9BFB
Crystal structure of BRAF kinase domain with PF-07284890
This is a non-PDB format compatible entry.
Summary for 9BFB
| Entry DOI | 10.2210/pdb9bfb/pdb |
| Descriptor | Serine/threonine-protein kinase B-raf, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... (5 entities in total) |
| Functional Keywords | braf inhibitor, kinase domain, signaling protein |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 33855.47 |
| Authors | |
| Primary citation | Ren, L.,Moreno, D.,Baer, B.R.,Barbour, P.,Bettendorf, T.,Bouhana, K.,Brown, K.,Brown, S.A.,Fell, J.B.,Hartley, D.P.,Hicken, E.J.,Laird, E.R.,Lee, P.,McCown, J.,Otten, J.N.,Prigaro, B.,Wallace, R.,Kahn, D. Identification of the Clinical Candidate PF-07284890 ( ARRY-461 ), a Highly Potent and Brain Penetrant BRAF Inhibitor for the Treatment of Cancer. J.Med.Chem., 67:13019-13032, 2024 Cited by PubMed: 39077892DOI: 10.1021/acs.jmedchem.4c00998 PDB entries with the same primary citation |
| Experimental method |
Structure validation
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