PDB: 245663 件ウェブページステータス検索Chemie searchBIRD

---

5JNB	structure of GLD-2/RNP-8 complex 分子名称: 1,2-ETHANEDIOL, MAGNESIUM ION, Poly(A) RNA polymerase gld-2, ... 著者 Nakel, K, Bonneau, F, Basquin, C, Eckmann, C.R, Conti, E. 登録日 2016-04-29 公開日 2016-06-22 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.486 Å) 主引用文献 Structural basis for the antagonistic roles of RNP-8 and GLD-3 in GLD-2 poly(A)-polymerase activity. Rna, 22, 2016
6OP9	HER3 pseudokinase domain bound to bosutinib 分子名称: 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile, Receptor tyrosine-protein kinase erbB-3 著者 Littlefield, P, Agnew, C, Jura, N. 登録日 2019-04-24 公開日 2019-08-21 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.501 Å) 主引用文献 Targetable HER3 functions driving tumorigenic signaling in HER2-amplified cancers. Cell Rep, 38, 2022
7RLV	Antibody 2F2 in complex with P. vivax CSP peptide GDRADGQPAGDRADGQPA 分子名称: 1,2-ETHANEDIOL, 2F2 Fab heavy chain, 2F2 Fab light chain, ... 著者 Kucharska, I, Julien, J.P. 登録日 2021-07-26 公開日 2022-01-26 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural basis of Plasmodium vivax inhibition by antibodies binding to the circumsporozoite protein repeats. Elife, 11, 2022
9MJ3	Crystal structure of the VRC01-class antibody 12A01, derived from GT1.1 vaccination, in complex with eOD-GT8 分子名称: 12A01 Fab heavy chain, 12A01 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Agrawal, S, Wilson, I.A. 登録日 2024-12-13 公開日 2025-05-28 最終更新日 2025-08-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Precise targeting of HIV broadly neutralizing antibody precursors in humans. Science, 389, 2025
8UNP	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class E) 分子名称: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Papasergi-Scott, M.M, Skiniotis, G. 登録日 2023-10-19 公開日 2024-03-06 最終更新日 2024-11-20 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8P78	Cryo-EM structure of CAK in complex with inhibitor dinaciclib 分子名称: 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, CDK-activating kinase assembly factor MAT1, Cyclin-H, ... 著者 Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J. 登録日 2023-05-30 公開日 2024-03-20 最終更新日 2024-10-09 実験手法 ELECTRON MICROSCOPY (1.9 Å) 主引用文献 High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design. Nat Commun, 15, 2024
5JDG	Structural mechanisms of extracellular ion exchange and induced binding-site occlusion in the sodium-calcium exchanger NCX_Mj soaked with 2.5 mM Na+ and 0.1mM Ca2+ 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... 著者 Liao, J, Jiang, Y.X, Faraldo-Gomez, J.D. 登録日 2016-04-16 公開日 2016-05-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.407 Å) 主引用文献 Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger. Nat.Struct.Mol.Biol., 23, 2016
5JDL	Structural mechanisms of extracellular ion exchange and induced binding-site occlusion in the sodium-calcium exchanger NCX_Mj soaked with 2.5 mM Na+ and 1mM Sr2+ 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHLORIDE ION, PENTADECANE, ... 著者 Liao, J, Jiang, Y.X, Faraldo-Gomez, J.D. 登録日 2016-04-17 公開日 2016-05-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.904 Å) 主引用文献 Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger. Nat.Struct.Mol.Biol., 23, 2016
6QTJ	Crystal structure of human CDK8/CYCC in complex with BI 919811 分子名称: Cyclin-C, Cyclin-dependent kinase 8, ~{N},~{N}-dimethyl-2-[4-[4-(2,6-naphthyridin-4-yl)phenyl]pyrazol-1-yl]ethanamide 著者 Boettcher, J. 登録日 2019-02-25 公開日 2020-03-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.48 Å) 主引用文献 Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance. Mol.Cancer Ther., 19, 2020
6TS9	Crystal structure of GES-5 carbapenemase 分子名称: 1,2-ETHANEDIOL, BROMIDE ION, Beta-lactamase, ... 著者 Maso, L, Tondi, D, Klein, R, Montanari, M, Bellio, C, Celenza, G, Brenk, R, Cendron, L. 登録日 2019-12-20 公開日 2020-03-04 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Targeting the Class A Carbapenemase GES-5 via Virtual Screening. Biomolecules, 10, 2020
8PKC	Structure of Api m1 in complex with the AM1-4 nanobody 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, AM1-4 nanobody, Phospholipase A2 著者 Aagaard, J.B, Gandini, R, Spillner, E, Miehe, M. 登録日 2023-06-26 公開日 2024-05-08 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (4.1 Å) 主引用文献 Nanobody-based IgG formats as blocking antibodies of the major honeybee venom allergen Api m 1 To be published
7MPS	Brucella melitensis NrnC with engaged loop 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, NanoRNase C, SULFATE ION 著者 Lormand, J.D, Sondermann, H. 登録日 2021-05-04 公開日 2021-09-15 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structural characterization of NrnC identifies unifying features of dinucleotidases. Elife, 10, 2021
8IVX	Crystal structure of NRP2 in complex with aNRP2-14 Fab fragment 分子名称: 1,2-ETHANEDIOL, Heavy chain of antibody 14V4 Fab fragment, Light chain of antibody 14V4 Fab fragment, ... 著者 Geng, Y, Zhai, L. 登録日 2023-03-29 公開日 2023-07-12 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer. Sci Transl Med, 15, 2023
9GIO	Crystal structure of the VHL-EloC-EloB complex with a covalent compound bound to C77 of VHL. 分子名称: Elongin-B, Isoform 2 of Elongin-C, N-[2-(dimethylsulfamoyl)-5-[(1-methylpyrazol-4-yl)methoxy]phenyl]propanamide, ... 著者 Collie, G.W. 登録日 2024-08-19 公開日 2025-03-26 最終更新日 2025-04-30 実験手法 X-RAY DIFFRACTION (1.486 Å) 主引用文献 Discovery of a Series of Covalent Ligands That Bind to Cys77 of the Von Hippel-Lindau Tumor Suppressor Protein (VHL). Acs Med.Chem.Lett., 16, 2025
6QPK	Zt-KP6-1: an effector from Zymoseptoria tritici 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CITRIC ACID, SULFATE ION, ... 著者 Padilla, A, Hoh, F, De guillen, K. 登録日 2019-02-14 公開日 2020-03-04 最終更新日 2025-01-29 実験手法 X-RAY DIFFRACTION (1.36 Å) 主引用文献 Zymoseptoria tritici effectors structurally related to killer proteins UmV-KP4 and UmV-KP6 are toxic to fungi, and define extended protein families in fungi Biorxiv, 2024
5XM5	Crystal structure of Zinc binding protein ZinT at 1.49 Angstrom from E. coli 分子名称: Metal-binding protein ZinT, SODIUM ION, ZINC ION 著者 Chen, J, Wang, L, Guo, J, Xu, Y. 登録日 2017-05-12 公開日 2017-05-31 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.493 Å) 主引用文献 Crystal structure of Zinc binding protein ZinT at 1.49 Angstrom from E. coli To Be Published
7BJS	Crystal structure of Khc/atypical Tm1 complex 分子名称: Kinesin heavy chain, SD21996p 著者 Dimitrova-Paternoga, L, Jagtap, P.K.A, Ephrussi, A, Hennig, J. 登録日 2021-01-14 公開日 2021-05-26 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Molecular basis of mRNA transport by a kinesin-1-atypical tropomyosin complex. Genes Dev., 35, 2021
7BJN	Crystal structure of atypical Tm1 (Tm1-I/C), residues 270-334 分子名称: SD21996p 著者 Dimitrova-Paternoga, L, Jagtap, P.K.A, Ephrussi, A, Hennig, J. 登録日 2021-01-14 公開日 2021-05-26 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Molecular basis of mRNA transport by a kinesin-1-atypical tropomyosin complex. Genes Dev., 35, 2021
6X2Y	Crystal Structure of mDia2NES peptide bound to CRM1(E571K) 分子名称: 1,2-ETHANEDIOL, Exportin-1, GLYCEROL, ... 著者 Baumhardt, J.M. 登録日 2020-05-21 公開日 2020-07-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.304 Å) 主引用文献 Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
6O9W	Crystal structure of Staphylococcus aureus BlaR1 antibiotic-sensor domain in complex with avibactam 分子名称: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Regulatory protein BlaR1 著者 Alexander, J.A.N, Strynadka, N.C.J. 登録日 2019-03-15 公開日 2020-06-10 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural analysis of avibactam-mediated activation of the bla and mec divergons in methicillin-resistant Staphylococcus aureus . J.Biol.Chem., 295, 2020
6HZK	Crystal structure of redox-inhibited phosphoribulokinase from Synechococcus sp. (strain PCC 6301) 分子名称: Phosphoribulokinase 著者 Wilson, R.H, Bracher, A, Hartl, F.U, Hayer-Hartl, M. 登録日 2018-10-23 公開日 2019-03-27 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of phosphoribulokinase from Synechococcus sp. strain PCC 6301. Acta Crystallogr.,Sect.F, 75, 2019
5LNC	Structure of SPX domain of the yeast inorganic polyphophate polymerase Vtc4 crystallized by carrier-driven crystallization in fusion with the macro domain of human histone macroH2A1.1 分子名称: Vacuolar transporter chaperone 4,Core histone macro-H2A.1 著者 Wild, R, Hothorn, M. 登録日 2016-08-03 公開日 2016-11-09 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.29 Å) 主引用文献 The macro domain as fusion tag for carrier-driven crystallization. Protein Sci., 26, 2017
6HZY	Crystal structure of a bacterial fucosidase with inhibitor FucPUG 分子名称: 1,2-ETHANEDIOL, Alpha-L-fucosidase, SULFATE ION, ... 著者 Wu, L, Davies, G.J, Stubbs, K.A, Coyle, T, Debowski, A.W. 登録日 2018-10-24 公開日 2019-02-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Synthetic and Crystallographic Insight into Exploiting sp2Hybridization in the Development of alpha-l-Fucosidase Inhibitors. Chembiochem, 20, 2019
9GGW	Human KRas4A (GDP) in complex with compound 16 分子名称: 1,2-ETHANEDIOL, 11-(4-aminocyclohexyl)-16-chloro-1,15-dihydroxy-10,10-dioxo-10lambda6-thia-2,11lambda6-diaza-1lambda6,15lambda6-diphospha-3-phosphoniapentacyclo[7.5.1.01,15.03,15.013,15]hexadecan-12-one, GTPase KRas, ... 著者 Schuettelkopf, A.W. 登録日 2024-08-14 公開日 2025-04-16 最終更新日 2025-05-21 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Reversible Small Molecule Multivariant Ras Inhibitors Display Tunable Affinity for the Active and Inactive Forms of Ras. J.Med.Chem., 68, 2025
6HDI	R49A variant of beta-phosphoglucomutase from Lactococcus lactis in an open conformer to 2.0 A. 分子名称: 1,2-ETHANEDIOL, Beta-phosphoglucomutase, MAGNESIUM ION 著者 Robertson, A.J, Bisson, C, Waltho, J.P. 登録日 2018-08-17 公開日 2020-08-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Transition state of phospho-enzyme hydrolysis in beta-phosphoglucomutase. To Be Published

<1841184218431844184518461847184818491850185118521853185418551856>