5CR5
 
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5A6S
 | | Crystal structure of the CTP1L endolysin reveals how its activity is regulated by a secondary translation product | | 分子名称: | ENDOLYSIN, GLYCEROL, PENTAETHYLENE GLYCOL, ... | | 著者 | Dunne, M, Leicht, S, Krichel, B, Mertens, H.D.T, Thompson, A, Krijgsveld, J, Svergun, D.I, GomezTorres, N, Garde, S, Uetrecht, C, Narbad, A, Mayer, M.J, Meijers, R. | | 登録日 | 2015-07-01 | | 公開日 | 2015-12-30 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal Structure of the Ctp1L Endolysin Reveals How its Activity is Regulated by a Secondary Translation Product.
J.Biol.Chem., 291, 2016
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3QGH
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3QE5
 | | Complete structure of Streptococcus mutans Antigen I/II carboxy-terminus | | 分子名称: | CALCIUM ION, MAGNESIUM ION, Major cell-surface adhesin PAc, ... | | 著者 | Larson, M.R, Rajashankar, K.R, Crowley, P.J, Kelly, C, Mitchell, T.J, Brady, L.J, Deivanayagam, C. | | 登録日 | 2011-01-19 | | 公開日 | 2011-04-20 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal Structure of the C-terminal Region of Streptococcus mutans Antigen I/II and Characterization of Salivary Agglutinin Adherence Domains.
J.Biol.Chem., 286, 2011
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5KQ5
 | | AMPK bound to allosteric activator | | 分子名称: | 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... | | 著者 | Calabrese, M.F, Kurumbail, R.G. | | 登録日 | 2016-07-05 | | 公開日 | 2016-08-17 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.41 Å) | | 主引用文献 | Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.
J.Med.Chem., 59, 2016
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3QGI
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8OES
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7B9H
 | | Crystal structure of the PDE4D catalytic domain in complex with GEBR-42a | | 分子名称: | 1,2-ETHANEDIOL, 3-[(~{E})-1-(3-cyclopentyloxy-4-methoxy-phenyl)ethylideneamino]oxy-1-morpholin-4-yl-propan-1-one, MAGNESIUM ION, ... | | 著者 | Torretta, A, Abbate, S, Parisini, E. | | 登録日 | 2020-12-14 | | 公開日 | 2021-06-30 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Design, synthesis, biological evaluation and structural characterization of novel GEBR library PDE4D inhibitors.
Eur.J.Med.Chem., 223, 2021
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1D8E
 | | Zinc-depleted FTase complexed with K-RAS4B peptide substrate and FPP analog. | | 分子名称: | ACETATE ION, FARNESYLTRANSFERASE (ALPHA SUBUNIT), FARNESYLTRANSFERASE (BETA SUBUNIT), ... | | 著者 | Long, S.B, Casey, P.J, Beese, L.S. | | 登録日 | 1999-10-22 | | 公開日 | 2000-03-20 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures.
Structure Fold.Des., 8, 2000
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8OER
 | | MUC5B amino acids 26-1435 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Mucin-5B | | 著者 | Khmelnitsky, L, Fass, D. | | 登録日 | 2023-03-12 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Pulmonary Fibrosis Linked to Impaired Mucin 5B Supramolecular Assembly
To Be Published
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5D6M
 | | Mn(II)-loaded MnCcP.1 | | 分子名称: | Cytochrome c peroxidase, mitochondrial, MANGANESE (II) ION, ... | | 著者 | Robinson, H, Gao, Y.-G, Hosseinzadeh, P, Lu, Y. | | 登録日 | 2015-08-12 | | 公開日 | 2016-03-09 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.653 Å) | | 主引用文献 | Enhancing Mn(II)-Binding and Manganese Peroxidase Activity in a Designed Cytochrome c Peroxidase through Fine-Tuning Secondary-Sphere Interactions.
Biochemistry, 55, 2016
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5SV8
 | | Crystal Structure of the catalytic nucleophile and surface cysteine mutant of VvEG16 in complex with a xyloglucan oligosaccharide | | 分子名称: | alpha-D-xylopyranose-(1-6)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-[alpha-D-xylopyranose-(1-6)]beta-D-glucopyranose-(1-4)-beta-D-glucopyranose, probable xyloglucan endotransglucosylase/hydrolase protein 19 | | 著者 | McGregor, N.G.S, Tung, C.C, Van Petegem, F, Brumer, H. | | 登録日 | 2016-08-05 | | 公開日 | 2016-09-21 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.588 Å) | | 主引用文献 | Crystallographic insight into the evolutionary origins of xyloglucan endotransglycosylases and endohydrolases.
Plant J., 89, 2017
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3K0J
 | | Crystal structure of the E. coli ThiM riboswitch in complex with thiamine pyrophosphate and the U1A crystallization module | | 分子名称: | MAGNESIUM ION, RNA (87-MER), THIAMINE DIPHOSPHATE, ... | | 著者 | Kulshina, N, Edwards, T.E, Ferre-D'Amare, A.R. | | 登録日 | 2009-09-24 | | 公開日 | 2009-12-22 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Thermodynamic analysis of ligand binding and ligand binding-induced tertiary structure formation by the thiamine pyrophosphate riboswitch.
Rna, 16, 2010
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8JTR
 | | Cryo-EM structure of GeoCas9-sgRNA binary complex | | 分子名称: | CRISPR-associated endonuclease Cas9, sgRNA (139-bp) | | 著者 | Shen, P.P, Liu, B.B, Li, X, Zhang, L.L, Chen, C.-C, Guo, R.-T. | | 登録日 | 2023-06-22 | | 公開日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | | 主引用文献 | Cryo-EM structure of GeoCas9-sgRNA binary complex
To Be Published
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8R1V
 | | Pseudomonas aeruginosa FabF C164A in complex with N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-methoxyphenoxy)acetamide | | 分子名称: | 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, FORMIC ACID, ... | | 著者 | Yadrykhinsky, V, Brenk, R. | | 登録日 | 2023-11-02 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.087 Å) | | 主引用文献 | Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection.
Rsc Med Chem, 15, 2024
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8R0I
 | | Pseudomonas aeruginosa FabF C164A in complex with 3-amino-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)benzamide | | 分子名称: | 1,2-ETHANEDIOL, 3-azanyl-N-(1,5-dimethyl-3-oxidanylidene-2-phenyl-pyrazol-4-yl)benzamide, 3-oxoacyl-[acyl-carrier-protein] synthase 2, ... | | 著者 | Yadrykhinsky, V, Brenk, R. | | 登録日 | 2023-10-31 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | | 主引用文献 | Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection.
Rsc Med Chem, 15, 2024
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3HA8
 | | THE COMPLEX STRUCTURE OF THE MAP KINASE P38/Compound 14b | | 分子名称: | Mitogen-activated protein kinase 14, N~2~-{4-[6-(3,4-dihydroquinolin-1(2H)-ylcarbonyl)-1H-benzimidazol-1-yl]-6-ethoxy-1,3,5-triazin-2-yl}-3-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-N-methyl-L-alaninamide | | 著者 | Zhao, B, Clark, M.A. | | 登録日 | 2009-05-01 | | 公開日 | 2009-08-04 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | Design, synthesis and selection of DNA-encoded small-molecule libraries.
Nat.Chem.Biol., 5, 2009
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3HCK
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5IKX
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8RP4
 | | Alpha-Methylacyl-CoA racemase from Mycobacterium tuberculosis (D156A mutant) | | 分子名称: | 1,2-ETHANEDIOL, Alpha-methylacyl-CoA racemase, DI(HYDROXYETHYL)ETHER | | 著者 | Mojanaga, O.O, Acharya, K.R, Lloyd, M.D. | | 登録日 | 2024-01-12 | | 公開日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | | 主引用文献 | alpha-Methylacyl-CoA Racemase from Mycobacterium tuberculosis -Detailed Kinetic and Structural Characterization of the Active Site.
Biomolecules, 14, 2024
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8S3E
 | | Structure of rabbit Slo1 in complex with gamma1/LRRC26 | | 分子名称: | (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, CALCIUM ION, CHOLESTEROL, ... | | 著者 | Redhardt, M, Raunser, S, Raisch, T. | | 登録日 | 2024-02-20 | | 公開日 | 2024-04-10 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (2.39 Å) | | 主引用文献 | Cryo-EM structure of the Slo1 potassium channel with the auxiliary gamma 1 subunit suggests a mechanism for depolarization-independent activation.
Febs Lett., 598, 2024
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8RMW
 | | Alpha-Methylacyl-CoA racemase from Mycobacterium tuberculosis. | | 分子名称: | 1,2-ETHANEDIOL, Alpha-methylacyl-CoA racemase, DI(HYDROXYETHYL)ETHER | | 著者 | Mojanaga, O.O, Acharya, K.R, Lloyd, M.D. | | 登録日 | 2024-01-09 | | 公開日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | alpha-Methylacyl-CoA Racemase from Mycobacterium tuberculosis -Detailed Kinetic and Structural Characterization of the Active Site.
Biomolecules, 14, 2024
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8RP3
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8RP5
 | | Alpha-Methylacyl-CoA racemase from Mycobacterium tuberculosis (E241A mutant) | | 分子名称: | 1,2-ETHANEDIOL, Alpha-methylacyl-CoA racemase, TRIETHYLENE GLYCOL | | 著者 | Mojanaga, O.O, Acharya, K.R, Lloyd, M.D. | | 登録日 | 2024-01-12 | | 公開日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | alpha-Methylacyl-CoA Racemase from Mycobacterium tuberculosis -Detailed Kinetic and Structural Characterization of the Active Site.
Biomolecules, 14, 2024
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8PJ0
 | | Pseudomonas aeruginosa FabF C164A mutant in complex with N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methylbutanamide | | 分子名称: | 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, FORMIC ACID, ... | | 著者 | Georgiou, C, Brenk, R, Espeland, L.O. | | 登録日 | 2023-06-22 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection.
Rsc Med Chem, 15, 2024
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