos, S.E, Chrysina, E.D, Oikonomakos, N.G. 登録日 2007-11-13 公開日 2008-11-18 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 D-Glucopyranosyl pyrimidine nucleoside binding to muscle glycogen phosphorylase b To be Published
1WL2	Crystal Structure Of Octaprenyl Pyrophosphate Synthase From Hyperthermophilic Thermotoga Maritima R90A mutant 分子名称: SULFATE ION, octoprenyl-diphosphate synthase 著者 Guo, R.T, Kuo, C.J, Cheng, Y.S, Cheng, Y.L, Liang, P.H, Wang, A.H.-J. 登録日 2004-06-18 公開日 2005-06-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Biochemical and Structural Basis for Octaprenyl Pyrophosphate Synthase To be Published
3B7L	Human farnesyl diphosphate synthase complexed with MG and minodronate 分子名称: (1-HYDROXY-2-IMIDAZO[1,2-A]PYRIDIN-3-YLETHANE-1,1-DIYL)BIS(PHOSPHONIC ACID), Farnesyl pyrophosphate synthetase, MAGNESIUM ION 著者 Pilka, E.S, Dunford, J.E, Guo, K, Pike, A.C.W, Kavanagh, K.L, von Delft, F, Ebetino, F.H, Arrowsmith, C.H, Edwards, A.M, Russell, R.G.G, Oppermann, U, Structural Genomics Consortium (SGC) 登録日 2007-10-31 公開日 2007-11-13 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Human farnesyl diphosphate synthase complexed with MG and minodronate. TO BE PUBLISHED
3BDA	Glycogen Phosphorylase complex with 1(-D-glucopyranosyl) cyanuric acid 分子名称: 1-beta-D-glucopyranosyl-1,3,5-triazinane-2,4,6-trione, Glycogen phosphorylase, muscle form, ... 著者 Sovantzis, D.A, Hadjiloi, T, Hayes, J.M, Zographos, S.E, Chrysina, E.D, Oikonomakos, N.G. 登録日 2007-11-14 公開日 2008-11-18 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 D-Glucopyranosyl pyrimidine nucleoside binding to muscle glycogen phosphorylase b To be Published
1WQ8	Crystal structure of Vammin, a VEGF-F from a snake venom 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Vascular endothelial growth factor toxin 著者 Suto, K, Yamazaki, Y, Morita, T, Mizuno, H. 登録日 2004-09-23 公開日 2004-12-07 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structures of novel vascular endothelial growth factors (VEGF) from snake venoms: insight into selective VEGF binding to kinase insert domain-containing receptor but not to fms-like tyrosine kinase-1. J.Biol.Chem., 280, 2005
1WUT	Acyl Ureas as Human Liver Glycogen Phosphorylase Inhibitors for the Treatment of Type 2 Diabetes 分子名称: 7-[2,6-DICHLORO-4-({[(2-CHLOROBENZOYL)AMINO]CARBONYL}AMINO)PHENOXY]HEPTANOIC ACID, Glycogen phosphorylase, muscle form, ... 著者 Klabunde, T, Wendt, K.U, Kadereit, D, Brachvogel, V, Burger, H.-J, Herling, A.W, Oikonomakos, N.G, Kosmopoulou, M.N, Schmoll, D, Sarubbi, E, von Roedern, E, Schonafinger, K, Defossa, E. 登録日 2004-12-08 公開日 2005-12-08 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs Protein Sci., 14, 2005
6Y5O	The crystal structure of glycogen phosphorylase in complex with 20 分子名称: 2-(4-fluorophenyl)-5,7-bis(oxidanyl)chromen-4-one, Glycogen phosphorylase, muscle form 著者 Kyriakis, E, Koulas, S.M, Skamnaki, V.T, Leonidas, D.D. 登録日 2020-02-25 公開日 2020-08-19 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors. Bioorg.Chem., 102, 2020
3CP6	Crystal structure of human farnesyl diphosphate synthase (T201A mutant) complexed with Mg and biphosphonate inhibitor 分子名称: (4aS,7aR)-octahydro-1H-cyclopenta[b]pyridine-6,6-diylbis(phosphonic acid), Farnesyl pyrophosphate synthetase, MAGNESIUM ION 著者 Pilka, E.S, Dunford, J.E, Guo, K, Pike, A.C.W, von Delft, F, Barnett, B.L, Ebetino, F.H, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Russell, R.G.G, Oppermann, U, Structural Genomics Consortium (SGC) 登録日 2008-03-31 公開日 2008-04-15 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Human farnesyl diphosphate synthase (T201A mutant) complexed with Mg and biphosphonate inhibitor. To be Published
6Y8I	Fragment KCL_I013 in complex with IL-1-beta 分子名称: 1-(5-bromanylpyridin-2-yl)-3-(2-hydroxyethyl)urea, Interleukin-1 beta, SULFATE ION 著者 De Nicola, G.F, Nichols, C.E. 登録日 2020-03-05 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 Fragment KCL_I013 in complex with IL-1-beta To Be Published
3CEM	Human glycogen phosphorylase (tense state) in complex with the allosteric inhibitor AVE9423 分子名称: 1-(2-carboxyphenyl)-7-chloro-6-[(2-chloro-4,6-difluorophenyl)amino]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, Glycogen phosphorylase, liver form, ... 著者 Wendt, K.U, Dreyer, M.K, Anderka, O, Klabunde, T, Loenze, P, Defossa, E, Schmoll, D. 登録日 2008-02-29 公開日 2008-05-27 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 Thermodynamic characterization of allosteric glycogen phosphorylase inhibitors. Biochemistry, 47, 2008
1WL1	Crystal Structure Of Octaprenyl Pyrophosphate Synthase From Hyperthermophilic Thermotoga Maritima H74A mutant 分子名称: octoprenyl-diphosphate synthase 著者 Guo, R.T, Kuo, C.J, Cheng, Y.S, Cheng, Y.L, Liang, P.H, Wang, A.H.-J. 登録日 2004-06-18 公開日 2005-06-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 Biochemical and Structural Basis for Octaprenyl Pyrophosphate Synthase To be Published

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