5A1T
 
 | | Trichomonas vaginalis lactate dehydrogenase in complex with NADH and oxamate | | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, L-LACTATE DEHYDROGENASE, OXAMIC ACID | | 著者 | Steindel, P.A, Chen, E.H, Theobald, D.L. | | 登録日 | 2015-05-05 | | 公開日 | 2016-03-02 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Gradual Neofunctionalization in the Convergent Evolution of Trichomonad Lactate and Malate Dehydrogenases.
Protein Sci., 25, 2016
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2ZQZ
 | | R-state structure of allosteric L-lactate dehydrogenase from Lactobacillus casei | | 分子名称: | L-lactate dehydrogenase, SULFATE ION | | 著者 | Arai, K, Ishimitsu, T, Fushinobu, S, Uchikoba, H, Matsuzawa, H, Taguchi, H. | | 登録日 | 2008-08-22 | | 公開日 | 2009-09-08 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Active and inactive state structures of unliganded Lactobacillus casei allosteric L-lactate dehydrogenase.
Proteins, 78, 2010
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2PWZ
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5UJK
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7X1L
 | | Malate dehydrogenase from Geobacillus stearothermophilus (gs-MDH) delta E311 mutant complexed with Nicotinamide Adenine Dinucleotide (NAD+) | | 分子名称: | Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Shimozawa, Y, Himiyama, T, Nakamura, T, Nishiya, Y. | | 登録日 | 2022-02-24 | | 公開日 | 2022-10-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Reducing substrate inhibition of malate dehydrogenase from Geobacillus stearothermophilus by C-terminal truncation.
Protein Eng.Des.Sel., 35, 2022
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5ULV
 | | Malate dehydrogenase from Methylobacterium extorquens | | 分子名称: | CALCIUM ION, Malate dehydrogenase | | 著者 | Gonzalez, J.M. | | 登録日 | 2017-01-25 | | 公開日 | 2017-02-08 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | Conformational changes on substrate binding revealed by structures of Methylobacterium extorquens malate dehydrogenase.
Acta Crystallogr F Struct Biol Commun, 74, 2018
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7XQN
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2ZQY
 | | T-state structure of allosteric L-lactate dehydrogenase from Lactobacillus casei | | 分子名称: | L-lactate dehydrogenase, NITRATE ION | | 著者 | Arai, K, Ishimitsu, T, Fushinobu, S, Uchikoba, H, Matsuzawa, H, Taguchi, H. | | 登録日 | 2008-08-22 | | 公開日 | 2009-09-08 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Active and inactive state structures of unliganded Lactobacillus casei allosteric L-lactate dehydrogenase.
Proteins, 78, 2010
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4ZVV
 | | Lactate dehydrogenase A in complex with a trisubstituted piperidine-2,4-dione inhibitor GNE-140 | | 分子名称: | (2~{R})-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4-oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one, L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | 著者 | Li, Y, Chen, Z, Eigenbrot, C. | | 登録日 | 2015-05-18 | | 公開日 | 2016-05-18 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition.
Nat.Chem.Biol., 12, 2016
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9FEF
 | | Cryo-EM structure of Trypanosoma cruzi (MDH)4-PEX5 complex | | 分子名称: | Peroxisome targeting signal 1 receptor, malate dehydrogenase | | 著者 | Lipinski, O, Sonani, R.R, Blat, A, Jemiola-Rzeminska, M, Patel, S.N, Sood, T, Dubin, G. | | 登録日 | 2024-05-19 | | 公開日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | | 主引用文献 | Cryo-EM structure of Trypanosoma cruzi (MDH)4-PEX5 complex
To Be Published
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9LDB
 | | DESIGN AND SYNTHESIS OF NEW ENZYMES BASED ON THE LACTATE DEHYDROGENASE FRAMEWORK | | 分子名称: | LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID, ... | | 著者 | Dunn, C.R, Holbrook, J.J, Muirhead, H. | | 登録日 | 1991-11-26 | | 公開日 | 1993-10-31 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Design and synthesis of new enzymes based on the lactate dehydrogenase framework.
Philos.Trans.R.Soc.London,Ser.B, 332, 1991
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9LDT
 | | DESIGN AND SYNTHESIS OF NEW ENZYMES BASED ON THE LACTATE DEHYDROGENASE FRAMEWORK | | 分子名称: | LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID, ... | | 著者 | Dunn, C.R, Holbrook, J.J, Muirhead, H. | | 登録日 | 1991-11-26 | | 公開日 | 1993-10-31 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Design and synthesis of new enzymes based on the lactate dehydrogenase framework.
Philos.Trans.R.Soc.London,Ser.B, 332, 1991
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3PQF
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7M2N
 | | Crystal structure of Human Lactate Dehydrogenase A with Inhibitor Compound 15 | | 分子名称: | 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 5-[(5'-{1-(4-carboxy-1,3-thiazol-2-yl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-3-yl}-2'-fluoro[1,1'-biphenyl]-4-yl)oxy]-1H-1,2,3-triazole-4-carboxylic acid, ... | | 著者 | Gumpena, R, Ding, J, Powell, D.A, Lowther, W.T. | | 登録日 | 2021-03-17 | | 公開日 | 2021-07-14 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria
ACS Medicinal Chemistry Letters, 12, 2021
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6LDH
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7NAY
 | | Crystal structure of lactate dehydrogenase from Selenomonas ruminantium with NADH. | | 分子名称: | 1,2-ETHANEDIOL, BORIC ACID, L-lactate dehydrogenase, ... | | 著者 | Bertrand, Q, Robin, A, Girard, E, Madern, D. | | 登録日 | 2021-01-25 | | 公開日 | 2021-02-10 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Biochemical, structural and dynamical characterizations of the lactate dehydrogenase from Selenomonas ruminantium provide information about an intermediate evolutionary step prior to complete allosteric regulation acquisition in the super family of lactate and malate dehydrogenases.
J.Struct.Biol., 215, 2023
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6MV8
 | | LDHA structure in complex with inhibitor 14 | | 分子名称: | (6S)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(2-hydroxyphenyl)-6-phenyl-5,6-dihydro-2H-pyran-2-one, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | 著者 | Eigenbrot, C.E, Ultsch, M, Wei, B. | | 登録日 | 2018-10-24 | | 公開日 | 2019-10-30 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structure-based Optimization of Potent, Cell-Active
Hydroxylactam Inhibitors of Lactate Dehydrogenase
To Be Published
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6MVA
 | | LDHA structure in complex with inhibitor 14 | | 分子名称: | (6R)-6-(3-aminophenyl)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(thiophen-3-yl)-5,6-dihydro-2H-pyran-2-one, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | 著者 | Eigenbrot, C.E, Ultsch, M, Wei, B. | | 登録日 | 2018-10-24 | | 公開日 | 2019-10-30 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Structure-based Optimization of Potent, Cell-Active
Hydroxylactam Inhibitors of Lactate Dehydrogenase
To Be Published
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7NRZ
 | | Crystal structure of malate dehydrogenase from Trypanosoma cruzi | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Sonani, R.R, Kurpiewska, K, Lewinski, K, Dubin, G. | | 登録日 | 2021-03-04 | | 公開日 | 2022-02-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Distinct sequence and structural feature of trypanosoma malate dehydrogenase.
Biochem.Biophys.Res.Commun., 557, 2021
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3TL2
 | | Crystal structure of Bacillus anthracis str. Ames malate dehydrogenase in closed conformation. | | 分子名称: | 1,2-ETHANEDIOL, Malate dehydrogenase, THIOCYANATE ION | | 著者 | Blus, B.J, Chruszcz, M, Tkaczuk, K.L, Osinski, T, Cymborowski, M, Kudritska, M, Grimshaw, S, Savchenko, A, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2011-08-29 | | 公開日 | 2011-09-21 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structure of Bacillus anthracis str. Ames malate dehydrogenase in closed conformation.
TO BE PUBLISHED
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3PQD
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5KVV
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6QSS
 | | Crystal Structure of Ignicoccus islandicus malate dehydrogenase co-crystallized with 10 mM Tb-Xo4 | | 分子名称: | CHLORIDE ION, Malate dehydrogenase, TERBIUM(III) ION, ... | | 著者 | Roche, J, Girard, E, Madern, D. | | 登録日 | 2019-02-21 | | 公開日 | 2019-07-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | SOLUTION SCATTERING (1.892 Å), X-RAY DIFFRACTION | | 主引用文献 | The archaeal LDH-like malate dehydrogenase from Ignicoccus islandicus displays dual substrate recognition, hidden allostery and a non-canonical tetrameric oligomeric organization.
J.Struct.Biol., 208, 2019
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5KKA
 | | E. coli malate dehydrogenase with the inhibitor 6DHNAD | | 分子名称: | Malate dehydrogenase, [[(2~{R},3~{S},4~{R},5~{R})-5-(5-aminocarbonyl-2~{H}-pyridin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate | | 著者 | Meneely, K.M, Lamb, A.L, Moran, G.R. | | 登録日 | 2016-06-21 | | 公開日 | 2016-11-02 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Ligand binding phenomena that pertain to the metabolic function of renalase.
Arch.Biochem.Biophys., 612, 2016
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6R8G
 | | Crystal structure of malate dehydrogenase from Plasmodium Falciparum in complex with 4-(3,4-difluorophenyl)thiazol-2-amine | | 分子名称: | 4-[3,4-bis(fluoranyl)phenyl]-1,3-thiazol-2-amine, Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | 著者 | Romero, A.R, Calderone, V, Gentili, M, Lunev, S, Groves, M, Popowicz, G, Domling, A, Sattler, M. | | 登録日 | 2019-04-01 | | 公開日 | 2020-04-15 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A Fragment-Based Approach Identifies an Allosteric Pocket that Impacts Malate Dehydrogenase Activity
Commun Biol, 2021
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