PDB: 1955 件ウェブページステータス検索Chemie searchBIRD

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4MK9	Hepatitis C Virus polymerase NS5B genotype 1b (BK) in complex with inhibitor 12 (N-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydropyridin-3-yl)phenyl]-1,3-benzoxazol-5-yl}methanesulfonamide) 分子名称: GLYCEROL, N-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydropyridin-3-yl)phenyl]-1,3-benzoxazol-5-yl}methanesulfonamide, RNA-DIRECTED RNA POLYMERASE 著者 Harris, S.F, Wong, A. 登録日 2013-09-04 公開日 2013-10-09 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Discovery of a Novel Series of Potent Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B. J.Med.Chem., 56, 2013
4MKA	Hepatitis C Virus polymerase NS5B genotype 1b (BK) in complex with inhibitor 13 (N-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydropyridin-3-yl)phenyl]-1,3-benzoxazol-5-yl}methanesulfonamide) 分子名称: DIMETHYL SULFOXIDE, GLYCEROL, N-{3-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydropyridin-3-yl)phenyl]-1-oxo-1H-isochromen-7-yl}methanesulfonamide, ... 著者 Harris, S.F, Wong, A. 登録日 2013-09-04 公開日 2013-10-09 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Discovery of a Novel Series of Potent Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B. J.Med.Chem., 56, 2013
7MPF	The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000986436 分子名称: 5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-oxo-2-[2-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... 著者 Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. 登録日 2021-05-04 公開日 2022-05-04 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
7ELH	In situ structure of transcriptional enzyme complex and capsid shell protein of mammalian reovirus at initiation state 分子名称: Lambda 1, Minor core protein mu2, PHOSPHATE ION, ... 著者 Zhou, Z.H, Pan, M. 登録日 2021-04-11 公開日 2021-10-20 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Asymmetric reconstruction of mammalian reovirus reveals interactions among RNA, transcriptional factor mu2 and capsid proteins. Nat Commun, 12, 2021
7D6N	Crystal structure of tick-borne encephalitis virus RNA-dependent RNA polymerase 分子名称: MAGNESIUM ION, Tick-borne encephalitis virus RNA-dependent RNA polymerase, ZINC ION 著者 Yang, J, Jing, X, Gong, P. 登録日 2020-10-01 公開日 2020-12-23 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.168 Å) 主引用文献 Crystal structure of tick-borne encephalitis virus Nucleic Acids Res., 2020
7CXN	Architecture of a SARS-CoV-2 mini replication and transcription complex 分子名称: Helicase, Non-structural protein 7, Non-structural protein 8, ... 著者 Yan, L, Zhang, Y, Ge, J, Zheng, L, Gao, Y, Wang, T, Jia, Z, Wang, H, Huang, Y, Li, M, Wang, Q, Rao, Z, Lou, Z. 登録日 2020-09-02 公開日 2020-11-04 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.84 Å) 主引用文献 Architecture of a SARS-CoV-2 mini replication and transcription complex. Nat Commun, 11, 2020
7CXM	Architecture of a SARS-CoV-2 mini replication and transcription complex 分子名称: Helicase, Non-structural protein 7, Non-structural protein 8, ... 著者 Yan, L, Zhang, Y, Ge, J, Zheng, L, Gao, Y, Wang, T, Jia, Z, Wang, H, Huang, Y, Li, M, Wang, Q, Rao, Z, Lou, Z. 登録日 2020-09-02 公開日 2020-11-04 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Architecture of a SARS-CoV-2 mini replication and transcription complex. Nat Commun, 11, 2020
8R6Y	Structure of the SFTSV L protein stalled in a transcription-specific early elongation state with bound capped RNA [TRANSCRIPTION-EARLY-ELONGATION] 分子名称: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, MAGNESIUM ION, RNA (5'-R(*(M7G)*AP*AP*A)-3'), ... 著者 Williams, H.M, Thorkelsson, S.R, Vogel, D, Busch, C, Milewski, M, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. 登録日 2023-11-23 公開日 2024-04-24 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural snapshots of phenuivirus cap-snatching and transcription. Nucleic Acids Res., 2024
5T2T	Crystal structure of Lymphocytic choriomeningitis mammarenavirus endonuclease bound to compound L742001 分子名称: (2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid, CHLORIDE ION, GLYCEROL, ... 著者 Saez-Ayala, M, Yekwa, E.L, Canard, B, Alvarez, K, Ferron, F. 登録日 2016-08-24 公開日 2017-09-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.967 Å) 主引用文献 Crystal structures ofLymphocytic choriomeningitis virusendonuclease domain complexed with diketo-acid ligands. IUCrJ, 5, 2018
8R6W	Structure of the SFTSV L protein in a transcription-priming state with bound capped RNA [TRANSCRIPTION-PRIMING] 分子名称: RNA (5'-R(*(M7G)*AP*AP*A)-3'), RNA (5'-R(*AP*CP*AP*C)-3'), RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*CP*AP*G)-3'), ... 著者 Williams, H.M, Thorkelsson, S.R, Vogel, D, Busch, C, Milewski, M, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. 登録日 2023-11-23 公開日 2024-04-24 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.35 Å) 主引用文献 Structural snapshots of phenuivirus cap-snatching and transcription. Nucleic Acids Res., 2024
8R6U	Structure of the SFTSV L protein in a transcription-priming state without capped RNA [TRANSCRIPTION-PRIMING (in vitro)] 分子名称: MAGNESIUM ION, RNA (5'-R(P*CP*UP*GP*GP*GP*CP*GP*GP*UP*CP*UP*UP*UP*GP*UP*GP*U)-3'), RNA primer, ... 著者 Williams, H.M, Thorkelsson, S.R, Vogel, D, Busch, C, Milewski, M, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. 登録日 2023-11-23 公開日 2024-04-24 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (2.98 Å) 主引用文献 Structural snapshots of phenuivirus cap-snatching and transcription. Nucleic Acids Res., 2024
5LTN	Crystal structure of Lymphocytic choriomeningitis mammarenavirus endonuclease complexed with DPBA 分子名称: 2-4-DIOXO-4-PHENYLBUTANOIC ACID, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Saez-Ayala, M, Yekwa, E.L, Canard, B, Alvarez, K, Ferron, F. 登録日 2016-09-07 公開日 2017-09-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Crystal structures of Lymphocytic choriomeningitis virusendonuclease domain complexed with diketo-acid ligands. Iucrj, 5, 2018
5LTF	Crystal structure of Lymphocytic choriomeningitis mammarenavirus endonuclease complexed with catalytic ions 分子名称: MAGNESIUM ION, RNA-directed RNA polymerase L 著者 Saez-Ayala, M, Yekwa, E.L, Canard, B, Ferron, F. 登録日 2016-09-06 公開日 2017-09-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Crystal structures ofLymphocytic choriomeningitis virusendonuclease domain complexed with diketo-acid ligands. IUCrJ, 5, 2018
5LTS	Crystal structure of Lymphocytic choriomeningitis mammarenavirus endonuclease Mutant D118A 分子名称: CHLORIDE ION, GLYCEROL, RNA-directed RNA polymerase L, ... 著者 Saez-Ayala, M, Yekwa, E.L, Canard, B, Alvarez, K, Ferron, F. 登録日 2016-09-07 公開日 2017-09-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 Crystal structures ofLymphocytic choriomeningitis virusendonuclease domain complexed with diketo-acid ligands. IUCrJ, 5, 2018
7LM4	The crystal structure of the I38T mutant PA Endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988503 分子名称: 5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-2-(2-methylphenyl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... 著者 Cuypers, M.G, Slavish, P.J, Jayaraman, S, Rankovic, Z, White, S.W. 登録日 2021-02-05 公開日 2022-02-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
7MTY	The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988569 分子名称: 2-(2,6-difluorophenyl)-5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-3,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... 著者 Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. 登録日 2021-05-13 公開日 2022-05-18 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
6OGZ	In situ structure of Rotavirus RNA-dependent RNA polymerase at transcript-elongated state 分子名称: GUANOSINE-5'-TRIPHOSPHATE, Inner capsid protein VP2, RNA (5'-R(P*AP*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*UP*A)-3'), ... 著者 Ding, K, Chang, T, Shen, W, Roy, P, Zhou, Z.H. 登録日 2019-04-03 公開日 2019-05-22 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release. Nat Commun, 10, 2019
7N47	The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988514 分子名称: 5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-2-(2-methylphenyl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... 著者 Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. 登録日 2021-06-03 公開日 2022-06-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
7N55	The crystal structure of the mutant I38T PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988514 分子名称: 5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-2-(2-methylphenyl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... 著者 Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. 登録日 2021-06-04 公開日 2022-06-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
7N8F	The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988288 分子名称: Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, Polymerase acidic protein, ... 著者 Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. 登録日 2021-06-14 公開日 2022-06-15 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
6OGY	In situ structure of Rotavirus RNA-dependent RNA polymerase at duplex-open state 分子名称: DNA/RNA (5'-D(*(GTG))-R(P*GP*C)-3'), Inner capsid protein VP2, RNA (5'-R(P*AP*GP*CP*C)-3'), ... 著者 Ding, K, Chang, T, Shen, W, Roy, P, Zhou, Z.H. 登録日 2019-04-03 公開日 2019-05-22 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release. Nat Commun, 10, 2019
7OYG	Dimeric form of SARS-CoV-2 RNA-dependent RNA polymerase 分子名称: RNA (5'-R(P*CP*UP*AP*CP*GP*CP*AP*GP*UP*G)-3'), RNA (5'-R(P*UP*GP*CP*AP*CP*UP*GP*CP*GP*UP*AP*G)-3'), SARS-CoV-2 RNA-dependent RNA polymerase (nsp12), ... 著者 Jochheim, F.A, Tegunov, D, Hillen, H.S, Schmitzova, J, Kokic, G, Dienemann, C, Cramer, P. 登録日 2021-06-24 公開日 2021-08-25 最終更新日 2021-09-01 実験手法 ELECTRON MICROSCOPY (5.5 Å) 主引用文献 The structure of a dimeric form of SARS-CoV-2 polymerase Communications Biology, 4, 2021
4MIW	High-resolution structure of the N-terminal endonuclease domain of the Lassa virus L polymerase 分子名称: MAGNESIUM ION, RNA-directed RNA polymerase L 著者 Wallat, G.D, Huang, Q, Wang, W, Dong, H, Ly, H, Liang, Y, Dong, C. 登録日 2013-09-02 公開日 2014-03-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 High-resolution structure of the N-terminal endonuclease domain of the lassa virus L polymerase in complex with magnesium ions. Plos One, 9, 2014
2E9Z	Foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA, ATP and UTP 分子名称: 5'-R(*CP*AP*UP*GP*GP*GP*CP*CP*C)-3', 5'-R(*GP*GP*GP*CP*CP*CP*A)-3', MAGNESIUM ION, ... 著者 Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. 登録日 2007-01-29 公開日 2007-06-26 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Sequential structures provide insights into the fidelity of RNA replication Proc.Natl.Acad.Sci.Usa, 104, 2007
5H0R	RNA dependent RNA polymerase ,vp4,dsRNA 分子名称: RNA (42-MER), RNA-dependent RNA polymerase, VP4 protein 著者 Li, X, Zhou, N, Chen, W, Zhu, B, Wang, X, Xu, B, Wang, J, Liu, H, Cheng, L. 登録日 2016-10-06 公開日 2017-01-25 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Near-Atomic Resolution Structure Determination of a Cypovirus Capsid and Polymerase Complex Using Cryo-EM at 200kV J. Mol. Biol., 429, 2017

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