PDB: 1396 件ウェブページステータス検索Chemie searchBIRD

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6UZB	Anthrax toxin protective antigen channels bound to edema factor 分子名称: CALCIUM ION, Calmodulin-sensitive adenylate cyclase, Protective antigen 著者 Hardenbrook, N.J, Liu, S, Zhou, K, Zhou, Z.H, Krantz, B.A. 登録日 2019-11-14 公開日 2020-03-04 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors. Nat Commun, 11, 2020
6UZE	Anthrax toxin protective antigen channels bound to edema factor 分子名称: CALCIUM ION, Calmodulin-sensitive adenylate cyclase, Protective antigen 著者 Hardenbrook, N.J, Liu, S, Zhou, K, Zhou, Z.H, Krantz, B.A. 登録日 2019-11-15 公開日 2020-03-04 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors. Nat Commun, 11, 2020
6UZD	Anthrax toxin protective antigen channels bound to edema factor 分子名称: CALCIUM ION, Calmodulin-sensitive adenylate cyclase, Protective antigen 著者 Hardenbrook, N.J, Liu, S, Zhou, K, Zhou, Z.H, Krantz, B.A. 登録日 2019-11-14 公開日 2020-03-04 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors. Nat Commun, 11, 2020
4TZR	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1561 分子名称: 1-{4-amino-3-[2-(cyclopropyloxy)quinolin-6-yl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-2-methylpropan-2-ol, Calmodulin-domain protein kinase 1 著者 Merritt, E.A. 登録日 2014-07-10 公開日 2014-08-27 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis. J. Med. Chem., 59, 2016
8DVE	RyR1 in presence of IpCa-T26E phosphomimetic and activating ligands 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, CALCIUM ION, ... 著者 Haji-Ghassemi, O, Van Petegm, F. 登録日 2022-07-28 公開日 2023-05-31 最終更新日 2023-07-05 実験手法 ELECTRON MICROSCOPY (3.84 Å) 主引用文献 Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation. Sci Adv, 9, 2023
2VB6	Myosin VI (MD-insert2-CaM, Delta Insert1) Post-rigor state (crystal form 2) 分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, CALCIUM ION, ... 著者 Menetrey, J, Llinas, P, Cicolari, J, Squires, G, Liu, X, Li, A, Sweeney, H.L, Houdusse, A. 登録日 2007-09-06 公開日 2007-12-11 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The Post-Rigor Structure of Myosin Vi and Implications for the Recovery Stroke. Embo J., 27, 2008
4JBV	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1268 分子名称: 1-[(1-methylpiperidin-4-yl)methyl]-3-[6-(2-methylpropoxy)naphthalen-2-yl]pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1 著者 Merritt, E.A, Larson, E.T. 登録日 2013-02-20 公開日 2014-03-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes. Eur.J.Med.Chem., 74, 2014
4M84	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1455 分子名称: 5-amino-1-tert-butyl-3-(quinolin-2-yl)-1H-pyrazole-4-carboxamide, Calmodulin-domain protein kinase 1 著者 Merritt, E.A. 登録日 2013-08-12 公開日 2013-10-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.998 Å) 主引用文献 Potent and selective inhibitors of CDPK1 from T. gondii and C. parvum based on a 5-aminopyrazole-4-carboxamide scaffold. ACS Med Chem Lett, 5, 2014
4JND	Structure of a C.elegans sex determining protein 分子名称: Ca(2+)/calmodulin-dependent protein kinase phosphatase, MAGNESIUM ION 著者 Feng, Y, Zhang, Y, Ge, J, Yang, M. 登録日 2013-03-15 公開日 2013-06-19 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.652 Å) 主引用文献 Structural insight into Caenorhabditis elegans sex-determining protein FEM-2. J.Biol.Chem., 288, 2013
5OW5	p60p80-CAMSAP complex 分子名称: 1,2-ETHANEDIOL, Calmodulin-regulated spectrin-associated protein, DI(HYDROXYETHYL)ETHER, ... 著者 Rezabkova, L, Capitani, G, Prota, A.E, Kammerer, R.A, Steinmetz, M.O. 登録日 2017-08-30 公開日 2018-07-11 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural Basis of Formation of the Microtubule Minus-End-Regulating CAMSAP-Katanin Complex. Structure, 26, 2018
7P1G	Structure of the P. aeruginosa ExoY-F-actin complex 分子名称: 3'-DEOXY-GUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, Actin, ... 著者 Belyy, A, Merino, F, Raunser, S. 登録日 2021-07-01 公開日 2021-11-17 最終更新日 2021-12-01 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Mechanism of actin-dependent activation of nucleotidyl cyclase toxins from bacterial human pathogens. Nat Commun, 12, 2021
7P1H	Structure of the V. vulnificus ExoY-G-actin-profilin complex 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Actin, cytoplasmic 1, ... 著者 Belyy, A, Merino, F, Raunser, S. 登録日 2021-07-01 公開日 2021-11-17 最終更新日 2021-12-01 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Mechanism of actin-dependent activation of nucleotidyl cyclase toxins from bacterial human pathogens. Nat Commun, 12, 2021
3T3U	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with Bumped Kinase Inhibitor, RM-1-130 分子名称: 1,2-ETHANEDIOL, 3-(6-methoxynaphthalen-2-yl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1, ... 著者 Larson, E.T, Merritt, E.A. 登録日 2011-07-25 公開日 2012-03-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. J.Med.Chem., 55, 2012
3SX9	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with Bumped Kinase Inhibitor, RM-1-132 分子名称: 3-(6-ethoxynaphthalen-2-yl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1 著者 Larson, E.T, Merritt, E.A. 登録日 2011-07-14 公開日 2012-03-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. J.Med.Chem., 55, 2012
3SXF	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with Bumped Kinase Inhibitor, RM-1-89 分子名称: 1,2-ETHANEDIOL, 3-(6-ethoxynaphthalen-2-yl)-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1, ... 著者 Larson, E.T, Merritt, E.A. 登録日 2011-07-14 公開日 2012-03-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. J.Med.Chem., 55, 2012
3T3V	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with Bumped Kinase Inhibitor, RM-1-87 分子名称: 1,2-ETHANEDIOL, 3-(6-methoxynaphthalen-2-yl)-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1 著者 Larson, E.T, Merritt, E.A. 登録日 2011-07-25 公開日 2012-03-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. J.Med.Chem., 55, 2012
8W41	Cryo-EM structure of Myosin VI in the autoinhibited state 分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Calmodulin-1, ... 著者 Niu, F, Wei, Z. 登録日 2023-08-23 公開日 2024-02-21 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.54 Å) 主引用文献 Autoinhibition and activation of myosin VI revealed by its cryo-EM structure. Nat Commun, 15, 2024
2P6B	Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide 分子名称: CALCIUM ION, Calcineurin subunit B isoform 1, Calmodulin-dependent calcineurin A subunit alpha isoform, ... 著者 Li, H, Zhang, L, Rao, A, Harrison, S.C, Hogan, P.G. 登録日 2007-03-16 公開日 2007-06-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of calcineurin in complex with PVIVIT peptide: Portrait of a low-affinity signalling interaction J.Mol.Biol., 369, 2007
7BYN	Cryo-EM structure of human KCNQ4 with linopirdine 分子名称: 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one, Calmodulin-3, Green fluorescent protein,Potassium voltage-gated channel subfamily KQT member 4, ... 著者 Shen, H, Li, T, Yue, Z. 登録日 2020-04-23 公開日 2020-12-02 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs. Mol.Cell, 81, 2021
7B55	Crystal structure of CaMKII-actinin complex bound to MES 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Alpha-actinin-2, Calcium/calmodulin-dependent protein kinase type II subunit alpha 著者 Zhu, J, Gold, M. 登録日 2020-12-03 公開日 2022-06-22 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal structure of CaMKII-actinin complex bound to MES To Be Published
7B56	Crystal structure of CaMKII-actinin complex bound to AMPPNP 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Alpha-actinin-2, Calcium/calmodulin-dependent protein kinase type II subunit alpha, ... 著者 Zhu, J, Gold, M. 登録日 2020-12-03 公開日 2022-06-22 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Crystal structure of CaMKII-actinin complex bound to MES To Be Published
7B57	Crystal structure of CaMKII-actinin complex bound to ADP 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, Alpha-actinin-2, ... 著者 Zhu, J, Gold, M. 登録日 2020-12-03 公開日 2022-06-22 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal structure of CaMKII-actinin complex bound to ADP To Be Published
1M63	Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes 分子名称: CALCINEURIN B SUBUNIT ISOFORM 1, CALCIUM ION, CYCLOSPORIN A, ... 著者 Huai, Q, Kim, H.-Y, Liu, Y, Zhao, Y, Mondragon, A, Liu, J.O, Ke, H. 登録日 2002-07-12 公開日 2002-09-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal Structure of Calcineurin-Cyclophilin-Cyclosporin Shows Common But Distinct Recognition of Immunophilin-Drug Complexes Proc.Natl.Acad.Sci.USA, 99, 2002
1GG3	CRYSTAL STRUCTURE OF THE PROTEIN 4.1R MEMBRANE BINDING DOMAIN 分子名称: ERYTHROID MEMBRANE PROTEIN 4.1R 著者 Han, B.G. 登録日 2000-07-11 公開日 2001-01-10 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Protein 4.1R core domain structure and insights into regulation of cytoskeletal organization. Nat.Struct.Biol., 7, 2000
5HU3	Drosophila CaMKII-D136N in complex with a phosphorylated fragment of the Eag potassium channel and Mg2+/ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Calcium/calmodulin-dependent protein kinase type II alpha chain, MAGNESIUM ION, ... 著者 Castro-Rodrigues, A.F, Morais-Cabral, J.H. 登録日 2016-01-27 公開日 2017-02-01 最終更新日 2019-11-13 実験手法 X-RAY DIFFRACTION (1.885 Å) 主引用文献 The Interaction between the Drosophila EAG Potassium Channel and the Protein Kinase CaMKII Involves an Extensive Interface at the Active Site of the Kinase. J.Mol.Biol., 430, 2018

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