6MM9
 
 | | Diheteromeric NMDA receptor GluN1/GluN2A in the '1-Knuckle' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 6.1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ... | | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | | 登録日 | 2018-09-29 | | 公開日 | 2018-11-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (5.97 Å) | | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
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6MMB
 | | Diheteromeric NMDA receptor GluN1/GluN2A in the 'Super-Splayed' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 6.1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ... | | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | | 登録日 | 2018-09-30 | | 公開日 | 2018-11-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (12.7 Å) | | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
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6MMG
 | | Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar EDTA, and at pH 7.4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | | 登録日 | 2018-09-30 | | 公開日 | 2018-11-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (6.23 Å) | | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
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6MMJ
 | | Diheteromeric NMDA receptor GluN1/GluN2A in the 'Super-Splayed' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar zinc chloride, and at pH 7.4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ... | | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | | 登録日 | 2018-09-30 | | 公開日 | 2018-11-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (16.5 Å) | | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
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6MMK
 | | Diheteromeric NMDA receptor GluN1/GluN2A in the '1-Knuckle' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | | 登録日 | 2018-09-30 | | 公開日 | 2018-11-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (6.08 Å) | | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
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6MMH
 | | Diheteromeric NMDA receptor GluN1/GluN2A in the 'Extended-2' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar zinc chloride, and at pH 7.4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ... | | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | | 登録日 | 2018-09-30 | | 公開日 | 2018-11-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (8.21 Å) | | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
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6MMI
 | | Diheteromeric NMDA receptor GluN1/GluN2A in the 'Splayed-Open' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar zinc chloride, and at pH 7.4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | | 登録日 | 2018-09-30 | | 公開日 | 2018-11-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (8.93 Å) | | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
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6MMM
 | | Diheteromeric NMDA receptor GluN1/GluN2A in the 'Extended-1' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | | 登録日 | 2018-09-30 | | 公開日 | 2018-11-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (6.84 Å) | | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
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6MML
 | | Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Asymmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | | 登録日 | 2018-09-30 | | 公開日 | 2018-11-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (7.14 Å) | | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
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6MMR
 | | Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar zinc chloride, 3 millimolar EDTA, and at pH 7.4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ... | | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | | 登録日 | 2018-10-01 | | 公開日 | 2018-11-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (5.13 Å) | | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
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6MMS
 | | Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar EDTA, and at pH 7.4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | | 登録日 | 2018-10-01 | | 公開日 | 2018-11-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (5.38 Å) | | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
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6MMV
 | | Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* Extracellular Domain in the '2-Knuckle-Asymmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | | 登録日 | 2018-10-01 | | 公開日 | 2018-11-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (4.71 Å) | | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
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6MMN
 | | Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 8.0 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | | 登録日 | 2018-10-01 | | 公開日 | 2018-11-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (7.51 Å) | | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
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6MMX
 | | Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* in the 'Extended' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | | 登録日 | 2018-10-01 | | 公開日 | 2018-11-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (6.99 Å) | | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
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6MMW
 | | Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | | 登録日 | 2018-10-01 | | 公開日 | 2018-11-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (6.2 Å) | | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
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6MMT
 | | Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* in the '1-Knuckle' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | | 登録日 | 2018-10-01 | | 公開日 | 2018-11-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (7.46 Å) | | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
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6MMU
 | | Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* in the '2-Knuckle-Asymmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | | 登録日 | 2018-10-01 | | 公開日 | 2018-11-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (5.3 Å) | | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
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6MMP
 | | Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 0.1 millimolar EDTA, and at pH 8.0 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | | 登録日 | 2018-10-01 | | 公開日 | 2018-11-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (6.88 Å) | | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor.
Cell, 175, 2018
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6IRA
 | | Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 7.8 | | 分子名称: | Glutamate receptor ionotropic, NMDA 1, NMDA 2A | | 著者 | Zhang, J, Chang, S, Zhang, X, Zhu, S. | | 登録日 | 2018-11-12 | | 公開日 | 2019-01-16 | | 最終更新日 | 2019-06-05 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors
Cell Rep, 25, 2018
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6IRH
 | | Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 6.3, Class III | | 分子名称: | Glutamate receptor ionotropic, NMDA 1, NMDA 2A | | 著者 | Zhang, J, Chang, S, Zhang, X, Zhu, S. | | 登録日 | 2018-11-12 | | 公開日 | 2019-01-16 | | 最終更新日 | 2019-06-05 | | 実験手法 | ELECTRON MICROSCOPY (7.8 Å) | | 主引用文献 | Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors
Cell Rep, 25, 2018
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6IRG
 | | Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 6.3, Class II | | 分子名称: | Glutamate receptor ionotropic, NMDA 1, NMDA 2A | | 著者 | Zhang, J, Chang, S, Zhang, X, Zhu, S. | | 登録日 | 2018-11-12 | | 公開日 | 2019-01-16 | | 最終更新日 | 2019-06-05 | | 実験手法 | ELECTRON MICROSCOPY (5.5 Å) | | 主引用文献 | Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors
Cell Rep, 25, 2018
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6IRF
 | | Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 6.3, Class I | | 分子名称: | Glutamate receptor ionotropic, NMDA 1, NMDA 2A | | 著者 | Zhang, J, Chang, S, Zhang, X, Zhu, S. | | 登録日 | 2018-11-12 | | 公開日 | 2019-01-16 | | 最終更新日 | 2019-06-05 | | 実験手法 | ELECTRON MICROSCOPY (5.1 Å) | | 主引用文献 | Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors
Cell Rep, 25, 2018
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6Q54
 | | Structure of GluA2 ligand-binding domain (S1S2J) in complex with the agonist (S)-2-Amino-3-(1-ethyl-4-hydroxy-1H-1,2,3-triazol-5-yl)propanoic acid at 1.4 A resolution | | 分子名称: | (2~{S})-2-azanyl-3-(3-ethyl-5-oxidanyl-1,2,3-triazol-4-yl)propanoic acid, CHLORIDE ION, CITRIC ACID, ... | | 著者 | Moellerud, S, Temperini, P, Kastrup, J.S. | | 登録日 | 2018-12-07 | | 公開日 | 2019-04-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands.
J.Med.Chem., 62, 2019
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6Q60
 | | Structure of GluA2 ligand-binding domain (S1S2J) in complex with the agonist (S)-2-Amino-3-(2-methyl-5-hydroxy-2H-1,2,3-triazol-4-yl)propanoic acid at 1.55 A resolution | | 分子名称: | (2~{S})-2-azanyl-3-(2-methyl-5-oxidanyl-1,2,3-triazol-4-yl)propanoic acid, CHLORIDE ION, GLYCEROL, ... | | 著者 | Moellerud, S, Temperini, P, Kastrup, J.S. | | 登録日 | 2018-12-10 | | 公開日 | 2019-04-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands.
J.Med.Chem., 62, 2019
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6NJL
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