8TKD
 
 | | Human Type 3 IP3 Receptor - Preactivated State (+IP3/ATP) | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Inositol 1,4,5-trisphosphate receptor type 3, ... | | 著者 | Paknejad, N, Sapuru, V, Hite, R.K. | | 登録日 | 2023-07-25 | | 公開日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural titration reveals Ca 2+ -dependent conformational landscape of the IP 3 receptor.
Nat Commun, 14, 2023
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8TKG
 | | Human Type 3 IP3 Receptor - Resting State (+IP3/ATP) | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... | | 著者 | Paknejad, N, Sapuru, V, Hite, R.K. | | 登録日 | 2023-07-25 | | 公開日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Structural titration reveals Ca 2+ -dependent conformational landscape of the IP 3 receptor.
Nat Commun, 14, 2023
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8TK8
 | | Human Type 3 IP3 Receptor - Resting State (+IP3/ATP) | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-TRIPHOSPHATE, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... | | 著者 | Paknejad, N, Sapuru, V, Hite, R.K. | | 登録日 | 2023-07-25 | | 公開日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural titration reveals Ca 2+ -dependent conformational landscape of the IP 3 receptor.
Nat Commun, 14, 2023
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8TLA
 | | Human Type 3 IP3 Receptor - Higher-Order Inhibited State - Symmetry Mate 1 | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... | | 著者 | Paknejad, N, Sapuru, V, Hite, R.K. | | 登録日 | 2023-07-26 | | 公開日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural titration reveals Ca 2+ -dependent conformational landscape of the IP 3 receptor.
Nat Commun, 14, 2023
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8TKH
 | | Human Type 3 IP3 Receptor - Labile Resting State 1 (+IP3/ATP) | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Inositol 1,4,5-trisphosphate receptor type 3, ... | | 著者 | Paknejad, N, Sapuru, V, Hite, R.K. | | 登録日 | 2023-07-25 | | 公開日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural titration reveals Ca 2+ -dependent conformational landscape of the IP 3 receptor.
Nat Commun, 14, 2023
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8THG
 | | Cryo-EM structure of Nav1.7 with RLZ | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Fan, X, Huang, J, Yan, N. | | 登録日 | 2023-07-16 | | 公開日 | 2023-11-22 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Dual-pocket inhibition of Na v channels by the antiepileptic drug lamotrigine.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8THH
 | | Cryo-EM structure of Nav1.7 with LTG | | 分子名称: | (6M)-6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | | 著者 | Fan, X, Huang, J, Yan, N. | | 登録日 | 2023-07-16 | | 公開日 | 2023-11-22 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Dual-pocket inhibition of Na v channels by the antiepileptic drug lamotrigine.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8TKI
 | | Human Type 3 IP3 Receptor - Labile Resting State 2 (+IP3/ATP) | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Inositol 1,4,5-trisphosphate receptor type 3, ... | | 著者 | Paknejad, N, Sapuru, V, Hite, R.K. | | 登録日 | 2023-07-25 | | 公開日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural titration reveals Ca 2+ -dependent conformational landscape of the IP 3 receptor.
Nat Commun, 14, 2023
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8SRJ
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8SRD
 | | Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium and ADP-ribose, open state | | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, CHOLESTEROL, MAGNESIUM ION, ... | | 著者 | Huang, Y, Kumar, S, Lu, W, Du, J. | | 登録日 | 2023-05-05 | | 公開日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | | 主引用文献 | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution
To Be Published
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8SRE
 | | Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium and ADP-ribose, closed state | | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, CHOLESTEROL, MAGNESIUM ION, ... | | 著者 | Huang, Y, Kumar, S, Lu, W, Du, J. | | 登録日 | 2023-05-05 | | 公開日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (2.52 Å) | | 主引用文献 | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution
To Be Published
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8TEO
 | | Shaker in low K+ (4mM K+) | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel protein Shaker | | 著者 | Tan, X, Swartz, K.J. | | 登録日 | 2023-07-06 | | 公開日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (2.39 Å) | | 主引用文献 | Eukaryotic Kv channel Shaker inactivates through selectivity filter dilation rather than collapse.
Sci Adv, 9, 2023
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8UQ5
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3BEH
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7AA5
 | | Human TRPV4 structure in presence of 4a-PDD | | 分子名称: | CALCIUM ION, Transient receptor potential cation channel subfamily V member 4,Green fluorescent protein | | 著者 | Botte, M, Ulrich, A.K.G, Adaixo, R, Gnutt, D, Brockmann, A, Bucher, D, Chami, M, Bocquet, M, Ebbinghaus-Kintscher, U, Puetter, V, Becker, A, Egner, U, Stahlberg, H, Hennig, M, Holton, S.J. | | 登録日 | 2020-09-03 | | 公開日 | 2021-08-18 | | 実験手法 | ELECTRON MICROSCOPY (4.18 Å) | | 主引用文献 | Cryo-EM structural studies of the agonist complexed human TRPV4 ion-channel reveals novel structural rearrangements resulting in an open-conformation
To Be Published
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6I9D
 | | MloK1 consensus structure from single particle analysis of 2D crystals | | 分子名称: | Cyclic nucleotide-gated potassium channel mll3241, POTASSIUM ION | | 著者 | Righetto, R, Biyani, N, Kowal, J, Chami, M, Stahlberg, H. | | 登録日 | 2018-11-23 | | 公開日 | 2019-04-24 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Retrieving high-resolution information from disordered 2D crystals by single-particle cryo-EM.
Nat Commun, 10, 2019
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2ZD9
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3J5R
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3J9P
 | | Structure of the TRPA1 ion channel determined by electron cryo-microscopy | | 分子名称: | Maltose-binding periplasmic protein, Transient receptor potential cation channel subfamily A member 1 chimera | | 著者 | Paulsen, C.E, Armache, J.-P, Gao, Y, Cheng, Y, Julius, D. | | 登録日 | 2015-02-14 | | 公開日 | 2015-04-08 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (4.24 Å) | | 主引用文献 | Structure of the TRPA1 ion channel suggests regulatory mechanisms.
Nature, 520, 2015
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3LNM
 | | F233W mutant of the Kv2.1 paddle-Kv1.2 chimera channel | | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, F233W mutant of the Kv2.1 paddle-Kv1.2 chimera, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Tao, X, Lee, A, Limapichat, W, Dougherty, D.A, MacKinnon, R. | | 登録日 | 2010-02-02 | | 公開日 | 2010-04-14 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | A gating charge transfer center in voltage sensors.
Science, 328, 2010
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3LUT
 | | A Structural Model for the Full-length Shaker Potassium Channel Kv1.2 | | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, Potassium voltage-gated channel subfamily A member 2, ... | | 著者 | Chen, X, Ni, F, Wang, Q, Ma, J. | | 登録日 | 2010-02-18 | | 公開日 | 2010-06-23 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement.
Proc.Natl.Acad.Sci.USA, 107, 2010
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2A79
 | | Mammalian Shaker Kv1.2 potassium channel- beta subunit complex | | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, Potassium voltage-gated channel subfamily A member 2, ... | | 著者 | Long, S.B, Campbell, E.B, MacKinnon, R. | | 登録日 | 2005-07-05 | | 公開日 | 2005-07-12 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Crystal structure of a mammalian voltage-dependent Shaker family K+ channel.
Science, 309, 2005
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7NMN
 | | Rabbit HCN4 stabilised in amphipol A8-35 | | 分子名称: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Rabbit HCN4 | | 著者 | Chaves-Sanjuan, A. | | 登録日 | 2021-02-23 | | 公開日 | 2021-06-30 | | 最終更新日 | 2021-07-28 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Gating movements and ion permeation in HCN4 pacemaker channels.
Mol.Cell, 81, 2021
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7NP4
 | | cAMP-bound rabbit HCN4 stabilized in LMNG-CHS detergent mixture | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | | 著者 | Giese, H, Chaves-Sanjuan, A, Saponaro, A, Clarke, O, Bolognesi, M, Mancia, F, Hendrickson, W.A, Thiel, G, Santoro, B, Moroni, A. | | 登録日 | 2021-02-26 | | 公開日 | 2021-08-11 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Gating movements and ion permeation in HCN4 pacemaker channels.
Mol.Cell, 81, 2021
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7NP3
 | | cAMP-free rabbit HCN4 stabilized in LMNG-CHS detergent mixture | | 分子名称: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | | 著者 | Giese, H.M, Chaves-Sanjuan, A, Saponaro, A, Clarke, O, Bolognesi, M, Mancia, F, Hendrickson, W.A, Thiel, G, Santoro, B, Moroni, A. | | 登録日 | 2021-02-26 | | 公開日 | 2021-08-11 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Gating movements and ion permeation in HCN4 pacemaker channels.
Mol.Cell, 81, 2021
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