2YXR
| |
2YXQ
| |
2ZJS
| Crystal Structure of SecYE translocon from Thermus thermophilus with a Fab fragment | 分子名称: | Fab56 (heavy chain), Fab56 (light chain), Preprotein translocase SecE subunit, ... | 著者 | Tsukazaki, T, Mori, H, Fukai, S, Ishitani, R, Perederina, A, Vassylyev, D.G, Ito, K, Nureki, O. | 登録日 | 2008-03-08 | 公開日 | 2008-10-14 | 最終更新日 | 2021-11-10 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Conformational transition of Sec machinery inferred from bacterial SecYE structures Nature, 455, 2008
|
|
2ZQP
| |
3JC2
| |
7ZL3
| |
8B6L
| Subtomogram average of the human Sec61-TRAP-OSTA-translocon | 分子名称: | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2, ... | 著者 | Gemmer, M, Fedry, J.M.M, Forster, F.G. | 登録日 | 2022-09-27 | 公開日 | 2022-12-07 | 最終更新日 | 2023-02-08 | 実験手法 | ELECTRON MICROSCOPY (7.6 Å) | 主引用文献 | Visualization of translation and protein biogenesis at the ER membrane. Nature, 614, 2023
|
|
8DNV
| |
8DO1
| |
8DNZ
| |
8DNW
| |
8DO2
| Cryo-EM structure of the human Sec61 complex inhibited by cyclotriazadisulfonamide (CADA) | 分子名称: | 9-benzyl-1,5-bis(4-methylbenzene-1-sulfonyl)-3-methylidene-1,5,9-triazacyclododecane, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... | 著者 | Park, E, Itskanov, S. | 登録日 | 2022-07-12 | 公開日 | 2023-05-24 | 最終更新日 | 2023-09-06 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
|
|
8DNX
| |
8DNY
| |
8DO0
| |
8DO3
| Cryo-EM structure of the human Sec61 complex inhibited by eeyarestatin I | 分子名称: | N'-(4-chlorophenyl)-N-[(4R)-3-(4-chlorophenyl)-5,5-dimethyl-1-(2-{(2E)-2-[(2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]hydrazinyl}-2-oxoethyl)-2-oxoimidazolidin-4-yl]-N-hydroxyurea, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... | 著者 | Park, E, Itskanov, S. | 登録日 | 2022-07-12 | 公開日 | 2023-05-24 | 最終更新日 | 2023-09-06 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | A common mechanism of Sec61 translocon inhibition by small molecules. Nat.Chem.Biol., 19, 2023
|
|
8BF9
| Molecular view of ER membrane remodeling by the Sec61/TRAP translocon. | 分子名称: | 60S ribosomal protein L39, Large ribosomal subunit protein eL31, Large ribosomal subunit protein eL38, ... | 著者 | Karki, S, Javanainen, M, Tranter, D, Rehan, S, Huiskonen, J, Happonen, L, Paavilainen, V. | 登録日 | 2022-10-24 | 公開日 | 2023-11-01 | 最終更新日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | 主引用文献 | Molecular view of ER membrane remodeling by the Sec61/TRAP translocon. Embo Rep., 24, 2023
|
|
5GAE
| RNC in complex with a translocating SecYEG | 分子名称: | 23S rRNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ... | 著者 | Jomaa, A, Boehringer, D, Leibundgut, M, Ban, N. | 登録日 | 2015-11-25 | 公開日 | 2016-01-27 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | 主引用文献 | Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon. Nat Commun, 7, 2016
|
|
7AFT
| Cryo-EM structure of the signal sequence-engaged post-translational Sec translocon | 分子名称: | Mating factor alpha-1,Mating factor alpha-1, Protein translocation protein SEC63, Protein transport protein SBH1, ... | 著者 | Weng, T.-H, Beatrix, B, Berninghausen, O, Becker, T, Cheng, J, Beckmann, R. | 登録日 | 2020-09-20 | 公開日 | 2020-12-02 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Architecture of the active post-translational Sec translocon. Embo J., 40, 2021
|
|
6W6L
| |
6R7Q
| Structure of XBP1u-paused ribosome nascent chain complex with Sec61. | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | 著者 | Shanmuganathan, V, Cheng, J, Braunger, K, Berninghausen, O, Beatrix, B, Beckmann, R. | 登録日 | 2019-03-29 | 公開日 | 2019-07-10 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
|
|
5NCO
| Quaternary complex between SRP, SR, and SecYEG bound to the translating ribosome | 分子名称: | 23S rRNA, 4.5S SRP RNA (Ffs), 50S ribosomal protein L10, ... | 著者 | Jomaa, A, Hwang Fu, Y, Boerhinger, D, Leibundgut, M, Shan, S.O, Ban, N. | 登録日 | 2017-03-06 | 公開日 | 2017-05-24 | 最終更新日 | 2018-03-28 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Structure of the quaternary complex between SRP, SR, and translocon bound to the translating ribosome. Nat Commun, 8, 2017
|
|
6N3Q
| Cryo-EM structure of the yeast Sec complex | 分子名称: | Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... | 著者 | Park, E, Itskanov, S. | 登録日 | 2018-11-16 | 公開日 | 2018-12-19 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | 主引用文献 | Structure of the posttranslational Sec protein-translocation channel complex from yeast. Science, 363, 2019
|
|
7TM3
| Structure of the rabbit 80S ribosome stalled on a 2-TMD Rhodopsin intermediate in complex with the multipass translocon | 分子名称: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | 著者 | Kim, M.K, Lewis, A.J.O, Keenan, R.J, Hegde, R.S. | 登録日 | 2022-01-19 | 公開日 | 2022-10-19 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Mechanism of an intramembrane chaperone for multipass membrane proteins. Nature, 611, 2022
|
|
7TUT
| Structure of the rabbit 80S ribosome stalled on a 4-TMD Rhodopsin intermediate in complex with the multipass translocon | 分子名称: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | 著者 | Kim, M.K, Lewis, A.J.O, Keenan, R.J, Hegde, R.S. | 登録日 | 2022-02-03 | 公開日 | 2022-10-19 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.88 Å) | 主引用文献 | Mechanism of an intramembrane chaperone for multipass membrane proteins. Nature, 611, 2022
|
|