4KPC

Crystal structure of the nucleoside diphosphate kinase b from Leishmania braziliensis

Summary for 4KPC

• Entry DOI: 10.2210/pdb4kpc/pdb
• Descriptor: Nucleoside diphosphate kinase b, PHOSPHATE ION (3 entities in total)
• Functional Keywords: ndpk superfamily, transferase
• Biological source: Leishmania braziliensis
• Total number of polymer chains: 2
• Total formula weight: 37952.68

Authors

Vieira, P.S.,Giuseppe, P.O.,Santos, C.R.,Cunha, E.M.F.,de Oliveira, A.H.C.,Murakami, M.T. (deposition date: 2013-05-13, release date: 2014-07-09, Last modification date: 2024-02-28)

Primary citation

Vieira, P.S.,de Giuseppe, P.O.,Murakami, M.T.,de Oliveira, A.H.
Crystal structure and biophysical characterization of the nucleoside diphosphate kinase from Leishmania braziliensis.
Bmc Struct.Biol., 15:2-2, 2015

PubMed Abstract: Nucleoside diphosphate kinase (NDK) is a housekeeping enzyme that plays key roles in nucleotide recycling and homeostasis in trypanosomatids. It is also secreted by the intracellular parasite Leishmania to modulate the host response. These functions make NDK an attractive target for drug design and for studies aiming at a better understanding of the mechanisms mediating host-pathogen interactions.

PubMed: 25643978
DOI: 10.1186/s12900-015-0030-8

Experimental method

X-RAY DIFFRACTION (2.7 Å)