6FMC
| Neuropilin1-b1 domain in complex with EG01377, 0.9 Angstrom structure | 分子名称: | (2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic acid, Neuropilin-1 | 著者 | Yelland, T, Djordjevic, S, Fotinou, K, Selwood, D, Zachary, I, Frankel, P. | 登録日 | 2018-01-30 | 公開日 | 2018-10-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (0.9 Å) | 主引用文献 | Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF beta ) Production in Regulatory T-Cells. J. Med. Chem., 61, 2018
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5KAY
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6GG5
| Crystal structure of M2 PYK in complex with Tryptophan. | 分子名称: | PHOSPHATE ION, POTASSIUM ION, Pyruvate kinase PKM, ... | 著者 | McNae, I.W, Yuan, M, Walkinshaw, M.D. | 登録日 | 2018-05-02 | 公開日 | 2018-05-23 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor. Biochem. J., 475, 2018
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6GIZ
| PURPLE ACID PHYTASE FROM WHEAT ISOFORM B2 - SUBSTRATE COMPLEX | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Faba-Rodriguez, R, Brearley, C.A, Hemmings, A.M. | 登録日 | 2018-05-15 | 公開日 | 2019-11-27 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Structure of a cereal purple acid phytase provides new insights to phytate degradation in plants. Plant Commun., 3, 2022
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1NHO
| Structural and Functional characterization of a Thioredoxin-like Protein from Methanobacterium thermoautotrophicum | 分子名称: | Probable Thioredoxin | 著者 | Amegbey, G.Y, Monzavi, H, Habibi-Nazhad, B, Bhattacharyya, S, Wishart, D.S. | 登録日 | 2002-12-19 | 公開日 | 2003-08-26 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural and Functional Characterization of a Thioredoxin-like Protein (Mt0807) from Methanobacterium thermoautotrophicum Biochemistry, 42, 2003
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6TYH
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6U0W
| Crystal structure of Staphylococcal nuclease variant Delta+PHS K133M at cryogenic temperature | 分子名称: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | 著者 | Jeliazkov, J.R, Robinson, A.C, Berger, J.M, Garcia-Moreno E, B, Gray, J.G. | 登録日 | 2019-08-15 | 公開日 | 2019-08-28 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Toward the computational design of protein crystals with improved resolution. Acta Crystallogr D Struct Biol, 75, 2019
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6GJ2
| PURPLE ACID PHYTASE FROM WHEAT ISOFORM B2 - COMPLEX WITH INOSITOL HEXASULPHATE | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Faba-Rodriguez, R, Brearley, C.A, Hemmings, A.M. | 登録日 | 2018-05-15 | 公開日 | 2019-11-27 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Structure of a cereal purple acid phytase provides new insights to phytate degradation in plants. Plant Commun., 3, 2022
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5KJF
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5KKR
| KSR2:MEK1 Complex Bound to the Small Molecule APS-2-79 | 分子名称: | 6,7-dimethoxy-~{N}-(2-methyl-4-phenoxy-phenyl)quinazolin-4-amine, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2 | 著者 | Dhawan, N.S, Scopton, A.P, Dar, A.C. | 登録日 | 2016-06-22 | 公開日 | 2016-08-31 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.509 Å) | 主引用文献 | Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Nature, 537, 2016
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6U4S
| wild type cysteine dioxygenase | 分子名称: | Cysteine dioxygenase type 1, FE (III) ION | 著者 | Meneely, K.M, Chilton, A.S, Forbes, D.L, Ellis, H.R, Lamb, A.L. | 登録日 | 2019-08-26 | 公開日 | 2020-07-08 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | The 3-His Metal Coordination Site Promotes the Coupling of Oxygen Activation to Cysteine Oxidation in Cysteine Dioxygenase. Biochemistry, 59, 2020
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5KJ6
| V197I Horse liver alcohol dehydrogenase complexed with NAD+ and pentafluorobenzyl alcohol | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, 2,3,4,5,6-PENTAFLUOROBENZYL ALCOHOL, Alcohol dehydrogenase E chain, ... | 著者 | Plapp, B.V. | 登録日 | 2016-06-17 | 公開日 | 2016-07-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.14 Å) | 主引用文献 | Contribution of buried distal amino acid residues in horse liver alcohol dehydrogenase to structure and catalysis. Protein Sci., 27, 2018
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6GG6
| Crystal structure of M2 PYK in complex with Serine. | 分子名称: | MAGNESIUM ION, PHOSPHATE ION, POTASSIUM ION, ... | 著者 | McNae, I.W, Yuan, M, Walkinshaw, M.D. | 登録日 | 2018-05-02 | 公開日 | 2018-05-23 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.96 Å) | 主引用文献 | An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor. Biochem. J., 475, 2018
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6GG3
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5JH6
| Crystal structure of TL10-92 bound to TAK1-TAB1 | 分子名称: | 2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl prop-2-enoate, Mitogen-activated protein kinase kinase kinase 7,TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | 著者 | Gurbani, D, Westover, K.D. | 登録日 | 2016-04-20 | 公開日 | 2017-02-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.365 Å) | 主引用文献 | Structure-guided development of covalent TAK1 inhibitors. Bioorg. Med. Chem., 25, 2017
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6TSP
| Marasmius oreades agglutinin (MOA) inhibited by zinc | 分子名称: | 1,2-ETHANEDIOL, Agglutinin, CALCIUM ION, ... | 著者 | Cordara, G, Manna, D, Krengel, U. | 登録日 | 2019-12-21 | 公開日 | 2020-08-05 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal structure of MOA in complex with a peptide fragment: a protease caught in flagranti Curr Res Struct Biol, 2, 2020
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6GIT
| PURPLE ACID PHYTASE FROM WHEAT ISOFORM B2 - PRODUCT COMPLEX | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Faba-Rodriguez, R, Brearley, C.A, Hemmings, A.M. | 登録日 | 2018-05-15 | 公開日 | 2019-11-27 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.418 Å) | 主引用文献 | Structure of a cereal purple acid phytase provides new insights to phytate degradation in plants. Plant Commun., 3, 2022
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1OM1
| Crystal structure of maize CK2 alpha in complex with IQA | 分子名称: | (5-OXO-5,6-DIHYDRO-INDOLO[1,2-A]QUINAZOLIN-7-YL)-ACETIC ACID, Casein kinase II, alpha chain | 著者 | Battistutta, R, De Moliner, E, Zanotti, G. | 登録日 | 2003-02-24 | 公開日 | 2004-02-24 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA). Biochem.J., 374, 2003
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5J5D
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5J74
| Fluorogen activating protein AM2.2 in complex with TO1-2p | 分子名称: | 1-(17-amino-5,8-dioxo-12,15-dioxa-4,9-diazaheptadecan-1-yl)-4-{[3-(3-sulfopropyl)-1,3-benzothiazol-3-ium-2-yl]methyl}quinolin-1-ium, PHOSPHATE ION, scFv AM2.2 | 著者 | Stanfield, R.L, Wilson, I.A, Wu, Y. | 登録日 | 2016-04-05 | 公開日 | 2016-05-25 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Discovery of Small-Molecule Nonfluorescent Inhibitors of Fluorogen-Fluorogen Activating Protein Binding Pair. J Biomol Screen, 21, 2016
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1P1R
| Horse liver alcohol dehydrogenase complexed with NADH and R-N-1-methylhexylformamide | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, (R)-N-(1-METHYL-HEXYL)-FORMAMIDE, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... | 著者 | Venkataramaiah, T.H, Plapp, B.V. | 登録日 | 2003-04-13 | 公開日 | 2003-07-15 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | Formamides mimic aldehydes and inhibit liver alcohol dehydrogenases and ethanol metabolism J.Biol.Chem., 278, 2003
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6T3O
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5KJC
| V222I horse liver alcohol dehydrogenase complexed with NAD+ and pentafluorobenzyl alcohol | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, 2,3,4,5,6-PENTAFLUOROBENZYL ALCOHOL, Alcohol dehydrogenase E chain, ... | 著者 | Plapp, B.V. | 登録日 | 2016-06-18 | 公開日 | 2016-06-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Contribution of buried distal amino acid residues in horse liver alcohol dehydrogenase to structure and catalysis. Protein Sci., 27, 2018
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5KMU
| CTX-M-9 beta lactamase mutant - T165W | 分子名称: | Beta-lactamase, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Latallo, M, Faham, S, Kasson, P.M. | 登録日 | 2016-06-27 | 公開日 | 2017-08-02 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Predicting allosteric mutants that increase activity of a major antibiotic resistance enzyme. Chem Sci, 8, 2017
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1PWG
| Covalent Penicilloyl Acyl Enzyme Complex Of The Streptomyces R61 DD-Peptidase With A Highly Specific Penicillin | 分子名称: | (2R,4S)-2-[(1R)-1-{[(6S)-6-carboxy-6-(glycylamino)hexanoyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, D-alanyl-D-alanine carboxypeptidase | 著者 | Silvaggi, N.R, Josephine, H.R, Pratt, R.F, Kelly, J.A. | 登録日 | 2003-07-01 | 公開日 | 2004-07-13 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.074 Å) | 主引用文献 | Crystal structures of complexes between the R61 DD-peptidase and peptidoglycan-mimetic beta-lactams: a non-covalent complex with a "perfect penicillin" J.Mol.Biol., 345, 2005
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