8XY7
| hPhK alpha-gamma subcomplex in active state | 分子名称: | FARNESYL, Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform, ... | 著者 | Yang, X.K, Xiao, J.Y. | 登録日 | 2024-01-19 | 公開日 | 2024-04-03 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Architecture and activation of human muscle phosphorylase kinase. Nat Commun, 15, 2024
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8XYA
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8RQQ
| In meso structure of the adenosine A2a G protein-coupled receptor, A2aR, in 7.10 monoacylglycerol | 分子名称: | 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, 7.10 monoacylglycerol (R-form), 7.10 monoacylglycerol (S-form), ... | 著者 | Smithers, L, Krawinski, P, Caffrey, M. | 登録日 | 2024-01-19 | 公開日 | 2024-04-03 | 最終更新日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | 主引用文献 | 7.10 MAG. A Novel Host Monoacylglyceride for In Meso (Lipid Cubic Phase) Crystallization of Membrane Proteins. Cryst.Growth Des., 24, 2024
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8XXM
| Cryo-EM structure of the human 40S ribosome with PDCD4 and eIF3G | 分子名称: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | 著者 | Ye, X, Huang, Z, Li, Y, Wang, M, Cheng, J. | 登録日 | 2024-01-18 | 公開日 | 2024-05-01 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation. Cell Res., 34, 2024
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8XXN
| Cryo-EM structure of the human 43S ribosome with PDCD4 | 分子名称: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | 著者 | Ye, X, Huang, Z, Li, Y, Wang, M, Cheng, J. | 登録日 | 2024-01-18 | 公開日 | 2024-05-01 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation. Cell Res., 34, 2024
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8XX1
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8RQC
| Crystal structure of CRBN-midi in complex with mezigdomide and IKZF1 ZF2 | 分子名称: | DNA-binding protein Ikaros, Mezigdomide, Protein cereblon, ... | 著者 | Furihata, H, Kroupova, A, Zollman, D, Ciulli, A. | 登録日 | 2024-01-17 | 公開日 | 2024-09-25 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders To Be Published
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8RQ4
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8RQ3
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8VQ4
| CDK2-CyclinE1 in complex with allosteric inhibitor I-125A. | 分子名称: | (8R)-6-(1-benzyl-1H-pyrazole-4-carbonyl)-N-[(2S,3R)-3-(2-cyclohexylethoxy)-1-(methylamino)-1-oxobutan-2-yl]-2-[(1S)-2,2-dimethylcyclopropane-1-carbonyl]-2,6-diazaspiro[3.4]octane-8-carboxamide, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1 | 著者 | Hirschi, M, Johnson, E, Zhang, Y, Liu, Z, Brodsky, O, Won, S.J, Nagata, A, Petroski, M.D, Majmudar, J.D, Niessen, S, VanArsdale, T, Gilbert, A.M, Hayward, M.M, Stewart, A.E, Nager, A.R, Melillo, B, Cravatt, B. | 登録日 | 2024-01-17 | 公開日 | 2024-01-31 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes. Nat.Chem.Biol., 2024
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8VQ3
| CDK2-CyclinE1 in complex with allosteric inhibitor I-198. | 分子名称: | (8R)-N-[(2S,3R)-3-(cyclohexylmethoxy)-1-(morpholin-4-yl)-1-oxobutan-2-yl]-2-[(1S)-2,2-dimethylcyclopropane-1-carbonyl]-6-(1,3-thiazole-5-carbonyl)-2,6-diazaspiro[3.4]octane-8-carboxamide, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1 | 著者 | Hirschi, M, Johnson, E, Zhang, Y, Liu, Z, Brodsky, O, Won, S.J, Nagata, A, Petroski, M.D, Majmudar, J.D, Niessen, S, VanArsdale, T, Gilbert, A.M, Hayward, M.M, Stewart, A.E, Nager, A.R, Melillo, B, Cravatt, B. | 登録日 | 2024-01-17 | 公開日 | 2024-01-31 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes. Nat.Chem.Biol., 2024
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8XWP
| Cryo-EM structure of ET-1 bound ETBR-DNGI complex | 分子名称: | Endothelin receptor type B, Endothelin-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Tani, K, Maki-Yonekura, S, Kanno, R, Negami, T, Hamaguchi, T, Hall, M, Mizoguchi, A, Humbel, B.M, Terada, T, Yonekura, K, Doi, T. | 登録日 | 2024-01-16 | 公開日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | 主引用文献 | Structure of endothelin ETB receptor-Gi complex in a conformation stabilized by the unique NPxxL motif Commun Biol, 2024
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8VOV
| Structure of VCP in complex with an ATPase activator and ADP (D2 domains only, hexameric form) | 分子名称: | (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | 著者 | Jones, N.H, Urnivicius, L, Kapoor, T.M. | 登録日 | 2024-01-16 | 公開日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry. Proc.Natl.Acad.Sci.USA, 121, 2024
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8XWQ
| Cryo-EM structure of ET-1 bound ETBR-DNGI complex | 分子名称: | Endothelin receptor type B, Endothelin-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Tani, K, Maki-Yonekura, S, Kanno, R, Negami, T, Hamaguchi, T, Hall, M, Mizoguchi, A, Humbel, B.M, Terada, T, Yonekura, K, Doi, T. | 登録日 | 2024-01-16 | 公開日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Structure of endothelin ETB receptor-Gi complex in a conformation stabilized by the unique NPxxL motif Commun Biol, 2024
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8RPM
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8VOH
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8VOF
| GI targeted CpPI4K inhibitor | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Isoform 2 of Phosphatidylinositol 4-kinase beta,Isoform 2 of Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ... | 著者 | Knapp, M.S, Cuellar, C, Mamo, M. | 登録日 | 2024-01-15 | 公開日 | 2024-09-04 | 最終更新日 | 2024-09-25 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Cryptosporidium PI(4)K inhibitor EDI048 is a gut-restricted parasiticidal agent to treat paediatric enteric cryptosporidiosis Nat Microbiol, 2024
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8XVJ
| Cryo-EM structure of ETAR bound with Macitentan | 分子名称: | 6-[2-(5-bromanylpyrimidin-2-yl)oxyethoxy]-5-(4-bromophenyl)-~{N}-(propylsulfamoyl)pyrimidin-4-amine, Endoglucanase H,Endothelin-1 receptor,Soluble cytochrome b562, anti-BRIL Fab Heavy chain, ... | 著者 | Hou, J.Y, Liu, S.H, Wu, L.J, Liu, Z.J, Hua, T. | 登録日 | 2024-01-15 | 公開日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | Structural basis of antagonist selectivity in endothelin receptors. Cell Discov, 10, 2024
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8XVK
| Cryo-EM structure of ETAR bound with Ambrisentan | 分子名称: | (2~{S})-2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenyl-propanoic acid, Endoglucanase H,Endothelin-1 receptor,Soluble cytochrome b562, anti-BRIL Fab Heavy chain, ... | 著者 | Hou, J.Y, Liu, S.H, Wu, L.J, Liu, Z.J, Hua, T. | 登録日 | 2024-01-15 | 公開日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | 主引用文献 | Structural basis of antagonist selectivity in endothelin receptors. Cell Discov, 10, 2024
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8XVL
| Cryo-EM structure of ETAR bound with Zibotentan | 分子名称: | Endoglucanase H,Endothelin-1 receptor,Soluble cytochrome b562, anti-BRIL Fab Heavy chain, anti-BRIL Fab Light chain, ... | 著者 | Hou, J.Y, Liu, S.H, Wu, L.J, Liu, Z.J, Hua, T. | 登録日 | 2024-01-15 | 公開日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Structural basis of antagonist selectivity in endothelin receptors. Cell Discov, 10, 2024
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8VOI
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8XVI
| Cryo-EM structure of ETAR bound with Endothelin1 | 分子名称: | Endoglucanase H,Endothelin-1 receptor, Endothelin-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Hou, J.Y, Liu, S.H, Wu, L.J, Liu, Z.J, Hua, T. | 登録日 | 2024-01-15 | 公開日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Structural basis of antagonist selectivity in endothelin receptors. Cell Discov, 10, 2024
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8XVH
| Cryo-EM structure of ETBR bound with Endothelin1 | 分子名称: | Endothelin-1, Exo-alpha-sialidase,Endothelin receptor type B, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Hou, J.Y, Liu, S.H, Wu, L.J, Liu, Z.J, Hua, T. | 登録日 | 2024-01-15 | 公開日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | Structural basis of antagonist selectivity in endothelin receptors. Cell Discov, 10, 2024
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8XVE
| Cryo-EM structure of ETBR bound with BQ3020 | 分子名称: | BQ3020, Exo-alpha-sialidase,Endothelin receptor type B, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Hou, J.Y, Liu, S.H, Wu, L.J, Liu, Z.J, Hua, T. | 登録日 | 2024-01-15 | 公開日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis of antagonist selectivity in endothelin receptors. Cell Discov, 10, 2024
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8XVT
| The core subcomplex of human NuA4/TIP60 complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | 著者 | Chen, K, Wang, L, Yu, Z, Yu, J, Ren, Y, Wang, Q, Xu, Y. | 登録日 | 2024-01-15 | 公開日 | 2024-07-24 | 最終更新日 | 2024-09-11 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure of the human TIP60 complex. Nat Commun, 15, 2024
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