PDB: 86 件ウェブページステータス検索Chemie searchBIRD

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6CGL	X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit dAMP-bound as-isolated (pH 4) 分子名称: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, Ribonucleoside-diphosphate reductase, SULFATE ION 著者 Maggiolo, A.O, Boal, A.K. 登録日 2018-02-20 公開日 2018-05-09 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3O0N	Thermotoga maritima Ribonucleotide Reductase, NrdJ, in complex with dTTP and Adenosylcobalamin 分子名称: 5'-DEOXYADENOSINE, CHLORIDE ION, COBALAMIN, ... 著者 Larsson, K.-M, Logan, D.T, Nordlund, P. 登録日 2010-07-19 公開日 2010-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural Basis for Adenosylcobalamin Activation in AdoCbl-Dependent Ribonucleotide Reductases. Acs Chem.Biol., 5, 2010
3PAW	Low resolution X-ray crystal structure of Yeast Rnr1p with dATP bound in the A-site 分子名称: Ribonucleoside-diphosphate reductase large chain 1 著者 Fairman, J.W, Wijerathna, S.R, Dealwis, C.G. 登録日 2010-10-19 公開日 2011-02-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (6.61 Å) 主引用文献 Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
6CGN	X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit dAMP-bound (pH 7) 分子名称: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, PHOSPHATE ION, ... 著者 Maggiolo, A.O, Boal, A.K. 登録日 2018-02-20 公開日 2018-05-09 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3HND	Crystal structure of human ribonucleotide reductase 1 bound to the effector TTP and substrate GDP 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... 著者 Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G. 登録日 2009-05-31 公開日 2011-02-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.21 Å) 主引用文献 Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
3HNF	Crystal structure of human ribonucleotide reductase 1 bound to the effectors TTP and dATP 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... 著者 Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G. 登録日 2009-05-31 公開日 2011-02-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.16 Å) 主引用文献 Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
3HNC	Crystal structure of human ribonucleotide reductase 1 bound to the effector TTP 分子名称: MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, SULFATE ION, ... 著者 Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G. 登録日 2009-05-31 公開日 2011-02-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
3HNE	Crystal structure of human ribonucleotide reductase 1 bound to the effectors TTP and ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... 著者 Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G. 登録日 2009-05-31 公開日 2011-02-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.11 Å) 主引用文献 Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
3K8T	Structure of eukaryotic rnr large subunit R1 complexed with designed adp analog compound 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 2'-deoxy-2'-(2-hydroxyethyl)adenosine 5'-(trihydrogen diphosphate), GLYCEROL, ... 著者 Sun, D, Xu, H, Dealwis, C, Lee, R.E. 登録日 2009-10-14 公開日 2010-03-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-Based Design, Synthesis, and Evaluation of 2'-(2-Hydroxyethyl)-2'-deoxyadenosine and the 5'-Diphosphate Derivative as Ribonucleotide Reductase Inhibitors Chemmedchem, 4, 2009
6L7L	Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 5-chloro-2-(N-((1S,2R)-2-(2,3-dihydro-1H-inden-4-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)sulfamoyl)benzamide 分子名称: 5-chloro-2-(N-((1S,2R)-2-(2,3-dihydro-1H-inden-4-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)sulfamoyl)benzamide, ACETATE ION, MAGNESIUM ION, ... 著者 Miyahara, S, Chong, K.T, Suzuki, T. 登録日 2019-11-01 公開日 2020-11-04 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.171 Å) 主引用文献 TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity To be published
6LKM	Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-sulfonamide 分子名称: 5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-sulfonamide, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... 著者 Miyahara, S, Chong, K.T, Suzuki, T. 登録日 2019-12-19 公開日 2020-12-23 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity To be published
6MT9	X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit with TTP, ATP, and ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Thomas, W.C, Brooks, F.P, Bacik, J.P, Ando, N. 登録日 2018-10-19 公開日 2019-06-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Convergent allostery in ribonucleotide reductase. Nat Commun, 10, 2019
6MV9	X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit with TTP and ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase, ... 著者 Thomas, W.C, Brooks, F.P, Bacik, J.P, Ando, N. 登録日 2018-10-24 公開日 2019-06-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Convergent allostery in ribonucleotide reductase. Nat Commun, 10, 2019
6MYX	EM structure of Bacillus subtilis ribonucleotide reductase inhibited double-helical filament of NrdE alpha subunit with dATP 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Ribonucleoside-diphosphate reductase 著者 Thomas, W.C, Bacik, J.P, Chen, J.Z, Ando, N. 登録日 2018-11-02 公開日 2019-06-19 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (6 Å) 主引用文献 Convergent allostery in ribonucleotide reductase. Nat Commun, 10, 2019
6MW3	EM structure of Bacillus subtilis ribonucleotide reductase inhibited filament composed of NrdE alpha subunit and NrdF beta subunit with dATP 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Ribonucleoside-diphosphate reductase, Ribonucleoside-diphosphate reductase NrdF beta subunit 著者 Thomas, W.C, Bacik, J.P, Kaelber, J.T, Ando, N. 登録日 2018-10-29 公開日 2019-06-19 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4.65 Å) 主引用文献 Convergent allostery in ribonucleotide reductase. Nat Commun, 10, 2019
6MVE	Reduced X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit with TTP, ATP, and ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Thomas, W.C, Brooks, F.P, Bacik, J.P, Ando, N. 登録日 2018-10-25 公開日 2019-06-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Convergent allostery in ribonucleotide reductase. Nat Commun, 10, 2019
3R1R	RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH AMPPNP OCCUPYING THE ACTIVITY SITE FROM ESCHERICHIA COLI 分子名称: ADENOSINE-5'-TRIPHOSPHATE, RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN 著者 Eriksson, M, Eklund, H. 登録日 1997-07-21 公開日 1998-01-28 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding. Structure, 5, 1997
3RSR	Crystal Structure of 5-NITP Inhibition of Yeast Ribonucleotide Reductase 分子名称: 1-{2-DEOXY-5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}PHOSPHORYL]-BETA-D-ERYTHRO-PENTOFURANOSYL}-5-NITRO-1H-INDOLE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large chain 1 著者 Wan, Q, Mohammed, F, Jha, S, Motea, E, Berdis, A, Dealwis, C.G. 登録日 2011-05-02 公開日 2012-11-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Evaluating the therapeutic potential of a non-natural nucleotide that inhibits human ribonucleotide reductase. Mol.Cancer Ther., 11, 2012
3S87	Structure of Yeast Ribonucleotide Reductase 1 with dGTP and ADP 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. 登録日 2011-05-27 公開日 2012-04-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase To be Published
3S8B	Structure of Yeast Ribonucleotide Reductase 1 with AMPPNP and CDP 分子名称: CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. 登録日 2011-05-27 公開日 2012-04-11 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase To be Published
3S8A	Structure of Yeast Ribonucleotide Reductase R293A with dGTP 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large chain 1 著者 Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. 登録日 2011-05-27 公開日 2012-04-11 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase To be Published
3TB9	Structure of Yeast Ribonucleotide Reductase 1 Q288A with AMPPNP and CDP 分子名称: CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. 登録日 2011-08-05 公開日 2012-04-04 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide Reductase. J.Mol.Biol., 419, 2012
3TBA	Structure of Yeast Ribonucleotide Reductase 1 Q288A with dGTP and ADP 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C. 登録日 2011-08-05 公開日 2012-04-04 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide Reductase. J.Mol.Biol., 419, 2012
3S8C	Structure of Yeast Ribonucleotide Reductase 1 R293A with AMPPNP and CDP 分子名称: CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. 登録日 2011-05-27 公開日 2012-04-11 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.77 Å) 主引用文献 Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase To be Published
2CVX	Structures of Yeast Ribonucleotide Reductase I 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Xu, H, Faber, C, Uchiki, T, Fairman, J.W, Racca, J, Dealwis, C. 登録日 2005-06-14 公開日 2006-03-07 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation Proc.Natl.Acad.Sci.Usa, 103, 2006

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