PDB: 680 件ウェブページステータス検索Chemie searchBIRD

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5ZAD	Human topoisomerase II beta in complex with DNA 分子名称: DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta 著者 Sun, L.Y, Zhu, L.W, Tang, Y.J. 登録日 2018-02-07 公開日 2019-03-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.54 Å) 主引用文献 Increasing the distance between two monomers of topoisomerase II beta under the action of antitumor agent 4 beta-sulfur-(benzimidazole) 4'-demethylepipodophyllotoxin. Sci Rep, 8, 2018
3M6K	Crystal Structure of N-terminal 44 kDa fragment of topoisomerase V in the presence of guanidium hydrochloride 分子名称: PHOSPHATE ION, Topoisomerase V 著者 Rajan, R, Taneja, B, Mondragon, A. 登録日 2010-03-15 公開日 2010-08-04 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structures of minimal catalytic fragments of topoisomerase v reveals conformational changes relevant for DNA binding. Structure, 18, 2010
4GFH	Topoisomerase II-DNA-AMPPNP complex 分子名称: DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*CP*GP*TP*CP*AP*TP*CP*C)-3'), DNA (5'-D(*CP*GP*CP*GP*GP*TP*AP*GP*CP*AP*GP*TP*AP*GP*G)-3'), DNA (5'-D(P*CP*CP*TP*AP*CP*TP*GP*CP*TP*AP*C)-3'), ... 著者 Schmidt, B.H, Osheroff, N, Berger, J.M. 登録日 2012-08-03 公開日 2012-10-03 最終更新日 2019-07-31 実験手法 X-RAY DIFFRACTION (4.408 Å) 主引用文献 Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity. Nat.Struct.Mol.Biol., 19, 2012
1A31	HUMAN RECONSTITUTED DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX 分子名称: DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*5IUP*5IU*TP*GP*AP*AP*AP*AP*AP*5IUP*5IUP*5IUP*5IUP*T)-3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*5IUP*5IUP*5IUP*5IUP*CP*AP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'), PROTEIN (TOPOISOMERASE I) 著者 Redinbo, M.R, Stewart, L, Kuhn, P, Champoux, J.J, Hol, W.G.J. 登録日 1998-01-27 公開日 1998-08-28 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science, 279, 1998
1A35	HUMAN TOPOISOMERASE I/DNA COMPLEX 分子名称: DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*(BRU)P*(BRU)P*TP*TP*T)-3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*+UP*+UP*+UP*+UP*CP*+UP*AP*AP*GP*TP*CP*TP*TP*TP*+ UP*T)-3'), PROTEIN (DNA TOPOISOMERASE I) 著者 Redinbo, M.R, Stewart, L, Kuhn, P, Champoux, J.J, Hol, W.G. 登録日 1998-01-29 公開日 1998-08-28 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science, 279, 1998
1A36	TOPOISOMERASE I/DNA COMPLEX 分子名称: DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*A P*TP*TP*TP*TP*T)- 3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*C P*TP*TP*TP*TP*T)- 3'), TOPOISOMERASE I 著者 Stewart, L, Redinbo, M.R, Qiu, X, Champoux, J.J, Hol, W.G.J. 登録日 1998-01-29 公開日 1998-08-12 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 A model for the mechanism of human topoisomerase I. Science, 279, 1998
2GAJ	Structure of Full Length Topoisomerase I from Thermotoga maritima in monoclinic crystal form 分子名称: DNA topoisomerase I 著者 Hansen, G. 登録日 2006-03-09 公開日 2006-04-25 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal Structure of Full Length Topoisomerase I from Thermotoga maritima J.Mol.Biol., 358, 2006
8GCC	T. cruzi topoisomerase II alpha bound to dsDNA and the covalent inhibitor CT1 分子名称: 2-{3-[(Z)-iminomethyl]-1H-1,2,4-triazol-1-yl}-1-{(3M)-3-[2-(trifluoromethyl)phenyl]-6H-pyrrolo[3,4-b]pyridin-6-yl}ethan-1-one, DNA (28-MER), DNA topoisomerase 2 著者 Schenk, A, Deniston, C, Noeske, J. 登録日 2023-03-01 公開日 2023-07-12 実験手法 ELECTRON MICROSCOPY (2.94 Å) 主引用文献 Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science, 380, 2023
3KSB	Detailed structural insight into the DNA cleavage complex of type IIA topoisomerases (re-sealed form) 分子名称: 5'-D(*AP*CP*CP*AP*AP*GP*GP*T*CP*AP*TP*GP*AP*AP*TP*GP*AP*CP*TP*AP*TP*GP*CP*AP*CP*GP*TP*AP*AP*AP*AP*CP*AP*G)-3', 5'-D(*CP*TP*GP*TP*TP*TP*TP*A*CP*GP*TP*GP*CP*AP*TP*AP*GP*TP*CP*AP*TP*TP*CP*AP*TP*GP*AP*CP*CP*TP*TP*GP*GP*T)-3', DNA topoisomerase 4 subunit A, ... 著者 Laponogov, I, Pan, X.-S, Veselkov, D.A, McAuley, K.E, Fisher, L.M, Sanderson, M.R. 登録日 2009-11-21 公開日 2010-05-05 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases Plos One, 5, 2010
3KSA	Detailed structural insight into the DNA cleavage complex of type IIA topoisomerases (cleaved form) 分子名称: 5'-D(*AP*CP*CP*AP*AP*GP*GP*T*CP*AP*TP*GP*AP*AP*T)-3', 5'-D(*CP*TP*GP*TP*TP*TP*TP*A*CP*GP*TP*GP*CP*AP*T)-3', 5'-D(P*AP*GP*TP*CP*AP*TP*TP*CP*AP*TP*GP*AP*CP*CP*TP*TP*GP*GP*T)-3', ... 著者 Laponogov, I, Pan, X.-S, Veselkov, D.A, McAuley, K.E, Fisher, L.M, Sanderson, M.R. 登録日 2009-11-21 公開日 2010-05-05 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases Plos One, 5, 2010
7LHZ	K. pneumoniae Topoisomerase IV (ParE-ParC) in complex with DNA and (3S)-10-[(3R)-3-(1-aminocyclopropyl)pyrrolidin-1-yl]-9-fluoro-3-methyl-5-oxo-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid (compound 25) 分子名称: (3S)-10-[(3R)-3-(1-aminocyclopropyl)pyrrolidin-1-yl]-9-fluoro-3-methyl-5-oxo-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid, (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(*GP*AP*TP*CP*AP*TP*AP*CP*AP*AP*CP*GP*TP*AP*A)-3'), ... 著者 Noeske, J, Shu, W, Bellamacina, C. 登録日 2021-01-26 公開日 2021-05-12 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria. J.Med.Chem., 64, 2021
4RUL	Crystal structure of full-length E.Coli topoisomerase I in complex with ssDNA 分子名称: DNA topoisomerase 1, GLYCEROL, SULFATE ION, ... 著者 Tan, K, Chen, B, Tse-Dinh, Y.C. 登録日 2014-11-20 公開日 2015-11-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis for suppression of hypernegative DNA supercoiling by E. coli topoisomerase I. Nucleic Acids Res., 43, 2015
7YQ8	Cryo-EM structure of human topoisomerase II beta in complex with DNA and etoposide 分子名称: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, 50-mer DNA, DNA topoisomerase 2-beta, ... 著者 Naganuma, M, Ehara, H, Kim, D, Nakagawa, R, Cong, A, Bu, H, Jeong, J, Jang, J, Schellenberg, M.J, Bunch, H, Sekine, S. 登録日 2022-08-05 公開日 2024-01-03 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 ERK2-topoisomerase II regulatory axis is important for gene activation in immediate early genes. Nat Commun, 14, 2023
1MX0	Structure of topoisomerase subunit 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SODIUM ION, ... 著者 Corbett, K.D, Berger, J.M. 登録日 2002-10-01 公開日 2003-01-07 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of the topoisomerase VI-B subunit: implications for type II topoisomerase mechanism and evolution Embo J., 22, 2003
6OZW	Crystal structure of the 65-kilodalton amino-terminal fragment of DNA topoisomerase I from Streptococcus mutans 分子名称: DNA topoisomerase 1, FORMIC ACID, MAGNESIUM ION 著者 Jones, J.A, Hevener, K.E. 登録日 2019-05-16 公開日 2019-06-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.063 Å) 主引用文献 Crystal structure of the 65-kilodalton amino-terminal fragment of DNA topoisomerase I from the gram-positive model organism Streptococcus mutans. Biochem.Biophys.Res.Commun., 516, 2019
1MU5	Structure of topoisomerase subunit 分子名称: CALCIUM ION, Type II DNA topoisomerase VI Subunit B 著者 Corbett, K.D, Berger, J.M. 登録日 2002-09-23 公開日 2003-01-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of the topoisomerase VI-B subunit: implications for type II topoisomerase mechanism and evolution Embo J., 22, 2003
6PCM	Crystal Structure of Mycobacterium smegmatis Topoisomerase I with ssDNA bound to both N- and C-terminal domains 分子名称: DNA (5'-D(P*AP*GP*TP*GP*AP*GP*CP*GP*AP*GP*CP*TP*TP*CP*CP*GP*CP*TP*TP*GP*AP*CP*TP*T)-3'), DNA topoisomerase 1, SULFATE ION 著者 Tan, K, Cao, N, Tse-Dinh, Y.C. 登録日 2019-06-17 公開日 2020-03-25 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.107 Å) 主引用文献 Mechanistic insights from structure of Mycobacterium smegmatis topoisomerase I with ssDNA bound to both N- and C-terminal domains. Nucleic Acids Res., 48, 2020
1MW9	Crystal Structure of H365R mutant of 67 kDA N-terminal fragment of E. coli DNA Topoisomerase I 分子名称: DNA Topoisomerase I, SULFATE ION 著者 Perry, K, Mondragon, A. 登録日 2002-09-27 公開日 2003-10-14 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Structure of a Complex between E. coli DNA Topoisomerase I and Single-Stranded DNA. Structure, 11, 2003
7ZBG	Human Topoisomerase II Beta ATPase ADP 分子名称: 4-[(2S,3R)-3-[3,5-bis(oxidanylidene)piperazin-1-ium-1-yl]butan-2-yl]piperazin-4-ium-2,6-dione, ADENOSINE-5'-DIPHOSPHATE, DNA topoisomerase 2-beta, ... 著者 Ling, E.M, Basle, A, Cowell, I.G, Blower, T.R, Austin, C.A. 登録日 2022-03-23 公開日 2022-05-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193. Structure, 30, 2022
1MW8	Crystal Structure of a Complex between H365R mutant of 67 kDA N-terminal fragment of E. coli DNA Topoisomerase I and 5'-ACTTCGGGATG-3' 分子名称: 5'-D(*AP*CP*TP*TP*CP*GP*GP*GP*AP*TP*G)-3', DNA Topoisomerase I, SULFATE ION, ... 著者 Perry, K, Mondragon, A. 登録日 2002-09-27 公開日 2003-10-14 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure of a Complex between E. coli DNA Topoisomerase I and Single-Stranded DNA. Structure, 11, 2003
2GAI	Structure of Full Length Topoisomerase I from Thermotoga maritima in triclinic crystal form 分子名称: DNA topoisomerase I 著者 Hansen, G. 登録日 2006-03-08 公開日 2006-04-25 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal Structure of Full Length Topoisomerase I from Thermotoga maritima J.Mol.Biol., 358, 2006
2O5E	Structure of E. coli topoisomerase III in complex with an 8-base single stranded oligonucleotide. Frozen in glucose pH 7.0 分子名称: 5'-D(*CP*GP*CP*AP*AP*CP*TP*T)-3', CHLORIDE ION, DNA topoisomerase 3, ... 著者 Changela, A, DiGate, R.J, Mondragon, A. 登録日 2006-12-05 公開日 2007-04-03 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural Studies of E. coli Topoisomerase III-DNA Complexes Reveal a Novel Type IA Topoisomerase-DNA Conformational Intermediate. J.Mol.Biol., 368, 2007
5UJ1	Crystal structure of Mycobacterium tuberculosis Topoisomerase I at 2.15A resolution limit 分子名称: DNA topoisomerase 1, SULFATE ION 著者 Cao, N, Tan, K, Tse-Dinh, Y.C. 登録日 2017-01-16 公開日 2018-01-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.153 Å) 主引用文献 Investigating mycobacterial topoisomerase I mechanism from the analysis of metal and DNA substrate interactions at the active site. Nucleic Acids Res., 46, 2018
2O5C	Structure of E. coli topoisomerase III in complex with an 8-base single stranded oligonucleotide. Frozen in glucose pH 5.5 分子名称: 5'-D(*CP*GP*CP*AP*AP*CP*TP*T)-3', CHLORIDE ION, DNA topoisomerase 3, ... 著者 Changela, A, DiGate, R.J, Mondragon, A. 登録日 2006-12-05 公開日 2007-04-03 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structural Studies of E. coli Topoisomerase III-DNA Complexes Reveal a Novel Type IA Topoisomerase-DNA Conformational Intermediate. J.Mol.Biol., 368, 2007
2O54	Structure of E. coli topoisomerase III in complex with an 8-base single stranded oligonucleotide. Frozen in glycerol at pH 7.0 分子名称: 5'-D(*CP*GP*CP*AP*AP*CP*TP*T)-3', ACETIC ACID, CHLORIDE ION, ... 著者 Changela, A, Digate, R.J, Mondragon, A. 登録日 2006-12-05 公開日 2007-04-03 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural Studies of E. coli Topoisomerase III-DNA Complexes Reveal a Novel Type IA Topoisomerase-DNA Conformational Intermediate. J.Mol.Biol., 368, 2007

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