9QCT
 
 | | Crystal structure of Rhizobium etli L-asparaginase ReAV R47A mutant | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, L-asparaginase II, ... | | 著者 | Pokrywka, K, Grzechowiak, M, Loch, J.I, Ruszkowski, M, Gilski, M, Jaskolski, M. | | 登録日 | 2025-03-05 | | 公開日 | 2025-07-16 | | 最終更新日 | 2025-08-06 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Probing the Active Site of Class 3 L-Asparaginase by Mutagenesis: Mutations of the Ser-Lys Tandems of ReAV.
Biomolecules, 15, 2025
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9QCU
 | | Crystal structure of Rhizobium etli L-asparaginase ReAV S48A mutant | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Pokrywka, K, Grzechowiak, M, Loch, J.I, Ruszkowski, M, Gilski, M, Jaskolski, M. | | 登録日 | 2025-03-05 | | 公開日 | 2025-07-16 | | 最終更新日 | 2025-08-06 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Probing the Active Site of Class 3 L-Asparaginase by Mutagenesis: Mutations of the Ser-Lys Tandems of ReAV.
Biomolecules, 15, 2025
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7PLN
 | | Structure of the APCbeta domain of Plasmodium vivax perforin-like protein 1 | | 分子名称: | Sporozoite micronemal protein essential for cell traversal, putative | | 著者 | Williams, S.I, Ni, T, Yu, X, Gilbert, R.J.C. | | 登録日 | 2021-08-31 | | 公開日 | 2022-06-29 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Structural, Functional and Computational Studies of Membrane Recognition by Plasmodium Perforin-Like Proteins 1 and 2
J.Mol.Biol., 434, 2022
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9QCY
 | | Crystal structure of Rhizobium etli L-asparaginase ReAV S80A mutant | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Pokrywka, K, Grzechowiak, M, Loch, J.I, Ruszkowski, M, Gilski, M, Jaskolski, M. | | 登録日 | 2025-03-05 | | 公開日 | 2025-07-16 | | 最終更新日 | 2025-08-06 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Probing the Active Site of Class 3 L-Asparaginase by Mutagenesis: Mutations of the Ser-Lys Tandems of ReAV.
Biomolecules, 15, 2025
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7A8S
 | | de novo designed ba8-barrel sTIM11 with an alpha-helical extension | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, sTIM11_h3 | | 著者 | Shanmugaratnam, S, Wiese, J.G, Hocker, B. | | 登録日 | 2020-08-31 | | 公開日 | 2021-03-24 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Extension of a de novo TIM barrel with a rationally designed secondary structure element.
Protein Sci., 30, 2021
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8QSY
 | | Portal capsid interface of full Haloferax tailed virus 1. | | 分子名称: | Capsid stabilization protein, HK97 gp5-like major capsid protein, HK97 gp6-like/SPP1 gp15-like head-tail connector, ... | | 著者 | Zhang, D, Daum, B, Isupov, M.N, McLaren, M. | | 登録日 | 2023-10-11 | | 公開日 | 2024-10-23 | | 最終更新日 | 2025-10-22 | | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | | 主引用文献 | Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail.
Sci Adv, 11, 2025
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9RP9
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7PGO
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6ZXM
 | | Diguanylate cyclase DgcR in complex with c-di-GMP | | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), MAGNESIUM ION, Putative GGDEF/response regulator receiver domain protein | | 著者 | Teixeira, R.D, Schirmer, T. | | 登録日 | 2020-07-29 | | 公開日 | 2021-03-31 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase.
Nat Commun, 12, 2021
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7PFN
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7NO0
 | | Structure of the mature RSV CA lattice: T=1 CA icosahedron | | 分子名称: | Capsid protein p27, alternate cleaved 1 | | 著者 | Obr, M, Ricana, C.L, Nikulin, N, Feathers, J.-P.R, Klanschnig, M, Thader, A, Johnson, M.C, Vogt, V.M, Schur, F.K.M, Dick, R.A. | | 登録日 | 2021-02-25 | | 公開日 | 2021-04-21 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer.
Nat Commun, 12, 2021
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8HF8
 | | Human PPAR delta ligand binding domain in complex with a synthetic agonist V1 | | 分子名称: | 2-[4-[[2,5-bis(oxidanylidene)-3-[4-(trifluoromethyl)phenyl]imidazolidin-1-yl]methyl]-2,6-dimethyl-phenoxy]-2-methyl-propanoic acid, Peroxisome proliferator-activated receptor delta, octyl beta-D-glucopyranoside | | 著者 | Dai, L, Sun, H.B, Yuan, H.L, Feng, Z.Q. | | 登録日 | 2022-11-09 | | 公開日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | Discovery of the First Subnanomolar PPAR alpha / delta Dual Agonist for the Treatment of Cholestatic Liver Diseases.
J.Med.Chem., 66, 2023
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6ZMD
 | | Crystal structure of HYPE covalently tethered to BiP bound to AMP-PNP | | 分子名称: | Endoplasmic reticulum chaperone BiP, MAGNESIUM ION, PHOSPHATE ION, ... | | 著者 | Fauser, J, Gulen, B, Pett, C, Hedberg, C, Itzen, A, Pogenberg, V. | | 登録日 | 2020-07-02 | | 公開日 | 2021-04-14 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | | 主引用文献 | Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD.
Nat Commun, 12, 2021
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7PEH
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9QQ1
 | | KRAS-G12D(1-169) - GDP IN covalent COMPLEX with compound (3S,4R)-8 | | 分子名称: | (2~{S})-4-[(1~{R},5~{S})-3-[7-(8-ethynyl-7-fluoranyl-3-oxidanyl-naphthalen-1-yl)-8-fluoranyl-2-[[(2~{R},8~{S})-2-fluoranyl-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]pyrido[4,3-d]pyrimidin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]-2-methyl-2-(oxan-4-ylmethyl)-4-oxidanylidene-butanoic acid, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ... | | 著者 | Ostermann, N. | | 登録日 | 2025-03-31 | | 公開日 | 2025-07-23 | | 最終更新日 | 2025-08-06 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Promise and Challenge of beta-Lactone Electrophiles to Target Aspartate 12 of Mutant KRAS G12D .
J.Med.Chem., 68, 2025
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8AYE
 | | E. coli 70S ribosome bound to thermorubin and fMet-tRNA | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Sanyal, S, Parajuli, N.P, Emmerich, A.G. | | 登録日 | 2022-09-02 | | 公開日 | 2023-03-01 | | 最終更新日 | 2025-03-12 | | 実験手法 | ELECTRON MICROSCOPY (1.96 Å) | | 主引用文献 | Antibiotic thermorubin tethers ribosomal subunits and impedes A-site interactions to perturb protein synthesis in bacteria.
Nat Commun, 14, 2023
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8AQV
 | | BA.2.12.1 SARS-CoV-2 Spike bound to mouse ACE2 (local) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2,Ig gamma-2A chain C region, ... | | 著者 | Lau, K, Ni, D, Beckert, B, Nazarov, S, Myasnikov, A, Pojer, F, Stahlberg, H, Uchikawa, E. | | 登録日 | 2022-08-13 | | 公開日 | 2023-03-01 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | | 主引用文献 | Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range.
Plos Pathog., 19, 2023
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6VXI
 | | Structure of ABCG2 bound to mitoxantrone | | 分子名称: | 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL | | 著者 | Orlando, B.J, Liao, M. | | 登録日 | 2020-02-21 | | 公開日 | 2020-05-13 | | 最終更新日 | 2025-05-14 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | ABCG2 transports anticancer drugs via a closed-to-open switch.
Nat Commun, 11, 2020
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8H25
 | | Lacticaseibacillus casei GH35 beta-galactosidase LBCZ_0230 | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-galactosidase, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Saburi, W, Ota, T, Kato, K, Tagami, T, Yamashita, K, Yao, M, Mori, H. | | 登録日 | 2022-10-04 | | 公開日 | 2023-08-16 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.295 Å) | | 主引用文献 | Function and Structure of Lacticaseibacillus casei GH35 beta-Galactosidase LBCZ_0230 with High Hydrolytic Activity to Lacto- N -biose I and Galacto- N -biose.
J Appl Glycosci (1999), 70, 2023
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9RM4
 | | Crystal Structure of ZIKV NS2B-NS3 protease in complex with ASAP-0015373 | | 分子名称: | SODIUM ION, Serine protease subunit NS2B,Serine protease NS3, ~{N}-[3-chloranyl-5-[(2-methyl-1-oxidanyl-propan-2-yl)carbamoyl]phenyl]-5-[(dimethylamino)methyl]-1~{H}-pyrrole-2-carboxamide | | 著者 | Ni, X, Marples, P.G, Godoy, A.S, Koekemoer, L, Aschenbrenner, J.C, Balcomb, B.H, Fairhead, M, Lithgo, R.M, Lee, A, Kenton, N, Thompson, W, Tomlinson, C.W.E, Wild, C, Winokan, M, Williams, E.P, Fearon, D, von Delft, F. | | 登録日 | 2025-06-17 | | 公開日 | 2025-07-23 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Crystal Structure of ZIKV NS2B-NS3 protease in complex with ASAP-0015373
To Be Published
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7PK8
 | | LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria | | 分子名称: | (2S,4S)-4-fluoranyl-N-[(3R,5R)-5-[[[4-[2-(4-methylphenyl)ethynyl]phenyl]carbonylamino]methyl]-1-(2-methylpropanoyl)pyrrolidin-3-yl]pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ... | | 著者 | Ryan, M.D, Pallin, T.D, Lamers, M.B.A.C, Leonard, P.M. | | 登録日 | 2021-08-25 | | 公開日 | 2022-09-07 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria
To Be Published
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7PJG
 | | LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria | | 分子名称: | (2R,4R)-N-[[4-(4-cyclopropylbuta-1,3-diynyl)phenyl]methyl]-1-(2-methylpropanoyl)-4-[[(2S,4R)-4-oxidanylpyrrolidin-2-yl]carbonylamino]pyrrolidine-2-carboxamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION | | 著者 | Ryan, M.D, Pallin, T.D, Lamers, M.B.A.C, Leonard, P.M. | | 登録日 | 2021-08-24 | | 公開日 | 2022-09-07 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria
To Be Published
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7NS3
 | | Substrate receptor scaffolding module of yeast Chelator-GID SR4 E3 ubiquitin ligase bound to Fbp1 substrate | | 分子名称: | BJ4_G0018240.mRNA.1.CDS.1, Fructose-bisphosphatase, Glucose-induced degradation protein 8, ... | | 著者 | Sherpa, D, Chrustowicz, J, Prabu, J.R, Schulman, B.A. | | 登録日 | 2021-03-05 | | 公開日 | 2021-05-05 | | 最終更新日 | 2025-07-09 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme.
Mol.Cell, 81, 2021
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9RM2
 | | BKPyV VP1 IN COMPLEX WITH 319C07-FAB | | 分子名称: | 1,2-ETHANEDIOL, 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, 319C07 antibody heavy chain, ... | | 著者 | Schmitt, S, Hillenbrand, M. | | 登録日 | 2025-06-17 | | 公開日 | 2025-07-09 | | 最終更新日 | 2025-07-30 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | A highly potent human antibody neutralizing all serotypes of BK polyomavirus.
Plos Pathog., 21, 2025
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7A9B
 | | Crystal structure of Shank1 PDZ domain with ARAP3-derived peptide | | 分子名称: | 1,2-ETHANEDIOL, SH3 and multiple ankyrin repeat domains protein 1,Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 | | 著者 | Mariam McAuley, M, Ali, M, Ivarsson, Y, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC) | | 登録日 | 2020-09-01 | | 公開日 | 2020-10-21 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of Shank1 PDZ domain with ARAP3-derived peptide
to be published
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