6RU0
| |
6PK7
| |
5DOU
| Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), ligand-bound form | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... | 著者 | de Cima, S, Polo, L.M, Fita, I, Rubio, V. | 登録日 | 2015-09-11 | 公開日 | 2015-12-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis. Sci Rep, 5, 2015
|
|
1GPW
| Structural evidence for ammonia tunneling across the (beta/alpha)8 barrel of the imidazole glycerol phosphate synthase bienzyme complex. | 分子名称: | AMIDOTRANSFERASE HISH, HISF PROTEIN, PHOSPHATE ION | 著者 | Walker, M, Beismann-Driemeyer, S, Sterner, R, Wilmanns, M. | 登録日 | 2001-11-12 | 公開日 | 2002-02-10 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural Evidence for Ammonia Tunneling Across the (Beta Alpha)(8) Barrel of the Imidazole Glycerol Phosphate Synthase Bienzyme Complex. Structure, 10, 2002
|
|
3UOW
| Crystal Structure of PF10_0123, a GMP Synthetase from Plasmodium Falciparum | 分子名称: | CALCIUM ION, GMP synthetase, XANTHOSINE-5'-MONOPHOSPHATE | 著者 | Wernimont, A.K, Dong, A, Hills, T, Amani, M, Perieteanu, A, Lin, Y.H, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Hui, R, Structural Genomics Consortium (SGC) | 登録日 | 2011-11-17 | 公開日 | 2011-12-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | 主引用文献 | Crystal Structure of PF10_0123, a GMP Synthetase from Plasmodium Falciparum TO BE PUBLISHED
|
|
5DOT
| Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), apo form | 分子名称: | 1,2-ETHANEDIOL, Carbamoyl-phosphate synthase [ammonia], mitochondrial, ... | 著者 | Polo, L.M, de Cima, S, Fita, I, Rubio, V. | 登録日 | 2015-09-11 | 公開日 | 2015-12-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis. Sci Rep, 5, 2015
|
|
1GPM
| |
3ZR4
| STRUCTURAL EVIDENCE FOR AMMONIA TUNNELING ACROSS THE (BETA-ALPHA)8 BARREL OF THE IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE BIENZYME COMPLEX | 分子名称: | GLUTAMINE, GLYCEROL, IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF, ... | 著者 | Vega, M.C, Kuper, J, Haeger, M.C, Mohrlueder, J, Marquardt, S, Sterner, R, Wilmanns, M. | 登録日 | 2011-06-13 | 公開日 | 2012-10-03 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Catalysis Uncoupling in a Glutamine Amidotransferase Bienzyme by Unblocking the Glutaminase Active Site. Chem.Biol., 19, 2012
|
|
2AD5
| Mechanisms of feedback regulation and drug resistance of CTP synthetases: structure of the E. coli CTPS/CTP complex at 2.8-Angstrom resolution. | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CTP synthase, CYTIDINE-5'-TRIPHOSPHATE, ... | 著者 | Endrizzi, J.A, Kim, H, Anderson, P.M, Baldwin, E.P. | 登録日 | 2005-07-19 | 公開日 | 2005-11-01 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Mechanisms of Product Feedback Regulation and Drug Resistance in Cytidine Triphosphate Synthetases from the Structure of a CTP-Inhibited Complex(,). Biochemistry, 44, 2005
|
|
2YWC
| Crystal structure of GMP synthetase from Thermus thermophilus in complex with XMP | 分子名称: | GMP synthase [glutamine-hydrolyzing], XANTHOSINE-5'-MONOPHOSPHATE | 著者 | Baba, S, Kanagawa, M, Kuramitsu, S, Yokoyama, S, Sampei, G, Kawai, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2007-04-20 | 公開日 | 2007-10-23 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of GMP synthetase from Thermus thermophilus To be Published
|
|
6UEL
| CPS1 bound to allosteric inhibitor H3B-193 | 分子名称: | Carbamoyl-phosphate synthase [ammonia], mitochondrial, N~1~-[(4-fluorophenyl)methyl]-N~1~-methyl-N~4~-(4-methyl-1,3-thiazol-2-yl)piperidine-1,4-dicarboxamide, ... | 著者 | Larsen, N.A, Nguyen, T.V. | 登録日 | 2019-09-21 | 公開日 | 2020-03-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket. Cell Chem Biol, 27, 2020
|
|
2YWB
| Crystal structure of GMP synthetase from Thermus thermophilus | 分子名称: | GMP synthase [glutamine-hydrolyzing] | 著者 | Baba, S, Kanagawa, M, Yanai, H, Ishii, T, Kuramitsu, S, Yokoyama, S, Sampei, G, Kawai, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2007-04-20 | 公開日 | 2007-10-23 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of GMP synthetase from Thermus thermophilus To be Published
|
|
3L7N
| |
4ZDJ
| Crystal structure of the M. tuberculosis CTP synthase PyrG in complex with two UTP molecules | 分子名称: | CTP synthase, GLYCEROL, MAGNESIUM ION, ... | 著者 | Bellinzoni, M, Barilone, N, Alzari, P.M. | 登録日 | 2015-04-17 | 公開日 | 2015-07-01 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG. Chem.Biol., 22, 2015
|
|
4ZDI
| |
6VTV
| Crystal structure of PuuD gamma-glutamyl-gamma-aminobutyrate hydrolase from E. coli | 分子名称: | Gamma-glutamyl-gamma-aminobutyrate hydrolase PuuD, MANGANESE (II) ION | 著者 | Stogios, P.J, EVDOKIMOVA, E, DI LEO, R, SAVCHENKO, A, JOACHIMIAK, A, SATCHELL, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2020-02-13 | 公開日 | 2020-02-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | PuuD gamma-glutamyl-gamma-aminobutyrate hydrolase To Be Published
|
|
3M3P
| Crystal structure of glutamine amido transferase from Methylobacillus Flagellatus | 分子名称: | Glutamine amido transferase | 著者 | Fedorov, A.A, Domagalski, M, Fedorov, E.V, Burley, S.K, Minor, W, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | 登録日 | 2010-03-09 | 公開日 | 2010-03-23 | 最終更新日 | 2022-04-13 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Crystal structure of glutamine amido transferase from Methylobacillus Flagellatus To be Published
|
|
6W2J
| CPS1 bound to allosteric inhibitor H3B-374 | 分子名称: | (2-fluoranyl-4-methoxy-phenyl)-[(3~{R},5~{R})-4-(2-fluoranyl-4-methoxy-phenyl)carbonyl-3,5-dimethyl-piperazin-1-yl]methanone, 1,2-ETHANEDIOL, Carbamoyl-phosphate synthase [ammonia], ... | 著者 | Larsen, N.A, Nguyen, T.V. | 登録日 | 2020-03-05 | 公開日 | 2021-01-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Discovery of 2,6-Dimethylpiperazines as Allosteric Inhibitors of CPS1. Acs Med.Chem.Lett., 11, 2020
|
|
2NV0
| |
7WIZ
| |
7WJ4
| |
4ZDK
| Crystal structure of the M. tuberculosis CTP synthase PyrG in complex with UTP, AMP-PCP and oxonorleucine | 分子名称: | 5-OXO-L-NORLEUCINE, CTP synthase, MAGNESIUM ION, ... | 著者 | Bellinzoni, M, Barilone, N, Alzari, P.M. | 登録日 | 2015-04-17 | 公開日 | 2015-07-01 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.49 Å) | 主引用文献 | Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG. Chem.Biol., 22, 2015
|
|
2NV2
| Structure of the PLP synthase complex Pdx1/2 (YaaD/E) from Bacillus subtilis | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, GLUTAMINE, ... | 著者 | Strohmeier, M, Tews, I, Sinning, I. | 登録日 | 2006-11-10 | 公開日 | 2006-12-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Structure of a bacterial pyridoxal 5'-phosphate synthase complex Proc.Natl.Acad.Sci.Usa, 103, 2006
|
|
3NVA
| Dimeric form of CTP synthase from Sulfolobus solfataricus | 分子名称: | CTP synthase | 著者 | Harris, P, Willemoes, M, Lauritsen, I, Johansson, E, Jensen, K.F. | 登録日 | 2010-07-08 | 公開日 | 2010-09-08 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.504 Å) | 主引用文献 | Structure of the dimeric form of CTP synthase from Sulfolobus solfataricus Acta Crystallogr.,Sect.F, 67, 2011
|
|
2YWJ
| |