PDB: 621 件ウェブページステータス検索Chemie searchBIRD

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6YOW	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521 分子名称: 14-3-3 protein sigma, 4-(methylsulfonyl)benzaldehyde, p65pS45 著者 Wolter, M, Ottmann, C. 登録日 2020-04-15 公開日 2020-09-23 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.23 Å) 主引用文献 Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering. Angew.Chem.Int.Ed.Engl., 59, 2020
6YPY	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-123 分子名称: 14-3-3 protein sigma, 4-(4-ethanoylpiperazin-1-yl)sulfonylbenzaldehyde, p65pS45 著者 Wolter, M, Ottmann, C. 登録日 2020-04-16 公開日 2020-09-23 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering. Angew.Chem.Int.Ed.Engl., 59, 2020
6Y3O	14-3-3 Sigma in complex with phosphorylated CAMKK2 peptide 分子名称: 14-3-3 protein sigma, CALCIUM ION, CAMKK2, ... 著者 Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C. 登録日 2020-02-18 公開日 2020-10-14 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 A new soaking procedure for X-ray crystallographic structural determination of protein-peptide complexes. Acta Crystallogr.,Sect.F, 76, 2020
6Y3W	Ternary complex of 14-3-3 sigma (C38N), Estrogen Related Receptor gamma (DBD) phosphopeptide, and disulfide PPI stabilizer 1 分子名称: 14-3-3 protein sigma, 3-fluoranyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ... 著者 Somsen, B.A, Ottmann, C. 登録日 2020-02-19 公開日 2020-11-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.34 Å) 主引用文献 Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers. Acs Chem.Biol., 15, 2020
6R5L	Fragment AZ-006 binding at the p53pT387/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 4-[[(2~{S})-1-azanylpropan-2-yl]amino]-6-(sulfanylmethyl)-1-benzothiophene-2-carboximidamide, CHLORIDE ION, ... 著者 Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Castaldi, P, Ottmann, C. 登録日 2019-03-25 公開日 2020-06-17 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.884 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6XY5	Ternary complex of 14-3-3 sigma (C38N), Estrogen Related Receptor gamma (DBD) phosphopeptide, and disulfide PPI stabilizer 5 分子名称: 14-3-3 protein sigma, 3-bromanyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ... 著者 Somsen, B.A, Ottmann, C. 登録日 2020-01-29 公開日 2020-11-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers. Acs Chem.Biol., 15, 2020
6YPL	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-037 分子名称: (2-methylsulfonylphenyl)methanol, 14-3-3 protein sigma, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2020-04-16 公開日 2020-09-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering. Angew.Chem.Int.Ed.Engl., 59, 2020
6QZR	14-3-3 sigma in complex with FOXO1 pT24 peptide 分子名称: 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Forkhead box protein O1, ... 著者 Ottmann, C, Wolter, M, Lau, R.A. 登録日 2019-03-12 公開日 2019-07-31 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins. J.Biol.Chem., 294, 2019
6RJL	Fragment AZ-018 binding at the TAZpS89/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 5-(3-azanylpropyl)-4-phenyl-thiophene-2-carboximidamide, TAZpS89 著者 Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-04-27 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RM7	Fragment AZ-026 binding at the p53pT387/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 5-[3-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide, CHLORIDE ION, ... 著者 Somsen, B, Wolter, M, Guillory, X, Genet, S, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-05-05 公開日 2020-06-17 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6YMO	Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pS617 peptide 分子名称: 14-3-3 protein zeta/delta, 2-HYDROXYBENZOIC ACID, Glucocorticoid receptor, ... 著者 Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. 登録日 2020-04-09 公開日 2021-03-24 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
6YOS	Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 pS617 peptide 分子名称: 14-3-3 protein zeta/delta, Glucocorticoid receptor,Glucocorticoid receptor 著者 Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. 登録日 2020-04-15 公開日 2021-03-24 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
6YO8	Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 peptide 分子名称: 14-3-3 protein zeta/delta, Glucocorticoid receptor 著者 Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. 登録日 2020-04-14 公開日 2021-03-24 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
6RWH	Fragment AZ-007 binding at a primary and secondary binding site of the the p53pT387/14-3-3 sigma complex 分子名称: 14-3-3 protein sigma, 5-(1~{H}-imidazol-5-yl)-4-phenyl-thiophene-2-carboximidamide, CALCIUM ION, ... 著者 Leysen, S, Guillory, X, Wolter, M, Genet, S, Somsen, B, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-06-05 公開日 2020-06-17 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6YE9	Small-molecule inhibitor of 14-3-3 protein-protein interactions 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, [2-[2-oxidanylidene-2-[(phenylmethyl)amino]ethoxy]phenyl]phosphonic acid 著者 Ottmann, C, Visser, E.J. 登録日 2020-03-24 公開日 2021-03-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-based conversion of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions To Be Published
6Y7T	Engineered conjugation of lysine-specific molecular tweezers with ExoS derived peptidic inhibitor enhance affinity towards target protein 14-3-3 through ditopic binding 分子名称: 14-3-3 protein sigma, ExoSTWZ molecular tweezer, Exoenzyme S, ... 著者 Guillory, X, Ottmann, C. 登録日 2020-03-02 公開日 2021-03-31 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Supramolecular Enhancement of a Natural 14-3-3 Protein Ligand. J.Am.Chem.Soc., 143, 2021
6RJQ	Fragment AZ-006 binding at the TAZpS89/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 4-[[(2~{S})-1-azanylpropan-2-yl]amino]-6-(sulfanylmethyl)-1-benzothiophene-2-carboximidamide, TAZpS89 著者 Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Castaldi, P, Ottmann, C, Patel, J. 登録日 2019-04-29 公開日 2020-06-17 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.885 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RM5	Fragment AZ-016 binding at the p53pT387/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 7-(6-azanyl-5-methyl-pyridin-2-yl)-1-benzothiophene-2-carboximidamide, CHLORIDE ION, ... 著者 Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-05-05 公開日 2020-06-17 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.884 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6YIA	14-3-3 sigma in complex with SMAD2 pS465 peptide 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Kiehstaller, S, Graf, S, Hennig, S. 登録日 2020-04-01 公開日 2021-04-14 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Identification and characterization of 14-3-3/SMAD protein-protein-interactions To Be Published
6YIC	14-3-3 sigma in complex with SMAD4 pS403 peptide 分子名称: 14-3-3 protein sigma, CALCIUM ION, GLYCEROL, ... 著者 Kiehstaller, S, Graf, S, Hennig, S. 登録日 2020-04-01 公開日 2021-04-14 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Identification and characterization of 14-3-3/SMAD protein-protein-interactions To Be Published
6YIB	14-3-3 sigma in complex with SMAD3 pS423 peptide 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Kiehstaller, S, Graf, S, Hennig, S. 登録日 2020-04-01 公開日 2021-04-14 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Identification and characterization of 14-3-3/SMAD protein-protein-interactions To Be Published
6YR7	14-3-3 sigma in complex with hDMX-342+367 peptide 分子名称: 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Protein Mdm4 著者 Wolter, M, Srdanovic, S, Warriner, S, Wilson, A, Ottmann, C. 登録日 2020-04-19 公開日 2021-11-03 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.105 Å) 主引用文献 Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study. Febs J., 2022
6YR5	14-3-3 sigma in complex with hDMX-367 peptide 分子名称: 14-3-3 protein sigma, Protein Mdm4, SULFATE ION 著者 Wolter, M, Srdanovic, S, Ottman, C, Warriner, S, Wilson, A. 登録日 2020-04-19 公開日 2021-11-03 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study. Febs J., 2022
6YR6	14-3-3 sigma in complex with hDM2-186 peptide 分子名称: 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, IODIDE ION, ... 著者 Wolter, M, Srdanovic, S, Warriner, S, Wilson, A, Ottmann, C. 登録日 2020-04-19 公開日 2021-11-03 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study. Febs J., 2022
6SLW	Fragment AZ-004 binding at the TAZpS89/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 4-methyl-5-phenyl-thiophene-2-carboximidamide, WW domain-containing transcription regulator protein 1 著者 Ottmann, C, Wolter, M, Guillory, X, Leysen, S, Genet, S, Somsen, B, Patel, J, Castaldi, P. 登録日 2019-08-20 公開日 2020-06-17 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020

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