PDB: 7770 件ウェブページステータス検索Chemie searchBIRD

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2ZCY	yeast 20S proteasome:syringolin A-complex 分子名称: (2S)-2-[[(2S)-1-[[(5S,8S,9E)-2,7-dioxo-5-propan-2-yl-1,6-diazacyclododeca-3,9-dien-8-yl]amino]-3-methyl-1-oxo-butan-2-yl]carbamoylamino]-3-methyl-butanoic acid, Proteasome component C1, Proteasome component C11, ... 著者 Groll, M, Dudler, R, Kaiser, M. 登録日 2007-11-15 公開日 2008-04-08 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism Nature, 452, 2008
2ZHU	Crystal structure of BACE1 at pH 5.0 分子名称: Beta-secretase 1 著者 Shimizu, H, Nukina, N. 登録日 2008-02-08 公開日 2008-04-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of an active form of BACE1, an enzyme responsible for amyloid beta protein production Mol.Cell.Biol., 28, 2008
2J4A	Human Thyroid hormone receptor beta ligand binding domain in complex with KB131084 分子名称: 3,5-DIBROMO-4-(3-ISOPROPYL-PHENOXY)BENZOIC ACID, THYROID HORMONE RECEPTOR BETA-1 著者 Farnegardh, M. 登録日 2006-08-28 公開日 2007-09-25 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Thyroid Receptor Ligands. 6. A High Affinity "Direct Antagonist" Selective for the Thyroid Hormone Receptor. J.Med.Chem., 49, 2006
2ZHS	Crystal structure of BACE1 at pH 4.0 分子名称: Beta-secretase 1 著者 Shimizu, H, Nukina, N. 登録日 2008-02-08 公開日 2008-04-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of an active form of BACE1, an enzyme responsible for amyloid beta protein production Mol.Cell.Biol., 28, 2008
2ZJ0	Crystal structure of Mycobacterium tuberculosis S-Adenosyl-L-homocysteine hydrolase in ternary complex with NAD and 2-fluoroadenosine 分子名称: 2-(6-AMINO-2-FLUORO-PURIN-9-YL)-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3,4-DIOL, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Reddy, M.C.M, Gokulan, K, Shetty, N.D, Owen, J.L, Ioerger, T.R, Sacchettini, J.C. 登録日 2008-02-29 公開日 2008-09-16 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors. Protein Sci., 17, 2008
2ZK4	Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with 15-oxo-eicosatetraenoic acid 分子名称: (5E,8E,11Z,13E)-15-oxoicosa-5,8,11,13-tetraenoic acid, Peroxisome proliferator-activated receptor gamma 著者 Waku, T, Shiraki, T, Oyama, T, Fujimoto, Y, Morikawa, K. 登録日 2008-03-12 公開日 2009-02-24 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids J.Mol.Biol., 385, 2009
2ZK0	Human peroxisome proliferator-activated receptor gamma ligand binding domain 分子名称: Peroxisome proliferator-activated receptor gamma 著者 Waku, T, Shiraki, T, Oyama, T, Fujimoto, Y, Morikawa, K. 登録日 2008-03-12 公開日 2009-02-24 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids J.Mol.Biol., 385, 2009
2SFA	SERINE PROTEINASE FROM STREPTOMYCES FRADIAE ATCC 14544 分子名称: SERINE PROTEINASE 著者 Kitadokoro, K, Tsuzuki, H. 登録日 1994-04-25 公開日 1996-06-20 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Purification, characterization, primary structure, crystallization and preliminary crystallographic study of a serine proteinase from Streptomyces fradiae ATCC 14544. Eur.J.Biochem., 220, 1994
2ZKS	Structural insights into the proteolytic machinery of apoptosis-inducing Granzyme M 分子名称: Granzyme M, SULFATE ION, hGzmM inhibitor 著者 Wu, L.F, Wang, L, Hua, G.Q, Liu, K, Yang, X, Zhai, Y.J, Sun, F, Fan, Z.S. 登録日 2008-03-28 公開日 2009-03-31 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M J.Immunol., 183, 2009
2ZM3	Complex Structure of Insulin-like Growth Factor Receptor and Isoquinolinedione Inhibitor 分子名称: (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione, Insulin-like growth factor 1 receptor 著者 Xu, W, Mayer, S.C, Boschelli, F, Johnson, M, Dwyer, B. 登録日 2008-04-10 公開日 2008-06-10 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment Bioorg.Med.Chem.Lett., 18, 2008
2ZN9	Crystal structure of Ca2+-bound form of des3-20ALG-2 分子名称: CALCIUM ION, DODECAETHYLENE GLYCOL, NONAETHYLENE GLYCOL, ... 著者 Suzuki, H, Kawasaki, M, Inuzuka, T, Kakiuchi, T, Shibata, H, Wakatsuki, S, Maki, M. 登録日 2008-04-22 公開日 2008-09-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural Basis for Ca(2+)-Dependent Formation of ALG-2/Alix Peptide Complex: Ca(2+)/EF3-Driven Arginine Switch Mechanism Structure, 16, 2008
2RG3	Covalent complex structure of elastase 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Leukocyte elastase 著者 Huang, W, Yamamoto, Y. 登録日 2007-10-02 公開日 2008-07-01 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 X-ray snapshot of the mechanism of inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives. J.Med.Chem., 51, 2008
2RDF	Crystal Structure of staphyloccocal nuclease VIAGAN/E75A variant at cryogenic temperature 分子名称: PHOSPHATE ION, Thermonuclease 著者 Baran, K, Schlessman, J.L, Garcia-Moreno, B.E. 登録日 2007-09-22 公開日 2008-06-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Electrostatic effects in a network of polar and ionizable groups in staphylococcal nuclease. J.Mol.Biol., 379, 2008
3I77	35/99/170-loops of FXa in SGT 分子名称: ACETATE ION, CALCIUM ION, SULFATE ION, ... 著者 Page, M.J, Di Cera, E. 登録日 2009-07-08 公開日 2010-06-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Combinatorial Enzyme Design Probes Allostery and Cooperativity in the Trypsin Fold. J.Mol.Biol., 399, 2010
2Z6H	Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain 分子名称: Catenin beta-1 著者 Xing, Y, Takemaru, K, Liu, J, Zheng, J, Moon, R, Xu, W. 登録日 2007-08-01 公開日 2008-02-12 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal Structure of a Full-Length beta-Catenin Structure, 16, 2008
2J0Y	L-ficolin complexed to b-1,3-D-glucan 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CALCIUM ION, ... 著者 Garlatti, V, Gaboriaud, C. 登録日 2006-08-08 公開日 2007-01-23 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structural Insights Into the Innate Immune Recognition Specificities of L- and H-Ficolins. Embo J., 26, 2007
2RBM	Crystal structure of Staphylococcal nuclease variant Delta+PHS I72K at cryogenic temperature 分子名称: CALCIUM ION, PHOSPHATE ION, THYMIDINE-3',5'-DIPHOSPHATE, ... 著者 Khangulov, V.S, Schlessman, J.L, Garcia-Moreno, E.B. 登録日 2007-09-19 公開日 2008-10-07 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of Staphylococcal nuclease variant Delta+PHS I72K at cryogenic temperature To be Published
2J3O	L-ficolin complexed to N-acetyl-D-glucosamine 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CALCIUM ION, ... 著者 Garlatti, V, Gaboriaud, C. 登録日 2006-08-22 公開日 2007-01-23 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structural Insights Into the Innate Immune Recognition Specificities of L- and H-Ficolins. Embo J., 26, 2007
2ZE1	X-ray structure of Bace-1 in complex with compound 6g 分子名称: 3-bromo-N-[4-[1-(2-carbamimidamido-2-oxo-ethyl)-5-phenyl-pyrrol-2-yl]phenyl]benzamide, Beta-secretase 1 著者 Chopra, R, Olland, A. 登録日 2007-12-05 公開日 2008-12-09 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets. Bioorg.Med.Chem.Lett., 18, 2008
2Z8K	Crystal Structure of Escherichia coli gamma-Glutamyltranspeptidase in Complex with Acivicin 分子名称: (2S)-AMINO[(5S)-3-CHLORO-4,5-DIHYDROISOXAZOL-5-YL]ACETIC ACID, Gamma-glutamyltranspeptidase 著者 Wada, K, Irie, M, Fukuyama, K. 登録日 2007-09-05 公開日 2008-06-24 最終更新日 2012-04-04 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal structures of Escherichia coli gamma-glutamyltranspeptidase in complex with azaserine and acivicin: novel mechanistic implication for inhibition by glutamine antagonists J.Mol.Biol., 380, 2008
2ZFT	Exploring trypsin S3 pocket 分子名称: (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentylamino)ethanoyl)pyrrolidine-2-carboxamide, CALCIUM ION, Cationic trypsin, ... 著者 Brandt, T, Baum, B, Heine, A, Klebe, G. 登録日 2008-01-11 公開日 2009-01-13 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Congeneric but still distinct: how closely related trypsin ligands exhibit different thermodynamic and structural properties J.Mol.Biol., 405, 2011
3IN7	Crystal Structure of the Grb2 SH2 Domain in Complex with a Cyclopropyl-constrained Ac-pY-Q-N-NH2 Tripeptide Mimic 分子名称: Growth factor receptor-bound protein 2, N~2~-({(1R,2R,3S)-2-(methylcarbamoyl)-3-[4-(phosphonooxy)phenyl]cyclopropyl}carbonyl)-D-glutaminyl-D-aspartamide 著者 Clements, J.H. 登録日 2009-08-11 公開日 2009-11-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization. J.Am.Chem.Soc., 131, 2009
2ZJJ	Crystal structure of the human BACE1 catalytic domain in complex with 4-(4-fluoro-benzyl)-piperazine-2-carboxylic acid (2-mercapto-ethyl)-amide 分子名称: (2S)-4-(4-fluorobenzyl)-N-(2-sulfanylethyl)piperazine-2-carboxamide, Beta-secretase 1 著者 Randal, M, Lam, M.B, Romanowski, M.J. 登録日 2008-03-07 公開日 2009-01-20 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Fragment-based discovery of novel BACE1 inhibitors using Tethering technology To be Published
2ZRQ	Crystal structure of S324A-subtilisin 分子名称: CALCIUM ION, Tk-subtilisin 著者 Tanaka, S, Takeuchi, Y, Matsumura, H, Koga, Y, Takano, K, Kanaya, S. 登録日 2008-08-28 公開日 2009-03-03 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 Crystal structure of Tk-subtilisin folded without propeptide: requirement of propeptide for acceleration of folding Febs Lett., 582, 2008
2ZU6	crystal structure of the eIF4A-PDCD4 complex 分子名称: 1,2-ETHANEDIOL, ACETIC ACID, Eukaryotic initiation factor 4A-I, ... 著者 Cho, Y, Chang, J.H, Sohn, S.Y. 登録日 2008-10-13 公開日 2009-02-24 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of the eIF4A-PDCD4 complex Proc.Natl.Acad.Sci.Usa, 106, 2009

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