PDB: 82 件ウェブページステータス検索Chemie searchBIRD

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6RRY	GOLGI ALPHA-MANNOSIDASE II in complex with (2S,3R)-2-(Hydroxymethyl)-1,2,3,6-tetrahydro-3-pyridinol 分子名称: (2~{S},3~{R})-2-(hydroxymethyl)-1,2,3,6-tetrahydropyridin-3-ol, 1,2-ETHANEDIOL, Alpha-mannosidase 2, ... 著者 Armstrong, Z, Lahav, D, Johnson, R, Kuo, C.L, Beenakker, T.J.M, de Boer, C, Wong, C.S, van Rijssel, E.R, Debets, M, Geurink, P.P, Ovaa, H, van der Stelt, M, Codee, J.D.C, Aerts, J.M.F.G, Wu, L, Overkleeft, H.S, Davies, G.J. 登録日 2019-05-20 公開日 2020-07-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Manno- epi -cyclophellitols Enable Activity-Based Protein Profiling of Human alpha-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors. J.Am.Chem.Soc., 142, 2020
6RRJ	GOLGI ALPHA-MANNOSIDASE II in complex with 5-(Adamantan-1yl-methoxy)-pentyl 2,5-dideoxy-2,5-imino-D-talo-hexonamide 分子名称: (2~{S},3~{R},4~{S},5~{R})-~{N}-[5-(1-adamantylmethoxy)pentyl]-5-(hydroxymethyl)-3,4-bis(oxidanyl)pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, Alpha-mannosidase 2, ... 著者 Armstrong, Z, Lahav, D, Johnson, R, Kuo, C.L, Beenakker, T.J.M, de Boer, C, Wong, C.S, van Rijssel, E.R, Debets, M, Geurink, P.P, Ovaa, H, van der Stelt, M, Codee, J.D.C, Aerts, J.M.F.G, Wu, L, Overkleeft, H.S, Davies, G.J. 登録日 2019-05-20 公開日 2020-07-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Manno- epi -cyclophellitols Enable Activity-Based Protein Profiling of Human alpha-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors. J.Am.Chem.Soc., 142, 2020
6RRU	GOLGI ALPHA-MANNOSIDASE II in complex with (5R,6R,7S,8S)-5,6,7,8-tetrahydro-5-(hydroxymethyl)-3-(3-phenylpropyl)imidazo[1,2-a]pyridine-6,7,8-triol 分子名称: (5~{R},6~{R},7~{S},8~{S})-5-(hydroxymethyl)-2-(3-phenylpropyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-6,7,8-triol, Alpha-mannosidase 2, ZINC ION 著者 Armstrong, Z, Lahav, D, Johnson, R, Kuo, C.L, Beenakker, T.J.M, de Boer, C, Wong, C.S, van Rijssel, E.R, Debets, M, Geurink, P.P, Ovaa, H, van der Stelt, M, Codee, J.D.C, Aerts, J.M.F.G, Wu, L, Overkleeft, H.S, Davies, G.J. 登録日 2019-05-20 公開日 2020-07-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Manno- epi -cyclophellitols Enable Activity-Based Protein Profiling of Human alpha-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors. J.Am.Chem.Soc., 142, 2020
6RRX	GOLGI ALPHA-MANNOSIDASE II in complex with (2S,3R)-2-(Hydroxymethyl)-3-piperidinol 分子名称: (2~{S},3~{R})-2-(hydroxymethyl)piperidin-3-ol, 1,2-ETHANEDIOL, Alpha-mannosidase 2, ... 著者 Armstrong, Z, Lahav, D, Johnson, R, Kuo, C.L, Beenakker, T.J.M, de Boer, C, Wong, C.S, van Rijssel, E.R, Debets, M, Geurink, P.P, Ovaa, H, van der Stelt, M, Codee, J.D.C, Aerts, J.M.F.G, Wu, L, Overkleeft, H.S, Davies, G.J. 登録日 2019-05-20 公開日 2020-07-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Manno- epi -cyclophellitols Enable Activity-Based Protein Profiling of Human alpha-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors. J.Am.Chem.Soc., 142, 2020
6RS0	GOLGI ALPHA-MANNOSIDASE II in complex with (2S,3S,4R,5R)-1-(2-(Benzyloxy)ethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol 分子名称: (2~{S},3~{S},4~{R})-2-(hydroxymethyl)-1-(2-phenylmethoxyethyl)piperidine-3,4,5-triol, 1,2-ETHANEDIOL, Alpha-mannosidase 2, ... 著者 Armstrong, Z, Lahav, D, Johnson, R, Kuo, C.L, Beenakker, T.J.M, de Boer, C, Wong, C.S, van Rijssel, E.R, Debets, M, Geurink, P.P, Ovaa, H, van der Stelt, M, Codee, J.D.C, Aerts, J.M.F.G, Wu, L, Overkleeft, H.S, Davies, G.J. 登録日 2019-05-20 公開日 2020-07-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Manno- epi -cyclophellitols Enable Activity-Based Protein Profiling of Human alpha-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors. J.Am.Chem.Soc., 142, 2020
2ALW	Golgi alpha-mannosidase II complex with Noeuromycin 分子名称: (2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-HYDROXYMETHYL-PIPERIDINE, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kuntz, D.A, Bols, M.B, Liu, H, Rose, D.R. 登録日 2005-08-08 公開日 2006-07-04 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 The role of the active site Zn in the catalytic mechanism of the GH38 Golgi alpha-mannosidase II: implications from noeuromycin inhibition Biocatal.Biotransfor., 34, 2006
2F7O	Golgi alpha-mannosidase II complex with mannostatin A 分子名称: (1R,2R,3R,4S,5R)-4-AMINO-5-(METHYLTHIO)CYCLOPENTANE-1,2,3-TRIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kuntz, D.A, Rose, D.R. 登録日 2005-12-01 公開日 2006-07-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.43 Å) 主引用文献 Structural Basis of the Inhibition of Golgi alpha-Mannosidase II by Mannostatin A and the Role of the Thiomethyl Moiety in Ligand-Protein Interactions. J.Am.Chem.Soc., 128, 2006
2F7Q	Golgi alpha-mannosidase II complex with aminocyclopentitetrol 分子名称: (1R,2R,3S,4S,5R)-5-AMINOCYCLOPENTANE-1,2,3,4-TETROL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kuntz, D.A, Rose, D.R. 登録日 2005-12-01 公開日 2006-12-12 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Golgi alpha-mannosidase II complex with aminocyclopentitetrol To be Published
2F1A	GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH (2R,3R,4S)-2-({[(1S)-2-hydroxy-1-phenylethyl]amino}methyl)pyrrolidine-3,4-diol 分子名称: (2R,3R,4S)-2-({[(1S)-2-HYDROXY-1-PHENYLETHYL]AMINO}METHYL)PYRROLIDINE-3,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kuntz, D.A, Rose, D.R. 登録日 2005-11-14 公開日 2006-12-05 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Evaluation of docking programs for predicting binding of Golgi alpha-mannosidase II inhibitors: a comparison with crystallography. Proteins, 69, 2007
2F7P	Golgi alpha-mannosidase II complex with benzyl-mannostatin A 分子名称: (1R,2R,3R,4S,5R)-4-(BENZYLAMINO)-5-(METHYLTHIO)CYCLOPENTANE-1,2,3-TRIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kuntz, D.A, Rose, D.R. 登録日 2005-12-01 公開日 2006-07-04 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 Structural Basis of the Inhibition of Golgi alpha-Mannosidase II by Mannostatin A and the Role of the Thiomethyl Moiety in Ligand-Protein Interactions. J.Am.Chem.Soc., 128, 2006
2F1B	GOLGI ALPHA-MANNOSIDASE II COMPLEX WITH (2R,3R,4S,5R)-2-({[(1R)-2-hydroxy-1-phenylethyl]amino}methyl)-5-methylpyrrolidine-3,4-diol 分子名称: (2R,3R,4S,5R)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO}METHYL)-5-METHYLPYRROLIDINE-3,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kuntz, D.A, Rose, D.R. 登録日 2005-11-14 公開日 2006-12-05 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Evaluation of docking programs for predicting binding of Golgi alpha-mannosidase II inhibitors: a comparison with crystallography. Proteins, 69, 2007
2F18	GOLGI ALPHA-MANNOSIDASE II complex with (2R,3R,4S)-2-({[(1R)-2-hydroxy-1-phenylethyl]amino}methyl)pyrrolidine-3,4-diol 分子名称: (2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO}METHYL)PYRROLIDINE-3,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kuntz, D.A, Rose, D.R. 登録日 2005-11-14 公開日 2006-12-05 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Evaluation of docking programs for predicting binding of Golgi alpha-mannosidase II inhibitors: a comparison with crystallography. Proteins, 69, 2007
2F7R	Golgi alpha-mannosidase II complex with benzyl-aminocyclopentitetrol 分子名称: (1R,2R,3S,4S,5R)-5-(BENZYLAMINO)CYCLOPENTANE-1,2,3,4-TETROL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kuntz, D.A, Rose, D.R. 登録日 2005-12-01 公開日 2006-12-12 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Golgi alpha-mannosidase II complex with benzyl-aminocyclopentitetrol To be Published
2FYV	Golgi alpha-mannosidase II complex with an amino-salacinol carboxylate analog 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-DEOXY-6-[(2R,3R,4R)-3,4-DIHYDROXY-2-(HYDROXYMETHYL)PYRROLIDIN-1-YL]-L-GULONIC ACID, ... 著者 Kuntz, D.A, Hamlet, T, Rose, D.R. 登録日 2006-02-08 公開日 2006-12-26 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Synthesis, enzymatic activity, and X-ray crystallography of an unusual class of amino acids. Bioorg.Med.Chem., 14, 2006
1PS3	Golgi alpha-mannosidase II in complex with kifunensine 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-mannosidase II, ... 著者 Shah, N, Kuntz, D.A, Rose, D.R. 登録日 2003-06-20 公開日 2003-12-16 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Comparison of Kifunensine and 1-Deoxymannojirimycin Binding to Class I and II alpha-Mannosidases Demonstrates Different Saccharide Distortions in Inverting and Retaining Catalytic Mechanisms Biochemistry, 42, 2003
1QWN	GOLGI ALPHA-MANNOSIDASE II Covalent Intermediate Complex with 5-fluoro-gulosyl-fluoride 分子名称: (2R,3S,4R,5S)-2,6-difluoro-2-(hydroxymethyl)oxane-3,4,5-triol, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... 著者 Numao, S, Kuntz, D.A, Withers, S.G, Rose, D.R. 登録日 2003-09-02 公開日 2003-10-07 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates. J.Biol.Chem., 278, 2003
1QWU	Golgi alpha-mannosidase II D341N mutant complex with 5-F-guloside 分子名称: (2R,3S,4R,5S)-2,6-difluoro-2-(hydroxymethyl)oxane-3,4,5-triol, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Numao, S, Kuntz, D.A, Withers, S.G, Rose, D.R. 登録日 2003-09-03 公開日 2003-10-07 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates. J.Biol.Chem., 278, 2003
1QX1	Golgi alpha-mannosidase II D341N mutant complex with 2-F-mannosyl-F 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-deoxy-2-fluoro-beta-D-mannopyranosyl fluoride, ... 著者 Numao, S, Kuntz, D.A, Withers, S.G, Rose, D.R. 登録日 2003-09-04 公開日 2003-10-07 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates. J.Biol.Chem., 278, 2003
1R33	Golgi alpha-mannosidase II complex with 5-thio-D-mannopyranosylamine 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-thio-alpha-D-mannopyranosylamine, ... 著者 Kuntz, D.A, Xin, W, Kavelekar, L.M, Rose, D.R, Pinto, B.M. 登録日 2003-09-30 公開日 2004-11-02 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 5-Thio-d-glycopyranosylamines and their amidinium salts as potential transition-state mimics of glycosyl hydrolases: synthesis, enzyme inhibitory activities, X-ray crystallography, and molecular modeling TETRAHEDRON ASYMMETRY, 16, 2005
1R34	Golgi alpha-mannosidase II complex with 5-thio-D-mannopyranosylamidinium salt 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-[(1Z)-2-phenylethanimidoyl]-5-thio-alpha-D-mannopyranosylamine, ... 著者 Kuntz, D.A, Xin, W, Kavelekar, L.M, Rose, D.R, Pinto, B.M. 登録日 2003-09-30 公開日 2004-11-02 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 5-Thio-d-glycopyranosylamines and their amidinium salts as potential transition-state mimics of glycosyl hydrolases: synthesis, enzyme inhibitory activities, X-ray crystallography, and molecular modeling TETRAHEDRON ASYMMETRY, 16, 2005
1TQV	Golgi alpha-Mannosidase II In Complex With Seleno-Salacinol (Blintol) 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 1,4-DIDEOXY-1,4-[[2S,3S)-2,4-DIHYDROXY-3-(SULFOXY)BUTYL]EPISELENONIUMYLIDENE]-D-ARABINITOL INNER SALT, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kuntz, D.A, Ghavami, A, Johnston, B.D, Pinto, B.M, Rose, D.R. 登録日 2004-06-18 公開日 2005-02-01 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Crystallographic analysis of the interactions of Drosophila melanogaster Golgi alpha-mannosidase II with the naturally occurring glycomimetic salacinol and its analogues TETRAHEDRON ASYMMETRY, 16, 2005
1TQW	Golgi alpha-Mannosidase II In Complex With A Diastereomer of Seleno-Salacinol 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 1,4-DIDEOXY-1,4-[[2R,3R)-2,4-DIHYDROXY-3-(SULFOXY)BUTYL]EPISELENONIUMYLIDENE]-D-ARABINITOL INNER SALT, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kuntz, D.A, Ghavami, A, Johnston, B.D, Pinto, B.M, Rose, D.R. 登録日 2004-06-18 公開日 2005-02-01 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Insights into the Mechanism of Drosophila melanogaster Golgi a-Mannosidase II Through Crystallographic Analysis of the Interactions with Analogues of the Naturally Occurring Glycomimetic Salacinol TETRAHEDRON ASYMMETRY, 16, 2005
1TQT	Golgi alpha-Mannosidase II In Complex With A Diastereomer of Salacinol 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 1,4-DIDEOXY-1,4-[[2R,3R)-2,4-DIHYDROXY-3-(SULFOXY)BUTYL]EPISULFONIUMYLIDENE]-D-ARABINITOL INNER SALT, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kuntz, D.A, Ghavami, A, Johnston, B.D, Pinto, B.M, Rose, D.R. 登録日 2004-06-18 公開日 2005-01-25 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystallographic analysis of the interactions of Drosophila melanogaster Golgi alpha-mannosidase II with the naturally occurring glycomimetic salacinol and its analogues Tetrahedron Asymmetry, 16, 2005
1TQS	Golgi alpha-Mannosidase II In Complex With Salacinol 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 1,4-DIDEOXY-1,4-[[2S,3S)-2,4-DIHYDROXY-3-(SULFOXY)BUTYL]EPISULFONIUMYLIDENE]-D-ARABINITOL INNER SALT, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kuntz, D.A, Ghavami, A, Johnston, B.D, Pinto, B.M, Rose, D.R. 登録日 2004-06-18 公開日 2005-01-25 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Crystallographic analysis of the interactions of Drosophila melanogaster Golgi alpha-mannosidase II with the naturally occurring glycomimetic salacinol and its analogues Tetrahedron Asymmetry, 16, 2005
1TQU	Golgi alpha-Mannosidase II In Complex With The Salacinol Analog Ghavamiol 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 1'-((1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL)-4-N-AMMONIUM)-1'-DEOXY-L-ERYTHRITOL-3'-SULFATE INNER SALT, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kuntz, D.A, Ghavami, A, Johnston, B.D, Pinto, B.M, Rose, D.R. 登録日 2004-06-18 公開日 2005-01-25 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Crystallographic analysis of the interactions of Drosophila melanogaster Golgi alpha-mannosidase II with the naturally occurring glycomimetic salacinol and its analogues Tetrahedron Asymmetry, 16, 2005

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