PDB: 30476 件ウェブページステータス検索Chemie searchBIRD

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4CZA	Structure of the sodium proton antiporter PaNhaP from Pyrococcus abyssii with bound thallium ion. 分子名称: ACETATE ION, NA+/H+ ANTIPORTER, PUTATIVE, ... 著者 Woehlert, D, Kuhlbrandt, W, Yildiz, O. 登録日 2014-04-16 公開日 2014-12-17 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structure and substrate ion binding in the sodium/proton antiporter PaNhaP. Elife, 3, 2014
4D2C	Structure of a di peptide bound POT family peptide transporter 分子名称: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, ALANINE, ... 著者 Lyons, J.A, Parker, J.L, Solcan, N, Brinth, A, Li, D, Shah, S.T.A, Caffrey, M, Newstead, S. 登録日 2014-05-09 公開日 2014-06-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 Structural Basis for Polyspecificity in the Pot Family of Proton-Coupled Oligopeptide Transporters. Embo Rep., 15, 2014
4D37	Structure of bovine endothelial nitric oxide synthase heme domain in complex with N-{[(1R,2R)-2-(3-fluorophenyl)cyclopropyl]methyl}-2-[2-(1H-imidazol-1-yl) pyrimidin-4-yl]ethanamine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, GLYCEROL, ... 著者 Li, H, Poulos, T.L. 登録日 2014-10-20 公開日 2014-12-24 最終更新日 2015-03-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase. J.Med.Chem., 58, 2015
4D4C	The catalytic domain, BcGH76, of Bacillus circulans Aman6 in complex with 1,6-ManDMJ 分子名称: 1,2-ETHANEDIOL, 1-DEOXYMANNOJIRIMYCIN, ALPHA-1,6-MANNANASE, ... 著者 Thompson, A.J, Speciale, G, Iglesias-Fernandez, J, Hakki, Z, Belz, T, Cartmell, A, Spears, R.J, Stepper, J, Gilbert, H.J, Rovira, C, Williams, S.J, Davies, G.J. 登録日 2014-10-27 公開日 2015-03-25 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Evidence for a Boat Conformation at the Transition State of Gh76 Alpha-1,6-Mannanases- Key Enzymes in Bacterial and Fungal Mannoprotein Metabolism Angew.Chem.Int.Ed.Engl., 54, 2015
5QII	CRYSTAL STRUCTURE OF 11BETA-HSD1 DOUBLE MUTANT (L262R, F278E) COMPLEXED WITH 2-(3-(1-(4-CHLOROPHENYL)CYCLOPROPYL) -[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-8-YL)PROPAN-2-OL 分子名称: 2-{3-[1-(4-chlorophenyl)cyclopropyl][1,2,4]triazolo[4,3-a]pyridin-8-yl}propan-2-ol, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Sheriff, S. 登録日 2018-07-03 公開日 2018-12-19 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD-1). ACS Med Chem Lett, 9, 2018
4D3B	Structure of rat neuronal nitric oxide synthase heme domain in complex with N1-(2-(1H-imidazol-1-yl)pyrimidin-4-yl)-N2-(3- fluorophenethyl)ethane-1,2-diamine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, N-[2-(3-fluorophenyl)ethyl]-N'-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]ethane-1,2-diamine, ... 著者 Li, H, Poulos, T.L. 登録日 2014-10-20 公開日 2014-12-24 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.798 Å) 主引用文献 Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase. J.Med.Chem., 58, 2015
4CZW	Structure of the Neurospora crassa Pan2 catalytic unit (protease and nuclease domain) 分子名称: PAB-DEPENDENT POLY(A)-SPECIFIC RIBONUCLEASE SUBUNIT PAN2, ZINC ION 著者 Christie, M, Izaurralde, E, Weichenrieder, O. 登録日 2014-04-22 公開日 2014-06-04 最終更新日 2014-07-16 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 An Asymmetric Pan3 Dimer Recruits a Single Pan2 Exonuclease to Mediate Mrna Deadenylation and Decay. Nat.Struct.Mol.Biol., 21, 2014
5QCM	FACTOR XIA IN COMPLEX WITH THE INHIBITOR methyl ~{N}-[4-[[(1~{S})-2-[(~{E})-3-[3-chloranyl-2-fluoranyl-6-(1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoyl]-3,4-dihydro-1~{H}-isoquinolin-1-yl]carbonylamino]phenyl]carbamate 分子名称: 1,2-ETHANEDIOL, Coagulation factor XI, SULFATE ION, ... 著者 Sheriff, S. 登録日 2017-08-10 公開日 2017-11-08 最終更新日 2018-02-21 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212). J. Med. Chem., 60, 2017
4CVU	Structure of Fungal beta-mannosidase from Glycoside Hydrolase Family 2 of Trichoderma harzianum 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, BETA-MANNOSIDASE, CADMIUM ION, ... 著者 Muniz, J.R.C, Aparicio, R, Santos, J.C, Nascimento, A.S, Golubev, A.M, Polikarpov, I. 登録日 2014-03-31 公開日 2014-07-09 最終更新日 2023-07-05 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Insights into the structure and function of fungal beta-mannosidases from glycoside hydrolase family 2 based on multiple crystal structures of the Trichoderma harzianum enzyme. FEBS J., 281, 2014
4CN1	GlgE isoform 1 from Streptomyces coelicolor D394A mutant with maltose- 1-phosphate bound 分子名称: ALPHA-1,4-GLUCAN: MALTOSE-1-PHOSPHATE MALTOSYLTRANSFERASE 1, alpha-D-glucopyranose-(1-4)-1-O-phosphono-alpha-D-glucopyranose 著者 Syson, K, Stevenson, C.E.M, Rashid, A.M, Saalbach, G, Tang, M, Tuukanen, A, Svergun, D.I, Withers, S.G, Lawson, D.M, Bornemann, S. 登録日 2014-01-21 公開日 2014-05-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Structural Insight Into How Streptomyces Coelicolor Maltosyl Transferase Glge Binds Alpha-Maltose 1-Phosphate and Forms a Maltosyl-Enzyme Intermediate. Biochemistry, 53, 2014
4CRG	Creating novel F1 inhibitors through fragment based lead generation and structure aided drug design 分子名称: 6-carbamimidoyl-N-phenyl-4-(pyrimidin-2-ylamino)naphthalene-2-carboxamide, COAGULATION FACTOR XI, GLYCEROL, ... 著者 Sandmark, J, Oster, L, Fjellstrom, O, Akkaya, S, Beisel, H.G, Eriksson, P.O, Erixon, K, Gustafsson, D, Jurva, U, Kang, D, Karis, D, Knecht, W, Nerme, V, Nilsson, I, Olsson, T, Redzic, A, Roth, R, Tigerstrom, A. 登録日 2014-02-26 公開日 2015-02-11 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Creating Novel Activated Factor Xi Inhibitors Through Fragment Based Lead Generation and Structure Aided Drug Design. Plos One, 10, 2015
4CRZ	Direct visualisation of strain-induced protein prost-translational modification 分子名称: ACETYL COENZYME *A, ASPARTATE 1-DECARBOXYLASE, MAGNESIUM ION, ... 著者 Monteiro, D.C.F, Patel, V, Bartlett, C.P, Grant, T.D, Nozaki, S, Gowdy, J.A, Snell, E.H, Niki, H, Pearson, A.R, Webb, M.E. 登録日 2014-03-02 公開日 2015-03-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The Structure of the Pand/Panz Protein Complex Reveals Negative Feedback Regulation of Pantothenate Biosynthesis by Coenzyme A. Chem.Biol., 22, 2015
4D3O	Structure of Bacillus subtilis Nitric Oxide Synthase in complex with 6-(3-(2-(1H-Pyrrolo(2,3-b)pyridin-6-yl)ethyl)-5-(aminomethyl) phenethyl)-4-methylpyridin-2-amine 分子名称: 6-(2-{3-(aminomethyl)-5-[2-(1H-pyrrolo[2,3-b]pyridin-6-yl)ethyl]phenyl}ethyl)-4-methylpyridin-2-amine, CHLORIDE ION, GLYCEROL, ... 著者 Holden, J.K, Poulos, T.L. 登録日 2014-10-23 公開日 2015-01-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors. J.Med.Chem., 58, 2015
4CPC	Crystal structure of human synaptonemal complex protein SYCP3 分子名称: SYNAPTONEMAL COMPLEX PROTEIN 3 著者 Syrjanen, J.L, Pellegrini, L, Davies, O.R. 登録日 2014-02-05 公開日 2014-07-02 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 A molecular model for the role of SYCP3 in meiotic chromosome organisation. Elife, 3, 2014
4CI7	The crystal structure of the cysteine protease and lectin-like domains of Cwp84, a surface layer associated protein of Clostridium difficile 分子名称: CALCIUM ION, CELL SURFACE PROTEIN (PUTATIVE CELL SURFACE-ASSOCIATED CYSTEINE PROTEASE), GLYCEROL, ... 著者 Bradshaw, W.J, Kirby, J.M, Thiyagarajan, N, Chambers, C.J, Davies, A.H, Roberts, A.K, Shone, C.C, Acharya, K.R. 登録日 2013-12-06 公開日 2014-05-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 The Structure of the Cysteine Protease and Lectin-Like Domains of Cwp84, a Surface Layer-Associated Protein from Clostridium Difficile Acta Crystallogr.,Sect.D, 70, 2014
4CN4	GlgE isoform 1 from Streptomyces coelicolor E423A mutant with 2-deoxy- 2-fluoro-beta-maltosyl modification 分子名称: ALPHA-1,4-GLUCAN:MALTOSE-1-PHOSPHATE MALTOSYLTRANSFERASE 1, alpha-D-glucopyranose-(1-4)-2-deoxy-2-fluoro-beta-D-glucopyranose 著者 Syson, K, Stevenson, C.E.M, Rashid, A.M, Saalbach, G, Tang, M, Tuukanen, A, Svergun, D.I, Withers, S.G, Lawson, D.M, Bornemann, S. 登録日 2014-01-21 公開日 2014-05-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural Insight Into How Streptomyces Coelicolor Maltosyl Transferase Glge Binds Alpha-Maltose 1-Phosphate and Forms a Maltosyl-Enzyme Intermediate. Biochemistry, 53, 2014
4CQO	Structure of the human CNOT1 superfamily homology domain in complex with a Nanos1 peptide 分子名称: CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, NANOS HOMOLOG 1 著者 Raisch, T, Jonas, S, Weichenrieder, O, Bhandari, D, Izaurralde, E. 登録日 2014-02-21 公開日 2014-04-23 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural Basis for the Nanos-Mediated Recruitment of the Ccr4-not Complex and Translational Repression Genes Dev., 28, 2014
4CRY	Direct visualisation of strain-induced protein post-translational modification 分子名称: ACETYL COENZYME *A, ASPARTATE 1-DECARBOXYLASE, CHLORIDE ION, ... 著者 Monteiro, D.C.F, Patel, V, Bartlett, C.P, Grant, T.D, Nozaki, S, Gowdy, J.A, Snell, E.H, Niki, H, Pearson, A.R, Webb, M.E. 登録日 2014-03-02 公開日 2015-03-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Direct Visualisation of Strain-Induced Protein Post-Translational Modification To be Published
4CGQ	Full length Tah1 bound to HSP90 peptide SRMEEVD 分子名称: CHLORIDE ION, HEAT SHOCK PROTEIN HSP 90-ALPHA, TPR REPEAT-CONTAINING PROTEIN ASSOCIATED WITH HSP90 著者 Roe, S.M, Pal, M. 登録日 2013-11-26 公開日 2014-12-17 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Tah1 Helix-Swap Dimerization Prevents Mixed Hsp90 Co-Chaperone Complexes Acta Crystallogr.,Sect.F, 71, 2015
4CS0	Direct visualisation of strain-induced protein post-translational modification 分子名称: ACETYL COENZYME *A, ASPARTATE 1-DECARBOXYLASE, MAGNESIUM ION, ... 著者 Monteiro, D.C.F, Patel, V, Bartlett, C.P, Grant, T.D, Nozaki, S, Gowdy, J.A, Snell, E.H, Niki, H, Pearson, A.R, Webb, M.E. 登録日 2014-03-02 公開日 2015-03-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The Structure of the Pand/Panz Protein Complex Reveals Negative Feedback Regulation of Pantothenate Biosynthesis by Coenzyme A. Chem.Biol., 22, 2015
4CN6	GlgE isoform 1 from Streptomyces coelicolor E423A mutant with maltose bound 分子名称: ALPHA-1,4-GLUCAN:MALTOSE-1-PHOSPHATE MALTOSYLTRANSFERASE 1, alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose 著者 Syson, K, Stevenson, C.E.M, Rashid, A.M, Saalbach, G, Tang, M, Tuukanen, A, Svergun, D.I, Withers, S.G, Lawson, D.M, Bornemann, S. 登録日 2014-01-21 公開日 2014-05-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Structural Insight Into How Streptomyces Coelicolor Maltosyl Transferase Glge Binds Alpha-Maltose 1-Phosphate and Forms a Maltosyl-Enzyme Intermediate. Biochemistry, 53, 2014
4D36	Structure of bovine endothelial nitric oxide synthase heme domain in complex with N-2-(2-(1H-imidazol-1-yl)pyrimidin-4-yl)ethyl-3-(3- chlorophenyl)propan-1-amine 分子名称: 3-(3-chlorophenyl)-N-{2-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]ethyl}propan-1-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... 著者 Li, H, Poulos, T.L. 登録日 2014-10-20 公開日 2014-12-24 最終更新日 2015-03-04 実験手法 X-RAY DIFFRACTION (2.052 Å) 主引用文献 Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase. J.Med.Chem., 58, 2015
4D4D	The catalytic domain, BcGH76, of Bacillus circulans Aman6 in complex with 1,6-ManIFG 分子名称: 1,2-ETHANEDIOL, 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE, ALPHA-1,6-MANNANASE, ... 著者 Thompson, A.J, Speciale, G, Iglesias-Fernandez, J, Hakki, Z, Belz, T, Cartmell, A, Spears, R.J, Stepper, J, Gilbert, H.J, Rovira, C, Williams, S.J, Davies, G.J. 登録日 2014-10-27 公開日 2015-03-25 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Evidence for a Boat Conformation at the Transition State of Gh76 Alpha-1,6-Mannanases- Key Enzymes in Bacterial and Fungal Mannoprotein Metabolism Angew.Chem.Int.Ed.Engl., 54, 2015
4D72	Crystal structure of a family 98 glycoside hydrolase catalytic module (Sp3GH98) in complex with the type 2 blood group A-tetrasaccharide (E558A L19 mutant) 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-alpha-D-galactopyranose, GLYCOSIDE HYDROLASE, ... 著者 Kwan, D.H, Constantinescu, I, Chapanian, R, Higgins, M.A, Samain, E, Boraston, A.B, Kizhakkedathu, J.N, Withers, S.G. 登録日 2014-11-19 公開日 2015-01-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Towards Efficient Enzymes for the Generation of Universal Blood Through Structure-Guided Directed Evolution. J.Am.Chem.Soc., 137, 2015
4D4X	Nitrosyl complex of the D121I variant of cytochrome c prime from Alcaligenes xylosoxidans 分子名称: CYTOCHROME C', HEME C, NITRIC OXIDE 著者 Gahfoor, D.D, Kekilli, D, Abdullah, G.H, Dworkowski, F.S.N, Hassan, H.G, Wilson, M.T, Hough, M.A, Strange, R.W. 登録日 2014-10-31 公開日 2015-09-09 最終更新日 2020-03-11 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Hydrogen Bonding of the Dissociated Histidine Ligand is not Required for Formation of a Proximal No Adduct in Cytochrome C'. J.Biol.Inorg.Chem., 20, 2015

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