6GJC
 
 | | Structure of Mycobacterium tuberculosis Fatty Acid Synthase - I | | 分子名称: | FLAVIN MONONUCLEOTIDE, Fatty acid synthase | | 著者 | Elad, N, Baron, S, Shakked, Z, Zimhony, O, Diskin, R. | | 登録日 | 2018-05-16 | | 公開日 | 2018-09-05 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 angstrom resolution.
Nat Commun, 9, 2018
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4PIV
 | | Human Fatty Acid Synthase Psi/KR Tri-Domain with NADPH and GSK2194069 | | 分子名称: | 4-[4-(1-benzofuran-5-yl)phenyl]-5-{[(3S)-1-(cyclopropylcarbonyl)pyrrolidin-3-yl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, CACODYLATE ION, Fatty acid synthase, ... | | 著者 | Williams, S.P, Wang, L, Brown, K.K, Parrish, C.A, Hardwicke, M.A. | | 登録日 | 2014-05-09 | | 公開日 | 2014-07-23 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.299 Å) | | 主引用文献 | A human fatty acid synthase inhibitor binds beta-ketoacyl reductase in the keto-substrate site.
Nat.Chem.Biol., 10, 2014
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6NNA
 | | Human Fatty Acid Synthase Psi/KR Tri-Domain with NADPH and Compound 22 | | 分子名称: | 1,2-ETHANEDIOL, Fatty acid synthase,Fatty acid synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Toms, A.V, Martin, M.W. | | 登録日 | 2019-01-14 | | 公開日 | 2019-02-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN).
Bioorg. Med. Chem. Lett., 29, 2019
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3HHD
 | | Structure of the Human Fatty Acid Synthase KS-MAT Didomain as a Framework for Inhibitor Design. | | 分子名称: | CHLORIDE ION, Fatty acid synthase | | 著者 | Pappenberger, G.M, Benz, J, Thoma, R, Rudolph, M.G. | | 登録日 | 2009-05-15 | | 公開日 | 2010-02-09 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structure of the human fatty acid synthase KS-MAT didomain as a framework for inhibitor design.
J.Mol.Biol., 397, 2010
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5C37
 | | Structure of the beta-ketoacyl reductase domain of human fatty acid synthase bound to a spiro-imidazolone inhibitor | | 分子名称: | 6-{[(3R)-1-(cyclopropylcarbonyl)pyrrolidin-3-yl]methyl}-5-[4-(1-methyl-1H-indazol-5-yl)phenyl]-4,6-diazaspiro[2.4]hept-4-en-7-one, CHLORIDE ION, Fatty acid synthase, ... | | 著者 | Schubert, C, Milligan, C.M, Vo, K, Grasberger, B. | | 登録日 | 2015-06-17 | | 公開日 | 2016-06-22 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy.
Bioorg.Med.Chem.Lett., 28, 2018
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2PX6
 | | Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat | | 分子名称: | (2S,3S,5S)-5-[(N-FORMYL-L-LEUCYL)OXY]-2-HEXYL-3-HYDROXYHEXADECANOIC ACID, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Thioesterase domain | | 著者 | Pemble IV, C.W, Johnson, L.C, Kridel, S.J, Lowther, W.T. | | 登録日 | 2007-05-14 | | 公開日 | 2007-07-10 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat.
Nat.Struct.Mol.Biol., 14, 2007
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6ROP
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8PS8
 | | Asymmetric unit of the yeast fatty acid synthase in the semi non-rotated state with ACP at the enoyl reductase domain (FASam sample) | | 分子名称: | Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta | | 著者 | Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. | | 登録日 | 2023-07-26 | | 公開日 | 2023-11-22 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
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7QOS
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2CDH
 | | ARCHITECTURE OF THE THERMOMYCES LANUGINOSUS FUNGAL FATTY ACID SYNTHASE AT 5 ANGSTROM RESOLUTION. | | 分子名称: | DEHYDRATASE, ENOYL REDUCTASE, KETOACYL REDUCTASE, ... | | 著者 | Jenni, S, Leibundgut, M, Maier, T, Ban, N. | | 登録日 | 2006-01-24 | | 公開日 | 2006-03-07 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | | 主引用文献 | Architecture of a Fungal Fatty Acid Synthase at 5 A Resolution.
Science, 311, 2006
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5MY0
 | | KS-MAT DI-DOMAIN OF MOUSE FAS WITH MALONYL-COA | | 分子名称: | COENZYME A, Fatty acid synthase, MALONYL-COENZYME A | | 著者 | Paithankar, K.S, Rittner, A, Huu, K.V, Grininger, M. | | 登録日 | 2017-01-25 | | 公開日 | 2018-01-24 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | | 主引用文献 | Characterization of the Polyspecific Transferase of Murine Type I Fatty Acid Synthase (FAS) and Implications for Polyketide Synthase (PKS) Engineering.
ACS Chem. Biol., 13, 2018
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8PS1
 | | Asymmetric unit of the yeast fatty acid synthase in the non-rotated state with ACP at the ketosynthase domain (FASamn sample) | | 分子名称: | COENZYME A, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ... | | 著者 | Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. | | 登録日 | 2023-07-13 | | 公開日 | 2023-11-22 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
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8PSA
 | | Asymmetric unit of the yeast fatty acid synthase in the semi non-rotated state with ACP at the ketosynthase domain (FASam sample) | | 分子名称: | FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta | | 著者 | Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. | | 登録日 | 2023-07-13 | | 公開日 | 2023-11-22 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
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8PS9
 | | Asymmetric unit of the yeast fatty acid synthase in the non-rotated state with ACP at the ketosynthase domain (FASam sample) | | 分子名称: | FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, ... | | 著者 | Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. | | 登録日 | 2023-07-13 | | 公開日 | 2023-11-22 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
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8PSL
 | | Asymmetric unit of the yeast fatty acid synthase in the semi non-rotated state with ACP at the ketosynthase domain (FASx sample) | | 分子名称: | FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta | | 著者 | Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. | | 登録日 | 2023-07-13 | | 公開日 | 2023-11-22 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
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8PSK
 | | Asymmetric unit of the yeast fatty acid synthase in the non-rotated state with ACP at the ketosynthase domain (FASx sample) | | 分子名称: | FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta | | 著者 | Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. | | 登録日 | 2023-07-13 | | 公開日 | 2023-11-22 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
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8PSP
 | | Asymmetric unit of the yeast fatty acid synthase in rotated state with ACP at the acetyl transferase domain (FASx sample) | | 分子名称: | 4'-PHOSPHOPANTETHEINE, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ... | | 著者 | Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. | | 登録日 | 2023-07-13 | | 公開日 | 2023-11-22 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
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8PSJ
 | | Asymmetric unit of the yeast fatty acid synthase in the semi rotated state with ACP at the acetyl transferase domain (FASx sample) | | 分子名称: | 4'-PHOSPHOPANTETHEINE, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ... | | 著者 | Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. | | 登録日 | 2023-07-13 | | 公開日 | 2023-11-22 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
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8PRW
 | | Cryo-EM structure of the yeast fatty acid synthase at 1.9 angstrom resolution | | 分子名称: | 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, COENZYME A, Fatty acid synthase subunit alpha, ... | | 著者 | Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. | | 登録日 | 2023-07-12 | | 公開日 | 2023-11-22 | | 実験手法 | ELECTRON MICROSCOPY (1.9 Å) | | 主引用文献 | Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
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8PSG
 | | Asymmetric unit of the yeast fatty acid synthase in the semi non-rotated state with ACP at the acetyl transferase domain (FASx sample) | | 分子名称: | FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta | | 著者 | Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. | | 登録日 | 2023-07-13 | | 公開日 | 2023-11-22 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
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8PSF
 | | Asymmetric unit of the yeast fatty acid synthase in non-rotated state with ACP at the acetyl transferase domain (FASx sample) | | 分子名称: | 4'-PHOSPHOPANTETHEINE, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ... | | 著者 | Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. | | 登録日 | 2023-07-13 | | 公開日 | 2023-11-22 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
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8PSM
 | | Asymmetric unit of the yeast fatty acid synthase in the non-rotated state with ACP at the malonyl/palmitoyl transferase domain (FASx sample) | | 分子名称: | 4'-PHOSPHOPANTETHEINE, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ... | | 著者 | Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. | | 登録日 | 2023-07-13 | | 公開日 | 2023-11-22 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
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8PS2
 | | Asymmetric unit of the yeast fatty acid synthase with ACP at the enoyl reductase domain (FASam sample) | | 分子名称: | FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, ... | | 著者 | Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. | | 登録日 | 2023-07-13 | | 公開日 | 2023-11-22 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
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8PRV
 | | Asymmetric unit of the yeast fatty acid synthase in the non-rotated state with ACP at the ketosreductase domain (FASamn sample) | | 分子名称: | COENZYME A, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ... | | 著者 | Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. | | 登録日 | 2023-07-12 | | 公開日 | 2023-11-22 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots.
Cell, 186, 2023
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6JSH
 | | Apo-state Fatty Acid Synthase | | 分子名称: | Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta | | 著者 | Qiu, S.W, Liu, S. | | 登録日 | 2019-04-08 | | 公開日 | 2019-09-25 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (5.1 Å) | | 主引用文献 | Modulation of fatty acid synthase by ATR checkpoint kinase Rad3.
J Mol Cell Biol, 11, 2019
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