6WR0
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![BU of 6wr0 by Molmil](/molmil-images/mine/6wr0) | Human steroidogenic cytochrome P450 17A1 with 3-keto-delta4-abiraterone analog | 分子名称: | (8alpha)-17-(pyridin-3-yl)androsta-4,16-dien-3-one, CHLORIDE ION, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Petrunak, E.M, Bart, A.G, Scott, E.E. | 登録日 | 2020-04-29 | 公開日 | 2021-05-05 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Human cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site. J.Biol.Chem., 299, 2023
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6WW0
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![BU of 6ww0 by Molmil](/molmil-images/mine/6ww0) | Human steroidogenic cytochrome P450 17A1 with 3-keto-5alpha-abiraterone analog | 分子名称: | (5alpha,8alpha)-17-(pyridin-3-yl)androst-16-en-3-one, CHLORIDE ION, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Petrunak, E.M, Bart, A.G, Scott, E.E. | 登録日 | 2020-05-07 | 公開日 | 2021-05-26 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Human cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site. J.Biol.Chem., 299, 2023
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6PRR
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![BU of 6prr by Molmil](/molmil-images/mine/6prr) | The crystal structure of 3-methylaminobenzoate-bound CYP199A4 | 分子名称: | 3-(methylamino)benzoic acid, CHLORIDE ION, Cytochrome P450, ... | 著者 | Podgorski, M.N, Bruning, J.B, Bell, S.G. | 登録日 | 2019-07-11 | 公開日 | 2019-11-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Investigation of the requirements for efficient and selective cytochrome P450 monooxygenase catalysis across different reactions. J.Inorg.Biochem., 203, 2019
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6PQ6
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![BU of 6pq6 by Molmil](/molmil-images/mine/6pq6) | The crystal structure of 3-methoxybenzoate-bound CYP199A4 | 分子名称: | 3-methoxybenzoic acid, CHLORIDE ION, Cytochrome P450, ... | 著者 | Podgorski, M.N, Bell, S.G, Bruning, J.B. | 登録日 | 2019-07-08 | 公開日 | 2019-11-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.658 Å) | 主引用文献 | Investigation of the requirements for efficient and selective cytochrome P450 monooxygenase catalysis across different reactions. J.Inorg.Biochem., 203, 2019
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6PQS
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![BU of 6pqs by Molmil](/molmil-images/mine/6pqs) | The crystal structure of 4-methylbenzoate-bound CYP199A4 | 分子名称: | 4-METHYLBENZOIC ACID, CHLORIDE ION, Cytochrome P450, ... | 著者 | Podgorski, M.N, Bruning, J.B, Bell, S.G. | 登録日 | 2019-07-10 | 公開日 | 2019-11-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Investigation of the requirements for efficient and selective cytochrome P450 monooxygenase catalysis across different reactions. J.Inorg.Biochem., 203, 2019
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6PRS
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![BU of 6prs by Molmil](/molmil-images/mine/6prs) | The crystal structure of 3-ethoxybenzoate-bound CYP199A4 | 分子名称: | 3-ethoxybenzoic acid, CHLORIDE ION, Cytochrome P450, ... | 著者 | Podgorski, M.N, Bruning, J.B, Bell, S.G. | 登録日 | 2019-07-11 | 公開日 | 2019-11-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.373 Å) | 主引用文献 | Investigation of the requirements for efficient and selective cytochrome P450 monooxygenase catalysis across different reactions. J.Inorg.Biochem., 203, 2019
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6PQD
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![BU of 6pqd by Molmil](/molmil-images/mine/6pqd) | The crystal structure of 3-methylthiobenzoate-bound CYP199A4 | 分子名称: | 3-(methylsulfanyl)benzoic acid, CHLORIDE ION, Cytochrome P450, ... | 著者 | Podgorski, M.N, Bruning, J.B, Bell, S.G. | 登録日 | 2019-07-09 | 公開日 | 2019-11-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Investigation of the requirements for efficient and selective cytochrome P450 monooxygenase catalysis across different reactions. J.Inorg.Biochem., 203, 2019
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6PQW
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![BU of 6pqw by Molmil](/molmil-images/mine/6pqw) | The crystal structure of 3-methylbenzoate-bound CYP199A4 | 分子名称: | 3-methylbenzoic acid, CHLORIDE ION, Cytochrome P450, ... | 著者 | Podgorski, M.N, Bruning, J.B, Bell, S.G. | 登録日 | 2019-07-10 | 公開日 | 2019-11-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.679 Å) | 主引用文献 | Investigation of the requirements for efficient and selective cytochrome P450 monooxygenase catalysis across different reactions. J.Inorg.Biochem., 203, 2019
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3CP4
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6CPP
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![BU of 6cpp by Molmil](/molmil-images/mine/6cpp) | CRYSTAL STRUCTURES OF CYTOCHROME P450-CAM COMPLEXED WITH CAMPHANE, THIOCAMPHOR, AND ADAMANTANE: FACTORS CONTROLLING P450 SUBSTRATE HYDROXYLATION | 分子名称: | CAMPHANE, CYTOCHROME P450-CAM, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Raag, R, Poulos, T.L. | 登録日 | 1990-05-18 | 公開日 | 1991-07-15 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structures of cytochrome P-450CAM complexed with camphane, thiocamphor, and adamantane: factors controlling P-450 substrate hydroxylation. Biochemistry, 30, 1991
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7Q9E
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![BU of 7q9e by Molmil](/molmil-images/mine/7q9e) | CYP106A1 | 分子名称: | COBALT (II) ION, Cytochrome P450, DI(HYDROXYETHYL)ETHER, ... | 著者 | Carius, Y, Hutter, M, Kiss, F, Bernhardt, R, Lancaster, C.R.D. | 登録日 | 2021-11-12 | 公開日 | 2022-10-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural comparison of the cytochrome P450 enzymes CYP106A1 and CYP106A2 provides insight into their differences in steroid conversion. Febs Lett., 596, 2022
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3FJO
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![BU of 3fjo by Molmil](/molmil-images/mine/3fjo) | Structure of chimeric YH CPR | 分子名称: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADPH-cytochrome P450 reductase | 著者 | Morera, S, Aigrain, L, Truan, G. | 登録日 | 2008-12-15 | 公開日 | 2009-06-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of the open conformation of a functional chimeric NADPH cytochrome P450 reductase Embo Rep., 10, 2009
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8JNC
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![BU of 8jnc by Molmil](/molmil-images/mine/8jnc) | Crystal structure of cytochrome P450 IkaD from Streptomyces sp. ZJ306, in complex with the substrate 10-epi-maltophilin | 分子名称: | (1Z,3E,5S,8R,9S,10S,11R,13R,15R,16S,18Z,24S,25S)-11-ethyl-2,24-dihydroxy-10-methyl-21,26-diazapentacyclo[23.2.1.09,13.08,15.05,16]octacosa-1(2),3,18-triene-7,20,27,28-tetraone, Cytochrome P450, FORMIC ACID, ... | 著者 | Zhang, Y.L, Zhang, L.P, Zhang, C.S. | 登録日 | 2023-06-06 | 公開日 | 2023-11-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A Mechanistic Understanding of the Distinct Regio- and Chemoselectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates. Angew.Chem.Int.Ed.Engl., 62, 2023
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8JOO
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![BU of 8joo by Molmil](/molmil-images/mine/8joo) | Crystal structure of cytochrome P450 IkaD from Streptomyces sp. ZJ306, in complex with the substrate ikarugamycin | 分子名称: | (1Z,3E,5S,7R,8R,10R,11R,12S,15R,16S,18Z,25S)-11-ethyl-2-hydroxy-10-methyl-21,26-diazapentacyclo[23.2.1.05,16.07,15.08,12]octacosa-1(2),3,13,18-tetraene-20,27,28-trione, Cytochrome P450, FORMIC ACID, ... | 著者 | Zhang, Y.L, Zhang, L.P, Zhang, C.S. | 登録日 | 2023-06-08 | 公開日 | 2023-11-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | A Mechanistic Understanding of the Distinct Regio- and Chemoselectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates. Angew.Chem.Int.Ed.Engl., 62, 2023
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8JNO
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![BU of 8jno by Molmil](/molmil-images/mine/8jno) | Crystal structure of cytochrome P450 IkaD from Streptomyces sp. ZJ306, in complex with the substrate 10-epi-deOH-HSAF | 分子名称: | (1Z,3E,5S,7S,8R,9S,10S,11R,13R,15R,16S,18Z,25S)-11-ethyl-2,7-dihydroxy-10-methyl-21,26-diazapentacyclo[23.2.1.09,13.08,15.05,16]octacosa-1(2),3,18-triene-20,27,28-trione, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Zhang, Y.L, Zhang, L.P, Zhang, C.S. | 登録日 | 2023-06-06 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A Mechanistic Understanding of the Distinct Regio- and Chemoselectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates. Angew.Chem.Int.Ed.Engl., 62, 2023
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8JUA
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![BU of 8jua by Molmil](/molmil-images/mine/8jua) | Multifunctional cytochrome P450 enzyme IkaD from Streptomyces sp. ZJ306, in complex with epoxyikarugamycin | 分子名称: | (1Z,3E,5S,7R,8R,10R,11R,12S,13R,15S,16R,17S,19Z,26S)-11-ethyl-2-hydroxy-10-methyl-22,27-diaza-14 oxahexacyclo[24.2.1.05,17.07,16.013,15.08,12]nonacosa-1(2),3,19-triene-21,28,29-trione, Cytochrome P450, FORMIC ACID, ... | 著者 | Zhang, Y.L, Zhang, L.P, Zhang, C.S. | 登録日 | 2023-06-26 | 公開日 | 2023-11-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.00001121 Å) | 主引用文献 | A Mechanistic Understanding of the Distinct Regio- and Chemoselectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates. Angew.Chem.Int.Ed.Engl., 62, 2023
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8Q6Y
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![BU of 8q6y by Molmil](/molmil-images/mine/8q6y) | Crystal structure of Cytochrome P450 GymB5 from Streptomyces katrae in complex with cYY and Hypoxanthine | 分子名称: | (3S,6S)-3,6-bis(4-hydroxybenzyl)piperazine-2,5-dione, 1,2-ETHANEDIOL, Cytochrome P450, ... | 著者 | Freytag, J, Mueller, J.M, Stehle, T, Zocher, G. | 登録日 | 2023-08-15 | 公開日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Intramolecular Coupling and Nucleobase Transfer - How Cytochrome P450 Enzymes GymBx Establish Their Chemoselectivity Chemcatchem, 16, 2024
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7LAD
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![BU of 7lad by Molmil](/molmil-images/mine/7lad) | Clobetasol propionate bound to CYP3A5 | 分子名称: | Clobetasol propionate, Cytochrome P450 3A5, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Buchman, C.D, Miller, D, Wang, J, Jayaraman, S, Chen, T. | 登録日 | 2021-01-06 | 公開日 | 2021-10-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5. J.Am.Chem.Soc., 143, 2021
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1SMI
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![BU of 1smi by Molmil](/molmil-images/mine/1smi) | A single mutation of P450 BM3 induces the conformational rearrangement seen upon substrate-binding in wild-type enzyme | 分子名称: | Bifunctional P-450:NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Joyce, M.G, Girvan, H.M, Munro, A.W, Leys, D. | 登録日 | 2004-03-09 | 公開日 | 2004-06-08 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A Single Mutation in Cytochrome P450 BM3 Induces the Conformational Rearrangement Seen upon Substrate Binding in the Wild-type Enzyme J.Biol.Chem., 279, 2004
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2IJ4
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![BU of 2ij4 by Molmil](/molmil-images/mine/2ij4) | Structure of the A264K mutant of cytochrome P450 BM3 | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, cytochrome P450 BM3 | 著者 | Toogood, H.S, Leys, D. | 登録日 | 2006-09-29 | 公開日 | 2006-11-07 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural and spectroscopic characterization of P450 BM3 mutants with unprecedented P450 heme iron ligand sets. New heme ligation states influence conformational equilibria in P450 BM3. J.Biol.Chem., 282, 2007
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2QBN
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![BU of 2qbn by Molmil](/molmil-images/mine/2qbn) | Crystal structure of ferric G248V cytochrome P450cam | 分子名称: | CAMPHOR, Cytochrome P450-cam, POTASSIUM ION, ... | 著者 | von Koenig, K, Makris, T.M, Sligar, S.D, Schlichting, I. | 登録日 | 2007-06-18 | 公開日 | 2007-12-25 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Alteration of P450 Distal Pocket Solvent Leads to Impaired Proton Delivery and Changes in Heme Geometry. Biochemistry, 46, 2007
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8TAY
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![BU of 8tay by Molmil](/molmil-images/mine/8tay) | |
8TAW
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![BU of 8taw by Molmil](/molmil-images/mine/8taw) | |
8TNK
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![BU of 8tnk by Molmil](/molmil-images/mine/8tnk) | |
2QBL
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![BU of 2qbl by Molmil](/molmil-images/mine/2qbl) | Crystal structure of ferric G248T cytochrome P450cam | 分子名称: | CAMPHOR, Cytochrome P450-cam, POTASSIUM ION, ... | 著者 | von Koenig, K, Makris, T.M, Sligar, S.D, Schlichting, I. | 登録日 | 2007-06-18 | 公開日 | 2007-12-25 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Alteration of P450 Distal Pocket Solvent Leads to Impaired Proton Delivery and Changes in Heme Geometry. Biochemistry, 46, 2007
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