9B9L
 
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2INC
 | | Native Toluene/o-xylene Monooxygenase Hydroxylase X-ray Crystal Structure | | 分子名称: | FE (III) ION, HEXAETHYLENE GLYCOL, Toluene, ... | | 著者 | McCormick, M.S, Sazinsky, M.H, Condon, K.L, Lippard, S.J. | | 登録日 | 2006-10-06 | | 公開日 | 2006-11-28 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | X-ray crystal structures of manganese(II)-reconstituted and native toluene/o-xylene monooxygenase hydroxylase reveal rotamer shifts in conserved residues and an enhanced view of the protein interior.
J.Am.Chem.Soc., 128, 2006
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9BF1
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9BFB
 | | Crystal structure of BRAF kinase domain with PF-07284890 | | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, N-{2-chloro-3-[(3,5-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]-4-fluorophenyl}-3-fluoropropane-1-sulfonamide, ... | | 著者 | Mou, T.-C. | | 登録日 | 2024-04-17 | | 公開日 | 2024-08-14 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | Identification of the Clinical Candidate PF-07284890 ( ARRY-461 ), a Highly Potent and Brain Penetrant BRAF Inhibitor for the Treatment of Cancer.
J.Med.Chem., 67, 2024
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2J73
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9B1U
 | | Crystal structure of PqqT with PQQ bound | | 分子名称: | PYRROLOQUINOLINE QUINONE, Putative ABC transporter periplasmic solute-binding protein, SODIUM ION | | 著者 | Boggs, D, Bruchs, A, Thompson, P, Olshansky, L, Bridwell-Rabb, J. | | 登録日 | 2024-03-13 | | 公開日 | 2024-08-21 | | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | | 主引用文献 | Structure-driven development of a biomimetic rare earth artificial metalloprotein.
Proc.Natl.Acad.Sci.USA, 121, 2024
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1L7X
 | | Human liver glycogen phosphorylase b complexed with caffeine, N-acetyl-beta-D-glucopyranosylamine, and CP-403,700 | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, CAFFEINE, Glycogen phosphorylase, ... | | 著者 | Ekstrom, J.L, Pauly, T.A, Carty, M.D, Soeller, W.C, Culp, J, Danley, D.E, Hoover, D.J, Treadway, J.L, Gibbs, E.M, Fletterick, R.J, Day, Y.S.N, Myszka, D.G, Rath, V.L. | | 登録日 | 2002-03-18 | | 公開日 | 2002-12-04 | | 最終更新日 | 2025-03-26 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure-activity analysis of the purine binding
site of human liver glycogen phosphorylase.
Chem.Biol., 9, 2002
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5K29
 | | Trypanosoma brucei bromodomain BDF5 (Tb427tmp.01.5000) | | 分子名称: | UNKNOWN ATOM OR ION, uncharacterized protein BDF5 | | 著者 | Lin, Y.H, Tempel, W, Walker, J.R, Loppnau, P, Amani, M, Hou, C.F.D, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Hui, R, Structural Genomics Consortium (SGC) | | 登録日 | 2016-05-18 | | 公開日 | 2016-07-13 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Trypanosoma brucei bromodomain BDF5 (Tb427tmp.01.5000)
To Be Published
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6TR7
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9BOH
 | | Room-temperature X-ray structure of Thermus Thermophilus serine hydroxymethyltransferase (SHMT) with PLP-glycine external aldimine and 5-formyltetrahydrofolate (folinic acid) | | 分子名称: | (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)glycine, N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, SULFATE ION, ... | | 著者 | Drago, V.N, Kovalevsky, A. | | 登録日 | 2024-05-03 | | 公開日 | 2024-08-28 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Universality of critical active site glutamate as an acid-base catalyst in serine hydroxymethyltransferase function.
Chem Sci, 15, 2024
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9BIW
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9BP9
 | | Human DNA polymerase theta helicase domain in complex with inhibitor AB25583, dimer form | | 分子名称: | (4P)-N-{5-[(4-chlorophenyl)methoxy]-1,3,4-thiadiazol-2-yl}-4-(2-methoxyphenyl)pyridine-3-carboxamide, DNA polymerase theta | | 著者 | Ito, F, Li, Z, Chen, X.S. | | 登録日 | 2024-05-07 | | 公開日 | 2024-08-28 | | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | | 主引用文献 | Structural basis for a Pol theta helicase small-molecule inhibitor revealed by cryo-EM.
Nat Commun, 15, 2024
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5K2K
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6TER
 | | Crystal structure of a galactokinase from Bifidobacterium infantis in complex with Galactose | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Keenan, T, Parmeggiani, F, Fontenelle, C.Q, Malassis, J, Vendeville, J, Offen, W.A, Both, P, Huang, K, Marchesi, A, Heyam, A, Young, C, Charnock, S, Davies, G.J, Linclau, B, Flitsch, S.L, Fascione, M.A. | | 登録日 | 2019-11-12 | | 公開日 | 2020-06-10 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | | 主引用文献 | Profiling Substrate Promiscuity of Wild-Type Sugar Kinases for Multi-fluorinated Monosaccharides.
Cell Chem Biol, 27, 2020
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5K2Q
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9BOX
 | | Room-temperature X-ray structure of human mitochondrial serine hydroxymethyltransferase (hSHMT2) with PLP-glycine external aldimine and 5-formyltetrahydrofolate (folinic acid) | | 分子名称: | (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)glycine, N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, Serine hydroxymethyltransferase, ... | | 著者 | Drago, V.N, Kovalevsky, A. | | 登録日 | 2024-05-06 | | 公開日 | 2024-08-28 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Universality of critical active site glutamate as an acid-base catalyst in serine hydroxymethyltransferase function.
Chem Sci, 15, 2024
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9BEM
 | | Tungstate binding protein (Tungbindin) from Eubacterium limosum with seven Tungstates bound | | 分子名称: | Molybdenum-pterin-binding protein, SULFATE ION, TUNGSTATE(VI)ION | | 著者 | Zhou, D, Rose, J.P, Chen, L, Wang, B.C. | | 登録日 | 2024-04-15 | | 公開日 | 2024-09-04 | | 最終更新日 | 2025-04-23 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Storage of the vital metal tungsten in a dominant SCFA-producing human gut microbe Eubacterium limosum and implications for other gut microbes.
Mbio, 16, 2025
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5K3A
 | | Crystal Structure of the Fluoroacetate Dehalogenase RPA1163 - His280Asn/Fluoroacetate - Cocrystallized - Both Protomers Reacted with Ligand | | 分子名称: | CHLORIDE ION, Fluoroacetate dehalogenase | | 著者 | Mehrabi, P, Kim, T.H, Prosser, S.R, Pai, E.F. | | 登録日 | 2016-05-19 | | 公開日 | 2017-02-01 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.511 Å) | | 主引用文献 | The role of dimer asymmetry and protomer dynamics in enzyme catalysis.
Science, 355, 2017
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9B4E
 | | Structure of wild type human PSS1 | | 分子名称: | (2R)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dihexadecanoate, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, CALCIUM ION, ... | | 著者 | Long, T, Li, X. | | 登録日 | 2024-03-20 | | 公開日 | 2024-09-04 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Molecular insights into human phosphatidylserine synthase 1 reveal its inhibition promotes LDL uptake.
Cell, 187, 2024
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2IPT
 | | PFA1 Fab Fragment | | 分子名称: | ACETAMIDE, IgG2a Fab fragment Heavy Chain, IgG2a Fab fragment Light Chain Kappa | | 著者 | Gardberg, A.S, Dealwis, C. | | 登録日 | 2006-10-12 | | 公開日 | 2007-10-09 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Molecular basis for passive immunotherapy of Alzheimer's disease
Proc.Natl.Acad.Sci.Usa, 104, 2007
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9BEB
 | | Tungstate binding protein (Tungbindin) from Eubacterium limosum with eight Tungstates bound | | 分子名称: | Molybdenum-pterin binding domain-containing protein, TUNGSTATE(VI)ION | | 著者 | Zhou, D, Rose, J.P, Chen, L, Wang, B.C. | | 登録日 | 2024-04-15 | | 公開日 | 2024-09-04 | | 最終更新日 | 2025-04-23 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Storage of the vital metal tungsten in a dominant SCFA-producing human gut microbe Eubacterium limosum and implications for other gut microbes.
Mbio, 16, 2025
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5K56
 | | Human muscle fructose-1,6-bisphosphatase in active R-state in complex with fructose-1,6-bisphosphate | | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase isozyme 2 | | 著者 | Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D. | | 登録日 | 2016-05-23 | | 公開日 | 2017-06-07 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.198 Å) | | 主引用文献 | Structural studies of human muscle FBPase
To Be Published
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9BKI
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5K9W
 | | Protein Tyrosine Phosphatase 1B (1-301) in complex with TCS401, closed state | | 分子名称: | 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | | 著者 | Choy, M.S, Peti, W, Page, R. | | 登録日 | 2016-06-01 | | 公開日 | 2017-03-01 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery.
Mol. Cell, 65, 2017
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9BOW
 | | X-ray structure of Thermus thermophilus serine hydroxymethyltransferase with PLP-L-Ser external aldimine and 5-formyltetrahydrofolate (folinic acid) | | 分子名称: | (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-serine, N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, SERINE, ... | | 著者 | Drago, V.N, Kovalevsky, A. | | 登録日 | 2024-05-06 | | 公開日 | 2024-08-28 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Universality of critical active site glutamate as an acid-base catalyst in serine hydroxymethyltransferase function.
Chem Sci, 15, 2024
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