6PD9
 
 | | Crystal structure of MYST acetyltransferase domain in complex with inhibitor 60 | | 分子名称: | 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-(1H-pyrazol-1-yl)benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... | | 著者 | Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. | | 登録日 | 2019-06-18 | | 公開日 | 2020-04-01 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents.
J.Med.Chem., 63, 2020
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6PDF
 | | Crystal structure of MYST acetyltransferase domain in complex with inhibitor 55 | | 分子名称: | 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-(2H-1,2,3-triazol-2-yl)benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... | | 著者 | Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. | | 登録日 | 2019-06-18 | | 公開日 | 2020-04-01 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents.
J.Med.Chem., 63, 2020
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6PD8
 | | Crystal structure of MYST acetyltransferase domain in complex with inhibitor 39 | | 分子名称: | 5-ethoxy-2-fluoro-3-methyl-N'-(phenylsulfonyl)benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... | | 著者 | Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. | | 登録日 | 2019-06-18 | | 公開日 | 2020-04-01 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.738 Å) | | 主引用文献 | Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents.
J.Med.Chem., 63, 2020
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6PDC
 | | Crystal structure of MYST acetyltransferase domain in complex with inhibitor 42 | | 分子名称: | 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-[(prop-2-en-1-yl)oxy]benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... | | 著者 | Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. | | 登録日 | 2019-06-18 | | 公開日 | 2020-04-01 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents.
J.Med.Chem., 63, 2020
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6PME
 | | TRK-A IN COMPLEX WITH LIGAND | | 分子名称: | High affinity nerve growth factor receptor, N-[2,4-bis(morpholin-4-yl)phenyl]-3-phenoxybenzamide, S,R MESO-TARTARIC ACID, ... | | 著者 | Subramanian, G, Brown, D.G. | | 登録日 | 2019-07-01 | | 公開日 | 2020-02-26 | | 最終更新日 | 2021-02-03 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Synthetic inhibitor leads of human tropomyosin receptor kinase A ( h TrkA).
Rsc Med Chem, 11, 2020
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8F6E
 | | Cryo-EM structure of a Zinc-loaded wild-type YiiP-Fab complex | | 分子名称: | Cadmium and zinc efflux pump FieF, Fab heavy chain, Fab light chain, ... | | 著者 | Lopez-Redondo, M.L, Hussein, A.K, Stokes, D.L. | | 登録日 | 2022-11-16 | | 公開日 | 2023-02-08 | | 最終更新日 | 2024-08-21 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Energy coupling and stoichiometry of Zn 2+ /H + antiport by the prokaryotic cation diffusion facilitator YiiP.
Elife, 12, 2023
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8F6K
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6PDB
 | | Crystal structure of MYST acetyltransferase domain in complex with inhibitor 80 | | 分子名称: | 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-(pyrimidin-2-yl)benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... | | 著者 | Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. | | 登録日 | 2019-06-18 | | 公開日 | 2020-04-01 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | | 主引用文献 | Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents.
J.Med.Chem., 63, 2020
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6PDD
 | | Crystal structure of MYST acetyltransferase domain in complex with inhibitor 41 | | 分子名称: | 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-[(propan-2-yl)oxy]benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... | | 著者 | Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. | | 登録日 | 2019-06-18 | | 公開日 | 2020-04-01 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents.
J.Med.Chem., 63, 2020
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8F6F
 | | Cryo-EM structure of a Zinc-loaded D51A mutant of the YiiP-Fab complex | | 分子名称: | Cadmium and zinc efflux pump FieF, Fab2r heavy chain, Fab2r light chain, ... | | 著者 | Lopez-Redondo, M.L, Hussein, A.K, Stokes, D.L. | | 登録日 | 2022-11-16 | | 公開日 | 2023-02-08 | | 最終更新日 | 2024-08-21 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Energy coupling and stoichiometry of Zn 2+ /H + antiport by the prokaryotic cation diffusion facilitator YiiP.
Elife, 12, 2023
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8F6J
 | | Cryo-EM structure of a Zinc-loaded D287A mutant of the YiiP-Fab complex | | 分子名称: | Cadmium and zinc efflux pump FieF, Fab2r heavy chain, Fab2r light chain, ... | | 著者 | Lopez-Redondo, M.L, Hussein, A.K, Stokes, D.L. | | 登録日 | 2022-11-16 | | 公開日 | 2023-02-08 | | 最終更新日 | 2024-08-21 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Energy coupling and stoichiometry of Zn 2+ /H + antiport by the prokaryotic cation diffusion facilitator YiiP.
Elife, 12, 2023
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8F6I
 | | Cryo-EM structure of a Zinc-loaded symmetrical D70A mutant of the YiiP-Fab complex | | 分子名称: | Cadmium and zinc efflux pump FieF, Fab2r heavy chain, Fab2r light chain, ... | | 著者 | Lopez-Redondo, M.L, Hussein, A.K, Stokes, D.L. | | 登録日 | 2022-11-16 | | 公開日 | 2023-02-08 | | 最終更新日 | 2024-08-21 | | 実験手法 | ELECTRON MICROSCOPY (4.03 Å) | | 主引用文献 | Energy coupling and stoichiometry of Zn 2+ /H + antiport by the prokaryotic cation diffusion facilitator YiiP.
Elife, 12, 2023
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6PMC
 | | TRK-A IN COMPLEX WITH LIGAND 1a | | 分子名称: | High affinity nerve growth factor receptor, N-(6-{[(5-chloro-2-methoxyphenyl)carbamoyl]amino}-1,3-benzothiazol-2-yl)benzamide | | 著者 | Subramanian, G, Brown, D.G. | | 登録日 | 2019-07-01 | | 公開日 | 2020-02-26 | | 最終更新日 | 2021-02-03 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Synthetic inhibitor leads of human tropomyosin receptor kinase A ( h TrkA).
Rsc Med Chem, 11, 2020
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6WB8
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1H0C
 | | The crystal structure of human alanine:glyoxylate aminotransferase | | 分子名称: | (AMINOOXY)ACETIC ACID, GLYCEROL, PYRIDOXAL-5'-PHOSPHATE, ... | | 著者 | Zhang, X, Danpure, C.J, Roe, S.M, Pearl, L.H. | | 登録日 | 2002-06-17 | | 公開日 | 2003-06-12 | | 最終更新日 | 2019-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal Structure of Alanine:Glyoxylate Aminotransferase and the Relationship between Genotype and Enzymatic Phenotype in Primary Hyperoxaluria Type 1.
J.Mol.Biol., 331, 2003
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6PZL
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6PYK
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8EU8
 | | Cryo-EM structure of CH848 10.17DT DS-SOSIP-2P Env | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CH848 10.17DT SOSIP Envelope glycoprotein gp160 | | 著者 | Wrapp, D, Acharya, P, Haynes, B.F. | | 登録日 | 2022-10-18 | | 公開日 | 2023-01-04 | | 最終更新日 | 2023-02-08 | | 実験手法 | ELECTRON MICROSCOPY (3.73 Å) | | 主引用文献 | Structure-Based Stabilization of SOSIP Env Enhances Recombinant Ectodomain Durability and Yield.
J.Virol., 97, 2023
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6W8U
 | | Cryo-EM of the Pyrobaculum arsenaticum pilus | | 分子名称: | pilin | | 著者 | Wang, F, Baquero, D.P, Su, Z, Beltran, L.C, Prangishvili, D, Krupovic, M, Egelman, E.H. | | 登録日 | 2020-03-21 | | 公開日 | 2020-07-08 | | 最終更新日 | 2021-10-06 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | The structures of two archaeal type IV pili illuminate evolutionary relationships.
Nat Commun, 11, 2020
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8F6H
 | | Cryo-EM structure of a Zinc-loaded asymmetrical TMD D70A mutant of the YiiP-Fab complex | | 分子名称: | Cadmium and zinc efflux pump FieF, Fab2r heavy chain, Fab2r light chain, ... | | 著者 | Lopez-Redondo, M.L, Hussein, A.K, Stokes, D.L. | | 登録日 | 2022-11-16 | | 公開日 | 2023-02-08 | | 最終更新日 | 2024-08-21 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Energy coupling and stoichiometry of Zn 2+ /H + antiport by the prokaryotic cation diffusion facilitator YiiP.
Elife, 12, 2023
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6Q2K
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6HXT
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7LXH
 | | Bacillus cereus DNA glycosylase AlkD bound to a CC1065-adenine nucleobase adduct and DNA containing an abasic site | | 分子名称: | 7-{7-[(1R)-1-{[(4P)-6-amino-3H-purin-3-yl]methyl}-5-hydroxy-8-methyl-1,6-dihydropyrrolo[3,2-e]indole-3(2H)-carbonyl]-4-hydroxy-5-methoxy-1,6-dihydropyrrolo[3,2-e]indole-3(2H)-carbonyl}-4-hydroxy-5-methoxy-1,6-dihydropyrrolo[3,2-e]indole-3(2H)-carboxamide, CALCIUM ION, DNA (5'-D(*AP*GP*CP*AP*AP*(ORP)P*GP*GP*C)-3'), ... | | 著者 | Mullins, E.A, Eichman, B.F. | | 登録日 | 2021-03-03 | | 公開日 | 2021-11-17 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.667 Å) | | 主引用文献 | Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites.
Nat Commun, 12, 2021
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7LXJ
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6Q2L
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