PDB: 84 件ウェブページステータス検索Chemie searchBIRD

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6QJE	Structure of human galactokinase 1 bound with 4-{[2-(Methylsulfonyl)-1H-imidazol-1-yl]methyl}-1,3-thiazole 分子名称: 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one, 4-[(2-methylsulfonylimidazol-1-yl)methyl]-1,3-thiazole, Galactokinase, ... 著者 Mackinnon, S.R, Bezerra, G.A, Zhang, M, Foster, W, Krojer, T, Brandao-Neto, J, Douangamath, A, Arrowsmith, C, Edwards, A, Bountra, C, Brennan, P, Lai, K, Yue, W.W. 登録日 2019-01-24 公開日 2019-02-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of human galactokinase 1 bound with 4-{[2-(Methylsulfonyl)-1H-imidazol-1-yl]methyl}-1,3-thiazole To Be Published
6Q91	Structure of human galactokinase 1 bound with 5-Chloro-N-isobutyl-2-methoxybenzamide 分子名称: 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one, 5-chloranyl-2-methoxy-~{N}-(2-methylpropyl)benzamide, Galactokinase, ... 著者 Mackinnon, S.R, Bezerra, G.A, Zhang, M, Foster, W, Krojer, T, Brandao-Neto, J, Douangamath, A, Arrowsmith, C, Edwards, A, Bountra, C, Brennan, P, Lai, K, Yue, W.W. 登録日 2018-12-17 公開日 2019-01-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of human galactokinase 1 bound with 5-Chloro-N-isobutyl-2-methoxybenzamide To Be Published
6Q90	Structure of human galactokinase 1 bound with 1-(4-Methoxyphenyl)-3-(4-pyridinyl)urea 分子名称: 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one, Galactokinase, N-(4-methoxyphenyl)-N'-pyridin-4-ylurea, ... 著者 Mackinnon, S.R, Bezerra, G.A, Zhang, M, Foster, W, Krojer, T, Brandao-Neto, J, Douangamath, A, Arrowsmith, C, Edwards, A, Bountra, C, Brennan, P, Lai, K, Yue, W.W. 登録日 2018-12-16 公開日 2019-01-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of human galactokinase 1 bound with 1-(4-Methoxyphenyl)-3-(4-pyridinyl)urea To Be Published
6Q8Z	Structure of human galactokinase 1 bound with N-(Cyclobutylmethyl)-1,5-dimethyl-1H-pyrazole-4-carboxamide 分子名称: 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one, Galactokinase, beta-D-galactopyranose, ... 著者 Mackinnon, S.R, Bezerra, G.A, Zhang, M, Foster, W, Krojer, T, Brandao-Neto, J, Douangamath, A, Arrowsmith, C, Edwards, A, Bountra, C, Brennan, P, Lai, K, Yue, W.W. 登録日 2018-12-16 公開日 2019-01-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of human galactokinase 1 bound with N-(Cyclobutylmethyl)-1,5-dimethyl-1H-pyrazole-4-carboxamide To Be Published
6Q3X	Structure of human galactokinase in complex with galactose and 2'-(benzo[d]oxazol-2-ylamino)-7',8'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'(6'H)-one 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one, Galactokinase, ... 著者 Bezerra, G.A, Mackinnon, S, Zhang, M, Foster, W, Bailey, H, Arrowsmith, C, Edwards, A, Bountra, C, Lai, K, Yue, W.W, Structural Genomics Consortium (SGC) 登録日 2018-12-04 公開日 2020-07-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia. Acs Chem.Biol., 16, 2021
6Q3W	Structure of human galactokinase 1 bound with Ethyl 1-(2-pyrazinyl)-4-piperidinecarboxylate 分子名称: 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one, Galactokinase, beta-D-galactopyranose, ... 著者 Mackinnon, S.R, Bezerra, G.A, Zhang, M, Foster, W, Krojer, T, Brandao-Neto, J, Douangamath, A, Arrowsmith, C, Edwards, A, Bountra, C, Brennan, P, Lai, K, Yue, W.W. 登録日 2018-12-04 公開日 2019-01-23 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.962 Å) 主引用文献 Structure of human galactokinase 1 bound with Ethyl 1-(2-pyrazinyl)-4-piperidinecarboxylate To Be Published
6MDF	Mevalonate kinase from Methanosarcina mazei with 5-phosphomevalonate bound 分子名称: (3R)-3-HYDROXY-3-METHYL-5-(PHOSPHONOOXY)PENTANOIC ACID, GLYCEROL, Mevalonate kinase 著者 Miller, B.R, Kung, Y. 登録日 2018-09-04 公開日 2018-12-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.46 Å) 主引用文献 Structural insight into substrate and product binding in an archaeal mevalonate kinase. PLoS ONE, 13, 2018
6MDE	Mevalonate kinase from Methanosarcina mazei with mevalonate bound 分子名称: (R)-MEVALONATE, GLYCEROL, Mevalonate kinase, ... 著者 Miller, B.R, Kung, Y. 登録日 2018-09-04 公開日 2018-12-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural insight into substrate and product binding in an archaeal mevalonate kinase. PLoS ONE, 13, 2018
6GR2	Structure of human galactokinase in complex with galactose and ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Galactokinase, SULFATE ION, ... 著者 Bezerra, G.A, Mackinnon, S, Williams, E, Zhang, M, Arrowsmith, C, Edwards, A, Bountra, C, Lai, K, Yue, W.W, Structural Genomics Consortium (SGC) 登録日 2018-06-08 公開日 2019-06-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Structure of human galactokinase in complex with galactose and ADP To Be Published
6CYZ	Mycobacterial homoserine kinase ThrB in complex with AMPPNP 分子名称: CHLORIDE ION, Homoserine kinase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Li, J, Korotkov, K.V. 登録日 2018-04-07 公開日 2018-04-18 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Mycobacterial homoserine kinase ThrB To Be Published
5YYS	Cryo-EM structure of L-fucokinase, GDP-fucose pyrophosphorylase (FKP)in Bacteroides fragilis 分子名称: L-fucokinase, L-fucose-1-P guanylyltransferase 著者 Wang, J, Hu, H, Liu, Y, Zhou, Q, Wu, P, Yan, N, Wang, H.W, Wu, J.W, Sun, L. 登録日 2017-12-11 公開日 2018-12-12 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Cryo-EM structure of L-fucokinase/GDP-fucose pyrophosphorylase (FKP) in Bacteroides fragilis. Protein Cell, 10, 2019
5WAT	Corynebacterium glutamicum Full length Homoserine kinase 分子名称: HEXAETHYLENE GLYCOL, Homoserine kinase, MAGNESIUM ION, ... 著者 Petit, C, Ronning, D.R. 登録日 2017-06-27 公開日 2018-02-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.141 Å) 主引用文献 Reduction of Feedback Inhibition in Homoserine Kinase (ThrB) ofCorynebacterium glutamicumEnhances l-Threonine Biosynthesis. ACS Omega, 3, 2018
5WAS	Corynebacterium glutamicum Hydrolyzed Homoserine kinase 分子名称: Homoserine kinase, PHOSPHATE ION 著者 Petit, C, Ronning, D.R. 登録日 2017-06-27 公開日 2018-02-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.799 Å) 主引用文献 Reduction of Feedback Inhibition in Homoserine Kinase (ThrB) ofCorynebacterium glutamicumEnhances l-Threonine Biosynthesis. ACS Omega, 3, 2018
4UTG	Burkholderia pseudomallei heptokinase WcbL,AMPPNP (ATP analogue) complex. 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, MAGNESIUM ION, ... 著者 Vivoli, M, Isupov, M.N, Nicholas, R, Hill, A, Scott, A, Kosma, P, Prior, J, Harmer, N.J. 登録日 2014-07-21 公開日 2016-01-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Unraveling the B.Pseudomallei Heptokinase Wcbl: From Structure to Drug Discovery. Chem.Biol., 22, 2015
4UT4	Burkholderia pseudomallei heptokinase WcbL, D-mannose complex. 分子名称: CHLORIDE ION, PUTATIVE SUGAR KINASE, alpha-D-mannopyranose 著者 Vivoli, M, Isupov, M.N, Nicholas, R, Hill, A, Scott, A, Kosma, P, Prior, J, Harmer, N.J. 登録日 2014-07-18 公開日 2016-01-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Unraveling the B.Pseudomallei Heptokinase Wcbl: From Structure to Drug Discovery. Chem.Biol., 22, 2015
4USM	WcbL complex with glycerol bound to sugar site 分子名称: CHLORIDE ION, GLYCEROL, PUTATIVE SUGAR KINASE 著者 Vivoli, M, Isupov, M.N, Nicholas, R, Hill, A, Scott, A, Kosma, P, Prior, J, Harmer, N.J. 登録日 2014-07-10 公開日 2016-01-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Unraveling the B.Pseudomallei Heptokinase Wcbl: From Structure to Drug Discovery. Chem.Biol., 22, 2015
4USK	Unravelling the B. pseudomallei heptokinase WcbL: from Structure to Drug Discovery. 分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, PUTATIVE SUGAR KINASE, ... 著者 Vivoli, M, Isupov, M.N, Nicholas, R, Hill, A, Scott, A, Kosma, P, Prior, J, Harmer, N.J. 登録日 2014-07-09 公開日 2016-01-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Unraveling the B.Pseudomallei Heptokinase Wcbl: From Structure to Drug Discovery. Chem.Biol., 22, 2015
4RPF	Crystal structure of homoserine kinase from Yersinia pestis Nepal516, NYSGRC target 032715 分子名称: CITRIC ACID, Homoserine kinase 著者 Ptskovsky, Y, Bhosle, R, Toro, R, Hillerich, B, Gizzi, A, Garforth, S, Kar, A, Chan, M.K, Lafluer, J, Patel, H, Matikainen, B, Chamala, S, Lim, S, Celikgil, A, Villegas, G, Evans, B, Love, J, Fiser, A, Seidel, R, Bonanno, J.B, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) 登録日 2014-10-30 公開日 2014-11-12 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal Structure of Homoserine Kinase from Yersinia Pestis Nepal516, Nysgrc Target 032715 To be Published
4N3O	2.4 Angstrom Resolution Crystal Structure of Putative Sugar Kinase from Campylobacter jejuni. 分子名称: CALCIUM ION, Putative D-glycero-D-manno-heptose 7-phosphate kinase 著者 Minasov, G, Wawrzak, Z, Gordon, E, Onopriyenko, O, Grimshaw, S, Kwon, K, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2013-10-07 公開日 2013-10-16 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 2.4 Angstrom Resolution Crystal Structure of Putative Sugar Kinase from Campylobacter jejuni. TO BE PUBLISHED
4HAC	Crystal Structure of the Mevalonate Kinase from an Archaeon Methanosarcina mazei 分子名称: MAGNESIUM ION, Mevalonate kinase 著者 Zhuang, N, Lee, K.H. 登録日 2012-09-26 公開日 2012-12-12 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Crystallization and preliminary X-ray diffraction analysis of mevalonate kinase from Methanosarcina mazei. Acta Crystallogr.,Sect.F, 68, 2012
4EMD	Crystal structure of IspE (4-diphosphocytidyl-2-C-methyl-D-erythritol kinase) from Mycobacterium abcessus, bound to CMP and SO4 分子名称: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CYTIDINE-5'-MONOPHOSPHATE, SULFATE ION 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2012-04-11 公開日 2012-04-25 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
4ED4	Crystal structure of IspE (4-diphosphocytidyl-2-C-methyl-D-erythritol kinase) from Mycobacterium abcessus, bound to ATP 分子名称: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, ADENOSINE-5'-TRIPHOSPHATE 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2012-03-26 公開日 2012-04-04 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
4DXL	Crystal structure of IspE (4-diphosphocytidyl-2-C-methyl-D-erythritol kinase) from Mycobacterium abscessus, bound to CMP and ATP 分子名称: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2012-02-27 公開日 2012-03-07 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
3V5R	Crystal structure of the unliganded form of Gal3p 分子名称: Protein GAL3, SULFATE ION 著者 Lavy, T, Kumar, P.R, He, H, Joshua-Tor, L. 登録日 2011-12-16 公開日 2012-02-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.099 Å) 主引用文献 The Gal3p transducer of the GAL regulon interacts with the Gal80p repressor in its ligand-induced closed conformation. Genes Dev., 26, 2012
3V2U	Crystal structure of the yeast GAL regulon complex of the repressor, Gal80p, and the transducer, Gal3p, with galactose and ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, Galactose/lactose metabolism regulatory protein GAL80, ... 著者 Lavy, T, Kumar, P.R, He, H, Joshua-Tor, L. 登録日 2011-12-12 公開日 2012-02-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.105 Å) 主引用文献 The Gal3p transducer of the GAL regulon interacts with the Gal80p repressor in its ligand-induced closed conformation. Genes Dev., 26, 2012

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