4C9X
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![BU of 4c9x by Molmil](/molmil-images/mine/4c9x) | Crystal structure of NUDT1 (MTH1) with S-crizotinib | 分子名称: | 3-[(1S)-1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHOXY]-5-(1-PIPERIDIN-4-YLPYRAZOL-4-YL)PYRIDIN-2-AMINE, 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, CHLORIDE ION, ... | 著者 | Elkins, J.M, Salah, E, Huber, K, Superti-Furga, G, Abdul Azeez, K.R, Krojer, T, von Delft, F, Bountra, C, Edwards, A, Knapp, S. | 登録日 | 2013-10-03 | 公開日 | 2014-04-02 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Stereospecific Targeting of Mth1 by (S)-Crizotinib as an Anticancer Strategy. Nature, 508, 2014
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4MPO
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![BU of 4mpo by Molmil](/molmil-images/mine/4mpo) | 1.90 A resolution structure of CT771 from Chlamydia trachomatis Bound to Hydrolyzed Ap4A Products | 分子名称: | ADENOSINE MONOPHOSPHATE, CHLORIDE ION, CT771, ... | 著者 | Barta, M.L, Lovell, S, Battaile, K.P, Hefty, P.S. | 登録日 | 2013-09-13 | 公開日 | 2014-01-22 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Chlamydia trachomatis CT771 (nudH) Is an Asymmetric Ap4A Hydrolase. Biochemistry, 53, 2014
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4N1U
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![BU of 4n1u by Molmil](/molmil-images/mine/4n1u) | Structure of human MTH1 in complex with TH588 | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, N~4~-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine, SULFATE ION | 著者 | Berntsson, R.P.-A, Jemth, A, Gustafsson, R, Svensson, L.M, Helleday, T, Stenmark, P. | 登録日 | 2013-10-04 | 公開日 | 2014-04-16 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature, 508, 2014
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4N1T
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![BU of 4n1t by Molmil](/molmil-images/mine/4n1t) | Structure of human MTH1 in complex with TH287 | 分子名称: | 6-(2,3-dichlorophenyl)-N~4~-methylpyrimidine-2,4-diamine, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION | 著者 | Berntsson, R.P.-A, Jemth, A, Gustafsson, R, Svensson, L.M, Helleday, T, Stenmark, P. | 登録日 | 2013-10-04 | 公開日 | 2014-04-16 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature, 508, 2014
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2FVV
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![BU of 2fvv by Molmil](/molmil-images/mine/2fvv) | Human Diphosphoinositol polyphosphate phosphohydrolase 1 | 分子名称: | CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Hallberg, B.M, Kursula, P, Ogg, D, Arrowsmith, C, Berglund, H, Edwards, A, Ehn, M, Flodin, S, Graslund, S, Hammarstrom, M, Hogbom, M, Holmberg-Schiavone, L, Kotenyova, T, Nilsson-Ehle, P, Nordlund, P, Nyman, T, Sagemark, J, Stenmark, P, Sundstrom, M, Thorsell, A.G, van den Berg, S, Weigelt, J, Persson, C, Structural Genomics Consortium (SGC) | 登録日 | 2006-01-31 | 公開日 | 2006-03-11 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Crystal structure of human diphosphoinositol phosphatase 1 Proteins, 77, 2009
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7N03
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![BU of 7n03 by Molmil](/molmil-images/mine/7n03) | Crystal structure of MTH1 in complex with compound 31 | 分子名称: | 4-anilino-6-(hexylamino)-N-methylquinoline-3-carboxamide, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION | 著者 | Eron, S.J. | 登録日 | 2021-05-24 | 公開日 | 2021-11-03 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | 主引用文献 | Development of an AchillesTAG degradation system and its application to control CAR-T activity Curr Res Chem Biol, 1, 2021
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7N13
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![BU of 7n13 by Molmil](/molmil-images/mine/7n13) | Crystal structure of MTH1 in complex with compound 32 | 分子名称: | 4-anilino-6-[4-(butylcarbamoyl)-3-fluorophenyl]-N-cyclopropyl-7-fluoroquinoline-3-carboxamide, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION | 著者 | Eron, S.J. | 登録日 | 2021-05-26 | 公開日 | 2021-11-03 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Development of an AchillesTAG degradation system and its application to control CAR-T activity Curr Res Chem Biol, 1, 2021
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7NNJ
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![BU of 7nnj by Molmil](/molmil-images/mine/7nnj) | Crystal Structure of NUDT4 (Diphosphoinositol polyphosphate phosphohydrolase 2) in complex with 4-O-Bn-1-PCP-InsP4 (AMR2105) | 分子名称: | 1,2-ETHANEDIOL, Diphosphoinositol polyphosphate phosphohydrolase 2, FORMIC ACID, ... | 著者 | Dubianok, Y, Arruda Bezerra, G, Raux, B, Diaz Saez, L, Riley, A.M, Potter, B.V.L, Huber, K.V.M, von Delft, F. | 登録日 | 2021-02-24 | 公開日 | 2022-03-23 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.755 Å) | 主引用文献 | Crystal Structure of NUDT4 (Diphosphoinositol polyphosphate phosphohydrolase 2) in complex with 4-O-Bn-1-PCP-InsP4 (AMR2105) To Be Published
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2G73
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![BU of 2g73 by Molmil](/molmil-images/mine/2g73) | Y104F mutant type 1 IPP isomerase complex with EIPP | 分子名称: | 4-HYDROXY-3-METHYL BUTYL DIPHOSPHATE, Isopentenyl-diphosphate delta-isomerase, MAGNESIUM ION, ... | 著者 | de Ruyck, J, Wouters, J. | 登録日 | 2006-02-27 | 公開日 | 2006-04-18 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Structural role for Tyr-104 in Escherichia coli isopentenyl-diphosphate isomerase: site-directed mutagenesis, enzymology, and protein crystallography. J.Biol.Chem., 281, 2006
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6PCK
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![BU of 6pck by Molmil](/molmil-images/mine/6pck) | Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 1 in complex with 1-IP7 | 分子名称: | (1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, ... | 著者 | Dollins, D.E, Neubauer, J, Dong, J, York, J.D. | 登録日 | 2019-06-17 | 公開日 | 2020-04-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling. Proc.Natl.Acad.Sci.USA, 117, 2020
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6P5R
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![BU of 6p5r by Molmil](/molmil-images/mine/6p5r) | Structure of T. brucei MERS1-GDP complex | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Mitochondrial edited mRNA stability factor 1 | 著者 | Schumacher, M.A. | 登録日 | 2019-05-30 | 公開日 | 2019-11-06 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Structures of MERS1, the 5' processing enzyme of mitochondrial mRNAs inTrypanosoma brucei. Rna, 26, 2020
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5U7E
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![BU of 5u7e by Molmil](/molmil-images/mine/5u7e) | |
7NR6
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![BU of 7nr6 by Molmil](/molmil-images/mine/7nr6) | |
5U7F
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![BU of 5u7f by Molmil](/molmil-images/mine/5u7f) | |
6PCL
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![BU of 6pcl by Molmil](/molmil-images/mine/6pcl) | Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 1 in complex with 5-IP7 | 分子名称: | (1r,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, ... | 著者 | Dollins, D.E, Neubauer, J, Dong, J, York, J.D. | 登録日 | 2019-06-17 | 公開日 | 2020-04-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling. Proc.Natl.Acad.Sci.USA, 117, 2020
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2W4E
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![BU of 2w4e by Molmil](/molmil-images/mine/2w4e) | Structure of an N-terminally truncated Nudix hydrolase DR2204 from Deinococcus radiodurans | 分子名称: | MUTT/NUDIX FAMILY PROTEIN | 著者 | Goncalves, A.M.D, Fioravanti, E, Stelter, M, McSweeney, S. | 登録日 | 2008-11-25 | 公開日 | 2009-12-01 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of an N-Terminally Truncated Nudix Hydrolase Dr2204 from Deinococcus Radiodurans. Acta Crystallogr.,Sect.F, 65, 2009
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5U7H
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5T3P
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![BU of 5t3p by Molmil](/molmil-images/mine/5t3p) | Crystal structure of Human Peroxisomal coenzyme A diphosphatase NUDT7 | 分子名称: | 1,2-ETHANEDIOL, Peroxisomal coenzyme A diphosphatase NUDT7 | 著者 | Srikannathasan, V, Nunez, C.A, Tallant, C, Siejka, P, Mathea, S, Kopec, J, Elkins, J.M, Burgess-Brown, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F, Huber, K. | 登録日 | 2016-08-26 | 公開日 | 2017-09-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Crystal structure of Human Peroxisomal coenzyme A diphosphatase NUDT7 To Be Published
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2VNP
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![BU of 2vnp by Molmil](/molmil-images/mine/2vnp) | Monoclinic form of IDI-1 | 分子名称: | 2-DIMETHYLAMINO-ETHYL-DIPHOSPHATE, ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE, MAGNESIUM ION, ... | 著者 | de Ruyck, J, Oudjama, Y, Wouters, J. | 登録日 | 2008-02-06 | 公開日 | 2008-03-18 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Monoclinic Form of Isopentenyl Diphosphate Isomerase: A Case of Polymorphism in Biomolecular Crystals. Acta Crystallogr.,Sect.F, 64, 2008
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3QSJ
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![BU of 3qsj by Molmil](/molmil-images/mine/3qsj) | Crystal structure of NUDIX hydrolase from Alicyclobacillus acidocaldarius | 分子名称: | CALCIUM ION, GLYCEROL, NUDIX hydrolase | 著者 | Michalska, K, Wu, R, Bearden, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2011-02-21 | 公開日 | 2011-04-13 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structure of NUDIX hydrolase from Alicyclobacillus acidocaldarius To be Published
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4S2W
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![BU of 4s2w by Molmil](/molmil-images/mine/4s2w) | Structure of E. coli RppH bound to sulfate ions | 分子名称: | RNA pyrophosphohydrolase, SULFATE ION | 著者 | Vasilyev, N, Serganov, A. | 登録日 | 2015-01-23 | 公開日 | 2015-02-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.992 Å) | 主引用文献 | Structures of RNA Complexes with the Escherichia coli RNA Pyrophosphohydrolase RppH Unveil the Basis for Specific 5'-End-dependent mRNA Decay. J.Biol.Chem., 290, 2015
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4S2Y
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2VNQ
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![BU of 2vnq by Molmil](/molmil-images/mine/2vnq) | Monoclinic form of IDI-1 | 分子名称: | IMIDAZOLE, ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE, MANGANESE (II) ION, ... | 著者 | de Ruyck, J, Oudjama, Y, Wouters, J. | 登録日 | 2008-02-06 | 公開日 | 2008-03-18 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Monoclinic Form of Isopentenyl Diphosphate Isomerase: A Case of Polymorphism in Biomolecular Crystals. Acta Crystallogr.,Sect.F, 64, 2008
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4S2V
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![BU of 4s2v by Molmil](/molmil-images/mine/4s2v) | E. coli RppH structure, KI soak | 分子名称: | ACETATE ION, CALCIUM ION, IODIDE ION, ... | 著者 | Vasilyev, N, Serganov, A. | 登録日 | 2015-01-23 | 公開日 | 2015-02-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structures of RNA Complexes with the Escherichia coli RNA Pyrophosphohydrolase RppH Unveil the Basis for Specific 5'-End-dependent mRNA Decay. J.Biol.Chem., 290, 2015
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3SHD
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![BU of 3shd by Molmil](/molmil-images/mine/3shd) | |