6N3I
 
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6THA
 | | Crystal structure of human sugar transporter GLUT1 (SLC2A1) in the inward conformation | | 分子名称: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, CHLORIDE ION, Solute carrier family 2, ... | | 著者 | Pedersen, B.P, Paulsen, P.A, Custodio, T.F. | | 登録日 | 2019-11-19 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in sugar porter family.
Life Sci Alliance, 4, 2021
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5EQH
 | | Human GLUT1 in complex with inhibitor (2~{S})-3-(2-bromophenyl)-2-[2-(4-methoxyphenyl)ethanoylamino]-~{N}-[(1~{S})-1-phenylethyl]propanamide | | 分子名称: | (2~{S})-3-(2-bromophenyl)-2-[2-(4-methoxyphenyl)ethanoylamino]-~{N}-[(1~{S})-1-phenylethyl]propanamide, Solute carrier family 2, facilitated glucose transporter member 1 | | 著者 | Kapoor, K, Finer-Moore, J, Pedersen, B.P, Caboni, L, Waight, A.B, Hillig, R, Bringmann, P, Heisler, I, Muller, T, Siebeneicher, H, Stroud, R.M. | | 登録日 | 2015-11-12 | | 公開日 | 2016-04-13 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | | 主引用文献 | Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides.
Proc.Natl.Acad.Sci.USA, 113, 2016
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7CRZ
 | | Crystal structure of human glucose transporter GLUT3 bound with C3361 | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S,3R,4S,5R,6R)-6-(hydroxymethyl)-4-undec-10-enoxy-oxane-2,3,5-triol, Solute carrier family 2, ... | | 著者 | Yuan, Y.Y, Zhang, S, Wang, N, Jiang, X, Yan, N. | | 登録日 | 2020-08-14 | | 公開日 | 2021-01-13 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents.
Proc.Natl.Acad.Sci.USA, 118, 2021
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6OOP
 | | protein B | | 分子名称: | 1,1'-dimethyl-4,4'-bipyridin-1-ium, Multidrug transporter MdfA, PRASEODYMIUM ION | | 著者 | Lu, M. | | 登録日 | 2019-04-23 | | 公開日 | 2019-09-04 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure of an engineered multidrug transporter MdfA reveals the molecular basis for substrate recognition.
Commun Biol, 2, 2019
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6OOQ
 | | protein C | | 分子名称: | (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, Multidrug transporter MdfA | | 著者 | Lu, M. | | 登録日 | 2019-04-23 | | 公開日 | 2019-09-04 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structure of an engineered multidrug transporter MdfA reveals the molecular basis for substrate recognition.
Commun Biol, 2, 2019
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4GBY
 | | The structure of the MFS (major facilitator superfamily) proton:xylose symporter XylE bound to D-xylose | | 分子名称: | D-xylose-proton symporter, beta-D-xylopyranose, nonyl beta-D-glucopyranoside | | 著者 | Sun, L.F, Zeng, X, Yan, C.Y, Yan, N. | | 登録日 | 2012-07-28 | | 公開日 | 2012-10-17 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.808 Å) | | 主引用文献 | Crystal structure of a bacterial homologue of glucose transporters GLUT1-4.
Nature, 490, 2012
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4JA3
 | | Partially occluded inward open conformation of the xylose transporter XylE from E. coli | | 分子名称: | CADMIUM ION, D-xylose-proton symporter, LUTETIUM (III) ION | | 著者 | Quistgaard, E.M, Low, C, Moberg, P, Tresaugues, L, Nordlund, P. | | 登録日 | 2013-02-18 | | 公開日 | 2013-05-01 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters.
Nat.Struct.Mol.Biol., 20, 2013
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4GC0
 | | The structure of the MFS (major facilitator superfamily) proton:xylose symporter XylE bound to 6-bromo-6-deoxy-D-glucose | | 分子名称: | 6-bromo-6-deoxy-beta-D-glucopyranose, D-xylose-proton symporter, nonyl beta-D-glucopyranoside | | 著者 | Yan, N, Sun, L.F, Zeng, X, Yan, C.Y. | | 登録日 | 2012-07-28 | | 公開日 | 2012-10-17 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal structure of a bacterial homologue of glucose transporters GLUT1-4.
Nature, 490, 2012
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5EQG
 | | Human GLUT1 in complex with inhibitor (2~{S})-3-(4-fluorophenyl)-2-[2-(3-hydroxyphenyl)ethanoylamino]-~{N}-[(1~{S})-1-phenylethyl]propanamide | | 分子名称: | (2~{S})-3-(4-fluorophenyl)-2-[2-(3-hydroxyphenyl)ethanoylamino]-~{N}-[(1~{S})-1-phenylethyl]propanamide, Solute carrier family 2, facilitated glucose transporter member 1 | | 著者 | Kapoor, K, Finer-Moore, J, Pedersen, B.P, Caboni, L, Waight, A.B, Hillig, R, Bringmann, P, Heisler, I, Muller, T, Siebeneicher, H, Stroud, R.M. | | 登録日 | 2015-11-12 | | 公開日 | 2016-04-13 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides.
Proc.Natl.Acad.Sci.USA, 113, 2016
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6GV1
 | | Crystal structure of E.coli Multidrug/H+ antiporter MdfA in outward open conformation with bound Fab fragment | | 分子名称: | Fab fragment YN1074 heavy chain, Fab fragment YN1074 light chain, Major Facilitator Superfamily multidrug/H+ antiporter MdfA from E.coli, ... | | 著者 | Nagarathinam, K, Parthier, C, Stubbs, M.T, Tanabe, M. | | 登録日 | 2018-06-20 | | 公開日 | 2018-10-03 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Outward open conformation of a Major Facilitator Superfamily multidrug/H+antiporter provides insights into switching mechanism.
Nat Commun, 9, 2018
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6H7D
 | | Crystal Structure of A. thaliana Sugar Transport Protein 10 in complex with glucose in the outward occluded state | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, PHOSPHATE ION, ... | | 著者 | Pedersen, B.P, Paulsen, P.A, Custodio, T.F. | | 登録日 | 2018-07-31 | | 公開日 | 2019-02-06 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of the plant symporter STP10 illuminates sugar uptake mechanism in monosaccharide transporter superfamily.
Nat Commun, 10, 2019
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5EQI
 | | Human GLUT1 in complex with Cytochalasin B | | 分子名称: | Cytochalasin B, Solute carrier family 2, facilitated glucose transporter member 1 | | 著者 | Kapoor, K, Finer-Moore, J, Pedersen, B.P, Caboni, L, Waight, A.B, Hillig, R, Bringmann, P, Heisler, I, Muller, T, Siebeneicher, H, Stroud, R.M. | | 登録日 | 2015-11-12 | | 公開日 | 2016-04-13 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.002 Å) | | 主引用文献 | Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides.
Proc.Natl.Acad.Sci.USA, 113, 2016
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4GBZ
 | | The structure of the MFS (major facilitator superfamily) proton:xylose symporter XylE bound to D-glucose | | 分子名称: | D-xylose-proton symporter, beta-D-glucopyranose, nonyl beta-D-glucopyranoside | | 著者 | Sun, L.F, Zeng, X, Yan, C.Y, Yan, N. | | 登録日 | 2012-07-28 | | 公開日 | 2012-10-17 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.894 Å) | | 主引用文献 | Crystal structure of a bacterial homologue of glucose transporters GLUT1-4.
Nature, 490, 2012
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6RW3
 | | The molecular basis for sugar import in malaria parasites. | | 分子名称: | Hexose transporter 1, alpha-D-glucopyranose, beta-D-glucopyranose | | 著者 | Qureshi, A, Matsuoka, R, Brock, J, Drew, D. | | 登録日 | 2019-06-03 | | 公開日 | 2020-01-29 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.65 Å) | | 主引用文献 | The molecular basis for sugar import in malaria parasites.
Nature, 578, 2020
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7D5Q
 | | Structure of NorC transporter (K398A mutant) in an outward-open conformation in complex with a single-chain Indian camelid antibody | | 分子名称: | Drug transporter, putative, ICab, ... | | 著者 | Kumar, S, Athreya, A, Penmatsa, A. | | 登録日 | 2020-09-27 | | 公開日 | 2021-06-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Structural basis of inhibition of a transporter from Staphylococcus aureus, NorC, through a single-domain camelid antibody.
Commun Biol, 4, 2021
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7D5P
 | | Structure of NorC transporter in an outward-open conformation in complex with a single-chain Indian camelid antibody | | 分子名称: | Drug transporter, putative, ICab, ... | | 著者 | Kumar, S, Athreya, A, Penmatsa, A. | | 登録日 | 2020-09-27 | | 公開日 | 2021-06-09 | | 最終更新日 | 2021-07-14 | | 実験手法 | X-RAY DIFFRACTION (3.65 Å) | | 主引用文献 | Structural basis of inhibition of a transporter from Staphylococcus aureus, NorC, through a single-domain camelid antibody.
Commun Biol, 4, 2021
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4JA4
 | | Inward open conformation of the xylose transporter XylE from E. coli | | 分子名称: | CADMIUM ION, D-xylose-proton symporter | | 著者 | Quistgaard, E.M, Low, C, Moberg, P, Tresaugues, L, Nordlund, P. | | 登録日 | 2013-02-18 | | 公開日 | 2013-05-01 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | | 主引用文献 | Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters.
Nat.Struct.Mol.Biol., 20, 2013
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6VS0
 | | protein B | | 分子名称: | CHLORAMPHENICOL, Multidrug transporter MdfA, PRASEODYMIUM ION | | 著者 | Lu, M, Lu, M.M. | | 登録日 | 2020-02-10 | | 公開日 | 2020-06-03 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure and mechanism of a redesigned multidrug transporter from the Major Facilitator Superfamily.
Sci Rep, 10, 2020
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6VS2
 | | protein D | | 分子名称: | LAURYL DIMETHYLAMINE-N-OXIDE, Multidrug transporter MdfA, PRASEODYMIUM ION | | 著者 | Lu, M, Lu, M.M. | | 登録日 | 2020-02-10 | | 公開日 | 2020-06-03 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structure and mechanism of a redesigned multidrug transporter from the Major Facilitator Superfamily.
Sci Rep, 10, 2020
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6VS1
 | | protein C | | 分子名称: | (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, Multidrug transporter MdfA, PRASEODYMIUM ION | | 著者 | Lu, M, Lu, M.M. | | 登録日 | 2020-02-10 | | 公開日 | 2020-06-03 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structure and mechanism of a redesigned multidrug transporter from the Major Facilitator Superfamily.
Sci Rep, 10, 2020
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6VRZ
 | | protein A | | 分子名称: | CHLORAMPHENICOL, Multidrug transporter MdfA, PRASEODYMIUM ION | | 著者 | Lu, M, Lu, M.M. | | 登録日 | 2020-02-10 | | 公開日 | 2020-06-03 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure and mechanism of a redesigned multidrug transporter from the Major Facilitator Superfamily.
Sci Rep, 10, 2020
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8UOA
 | | Structure of the synaptic vesicle protein 2A Luminal domain in complex with a nanobody | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody, Synaptic vesicle glycoprotein 2A, ... | | 著者 | Mittal, A, Martin, M.F, Levin, E, Adams, C, Yang, M, Ledecq, M, Horyani, P.S, Coleman, J.A. | | 登録日 | 2023-10-19 | | 公開日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structure of the synaptic vesicle protein 2A Luminal domain in complex with a nanobody
To Be Published
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8UO9
 | | Structure of synaptic vesicle protein 2A in complex with a nanobody | | 分子名称: | (4R)-1-{[(4S)-2-(methoxymethyl)-6-(trifluoromethyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]methyl}-4-(4,4,4-trifluorobutyl)pyrrolidin-2-one, 1,2-DIDECANOYL-SN-GLYCERO-3-[PHOSPHO-L-SERINE], 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Mittal, A, Martin, M.F, Levin, E, Adams, C, Yang, M, Ledecq, M, Horyani, P.S, Coleman, J.A. | | 登録日 | 2023-10-19 | | 公開日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure of synaptic vesicle protein 2A in complex with a nanobody
To Be Published
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8XOB
 | | VMAT2 protonated state | | 分子名称: | Synaptic vesicular amine transporter,transporter B | | 著者 | Jiang, D.H, Wu, D. | | 登録日 | 2023-12-31 | | 公開日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | | 主引用文献 | VMAT2 protonated state
To Be Published
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