PDB: 615 件ウェブページステータス検索Chemie searchBIRD

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8DGS	Cryo-EM structure of a RAS/RAF complex (state 1) 分子名称: 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ... 著者 Eck, M.J, Jeon, H, Park, E, Rawson, S. 登録日 2022-06-24 公開日 2023-07-05 最終更新日 2023-08-09 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Cryo-EM structure of a RAS/RAF recruitment complex. Nat Commun, 14, 2023
8DGT	Cryo-EM structure of a RAS/RAF complex (state 2) 分子名称: 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ... 著者 Eck, M.J, Jeon, H, Park, E, Rawson, S. 登録日 2022-06-24 公開日 2023-07-05 最終更新日 2023-08-09 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Cryo-EM structure of a RAS/RAF recruitment complex. Nat Commun, 14, 2023
8DP5	Structure of the PEAK3/14-3-3 complex 分子名称: 14-3-3 protein beta/alpha, 14-3-3 protein epsilon, Protein PEAK3, ... 著者 Torosyan, H, Paul, M, Jura, N, Verba, K.A. 登録日 2022-07-14 公開日 2023-06-28 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3. Nat Commun, 14, 2023
8EQ8	The crystal structure of 14-3-3 Beta containing 3-nitrotyrosine at position Y130 分子名称: 14-3-3 protein beta/alpha 著者 Zhu, P, Cooley, R.B. 登録日 2022-10-07 公開日 2023-01-25 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Genetic encoding of 3-nitro-tyrosine reveals the impacts of 14-3-3 nitration on client binding and dephosphorylation. Protein Sci., 32, 2023
8EQH	The crystal structure of 14-3-3 Beta containing 3-nitrotyrosine at position Y213 分子名称: 14-3-3 protein beta/alpha 著者 Zhu, P, Cooley, R.B. 登録日 2022-10-07 公開日 2023-01-25 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Genetic encoding of 3-nitro-tyrosine reveals the impacts of 14-3-3 nitration on client binding and dephosphorylation. Protein Sci., 32, 2023
8HEW	Potato 14-3-3 St14f 分子名称: 14-3-3 protein, StFDL1 peptide 著者 Taoka, K, Kawahara, I, Shinya, S, Harada, K, Muranaka, T, Furuita, K, Nakagawa, A, Fujiwara, T, Tsuji, H, Kojima, C. 登録日 2022-11-08 公開日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 Multifunctional chemical inhibitors of the florigen activation complex discovered by structure-based high-throughput screening. Plant J., 112, 2022
8P0D	Human 14-3-3 sigma in complex with human MDM2 peptide 分子名称: 14-3-3 protein sigma, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Roversi, P, Ward, J, Doveston, R, Kwon, H, Romartinez Alonso, B. 登録日 2023-05-10 公開日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Characterizing the protein-protein interaction between MDM2 and 14-3-3 sigma ; proof of concept for small molecule stabilization. J.Biol.Chem., 300, 2024
8P1H	Crystal structure of the chimera of human 14-3-3 zeta and phosphorylated cytoplasmic loop fragment of the alpha7 acetylcholine receptor 分子名称: 1,2-ETHANEDIOL, AZIDE ION, BENZOIC ACID, ... 著者 Boyko, K.M, Kapitonova, A.A, Tugaeva, K.V, Varfolomeeva, L.A, Lyukmanova, E.N, Sluchanko, N.N. 登録日 2023-05-12 公開日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal structure reveals canonical recognition of the phosphorylated cytoplasmic loop of human alpha7 nicotinic acetylcholine receptor by 14-3-3 protein. Biochem.Biophys.Res.Commun., 682, 2023
8Q1S	Pathogenic mutations of human phosphorylation sites affect protein-protein interactions 分子名称: 1,2-ETHANEDIOL, 14-3-3 protein epsilon, BROMIDE ION, ... 著者 Roske, Y, Daumke, O, Rrustemi, T, Selbach, M. 登録日 2023-08-01 公開日 2024-02-21 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (3.23 Å) 主引用文献 Pathogenic mutations of human phosphorylation sites affect protein-protein interactions. Nat Commun, 15, 2024
8Q4L	GBP1 bound by 14-3-3sigma 分子名称: 14-3-3 protein sigma, Guanylate-binding protein 1 著者 Pfleiderer, M.M, Liu, X, Fisch, D, Anastasakou, E, Frickel, E.M, Galej, W.P. 登録日 2023-08-07 公開日 2023-10-11 最終更新日 2023-10-18 実験手法 ELECTRON MICROSCOPY (5.12 Å) 主引用文献 PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection. Science, 382, 2023
8QT5	Crystal structure of Arabidopsis thaliana 14-3-3 isoform lambda in complex with a phosphopeptide from the transcription factor BZR1. 分子名称: 14-3-3-like protein G-BOX factor 14 lambda,Protein BRASSINAZOLE-RESISTANT 1, ACETATE ION 著者 Hothorn, M, Obergfell, E. 登録日 2023-10-12 公開日 2023-10-25 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
8QTC	Crystal structure of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the transcription factor BZR1. 分子名称: 14-3-3-like protein GF14 omega, COBALT (II) ION, Protein BRASSINAZOLE-RESISTANT 1, ... 著者 Hothorn, M, Obergfell, E. 登録日 2023-10-12 公開日 2023-11-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
8QTF	Crystal structure of a C-terminally truncated version of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the transcription factor BZR1. 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 14-3-3-like protein GF14 omega, ... 著者 Hothorn, M, Obergfell, E. 登録日 2023-10-12 公開日 2023-11-22 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
8QTT	Crystal structure of a C-terminally truncated version of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the inhibitor protein BKI1. 分子名称: 1,2-ETHANEDIOL, 14-3-3-like protein GF14 omega, BRI1 kinase inhibitor 1, ... 著者 Hothorn, M, Obergfell, E. 登録日 2023-10-13 公開日 2023-11-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
9AXA	CryoEM structure of activated CRAF/MEK/14-3-3 complex with NST-628 分子名称: 14-3-3 protein sigma, Dual specificity mitogen-activated protein kinase kinase 1, GST26/CRAF chimera, ... 著者 Quade, B, Cohen, S.E, Huang, X. 登録日 2024-03-06 公開日 2024-04-17 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (4.36 Å) 主引用文献 The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024

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