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7U8X
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hTRAP1 with inhibitors
分子名称: Heat shock protein 75 kDa, mitochondrial, [5-(4-fluoro-2H-isoindole-2-carbonyl)-2-hydroxyphenyl](5-methoxy-2H-isoindol-2-yl)methanone
著者Deng, J, Matts, R, Peng, S.
登録日2022-03-09
公開日2023-08-16
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
Eur.J.Med.Chem., 258, 2023
7U8U
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hTRAP1 with inhibitors
分子名称: Heat shock protein 75 kDa, mitochondrial, [2-hydroxy-5-(2H-isoindole-2-carbonyl)phenyl]{5-[3-(triphenyl-lambda~5~-phosphanyl)propoxy]-2H-isoindol-2-yl}methanone
著者Deng, J, Matts, R, Peng, S.
登録日2022-03-09
公開日2023-08-16
実験手法X-RAY DIFFRACTION (3.065 Å)
主引用文献Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
Eur.J.Med.Chem., 258, 2023
7U8V
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hTRAP1 with inhibitors
分子名称: (4-hydroxy-1,3-phenylene)bis[(2H-isoindol-2-yl)methanone], Heat shock protein 75 kDa, mitochondrial
著者Deng, J, Matts, R, Peng, S.
登録日2022-03-09
公開日2023-08-16
実験手法X-RAY DIFFRACTION (1.448 Å)
主引用文献Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
Eur.J.Med.Chem., 258, 2023
7KCK
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BU of 7kck by Molmil
Full-length human mitochondrial Hsp90 (TRAP1) with AMP-PNP
分子名称: Heat shock protein 75 kDa, mitochondrial, MAGNESIUM ION, ...
著者Liu, Y.X, Agard, D.A.
登録日2020-10-06
公開日2021-10-13
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.26 Å)
主引用文献Cryo-EM reveals the dynamic interplay between mitochondrial Hsp90 and SdhB folding intermediates
To Be Published
6D14
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BU of 6d14 by Molmil
Zebrafish TRAP1 bound to AMPPNP and calcium in the asymmetric closed state
分子名称: CALCIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, TNF receptor-associated protein 1
著者Elnatan, D, Agard, D.A.
登録日2018-04-11
公開日2018-04-25
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Calcium binding to a remote site can replace magnesium as cofactor for mitochondrial Hsp90 (TRAP1) ATPase activity.
J.Biol.Chem., 293, 2018
7EXP
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BU of 7exp by Molmil
Crystal structure of zebrafish TRAP1 with AMPPNP and MitoQ
分子名称: 2,3-dimethoxy-5-methyl-6-[10-(triphenyl-$l^{5}-phosphanyl)decyl]cyclohexa-2,5-diene-1,4-dione, COBALT (II) ION, MAGNESIUM ION, ...
著者Lee, H, Yoon, N.G, Kang, B.H, Lee, C.
登録日2021-05-28
公開日2022-01-05
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.297 Å)
主引用文献Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site.
J.Am.Chem.Soc., 143, 2021
6XG6
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BU of 6xg6 by Molmil
Full-length human mitochondrial Hsp90 (TRAP1) with ADP-BeF3
分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Heat shock protein 75 kDa, ...
著者Liu, Y.X, Wang, F, Agard, D.A.
登録日2020-06-17
公開日2020-09-30
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献General and robust covalently linked graphene oxide affinity grids for high-resolution cryo-EM.
Proc.Natl.Acad.Sci.USA, 117, 2020
4IVG
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BU of 4ivg by Molmil
Crystal structure of mitochondrial Hsp90 (TRAP1) NTD-Middle domain dimer with AMPPNP
分子名称: MAGNESIUM ION, PHOSPHATE ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Partridge, J.R, Lavery, L.A, Agard, D.A.
登録日2013-01-22
公開日2014-01-22
最終更新日2014-08-27
実験手法X-RAY DIFFRACTION (1.749 Å)
主引用文献Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism.
Mol.Cell, 53, 2014
4IYN
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Structure of mitochondrial Hsp90 (TRAP1) with ADP-ALF4-
分子名称: ADENOSINE-5'-DIPHOSPHATE, COBALT (II) ION, MAGNESIUM ION, ...
著者Partridge, J.R, Lavery, L.A, Agard, D.A.
登録日2013-01-28
公開日2014-01-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.312 Å)
主引用文献Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism.
Mol.Cell, 53, 2014
8EOA
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BU of 8eoa by Molmil
Cryo-EM structure of human HSP90B-AIPL1 complex
分子名称: Aryl-hydrocarbon-interacting protein-like 1, Heat shock protein HSP 90-beta, MAGNESIUM ION, ...
著者Srivastava, D, Artemyev, N.O.
登録日2022-10-02
公開日2023-01-25
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1.
Structure, 31, 2023
8EOB
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BU of 8eob by Molmil
Cryo-EM structure of human HSP90B in the closed state
分子名称: Heat shock protein HSP 90-beta, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Srivastava, D, Artemyev, N.O.
登録日2022-10-02
公開日2023-01-25
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1.
Structure, 31, 2023
2CG9
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BU of 2cg9 by Molmil
Crystal structure of an Hsp90-Sba1 closed chaperone complex
分子名称: ADENOSINE-5'-TRIPHOSPHATE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, CO-CHAPERONE PROTEIN SBA1
著者Ali, M.M.U, Roe, S.M, Prodromou, C, Pearl, L.H.
登録日2006-03-01
公開日2006-04-12
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Crystal Structure of an Hsp90-Nucleotide-P23/Sba1 Closed Chaperone Complex
Nature, 440, 2006
3K60
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BU of 3k60 by Molmil
Crystal structure of N-terminal domain of Plasmodium falciparum Hsp90 (PF07_0029) bound to ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, Heat shock protein 86, SULFATE ION
著者Corbett, K.D, Berger, J.M.
登録日2009-10-08
公開日2010-08-18
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of the ATP-binding domain of Plasmodium falciparum Hsp90.
Proteins, 78, 2010
4IPE
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BU of 4ipe by Molmil
Crystal structure of mitochondrial Hsp90 (TRAP1) with AMPPNP
分子名称: COBALT (II) ION, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Partridge, J.R, Lavery, L.A, Agard, D.A.
登録日2013-01-09
公開日2014-01-22
最終更新日2014-08-27
実験手法X-RAY DIFFRACTION (2.289 Å)
主引用文献Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism.
Mol.Cell, 53, 2014
4J0B
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BU of 4j0b by Molmil
Structure of mitochondrial Hsp90 (TRAP1) with ADP-BeF3
分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, COBALT (II) ION, ...
著者Partridge, J.R, Lavery, L.A, Agard, D.A.
登録日2013-01-30
公開日2014-01-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.352 Å)
主引用文献Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism.
Mol.Cell, 53, 2014
2IOQ
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BU of 2ioq by Molmil
Crystal Structure of full-length HTPG, the Escherichia coli HSP90
分子名称: Chaperone protein htpG
著者Shiau, A.K, Harris, S.F, Agard, D.A.
登録日2006-10-10
公開日2006-11-21
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements.
Cell(Cambridge,Mass.), 127, 2006
2IOP
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BU of 2iop by Molmil
Crystal Structure of Full-length HtpG, the Escherichia coli Hsp90, Bound to ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, Chaperone protein htpG
著者Shiau, A.K, Harris, S.F, Agard, D.A.
登録日2006-10-10
公開日2006-11-21
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.55 Å)
主引用文献Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements.
Cell(Cambridge,Mass.), 127, 2006
8U1N
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BU of 8u1n by Molmil
Cryo-EM structure of the cross-linked HSP90 dimer (NTD-MD) in the semi-open state
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein 83, MAGNESIUM ION
著者Finci, L.I, Simanshu, D.K.
登録日2023-09-01
公開日2024-03-13
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements.
Commun Biol, 7, 2024
8U1M
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BU of 8u1m by Molmil
Cryo-EM structure of the HSP90 dimer (NTD-MD) in the semi-open state
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein 83, MAGNESIUM ION
著者Finci, L.I, Simanshu, D.K.
登録日2023-09-01
公開日2024-03-13
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements.
Commun Biol, 7, 2024
2O1U
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BU of 2o1u by Molmil
Structure of full length GRP94 with AMP-PNP bound
分子名称: Endoplasmin, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T.
登録日2006-11-29
公開日2007-10-23
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
2O1V
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Structure of full length GRP94 with ADP bound
分子名称: ADENOSINE-5'-DIPHOSPHATE, Endoplasmin, MAGNESIUM ION
著者Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T.
登録日2006-11-29
公開日2007-10-23
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
2O1W
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BU of 2o1w by Molmil
Structure of N-terminal plus middle domains (N+M) of GRP94
分子名称: Endoplasmin
著者Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T.
登録日2006-11-29
公開日2007-10-23
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
1USV
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The Structure of the complex between Aha1 and HSP90
分子名称: AHA1, HEAT SHOCK PROTEIN HSP82
著者Meyer, P, Roe, S.M, Pearl, L.H.
登録日2003-12-01
公開日2004-01-29
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Basis for Recruitment of the ATPase Activator Aha1 to the Hsp90 Chaperone Machinery.
Embo J., 23, 2004
5TTH
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BU of 5tth by Molmil
Heterodimeric SpyCatcher/SpyTag-fused zebrafish TRAP1 in ATP/ADP-hybrid state
分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, C-terminal SpyCatcher fusion of wildtype zebrafish TNF receptor-associated protein 1, ...
著者Elnatan, D, Betegon, M, Liu, Y, Agard, D.A, Northeast Structural Genomics Consortium (NESG)
登録日2016-11-03
公開日2017-08-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1.
Elife, 6, 2017
5TVX
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Crystal structure of mitochondrial Hsp90 (TRAP1) with ATP in absence of Mg, fully hydrolyzed
分子名称: ADENOSINE-5'-DIPHOSPHATE, TNF receptor-associated protein 1
著者Elnatan, D, Betegon, M, Agard, D.A.
登録日2016-11-10
公開日2017-10-25
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1.
Elife, 6, 2017

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