6Q3X

Structure of human galactokinase in complex with galactose and 2'-(benzo[d]oxazol-2-ylamino)-7',8'-dihydro-1'H-spiro[cyclohexane-1,4'-quinazolin]-5'(6'H)-one

Summary for 6Q3X

• Entry DOI: 10.2210/pdb6q3x/pdb
• Related: 6Q3H
• Descriptor: Galactokinase, beta-D-galactopyranose, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (5 entities in total)
• Functional Keywords: ghmp kinase, galactose metabolism, inhibitor, structural genomics, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 86348.24

Authors

Bezerra, G.A.,Mackinnon, S.,Zhang, M.,Foster, W.,Bailey, H.,Arrowsmith, C.,Edwards, A.,Bountra, C.,Lai, K.,Yue, W.W.,Structural Genomics Consortium (SGC) (deposition date: 2018-12-04, release date: 2020-07-15, Last modification date: 2024-01-24)

• Primary citation: Mackinnon, S.R.,Krojer, T.,Foster, W.R.,Diaz-Saez, L.,Tang, M.,Huber, K.V.M.,von Delft, F.,Lai, K.,Brennan, P.E.,Arruda Bezerra, G.,Yue, W.W.; Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia.; Acs Chem.Biol., 16:586-595, 2021; PubMed: 33724769; DOI: 10.1021/acschembio.0c00498

Experimental method

X-RAY DIFFRACTION (2.1 Å)