7U8X
| hTRAP1 with inhibitors | 分子名称: | Heat shock protein 75 kDa, mitochondrial, [5-(4-fluoro-2H-isoindole-2-carbonyl)-2-hydroxyphenyl](5-methoxy-2H-isoindol-2-yl)methanone | 著者 | Deng, J, Matts, R, Peng, S. | 登録日 | 2022-03-09 | 公開日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes. Eur.J.Med.Chem., 258, 2023
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7U8U
| hTRAP1 with inhibitors | 分子名称: | Heat shock protein 75 kDa, mitochondrial, [2-hydroxy-5-(2H-isoindole-2-carbonyl)phenyl]{5-[3-(triphenyl-lambda~5~-phosphanyl)propoxy]-2H-isoindol-2-yl}methanone | 著者 | Deng, J, Matts, R, Peng, S. | 登録日 | 2022-03-09 | 公開日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (3.065 Å) | 主引用文献 | Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes. Eur.J.Med.Chem., 258, 2023
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7U8V
| hTRAP1 with inhibitors | 分子名称: | (4-hydroxy-1,3-phenylene)bis[(2H-isoindol-2-yl)methanone], Heat shock protein 75 kDa, mitochondrial | 著者 | Deng, J, Matts, R, Peng, S. | 登録日 | 2022-03-09 | 公開日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.448 Å) | 主引用文献 | Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes. Eur.J.Med.Chem., 258, 2023
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7KCK
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6D14
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7EXP
| Crystal structure of zebrafish TRAP1 with AMPPNP and MitoQ | 分子名称: | 2,3-dimethoxy-5-methyl-6-[10-(triphenyl-$l^{5}-phosphanyl)decyl]cyclohexa-2,5-diene-1,4-dione, COBALT (II) ION, MAGNESIUM ION, ... | 著者 | Lee, H, Yoon, N.G, Kang, B.H, Lee, C. | 登録日 | 2021-05-28 | 公開日 | 2022-01-05 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.297 Å) | 主引用文献 | Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site. J.Am.Chem.Soc., 143, 2021
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6XG6
| Full-length human mitochondrial Hsp90 (TRAP1) with ADP-BeF3 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Heat shock protein 75 kDa, ... | 著者 | Liu, Y.X, Wang, F, Agard, D.A. | 登録日 | 2020-06-17 | 公開日 | 2020-09-30 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | General and robust covalently linked graphene oxide affinity grids for high-resolution cryo-EM. Proc.Natl.Acad.Sci.USA, 117, 2020
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4IVG
| Crystal structure of mitochondrial Hsp90 (TRAP1) NTD-Middle domain dimer with AMPPNP | 分子名称: | MAGNESIUM ION, PHOSPHATE ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Partridge, J.R, Lavery, L.A, Agard, D.A. | 登録日 | 2013-01-22 | 公開日 | 2014-01-22 | 最終更新日 | 2014-08-27 | 実験手法 | X-RAY DIFFRACTION (1.749 Å) | 主引用文献 | Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism. Mol.Cell, 53, 2014
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4IYN
| Structure of mitochondrial Hsp90 (TRAP1) with ADP-ALF4- | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, COBALT (II) ION, MAGNESIUM ION, ... | 著者 | Partridge, J.R, Lavery, L.A, Agard, D.A. | 登録日 | 2013-01-28 | 公開日 | 2014-01-22 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.312 Å) | 主引用文献 | Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism. Mol.Cell, 53, 2014
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8EOA
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8EOB
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2CG9
| Crystal structure of an Hsp90-Sba1 closed chaperone complex | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, CO-CHAPERONE PROTEIN SBA1 | 著者 | Ali, M.M.U, Roe, S.M, Prodromou, C, Pearl, L.H. | 登録日 | 2006-03-01 | 公開日 | 2006-04-12 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Crystal Structure of an Hsp90-Nucleotide-P23/Sba1 Closed Chaperone Complex Nature, 440, 2006
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3K60
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4IPE
| Crystal structure of mitochondrial Hsp90 (TRAP1) with AMPPNP | 分子名称: | COBALT (II) ION, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Partridge, J.R, Lavery, L.A, Agard, D.A. | 登録日 | 2013-01-09 | 公開日 | 2014-01-22 | 最終更新日 | 2014-08-27 | 実験手法 | X-RAY DIFFRACTION (2.289 Å) | 主引用文献 | Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism. Mol.Cell, 53, 2014
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4J0B
| Structure of mitochondrial Hsp90 (TRAP1) with ADP-BeF3 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, COBALT (II) ION, ... | 著者 | Partridge, J.R, Lavery, L.A, Agard, D.A. | 登録日 | 2013-01-30 | 公開日 | 2014-01-22 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.352 Å) | 主引用文献 | Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism. Mol.Cell, 53, 2014
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2IOQ
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2IOP
| Crystal Structure of Full-length HtpG, the Escherichia coli Hsp90, Bound to ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Chaperone protein htpG | 著者 | Shiau, A.K, Harris, S.F, Agard, D.A. | 登録日 | 2006-10-10 | 公開日 | 2006-11-21 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.55 Å) | 主引用文献 | Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements. Cell(Cambridge,Mass.), 127, 2006
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8U1N
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8U1M
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2O1U
| Structure of full length GRP94 with AMP-PNP bound | 分子名称: | Endoplasmin, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T. | 登録日 | 2006-11-29 | 公開日 | 2007-10-23 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones. Mol.Cell, 28, 2007
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2O1V
| Structure of full length GRP94 with ADP bound | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Endoplasmin, MAGNESIUM ION | 著者 | Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T. | 登録日 | 2006-11-29 | 公開日 | 2007-10-23 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones. Mol.Cell, 28, 2007
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2O1W
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1USV
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5TTH
| Heterodimeric SpyCatcher/SpyTag-fused zebrafish TRAP1 in ATP/ADP-hybrid state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, C-terminal SpyCatcher fusion of wildtype zebrafish TNF receptor-associated protein 1, ... | 著者 | Elnatan, D, Betegon, M, Liu, Y, Agard, D.A, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2016-11-03 | 公開日 | 2017-08-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1. Elife, 6, 2017
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5TVX
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