4XHK
 
 | | PIM1 kinase in complex with Compound 1s | | 分子名称: | 2-(2,6-difluorophenyl)-N-{4-[(3S)-pyrrolidin-3-yloxy]pyridin-3-yl}-1,3-thiazole-4-carboxamide, Serine/threonine-protein kinase pim-1 | | 著者 | Marcotte, D.J, Silvian, L.F. | | 登録日 | 2015-01-05 | | 公開日 | 2015-02-11 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure-based design of low-nanomolar PIM kinase inhibitors.
Bioorg.Med.Chem.Lett., 25, 2015
|
|
4HSH
 | | tRNA-guanine transglycosylase Y106F, V233G mutant in complex with queuine | | 分子名称: | 2-amino-5-({[(1S,4S,5R)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, GLYCEROL, Queuine tRNA-ribosyltransferase, ... | | 著者 | Biela, I, Tidten-Luksch, N, Heine, A, Reuter, K, Klebe, G. | | 登録日 | 2012-10-30 | | 公開日 | 2012-11-28 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | Investigation of Specificity Determinants in Bacterial tRNA-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, as Inhibitor.
Plos One, 8, 2013
|
|
4QF0
 | |
4XHI
 | | Crystal structure of native Thosea asigna virus RNA-dependent RNA polymerase (RdRP) at 2.15 Angstrom resolution | | 分子名称: | GLYCEROL, RNA-dependent RNA polymerase, SULFATE ION | | 著者 | Ferrero, D.S, Buxaderas, M, Rodriguez, J.F, Verdaguer, N. | | 登録日 | 2015-01-05 | | 公開日 | 2015-11-04 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | The Structure of the RNA-Dependent RNA Polymerase of a Permutotetravirus Suggests a Link between Primer-Dependent and Primer-Independent Polymerases.
Plos Pathog., 11, 2015
|
|
6SDM
 | |
6SCH
 | | NADH-dependent variant of CBADH | | 分子名称: | MAGNESIUM ION, NADP-dependent isopropanol dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | 著者 | Selles Vidal, L, Murray, J.W, Heap, J.T. | | 登録日 | 2019-07-24 | | 公開日 | 2020-08-26 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Versatile selective evolutionary pressure using synthetic defect in universal metabolism.
Nat Commun, 12, 2021
|
|
4QES
 | |
4Q1B
 | |
4Q1D
 | | Human dCK C4S-S74E mutant in complex with UDP and the inhibitor 9 {2-{[(1R)-1-{2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-propyl-1,3-thiazol-4-yl}ethyl]sulfanyl}pyrimidine-4,6-diamine} | | 分子名称: | (R)-2-((1-(2-(3-(2-fluoroethoxy)-4-methoxyphenyl)-5-propylthiazol-4-yl)ethyl)thio)pyrimidine-4,6-diamine, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE | | 著者 | Nomme, J, Lavie, A. | | 登録日 | 2014-04-03 | | 公開日 | 2015-02-18 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability.
J.Med.Chem., 57, 2014
|
|
3E78
 | | Structure determination of the cancer-associated Mycoplasma hyorhinis protein Mh-p37 | | 分子名称: | CALCIUM ION, CHLORIDE ION, High affinity transport system protein p37, ... | | 著者 | Sippel, K.H, Robbins, A.H, Reutzel, R, Domsic, J, McKenna, R. | | 登録日 | 2008-08-18 | | 公開日 | 2008-10-21 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure determination of the cancer-associated Mycoplasma hyorhinis protein Mh-p37.
Acta Crystallogr.,Sect.D, 64, 2008
|
|
4Q18
 | | Human dCK C4S-S74E mutant in complex with UDP and the inhibitor 4 [1-[5-(4-{[(2,6-diaminopyrimidin-4-yl)sulfanyl]methyl}-5-propyl-1,3-thiazol-2-yl)-2-methoxyphenoxy]-2-methylpropan-2-ol] | | 分子名称: | 1-(5-(4-(((2,6-diaminopyrimidin-4-yl)thio)methyl)-5-propylthiazol-2-yl)-2-methoxyphenoxy)-2-methylpropan-2-ol, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE | | 著者 | Nomme, J, Lavie, A. | | 登録日 | 2014-04-03 | | 公開日 | 2014-11-05 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability.
J.Med.Chem., 57, 2014
|
|
4Q19
 | | Human dCK C4S-S74E mutant in complex with UDP and the inhibitor 5 {5-(4-{[(4,6-DIAMINOPYRIMIDIN-2-YL)SULFANYL]METHYL}-5-PROPYL-1,3-THIAZOL-2-YL)-2-METHOXYPHENOL} | | 分子名称: | 5-(4-(((4,6-diaminopyrimidin-2-yl)thio)methyl)-5-propylthiazol-2-yl)-2-methoxyphenol, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE | | 著者 | Nomme, J, Lavie, A. | | 登録日 | 2014-04-03 | | 公開日 | 2014-11-05 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability.
J.Med.Chem., 57, 2014
|
|
4XWF
 | |
4XJV
 | | Crystal structure of human thioesterase 2 | | 分子名称: | CHLORIDE ION, S-acyl fatty acid synthase thioesterase, medium chain | | 著者 | Ritchie, M.K, Kridel, S.J, Lowther, W.T. | | 登録日 | 2015-01-09 | | 公開日 | 2015-12-16 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal Structure and Substrate Specificity of Human Thioesterase 2: INSIGHTS INTO THE MOLECULAR BASIS FOR THE MODULATION OF FATTY ACID SYNTHASE.
J.Biol.Chem., 291, 2016
|
|
4QFF
 | |
2LXN
 | | Solution NMR structure of glutamine amido transferase subunit of gaunosine monophosphate synthetase from Methanocaldococcus jannaschii | | 分子名称: | GMP synthase [glutamine-hydrolyzing] subunit A | | 著者 | Ali, R, Kumar, S, Balaram, H, Sarma, S.P. | | 登録日 | 2012-08-30 | | 公開日 | 2013-06-12 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | 1H, 13C, 15N assignment and secondary structure determination of glutamine amido transferase subunit of gaunosine monophosphate synthetase from Methanocaldococcus jannaschii
Biomol.Nmr Assign., 6, 2012
|
|
4QLB
 | | Structural Basis for the Recruitment of Glycogen Synthase by Glycogenin | | 分子名称: | GLYCEROL, Probable glycogen [starch] synthase, Protein GYG-1, ... | | 著者 | Zeqiraj, E, Judd, A, Sicheri, F. | | 登録日 | 2014-06-11 | | 公開日 | 2014-07-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural basis for the recruitment of glycogen synthase by glycogenin.
Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
6SGA
 | | Body domain of the mt-SSU assemblosome from Trypanosoma brucei | | 分子名称: | 9S rRNA, MAGNESIUM ION, PHOSPHATE ION, ... | | 著者 | Saurer, M, Ramrath, D.J.F, Niemann, M, Calderaro, S, Prange, C, Mattei, S, Scaiola, A, Leitner, A, Bieri, P, Horn, E.K, Leibundgut, M, Boehringer, D, Schneider, A, Ban, N. | | 登録日 | 2019-08-03 | | 公開日 | 2019-09-18 | | 最終更新日 | 2019-09-25 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery.
Science, 365, 2019
|
|
4XW7
 | |
7WBN
 | | PDB structure of RevCC | | 分子名称: | RevCC | | 著者 | Han, S, Kim, D, Kaur, M, Lim, Y.B, Barnwal, R.P. | | 登録日 | 2021-12-17 | | 公開日 | 2022-10-26 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Pseudo-Isolated alpha-Helix Platform for the Recognition of Deep and Narrow Targets.
J.Am.Chem.Soc., 144, 2022
|
|
4YLP
 | |
4YH5
 | | Lipomyces starkeyi levoglucosan kinase bound to ADP and Manganese | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, Levoglucosan kinase, ... | | 著者 | Bacik, J.P. | | 登録日 | 2015-02-26 | | 公開日 | 2015-09-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Producing Glucose 6-Phosphate from Cellulosic Biomass: STRUCTURAL INSIGHTS INTO LEVOGLUCOSAN BIOCONVERSION.
J.Biol.Chem., 290, 2015
|
|
4YLO
 | |
7U07
 | |
7U91
 | | Crystal structure of queuine salvage enzyme DUF2419, in complex with queuosine-5'-monophosphate | | 分子名称: | 2-amino-5-({[(1S,4S,5R)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-7-(5-O-phosphono-beta-D-ribofuranosyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, AMMONIUM ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Hung, S.-H, Swairjo, M.A. | | 登録日 | 2022-03-09 | | 公開日 | 2022-12-21 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis of Qng1-mediated salvage of the micronutrient queuine from queuosine-5'-monophosphate as the biological substrate.
Nucleic Acids Res., 51, 2023
|
|
