2WCX
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6FHI
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6QNW
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6QPF
| Influenza A virus Polymerase Heterotrimer A/duck/Fujian/01/2002(H5N1) | 分子名称: | Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit | 著者 | Fan, H.T, Keown, J.R, Fodor, E, Grimes, J.M. | 登録日 | 2019-02-13 | 公開日 | 2019-09-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.634 Å) | 主引用文献 | Structures of influenza A virus RNA polymerase offer insight into viral genome replication. Nature, 573, 2019
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1GX5
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6FHH
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6RR7
| Influenza A virus (A/NT/60/1968) polymerase Heterotrimer bound to 3'5' vRNA promoter and capped RNA primer | 分子名称: | Polymerase acidic protein, Polymerase basic protein 2, RNA (5'-D(*(M7G))-R(P*AP*AP*UP*CP*U)-3'), ... | 著者 | Carrique, L, Keown, J.R, Fan, H, Fodor, E, Grimes, J.M. | 登録日 | 2019-05-17 | 公開日 | 2019-09-04 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | 主引用文献 | Structures of influenza A virus RNA polymerase offer insight into viral genome replication. Nature, 573, 2019
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4WYL
| Mutant K18E of 3D polymerase from Foot-and-Moth Disease Virus | 分子名称: | ACETATE ION, GLYCEROL, MANGANESE (II) ION, ... | 著者 | Ferrer-Orta, C, Verdaguer, N, de la Higuera, I, Domingo, E. | 登録日 | 2014-11-17 | 公開日 | 2015-05-06 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition. J.Virol., 89, 2015
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4WYW
| Mutant K20E of 3D polymerase from Foot-and-Mouth Disease Virus | 分子名称: | ACETATE ION, GLYCEROL, RNA-directed RNA polymerase 3D-POL, ... | 著者 | Ferrer-Orta, C, Verdaguer, N, de la Higuera, I, Domingo, E. | 登録日 | 2014-11-18 | 公開日 | 2015-05-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition. J.Virol., 89, 2015
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3H59
| Hepatitis C virus polymerase NS5B with thiazine inhibitor 2 | 分子名称: | N-{3-[(5S)-5-(1,1-dimethylpropyl)-1-(4-fluoro-3-methylbenzyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-1,1-dioxido-4H-1,4-benzothiazin-7-yl}methanesulfonamide, RNA-directed RNA polymerase | 著者 | Harris, S.F, Ghate, M. | 登録日 | 2009-04-21 | 公開日 | 2009-09-08 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Non-nucleoside inhibitors of HCV polymerase NS5B. Part 3: synthesis and optimization studies of benzothiazine-substituted tetramic acids Bioorg.Med.Chem.Lett., 19, 2009
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3U4R
| Novel HCV NS5B polymerase Inhibitors: Discovery of Indole C2 Acyl sulfonamides | 分子名称: | 1-[(2-aminopyridin-4-yl)methyl]-5-chloro-N-({3-[(methylsulfonyl)amino]phenyl}sulfonyl)-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxamide, RNA-directed RNA polymerase | 著者 | Anilkumar, G.N, Selyutin, O, Rosenblum, S.B, Zeng, Q, Jiang, Y, Chan, T.-Y, Pu, H, Wang, L, Bennett, F, Chen, K.X, Lesburg, C.A, Duca, J.S, Gavalas, S, Huang, Y, Pinto, P, Sannagrahi, M, Velazquez, F, Venkataraman, S, Vilbubhan, B, Agrawal, S, Ferrari, E, Jiang, C.-K, Huang, H.-C, Shih, N.-Y, Njoroge, F.G, Kozlowski, J.A. | 登録日 | 2011-10-10 | 公開日 | 2011-12-07 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | II. Novel HCV NS5B polymerase inhibitors: Discovery of indole C2 acyl sulfonamides. Bioorg.Med.Chem.Lett., 22, 2012
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3U4O
| Novel HCV NS5B polymerase Inhibitors: Discovery of Indole C2 Acyl sulfonamides | 分子名称: | 1-[(2-aminopyridin-4-yl)methyl]-5-chloro-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxylic acid, PHOSPHATE ION, RNA-directed RNA polymerase | 著者 | Anilkumar, G.N, Selyutin, O, Rosenblum, S.B, Zeng, Q, Jiang, Y, Chan, T.-Y, Pu, H, Wang, L, Bennett, F, Chen, K.X, Lesburg, C.A, Duca, J.S, Gavalas, S, Huang, Y, Pinto, P, Sannigrahi, M, Velazquez, F, Venkataraman, S, Vilbubhan, B, Agrawal, S, Ferrari, E, Jiang, C.-K, Huang, H.-C, Shih, N.-Y, Njoroge, F.G, Kozlowski, J.A. | 登録日 | 2011-10-10 | 公開日 | 2011-12-07 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | II. Novel HCV NS5B polymerase inhibitors: Discovery of indole C2 acyl sulfonamides. Bioorg.Med.Chem.Lett., 22, 2012
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6QPG
| Influenza A virus Polymerase Heterotrimer A/nt/60/1968(H3N2) in complex with Nanobody NB8205 | 分子名称: | Nanobody NB8205, Polymerase acidic protein, Polymerase basic protein 2, ... | 著者 | Fan, H.T, Keown, J.R, Fodor, E, Grimes, J.M. | 登録日 | 2019-02-13 | 公開日 | 2019-09-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.34 Å) | 主引用文献 | Structures of influenza A virus RNA polymerase offer insight into viral genome replication. Nature, 573, 2019
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3H5S
| Hepatitis C virus polymerase NS5B with saccharin inhibitor | 分子名称: | (5S)-5-tert-butyl-1-(4-fluoro-3-methylbenzyl)-4-hydroxy-3-[8-(methylsulfonyl)-1,1-dioxido-6,7,8,9-tetrahydroisothiazolo[4,5-h]isoquinolin-3-yl]-1,5-dihydro-2H-pyrrol-2-one, RNA-directed RNA polymerase | 著者 | Harris, S.F, Wong, A. | 登録日 | 2009-04-22 | 公開日 | 2009-09-08 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides Bioorg.Med.Chem.Lett., 19, 2009
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4MZ4
| Discovery of an Irreversible HCV NS5B Polymerase Inhibitor | 分子名称: | 1-[(2-chloroquinolin-3-yl)methyl]-6-fluoro-5-methyl-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxylic acid, PHOSPHATE ION, RNA-directed RNA polymerase | 著者 | Zeng, Q, Anilkumar, G.N, Rosenblum, S.B, Huang, H.-C, Lesburg, C.A, Jiang, Y, Selyutin, O, Chan, T.-Y, Bennett, F, Chen, K.X, Venkatraman, S, Sannigrahi, M, Velazquez, F, Duca, J.S, Gavalas, S, Huang, Y, Pu, H, Wang, L, Pinto, P, Vibulbhan, B, Agrawal, S, Ferrari, E, Jiang, C.-K, Li, C, Hesk, D, Gesell, J, Sorota, S, Shih, N.-Y, Njoroge, F.G, Kozlowski, J.A. | 登録日 | 2013-09-29 | 公開日 | 2013-12-11 | 最終更新日 | 2013-12-18 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Discovery of an irreversible HCV NS5B polymerase inhibitor. Bioorg.Med.Chem.Lett., 23, 2013
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3MF5
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4WSB
| Bat Influenza A polymerase with bound vRNA promoter | 分子名称: | Influenza A polymerase vRNA promoter 3' end, Influenza A polymerase vRNA promoter 5' end, PHOSPHATE ION, ... | 著者 | Cusack, S, Pflug, A, Guilligay, D, Reich, S. | 登録日 | 2014-10-26 | 公開日 | 2014-11-19 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structural insight into cap-snatching and RNA synthesis by influenza polymerase. Nature, 516, 2014
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3G86
| Hepatitis C virus polymerase NS5B (BK 1-570) with thiazine inhibitor | 分子名称: | N-{3-[6-fluoro-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-1,1-dioxido-4H-1,4-benzothiazin-7-yl}methanesulfonamide, NICKEL (II) ION, RNA-directed RNA polymerase | 著者 | Harris, S.F, Ghate, M. | 登録日 | 2009-02-11 | 公開日 | 2009-09-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure-activity relationships of benzothiazine-substituted quinolinediones Bioorg.Med.Chem.Lett., 19, 2009
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3H5U
| Hepatitis C virus polymerase NS5B with saccharin inhibitor 1 | 分子名称: | N-({3-[(5S)-5-tert-butyl-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-1,1-dioxido-1,2-benzisothiazol-7-yl}methyl)methanesulfonamide, RNA-directed RNA polymerase | 著者 | Harris, S.F, Ghate, M. | 登録日 | 2009-04-22 | 公開日 | 2009-09-08 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides Bioorg.Med.Chem.Lett., 19, 2009
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4WRT
| Crystal structure of Influenza B polymerase with bound vRNA promoter (form FluB2) | 分子名称: | Influenza virus polymerase vRNA promoter 3' end, Influenza virus polymerase vRNA promoter 5' end, PA, ... | 著者 | Reich, S, Guilligay, D, Pflug, A, Cusack, S. | 登録日 | 2014-10-25 | 公開日 | 2014-11-19 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural insight into cap-snatching and RNA synthesis by influenza polymerase. Nature, 516, 2014
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5JXS
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6U1X
| Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor (3.0 A resolution) | 分子名称: | Phosphoprotein, RNA-directed RNA polymerase L, ZINC ION | 著者 | Jenni, S, Bloyet, L.M, Dias-Avalos, R, Liang, B, Wheelman, S.P.J, Grigorieff, N, Harrison, S.C. | 登録日 | 2019-08-17 | 公開日 | 2020-01-22 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor. Cell Rep, 30, 2020
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4EO6
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4EO8
| HCV NS5B polymerase inhibitors: Tri-substituted acylhydrazines as tertiary amide bioisosteres | 分子名称: | 5-(3,3-dimethylbut-1-yn-1-yl)-3-{2,2-dimethyl-1-[(trans-4-methylcyclohexyl)carbonyl]hydrazinyl}thiophene-2-carboxylic acid, RNA-directed RNA polymerase | 著者 | Appleby, T.C, Canales, E, Watkins, W.J. | 登録日 | 2012-04-13 | 公開日 | 2012-06-27 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.798 Å) | 主引用文献 | Tri-substituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
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4WSA
| Crystal structure of Influenza B polymerase bound to the vRNA promoter (FluB1 form) | 分子名称: | Influenza B vRNA promoter 3' end, Influenza B vRNA promoter 5' end, PA, ... | 著者 | Reich, S, Guilligay, D, Pflug, A, Cusack, S. | 登録日 | 2014-10-26 | 公開日 | 2014-11-19 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Structural insight into cap-snatching and RNA synthesis by influenza polymerase. Nature, 516, 2014
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