5LGE
 
 | | Crystal Structure of human IDH1 mutant (R132H) in complex with NADP+ and an Inhibitor related to BAY 1436032 | | 分子名称: | 1,2-ETHANEDIOL, 2-[(4-propan-2-ylphenyl)amino]-1-[(1~{S},5~{S})-3,3,5-trimethylcyclohexyl]benzimidazole-5-carboxylic acid, ACETATE ION, ... | | 著者 | Hillig, R.C, Hars, U, Korndoerfer, I.P. | | 登録日 | 2016-07-07 | | 公開日 | 2017-02-08 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo.
Acta Neuropathol., 133, 2017
|
|
6A3W
 | | Complex structure of 4-1BB and utomilumab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor receptor superfamily member 9, utomilumab VH, ... | | 著者 | Li, Y, Tan, S, Zhang, C, Chai, Y, Qi, J, Tien, P, Gao, S, Gao, G.F. | | 登録日 | 2018-06-17 | | 公開日 | 2018-10-10 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab.
Cell Rep, 25, 2018
|
|
7D5Q
 | | Structure of NorC transporter (K398A mutant) in an outward-open conformation in complex with a single-chain Indian camelid antibody | | 分子名称: | Drug transporter, putative, ICab, ... | | 著者 | Kumar, S, Athreya, A, Penmatsa, A. | | 登録日 | 2020-09-27 | | 公開日 | 2021-06-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Structural basis of inhibition of a transporter from Staphylococcus aureus, NorC, through a single-domain camelid antibody.
Commun Biol, 4, 2021
|
|
1AWZ
 | | 3D SOLUTION STRUCTURE OF HUMAN ANGIOGENIN DETERMINED BY 1H, 15N NMR SPECTROSCOPY, 30 STRUCTURES | | 分子名称: | ANGIOGENIN | | 著者 | Lequin, O, Thuring, H, Robin, M, Lallemand, J.-Y. | | 登録日 | 1997-10-07 | | 公開日 | 1998-02-25 | | 最終更新日 | 2022-02-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Three-dimensional solution structure of human angiogenin determined by 1H,15N-NMR spectroscopy--characterization of histidine protonation states and pKa values.
Eur.J.Biochem., 250, 1997
|
|
7D5P
 | | Structure of NorC transporter in an outward-open conformation in complex with a single-chain Indian camelid antibody | | 分子名称: | Drug transporter, putative, ICab, ... | | 著者 | Kumar, S, Athreya, A, Penmatsa, A. | | 登録日 | 2020-09-27 | | 公開日 | 2021-06-09 | | 最終更新日 | 2021-07-14 | | 実験手法 | X-RAY DIFFRACTION (3.65 Å) | | 主引用文献 | Structural basis of inhibition of a transporter from Staphylococcus aureus, NorC, through a single-domain camelid antibody.
Commun Biol, 4, 2021
|
|
6RZW
 | | Structure of s-Mgm1 decorating the inner surface of tubulated lipid membranes in the GTPgammaS bound state | | 分子名称: | Putative mitochondrial dynamin protein | | 著者 | Faelber, K, Dietrich, L, Noel, J.K, Sanchez, R, Kudryashev, M, Kuelbrandt, W, Daumke, O. | | 登録日 | 2019-06-13 | | 公開日 | 2019-07-24 | | 最終更新日 | 2020-11-18 | | 実験手法 | ELECTRON MICROSCOPY (18.799999 Å) | | 主引用文献 | Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1.
Nature, 571, 2019
|
|
7W5M
 | |
1BGV
 | | GLUTAMATE DEHYDROGENASE | | 分子名称: | GLUTAMATE DEHYDROGENASE, GLUTAMIC ACID | | 著者 | Stillman, T.J, Baker, P.J, Britton, K.L, Rice, D.W. | | 登録日 | 1998-06-01 | | 公開日 | 1998-10-14 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Conformational flexibility in glutamate dehydrogenase. Role of water in substrate recognition and catalysis.
J.Mol.Biol., 234, 1993
|
|
5EYF
 | | Crystal Structure of Solute-binding Protein from Enterococcus faecium with Bound Glutamate | | 分子名称: | CHLORIDE ION, GLUTAMIC ACID, Glutamate ABC superfamily ATP binding cassette transporter, ... | | 著者 | Maltseva, N, Kim, Y, Mulligan, R, Shatsman, S, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2015-11-24 | | 公開日 | 2015-12-16 | | 最終更新日 | 2023-02-15 | | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | | 主引用文献 | Crystal Structure of Solute-binding Protein from Enterococcus faecium with Bound Glutamate
To Be Published
|
|
6AJP
 | | Complex form of Uracil DNA glycosylase X and deoxyuridine monophosphate. | | 分子名称: | 2'-DEOXYURIDINE-5'-MONOPHOSPHATE, IRON/SULFUR CLUSTER, Uracil DNA glycosylase superfamily protein | | 著者 | Ahn, W.C, Aroli, S, Varshney, U, Woo, E.J. | | 登録日 | 2018-08-28 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.334 Å) | | 主引用文献 | Covalent binding of uracil DNA glycosylase UdgX to abasic DNA upon uracil excision.
Nat.Chem.Biol., 15, 2019
|
|
7AOL
 | | Structure of SARS-CoV-2 Main Protease bound to Climbazole | | 分子名称: | (1~{S})-1-(4-chloranylphenoxy)-1-imidazol-1-yl-3,3-dimethyl-butan-2-one, 3C-like proteinase, DIMETHYL SULFOXIDE, ... | | 著者 | Guenther, S, Reinke, P, Oberthuer, D, Yefanov, O, Gelisio, L, Ginn, H, Lieske, J, Domaracky, M, Brehm, W, Rahmani Mashour, A, White, T.A, Knoska, J, Pena Esperanza, G, Koua, F, Tolstikova, A, Groessler, M, Fischer, P, Hennicke, V, Fleckenstein, H, Trost, F, Galchenkova, M, Gevorkov, Y, Li, C, Awel, S, Paulraj, L.X, Ullah, N, Falke, S, Alves Franca, B, Schwinzer, M, Brognaro, H, Werner, N, Perbandt, M, Tidow, H, Seychell, B, Beck, T, Meier, S, Doyle, J.J, Giseler, H, Melo, D, Dunkel, I, Lane, T.J, Peck, A, Saouane, S, Hakanpaeae, J, Meyer, J, Noei, H, Gribbon, P, Ellinger, B, Kuzikov, M, Wolf, M, Zhang, L, Ehrt, C, Pletzer-Zelgert, J, Wollenhaupt, J, Feiler, C, Weiss, M, Schulz, E.C, Mehrabi, P, Norton-Baker, B, Schmidt, C, Lorenzen, K, Schubert, R, Han, H, Chari, A, Fernandez Garcia, Y, Turk, D, Hilgenfeld, R, Rarey, M, Zaliani, A, Chapman, H.N, Pearson, A, Betzel, C, Meents, A. | | 登録日 | 2020-10-14 | | 公開日 | 2020-12-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | | 主引用文献 | X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease.
Science, 372, 2021
|
|
6AJ4
 | |
6AJQ
 | | E52Q mutant form of Uracil DNA glycosylase X from Mycobacterium smegmatis. | | 分子名称: | IRON/SULFUR CLUSTER, Uracil DNA glycosylase superfamily protein | | 著者 | Ahn, W.C, Aroli, S, Varshney, U, Woo, E.J. | | 登録日 | 2018-08-28 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.342 Å) | | 主引用文献 | Covalent binding of uracil DNA glycosylase UdgX to abasic DNA upon uracil excision.
Nat.Chem.Biol., 15, 2019
|
|
6AJL
 | | DOCK7 mutant I1836Y complexed with Cdc42 | | 分子名称: | Cell division control protein 42 homolog, Dedicator of cytokinesis protein 7 | | 著者 | Kukimoto-Niino, M, Shirouzu, M. | | 登録日 | 2018-08-28 | | 公開日 | 2019-03-20 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.23 Å) | | 主引用文献 | Structural Basis for the Dual Substrate Specificity of DOCK7 Guanine Nucleotide Exchange Factor.
Structure, 27, 2019
|
|
6S4M
 | | Crystal structure of the human organic anion transporter MFSD10 (TETRAN) | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CITRIC ACID, Major facilitator superfamily domain-containing protein 10 | | 著者 | Pascoa, T.C, Pike, A.C.W, Bushell, S.R, Quigley, A, Chu, A, Mukhopadhyay, S.M.M, Shrestha, L, Venkaya, S, Chalk, R, Burgess-Brown, N.A, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | | 登録日 | 2019-06-28 | | 公開日 | 2020-05-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of the human organic anion transporter TETRAN (MFSD10)
To be published
|
|
8HLB
 | | Cryo-EM structure of biparatopic antibody Bp109-92 in complex with TNFR2 | | 分子名称: | TR109 heavy chain, TR109 light chain, TR92 heavy chain, ... | | 著者 | Akiba, H, Fujita, J, Ise, T, Nishiyama, K, Miyata, T, Kato, T, Namba, K, Ohno, H, Kamada, H, Nagata, S, Tsumoto, K. | | 登録日 | 2022-11-29 | | 公開日 | 2023-10-04 | | 実験手法 | ELECTRON MICROSCOPY (3.63 Å) | | 主引用文献 | Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection.
Commun Biol, 6, 2023
|
|
6AJS
 | | H109S mutant form of Uracil DNA glycosylase X. | | 分子名称: | IRON/SULFUR CLUSTER, Uracil DNA glycosylase superfamily protein | | 著者 | Ahn, W.C, Aroli, S, Varshney, U, Woo, E.J. | | 登録日 | 2018-08-28 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.632 Å) | | 主引用文献 | Covalent binding of uracil DNA glycosylase UdgX to abasic DNA upon uracil excision.
Nat.Chem.Biol., 15, 2019
|
|
6ARD
 | |
4LV5
 | |
7UWR
 | | KSQ+AT from first module of the pikromycin synthase | | 分子名称: | Narbonolide/10-deoxymethynolide synthase PikA1, modules 1 and 2 | | 著者 | Keatinge-Clay, A.T, Dickinson, M.S, Miyazawa, T, McCool, R.S. | | 登録日 | 2022-05-03 | | 公開日 | 2022-06-08 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | | 主引用文献 | Priming enzymes from the pikromycin synthase reveal how assembly-line ketosynthases catalyze carbon-carbon chemistry.
Structure, 30, 2022
|
|
8XQR
 | | Structure 2 of human class T GPCR TAS2R14-miniGs/gust complex with Flufenamic acid. | | 分子名称: | 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | 登録日 | 2024-01-05 | | 公開日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 2024
|
|
8XQO
 | | Structure of human class T GPCR TAS2R14-Gi complex with Aristolochic acid A. | | 分子名称: | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | | 著者 | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | 登録日 | 2024-01-05 | | 公開日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | | 主引用文献 | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 2024
|
|
8XQN
 | | Structure of human class T GPCR TAS2R14-DNGi complex with Aristolochic acid A. | | 分子名称: | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | | 著者 | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | 登録日 | 2024-01-05 | | 公開日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 2024
|
|
8XQL
 | | Structure of human class T GPCR TAS2R14-miniGs/gust complex with Aristolochic acid A. | | 分子名称: | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | | 著者 | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | 登録日 | 2024-01-05 | | 公開日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | | 主引用文献 | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 2024
|
|
8XQS
 | | Structure of human class T GPCR TAS2R14-DNGi complex with Flufenamic acid. | | 分子名称: | 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | | 著者 | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | 登録日 | 2024-01-05 | | 公開日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 2024
|
|
