4R3F
 
 | | Structure of the spliceosomal peptidyl-prolyl cis-trans isomerase Cwc27 from Chaetomium thermophilum | | 分子名称: | 1,2-ETHANEDIOL, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, ACETATE ION, ... | | 著者 | Ulrich, A, Wahl, M.C. | | 登録日 | 2014-08-15 | | 公開日 | 2014-11-19 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Structure and evolution of the spliceosomal peptidyl-prolyl cis-trans isomerase Cwc27.
Acta Crystallogr.,Sect.D, 70, 2014
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8H6L
 | | Cryo-EM structure of human exon-defined spliceosome in the early B state. | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | | 著者 | Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. | | 登録日 | 2022-10-18 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structural insights into human exon-defined spliceosome prior to activation.
Cell Res., 34, 2024
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8H6K
 | | Cryo-EM structure of human exon-defined spliceosome in the mature B state. | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | | 著者 | Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. | | 登録日 | 2022-10-18 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural insights into human exon-defined spliceosome prior to activation.
Cell Res., 34, 2024
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8H6E
 | | Cryo-EM structure of human exon-defined spliceosome in the late pre-B state. | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | | 著者 | Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. | | 登録日 | 2022-10-17 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural insights into human exon-defined spliceosome prior to activation.
Cell Res., 34, 2024
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8H6J
 | | Cryo-EM structure of human exon-defined spliceosome in the mature pre-B state. | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | | 著者 | Zhang, W, Zhan, X, Zhang, X, Lei, J, Yan, C, Shi, Y. | | 登録日 | 2022-10-18 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | | 主引用文献 | Structural insights into human exon-defined spliceosome prior to activation.
Cell Res., 34, 2024
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7DCO
 | | Cryo-EM structure of the activated spliceosome (Bact complex) at an atomic resolution of 2.5 angstrom | | 分子名称: | BJ4_G0014900.mRNA.1.CDS.1, BJ4_G0027490.mRNA.1.CDS.1, BJ4_G0037700.mRNA.1.CDS.1, ... | | 著者 | Bai, R, Wan, R, Yan, C, Qi, J, Zhang, P, Lei, J, Shi, Y. | | 登録日 | 2020-10-26 | | 公開日 | 2021-03-17 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2.
Science, 371, 2021
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4WZJ
 | | Spliceosomal U4 snRNP core domain | | 分子名称: | Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, Small nuclear ribonucleoprotein G, ... | | 著者 | Leung, A.K.W, Nagai, K, Li, J. | | 登録日 | 2014-11-19 | | 公開日 | 2015-01-14 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis.
Nature, 473, 2011
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7ABH
 | | Human pre-Bact-2 spliceosome (SF3b/U2 snRNP portion) | | 分子名称: | Cell division cycle 5-like protein, DNA/RNA-binding protein KIN17, MINX M3 pre-mRNA, ... | | 著者 | Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. | | 登録日 | 2020-09-07 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
Science, 370, 2020
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2FHO
 | | NMR solution structure of the human spliceosomal protein complex p14-SF3b155 | | 分子名称: | spliceosomal protein SF3b155, spliceosomal protein p14 | | 著者 | Kuwasako, K, Dohmae, N, Inoue, M, Shirouzu, M, Guntert, P, Seraphin, B, Muto, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2005-12-26 | | 公開日 | 2006-12-26 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR solution structure of the human spliceosomal protein complex p14-SF3b155
To be Published
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4ZB4
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1MZW
 | | Crystal structure of a U4/U6 snRNP complex between human spliceosomal cyclophilin H and a U4/U6-60K peptide | | 分子名称: | U-snRNP-associated cyclophilin, U4/U6 snrnp 60kDa protein | | 著者 | Reidt, U, Wahl, M.C, Horowitz, D.S, Luehrmann, R, Ficner, R. | | 登録日 | 2002-10-10 | | 公開日 | 2003-08-19 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide
J.Mol.Biol., 331, 2003
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3CW1
 | | Crystal Structure of Human Spliceosomal U1 snRNP | | 分子名称: | Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, Small nuclear ribonucleoprotein G, ... | | 著者 | Pomeranz Krummel, D.A, Oubridge, C, Leung, A.K, Li, J, Nagai, K. | | 登録日 | 2008-04-21 | | 公開日 | 2009-03-24 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (5.493 Å) | | 主引用文献 | Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution.
Nature, 458, 2009
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7W5B
 | | The cryo-EM structure of human C* complex | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | | 著者 | Zhan, X, Lu, Y, Shi, Y. | | 登録日 | 2021-11-29 | | 公開日 | 2022-06-22 | | 最終更新日 | 2022-08-17 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Mechanism of exon ligation by human spliceosome.
Mol.Cell, 82, 2022
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7W5A
 | | The cryo-EM structure of human pre-C*-II complex | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | | 著者 | Zhan, X, Lu, Y, Shi, Y. | | 登録日 | 2021-11-29 | | 公開日 | 2022-06-22 | | 最終更新日 | 2022-08-17 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Mechanism of exon ligation by human spliceosome.
Mol.Cell, 82, 2022
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7W59
 | | The cryo-EM structure of human pre-C*-I complex | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | | 著者 | Zhan, X, Lu, Y, Shi, Y. | | 登録日 | 2021-11-29 | | 公開日 | 2022-06-22 | | 最終更新日 | 2022-08-17 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Mechanism of exon ligation by human spliceosome.
Mol.Cell, 82, 2022
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8Y6O
 | | Cryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U11 and tri-snRNP part | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, Centrosomal AT-AC splicing factor, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Bai, R, Yuan, M, Zhang, P, Luo, T, Shi, Y, Wan, R. | | 登録日 | 2024-02-02 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | | 主引用文献 | Structural basis of U12-type intron engagement by the fully assembled human minor spliceosome.
Science, 383, 2024
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8Y7E
 | | Cryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U12 snRNP part | | 分子名称: | PHD finger-like domain-containing protein 5A, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, ... | | 著者 | Bai, R, Yuan, M, Zhang, P, Luo, T, Shi, Y, Wan, R. | | 登録日 | 2024-02-04 | | 公開日 | 2024-03-13 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4.66 Å) | | 主引用文献 | Structural basis of U12-type intron engagement by the fully assembled human minor spliceosome.
Science, 383, 2024
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6AHD
 | | The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolution | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, Brr2, U5 small nuclear ribonucleoprotein 200 kDa helicase, ... | | 著者 | Zhan, X, Yan, C, Zhang, X, Shi, Y. | | 登録日 | 2018-08-17 | | 公開日 | 2018-11-14 | | 最終更新日 | 2021-06-30 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structures of the human pre-catalytic spliceosome and its precursor spliceosome.
Cell Res., 28, 2018
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6BK8
 | | S. cerevisiae spliceosomal post-catalytic P complex | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, Lea1, ... | | 著者 | Liu, S, Li, X, Zhou, Z.H, Zhao, R. | | 登録日 | 2017-11-07 | | 公開日 | 2018-02-21 | | 最終更新日 | 2020-10-14 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure of the yeast spliceosomal postcatalytic P complex.
Science, 358, 2017
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7A5P
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4PJ3
 | | Structural insight into the function and evolution of the spliceosomal helicase Aquarius, Structure of Aquarius in complex with AMPPNP | | 分子名称: | Intron-binding protein aquarius, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | 著者 | De, I, Bessonov, S, Hofele, R, dos Santos, K.F, Will, C.L, Urlaub, H, Luhrmann, R, Pena, V. | | 登録日 | 2014-05-11 | | 公開日 | 2015-01-21 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes.
Nat.Struct.Mol.Biol., 22, 2015
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6EXN
 | | Post-catalytic P complex spliceosome with 3' splice site docked | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, Intron lariat: UBC4 RNA, ... | | 著者 | Wilkinson, M.E, Fica, S.M, Galej, W.P, Norman, C.M, Newman, A.J, Nagai, K. | | 登録日 | 2017-11-08 | | 公開日 | 2018-01-17 | | 最終更新日 | 2020-10-07 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Postcatalytic spliceosome structure reveals mechanism of 3'-splice site selection.
Science, 358, 2017
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6QX9
 | | Structure of a human fully-assembled precatalytic spliceosome (pre-B complex). | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, AdML pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Charenton, C, Wilkinson, M.E, Nagai, K. | | 登録日 | 2019-03-07 | | 公開日 | 2019-04-17 | | 最終更新日 | 2020-10-07 | | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | | 主引用文献 | Mechanism of 5' splice site transfer for human spliceosome activation.
Science, 364, 2019
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2F9D
 | | 2.5 angstrom resolution structure of the spliceosomal protein p14 bound to region of SF3b155 | | 分子名称: | Pre-mRNA branch site protein p14, Splicing factor 3B subunit 1 | | 著者 | Schellenberg, M.J, Edwards, R.A, Ritchie, D.B, Glover, J.N.M, Macmillan, A.M. | | 登録日 | 2005-12-05 | | 公開日 | 2006-01-24 | | 最終更新日 | 2017-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structure of a core spliceosomal protein interface
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2F9J
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