8BSK
| Human GLS in complex with compound 3 | 分子名称: | Glutaminase kidney isoform, mitochondrial 65 kDa chain, N,N'-[sulfanediylbis(ethane-2,1-diyl-1,3,4-thiadiazole-5,2-diyl)]bis(2-phenylacetamide), ... | 著者 | Debreczeni, J.E. | 登録日 | 2022-11-25 | 公開日 | 2023-01-18 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery of a Thiadiazole-Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models. J Med Chem, 62, 2019
|
|
8BSM
| Human GLS in complex with compound 18 | 分子名称: | 2-phenyl-~{N}-[5-[[(3~{R})-1-[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]ethanamide, Glutaminase kidney isoform, mitochondrial 65 kDa chain, ... | 著者 | Debreczeni, J.E. | 登録日 | 2022-11-25 | 公開日 | 2023-01-18 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.782 Å) | 主引用文献 | Discovery of a Thiadiazole-Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models. J Med Chem, 62, 2019
|
|
8BSN
| Human GLS in complex with compound 27 | 分子名称: | (2~{S})-2-methoxy-2-phenyl-~{N}-[5-[[(3~{R})-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]ethanamide, Glutaminase kidney isoform, mitochondrial 65 kDa chain, ... | 著者 | Debreczeni, J.E. | 登録日 | 2022-11-25 | 公開日 | 2023-01-18 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.494 Å) | 主引用文献 | Discovery of a Thiadiazole-Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models. J Med Chem, 62, 2019
|
|
1DZP
| Porcine Odorant Binding Protein Complexed with diphenylmethanone | 分子名称: | DIPHENYLMETHANONE, ODORANT-BINDING PROTEIN | 著者 | Vincent, F, Spinelli, S, Cambillau, C, Tegoni, M. | 登録日 | 2000-03-06 | 公開日 | 2000-12-06 | 最終更新日 | 2013-11-13 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Complexes of Porcine Odorant Binding Protein with Odorant Molecules Belonging to Different Chemical Classes J.Mol.Biol., 300, 2000
|
|
1GT5
| Complexe of Bovine Odorant Binding Protein with benzophenone | 分子名称: | DIPHENYLMETHANONE, ODORANT-BINDING PROTEIN | 著者 | Vincent, F, Ramoni, R, Spinelli, S, Grolli, S, Conti, V, Cambillau, C, Tegoni, M. | 登録日 | 2002-01-10 | 公開日 | 2003-10-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Crystal Structures of Bovine Odorant-Binding Protein in Complex with Odorant Molecules. Eur.J.Biochem., 271, 2004
|
|
2WL9
| Crystal structure of catechol 2,3-dioxygenase | 分子名称: | 3-METHYLCATECHOL, CATECHOL 2,3-DIOXYGENASE, FE (III) ION, ... | 著者 | Cho, H.J, Kim, K.J, Kang, B.S. | 登録日 | 2009-06-23 | 公開日 | 2010-09-01 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Substrate-Binding Mechanism of a Type I Extradiol Dioxygenase. J.Biol.Chem., 285, 2010
|
|
7D9E
| Gamma-glutamyltranspeptidase from Pseudomonas nitroreducens complexed with L-DON | 分子名称: | 6-DIAZENYL-5-OXO-L-NORLEUCINE, GLYCEROL, Gamma-glutamyltransferase 1 Threonine peptidase. MEROPS family T03 | 著者 | Hibi, T, Sano, C, Itoh, T, Wakayama, M. | 登録日 | 2020-10-13 | 公開日 | 2021-06-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Mutagenesis and structure-based analysis of the role of Tryptophan525 of gamma-glutamyltranspeptidase from Pseudomonas nitroreducens. Biochem.Biophys.Res.Commun., 534, 2021
|
|
7D9W
| Gamma-glutamyltranspeptidase from Pseudomonas nitroreducens complexed with L-DON | 分子名称: | 6-DIAZENYL-5-OXO-L-NORLEUCINE, GLYCINE, Gamma-glutamyltransferase 1 Threonine peptidase. MEROPS family T03 | 著者 | Hibi, T, Sano, C, Putthapong, P, Hayashi, J, Itoh, T, Wakayama, M. | 登録日 | 2020-10-14 | 公開日 | 2021-06-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Mutagenesis and structure-based analysis of the role of Tryptophan525 of gamma-glutamyltranspeptidase from Pseudomonas nitroreducens. Biochem.Biophys.Res.Commun., 534, 2021
|
|
7DPT
| Structural basis for ligand binding modes of CTP synthase | 分子名称: | 6-DIAZENYL-5-OXO-L-NORLEUCINE, ADENOSINE-5'-DIPHOSPHATE, CTP synthase, ... | 著者 | Liu, J.L, Zhou, X, Guo, C.J, Chang, C.C. | 登録日 | 2020-12-21 | 公開日 | 2021-09-15 | 実験手法 | ELECTRON MICROSCOPY (2.48 Å) | 主引用文献 | Structural basis for ligand binding modes of CTP synthase. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
3EQQ
| Apo Toluene 2,3-Dioxygenase | 分子名称: | Benzene 1,2-dioxygenase subunit alpha, Benzene 1,2-dioxygenase subunit beta, FE (II) ION, ... | 著者 | Friemann, R, Lee, K, Brown, E.N, Gibson, D.T, Eklund, H, Ramaswamy, S. | 登録日 | 2008-10-01 | 公開日 | 2009-03-17 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structures of the multicomponent Rieske non-heme iron toluene 2,3-dioxygenase enzyme system Acta Crystallogr.,Sect.D, 65, 2009
|
|
2J2I
| Crystal Structure of the humab PIM1 in complex with LY333531 | 分子名称: | (9R)-9-[(DIMETHYLAMINO)METHYL]-6,7,10,11-TETRAHYDRO-9H,18H-5,21:12,17-DIMETHENODIBENZO[E,K]PYRROLO[3,4-H][1,4,13]OXADIA ZACYCLOHEXADECINE-18,20-DIONE, PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1, SULFATE ION | 著者 | Debreczeni, J.E, Bullock, A.N, von Delft, F, Sundstrom, M, Arrowsmith, C, Edwards, A, Weigelt, J, Knapp, S. | 登録日 | 2006-08-16 | 公開日 | 2007-02-13 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc. Natl. Acad. Sci. U.S.A., 104, 2007
|
|
2GZV
| The cystal structure of the PDZ domain of human PICK1 | 分子名称: | PRKCA-binding protein | 著者 | Debreczeni, J.E, Elkins, J.M, Yang, X, Berridge, G, Bray, J, Colebrook, S, Smee, C, Savitsky, P, Gileadi, O, Turnbull, A, von Delft, F, Doyle, D.A, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A, Structural Genomics Consortium (SGC) | 登録日 | 2006-05-12 | 公開日 | 2006-07-18 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | 主引用文献 | Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions. Protein Sci., 16, 2007
|
|
2X6W
| Tailspike protein mutant E372Q of E.coli bacteriophage HK620 in complex with hexasaccharide | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SODIUM ION, TAIL SPIKE PROTEIN, ... | 著者 | Lorenzen, N.K, Mueller, J.J, Heinemann, U, Seckler, R, Barbirz, S. | 登録日 | 2010-02-22 | 公開日 | 2011-03-02 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Single Amino Acid Exchange in Bacteriophage Hk620 Tailspike Protein Results in Thousand-Fold Increase of its Oligosaccharide Affinity. Glycobiology, 23, 2013
|
|
2X6Y
| Tailspike protein mutant D339A of E.coli bacteriophage HK620 in complex with hexasaccharide | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SODIUM ION, TAIL SPIKE PROTEIN, ... | 著者 | Lorenzen, N.K, Mueller, J.J, Heinemann, U, Seckler, R, Barbirz, S. | 登録日 | 2010-02-22 | 公開日 | 2011-03-02 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Single Amino Acid Exchange in Bacteriophage Hk620 Tailspike Protein Results in Thousand-Fold Increase of its Oligosaccharide Affinity. Glycobiology, 23, 2013
|
|
2X85
| Tailspike protein of E. coli bacteriophage HK620 in complex with hexasaccharide | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SODIUM ION, TAILSPIKE PROTEIN HK620, ... | 著者 | Lorenzen, N.K, Mueller, J.J, Heinemann, U, Seckler, R, Barbirz, S. | 登録日 | 2010-03-05 | 公開日 | 2011-03-23 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Single Amino Acid Exchange in Bacteriophage Hk620 Tailspike Protein Results in Thousand-Fold Increase of its Oligosaccharide Affinity. Glycobiology, 23, 2013
|
|
2X6X
| Tailspike protein mutant D339N of E.coli bacteriophage HK620 in complex with hexasaccharide | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, TAILSPIKE PROTEIN HK620, alpha-L-rhamnopyranose-(1-6)-alpha-D-glucopyranose-(1-4)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)]alpha-D-galactopyranose | 著者 | Lorenzen, N.K, Mueller, J.J, Heinemann, U, Seckler, R, Barbirz, S. | 登録日 | 2010-02-22 | 公開日 | 2011-03-02 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Single Amino Acid Exchange in Bacteriophage Hk620 Tailspike Protein Results in Thousand-Fold Increase of its Oligosaccharide Affinity. Glycobiology, 23, 2013
|
|
2CFV
| Crystal structure of human protein tyrosine phosphatase receptor type J | 分子名称: | CHLORIDE ION, HUMAN PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE J, NICKEL (II) ION | 著者 | Debreczeni, J.E, Barr, A.J, Eswaran, J, Ugochukwu, E, Sundstrom, M, Weigelt, J, Arrowsmith, C, Edwards, A, Knapp, S. | 登録日 | 2006-02-23 | 公開日 | 2006-03-09 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome. Cell(Cambridge,Mass.), 136, 2009
|
|
2CJZ
| crystal structure of the c472s mutant of human protein tyrosine phosphatase ptpn5 (step, striatum enriched phosphatase) in complex with phosphotyrosine | 分子名称: | 1,2-ETHANEDIOL, HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5, O-PHOSPHOTYROSINE | 著者 | Debreczeni, J.E, Barr, A.J, Eswaran, J, Smee, C, Burgess, N, Gileadi, O, Savitsky, P, Sundstrom, M, Arrowsmith, C, Edwards, A, Weigelt, J, Knapp, S, von Delft, F. | 登録日 | 2006-04-10 | 公開日 | 2006-05-16 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome. Cell(Cambridge,Mass.), 136, 2009
|
|
8JLV
| |
1V2K
| Factor XA specific Inhibitor in complex with bovine trypsin variant X(triple.Glu)bT.D2 | 分子名称: | CALCIUM ION, SULFATE ION, Trypsin, ... | 著者 | Rauh, D, Klebe, G, Stubbs, M.T. | 登録日 | 2003-10-17 | 公開日 | 2004-06-01 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Understanding protein-ligand interactions: the price of protein flexibility J.Mol.Biol., 335, 2004
|
|
1QL8
| |
1J17
| |
6JQZ
| ZHD/H242A complex with ZEN | 分子名称: | (3S,11E)-14,16-dihydroxy-3-methyl-3,4,5,6,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione, GLYCEROL, Zearalenone hydrolase | 著者 | Hu, X.J. | 登録日 | 2019-04-02 | 公開日 | 2020-04-08 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Structure of ZHD complex To Be Published
|
|
6JR9
| ZHD/W183F complex with ZEN | 分子名称: | (3S,11E)-14,16-dihydroxy-3-methyl-3,4,5,6,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione, GLYCEROL, POTASSIUM ION, ... | 著者 | Hu, X.J. | 登録日 | 2019-04-03 | 公開日 | 2020-04-08 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Structure of ZHD complex To Be Published
|
|
1QL7
| |