2C05

Crystal Structures of Eosinophil-derived Neurotoxin in Complex with the Inhibitors 5'-ATP, Ap3A, Ap4A and Ap5A

Summary for 2C05

Entry DOI	10.2210/pdb2c05/pdb
Related	1GQV 1HI2 1HI3 1HI4 1HI5 1K2A 2BEX 2BZZ 2C01 2C02
Descriptor	NONSECRETORY RIBONUCLEASE, ACETIC ACID, BIS(ADENOSINE)-5'-TETRAPHOSPHATE, ... (4 entities in total)
Functional Keywords	endonuclease, eosinophil, hydrolase, nuclease, ribonuclease, rnase us, rnase-2, inhibitor, 5'-atp, ap3a, ap4a, ap5a, chemotaxis, glycoprotein, polymorphism, sensory transduction
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Lysosome (Probable): P10153
Total number of polymer chains	1
Total formula weight	16508.19
Authors	Baker, M.D.,Holloway, D.E.,Swaminathan, G.J.,Acharya, K.R. (deposition date: 2005-08-25, release date: 2006-01-18, Last modification date: 2023-12-13)
Primary citation	Baker, M.D.,Holloway, D.E.,Swaminathan, G.J.,Acharya, K.R. Crystal Structures of Eosinophil-Derived Neurotoxin (Edn) in Complex with the Inhibitors 5'- ATP, Ap(3)A, Ap(4)A, and Ap(5)A. Biochemistry, 45:416-, 2006 Cited by PubMed: 16401072 DOI: 10.1021/BI0518592 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.86 Å)

Structure validation