9BFB

Crystal structure of BRAF kinase domain with PF-07284890

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Serine/threonine-protein kinase B-raf	polymer	294	33200.4	1	UniProt (P15056) Pfam (PF07714) In PDB	Homo sapiens (human)	Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1
2	A	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
3	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	A	N-{2-chloro-3-[(3,5-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]-4-fluorophenyl}-3-fluoropropane-1-sulfonamide	non-polymer		456.9	1	Chemie (A1AN9)
5		water	water		18.0	244	Chemie (HOH)

Sequence modifications

A: 445 - 723 (UniProt: P15056)

PDB	External Database	Details
Met 430	-	initiating methionine
Gly 431	-	expression tag
His 432	-	expression tag
His 433	-	expression tag
His 434	-	expression tag
His 435	-	expression tag
His 436	-	expression tag
His 437	-	expression tag
Gly 438	-	expression tag
Leu 439	-	expression tag
Val 440	-	expression tag
Pro 441	-	expression tag
Arg 442	-	expression tag
Gly 443	-	expression tag
Ser 444	-	expression tag
Ala 667	Phe 667	engineered mutation
Ala 671	Arg 671	engineered mutation
Ala 673	Tyr 673	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33200.4
Non-Polymers*	Number of molecules	3
	Total formula weight	655.1
All*	Total formula weight	33855.5

*Water molecules are not included.