PDB: 93 件ウェブページステータス検索Chemie searchBIRD

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7U8X	hTRAP1 with inhibitors 分子名称: Heat shock protein 75 kDa, mitochondrial, [5-(4-fluoro-2H-isoindole-2-carbonyl)-2-hydroxyphenyl](5-methoxy-2H-isoindol-2-yl)methanone 著者 Deng, J, Matts, R, Peng, S. 登録日 2022-03-09 公開日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes. Eur.J.Med.Chem., 258, 2023
7U8V	hTRAP1 with inhibitors 分子名称: (4-hydroxy-1,3-phenylene)bis[(2H-isoindol-2-yl)methanone], Heat shock protein 75 kDa, mitochondrial 著者 Deng, J, Matts, R, Peng, S. 登録日 2022-03-09 公開日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.448 Å) 主引用文献 Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes. Eur.J.Med.Chem., 258, 2023
7U8U	hTRAP1 with inhibitors 分子名称: Heat shock protein 75 kDa, mitochondrial, [2-hydroxy-5-(2H-isoindole-2-carbonyl)phenyl]{5-[3-(triphenyl-lambda~5~-phosphanyl)propoxy]-2H-isoindol-2-yl}methanone 著者 Deng, J, Matts, R, Peng, S. 登録日 2022-03-09 公開日 2023-08-16 実験手法 X-RAY DIFFRACTION (3.065 Å) 主引用文献 Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes. Eur.J.Med.Chem., 258, 2023
1Y6Z	Middle domain of Plasmodium falciparum putative heat shock protein PF14_0417 分子名称: heat shock protein, putative 著者 Lunin, V.V, Botchkareva, E, Loppnau, P, Amani, M, Bray, J, Vedadi, M, Edwards, A, Arrowsmith, C, Sundstrom, M, Bochkarev, A, Hui, R, Plotnikova, O, Structural Genomics Consortium (SGC) 登録日 2004-12-07 公開日 2005-02-08 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms. Mol.Biochem.Parasitol., 151, 2007
7KCK	Full-length human mitochondrial Hsp90 (TRAP1) with AMP-PNP 分子名称: Heat shock protein 75 kDa, mitochondrial, MAGNESIUM ION, ... 著者 Liu, Y.X, Agard, D.A. 登録日 2020-10-06 公開日 2021-10-13 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.26 Å) 主引用文献 Cryo-EM reveals the dynamic interplay between mitochondrial Hsp90 and SdhB folding intermediates To Be Published
7EXP	Crystal structure of zebrafish TRAP1 with AMPPNP and MitoQ 分子名称: 2,3-dimethoxy-5-methyl-6-[10-(triphenyl-$l^{5}-phosphanyl)decyl]cyclohexa-2,5-diene-1,4-dione, COBALT (II) ION, MAGNESIUM ION, ... 著者 Lee, H, Yoon, N.G, Kang, B.H, Lee, C. 登録日 2021-05-28 公開日 2022-01-05 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.297 Å) 主引用文献 Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site. J.Am.Chem.Soc., 143, 2021
5ULS	Structure of GRP94 in the active conformation 分子名称: Endoplasmin, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Huck, J.D, Que, N.L.S, Gewirth, D.T. 登録日 2017-01-25 公開日 2017-09-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.622 Å) 主引用文献 Structural and Functional Analysis of GRP94 in the Closed State Reveals an Essential Role for the Pre-N Domain and a Potential Client-Binding Site. Cell Rep, 20, 2017
6D14	Zebrafish TRAP1 bound to AMPPNP and calcium in the asymmetric closed state 分子名称: CALCIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, TNF receptor-associated protein 1 著者 Elnatan, D, Agard, D.A. 登録日 2018-04-11 公開日 2018-04-25 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Calcium binding to a remote site can replace magnesium as cofactor for mitochondrial Hsp90 (TRAP1) ATPase activity. J.Biol.Chem., 293, 2018
2IOQ	Crystal Structure of full-length HTPG, the Escherichia coli HSP90 分子名称: Chaperone protein htpG 著者 Shiau, A.K, Harris, S.F, Agard, D.A. 登録日 2006-10-10 公開日 2006-11-21 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements. Cell(Cambridge,Mass.), 127, 2006
8EOB	Cryo-EM structure of human HSP90B in the closed state 分子名称: Heat shock protein HSP 90-beta, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Srivastava, D, Artemyev, N.O. 登録日 2022-10-02 公開日 2023-01-25 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1. Structure, 31, 2023
8EOA	Cryo-EM structure of human HSP90B-AIPL1 complex 分子名称: Aryl-hydrocarbon-interacting protein-like 1, Heat shock protein HSP 90-beta, MAGNESIUM ION, ... 著者 Srivastava, D, Artemyev, N.O. 登録日 2022-10-02 公開日 2023-01-25 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1. Structure, 31, 2023
2IOP	Crystal Structure of Full-length HtpG, the Escherichia coli Hsp90, Bound to ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Chaperone protein htpG 著者 Shiau, A.K, Harris, S.F, Agard, D.A. 登録日 2006-10-10 公開日 2006-11-21 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.55 Å) 主引用文献 Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements. Cell(Cambridge,Mass.), 127, 2006
3K60	Crystal structure of N-terminal domain of Plasmodium falciparum Hsp90 (PF07_0029) bound to ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Heat shock protein 86, SULFATE ION 著者 Corbett, K.D, Berger, J.M. 登録日 2009-10-08 公開日 2010-08-18 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of the ATP-binding domain of Plasmodium falciparum Hsp90. Proteins, 78, 2010
2O1V	Structure of full length GRP94 with ADP bound 分子名称: ADENOSINE-5'-DIPHOSPHATE, Endoplasmin, MAGNESIUM ION 著者 Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T. 登録日 2006-11-29 公開日 2007-10-23 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones. Mol.Cell, 28, 2007
2CG9	Crystal structure of an Hsp90-Sba1 closed chaperone complex 分子名称: ADENOSINE-5'-TRIPHOSPHATE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, CO-CHAPERONE PROTEIN SBA1 著者 Ali, M.M.U, Roe, S.M, Prodromou, C, Pearl, L.H. 登録日 2006-03-01 公開日 2006-04-12 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Crystal Structure of an Hsp90-Nucleotide-P23/Sba1 Closed Chaperone Complex Nature, 440, 2006
2O1U	Structure of full length GRP94 with AMP-PNP bound 分子名称: Endoplasmin, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T. 登録日 2006-11-29 公開日 2007-10-23 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones. Mol.Cell, 28, 2007
2O1W	Structure of N-terminal plus middle domains (N+M) of GRP94 分子名称: Endoplasmin 著者 Dollins, D.E, Warren, J.J, Immormino, R.M, Gewirth, D.T. 登録日 2006-11-29 公開日 2007-10-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones. Mol.Cell, 28, 2007
8U1M	Cryo-EM structure of the HSP90 dimer (NTD-MD) in the semi-open state 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein 83, MAGNESIUM ION 著者 Finci, L.I, Simanshu, D.K. 登録日 2023-09-01 公開日 2024-03-13 最終更新日 2025-05-28 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements. Commun Biol, 7, 2024
8U1N	Cryo-EM structure of the cross-linked HSP90 dimer (NTD-MD) in the semi-open state 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein 83, MAGNESIUM ION 著者 Finci, L.I, Simanshu, D.K. 登録日 2023-09-01 公開日 2024-03-13 最終更新日 2025-05-21 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements. Commun Biol, 7, 2024
4IPE	Crystal structure of mitochondrial Hsp90 (TRAP1) with AMPPNP 分子名称: COBALT (II) ION, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Partridge, J.R, Lavery, L.A, Agard, D.A. 登録日 2013-01-09 公開日 2014-01-22 最終更新日 2024-11-27 実験手法 X-RAY DIFFRACTION (2.289 Å) 主引用文献 Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism. Mol.Cell, 53, 2014
8K2R	The structure of HtpG M domain in complex with unstructured D131D binding site b 分子名称: Disordered protein(D131D), Molecular chaperone HtpG (Fragment) 著者 Qu, X, Huang, C. 登録日 2023-07-13 公開日 2024-06-26 最終更新日 2024-10-30 実験手法 SOLUTION NMR 主引用文献 Structural basis for the dynamic chaperoning of disordered clients by Hsp90. Nat.Struct.Mol.Biol., 31, 2024
8K2T	Solution structure of full-length HtpG in complex with D131D 分子名称: Chaperone protein HtpG, Nuclease A 著者 Qu, X, Huang, C. 登録日 2023-07-13 公開日 2024-06-26 最終更新日 2024-10-30 実験手法 SOLUTION NMR 主引用文献 Structural basis for the dynamic chaperoning of disordered clients by Hsp90. Nat.Struct.Mol.Biol., 31, 2024
4J0B	Structure of mitochondrial Hsp90 (TRAP1) with ADP-BeF3 分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, COBALT (II) ION, ... 著者 Partridge, J.R, Lavery, L.A, Agard, D.A. 登録日 2013-01-30 公開日 2014-01-22 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.352 Å) 主引用文献 Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism. Mol.Cell, 53, 2014
5TVU	Crystal structure of mitochondrial Hsp90 (TRAP1) with ATP in absence of Mg 分子名称: ADENOSINE-5'-TRIPHOSPHATE, TNF receptor-associated protein 1 著者 Elnatan, D, Betegon, M, Agard, D.A. 登録日 2016-11-10 公開日 2018-03-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1. Elife, 6, 2017
4IVG	Crystal structure of mitochondrial Hsp90 (TRAP1) NTD-Middle domain dimer with AMPPNP 分子名称: MAGNESIUM ION, PHOSPHATE ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Partridge, J.R, Lavery, L.A, Agard, D.A. 登録日 2013-01-22 公開日 2014-01-22 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.749 Å) 主引用文献 Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism. Mol.Cell, 53, 2014

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