3JY9
 
 | | Janus Kinase 2 Inhibitors | | 分子名称: | (3S)-3-(4-hydroxyphenyl)-1,5-dihydro-1,5,12-triazabenzo[4,5]cycloocta[1,2,3-cd]inden-4(3H)-one, SODIUM ION, Tyrosine-protein kinase JAK2 | | 著者 | Zuccola, H.J, Ledeboer, M.W, Pierce, A.C. | | 登録日 | 2009-09-21 | | 公開日 | 2009-12-01 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Janus kinase 2 inhibitors. Synthesis and characterization of a novel polycyclic azaindole.
J.Med.Chem., 52, 2009
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3KO5
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6O1O
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5AWX
 | | Crystal structure of Human PTPRZ D1 domain | | 分子名称: | BROMIDE ION, Receptor-type tyrosine-protein phosphatase zeta | | 著者 | Sugawara, H. | | 登録日 | 2015-07-10 | | 公開日 | 2016-02-17 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Small-molecule inhibition of PTPRZ reduces tumor growth in a rat model of glioblastoma
Sci Rep, 6, 2016
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5AUL
 | | PI3K p85 C-terminal SH2 domain/CD28-derived peptide complex | | 分子名称: | GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, T-cell-specific surface glycoprotein CD28 | | 著者 | Inaba, S, Numoto, N, Morii, H, Ikura, T, Oda, M, Ito, N. | | 登録日 | 2015-04-28 | | 公開日 | 2016-05-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins
J. Biol. Chem., 292, 2017
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7Y6A
 | | Crystal structure of Chicken Egg Lysozyme | | 分子名称: | Lysozyme C, NITRATE ION | | 著者 | DeMirci, H. | | 登録日 | 2022-06-18 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Cryogenic X-ray crystallographic studies of biomacromolecules at Turkish Light Source " Turkish DeLight ".
Turk J Biol, 47, 2023
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5NJ7
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7XYE
 | | The apo structure of Orf1 | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, N-formimidoyl fortimicin A synthase | | 著者 | Wang, Y.L, Li, T.L. | | 登録日 | 2022-06-01 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.482 Å) | | 主引用文献 | N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry.
Nat Commun, 14, 2023
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7XXC
 | | Orf1-glycine-glycylthricin complex | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCINE, N-formimidoyl fortimicin A synthase, ... | | 著者 | Wang, Y.L, Li, T.L. | | 登録日 | 2022-05-29 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.989 Å) | | 主引用文献 | N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry.
Nat Commun, 14, 2023
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7YDO
 | | Crystal structure of Atg44 | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, Uncharacterized protein C26A3.14c | | 著者 | Maruyama, T, Noda, N.N. | | 登録日 | 2022-07-04 | | 公開日 | 2023-05-17 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | The mitochondrial intermembrane space protein mitofissin drives mitochondrial fission required for mitophagy.
Mol.Cell, 83, 2023
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5NNZ
 | | Crystal structure of human ODA16 | | 分子名称: | Dynein assembly factor with WDR repeat domains 1 | | 著者 | Lorentzen, E, Taschner, T, Basquin, J. | | 登録日 | 2017-04-10 | | 公開日 | 2017-06-07 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.651 Å) | | 主引用文献 | Purification and crystal structure of human ODA16: Implications for ciliary import of outer dynein arms by the intraflagellar transport machinery.
Protein Sci., 29, 2020
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7XXM
 | | Orf1-glycine-4-aminobutylthricin complex | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCINE, N-formimidoyl fortimicin A synthase, ... | | 著者 | Wang, Y.L, Li, T.L. | | 登録日 | 2022-05-30 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.119 Å) | | 主引用文献 | N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry.
Nat Commun, 14, 2023
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7XX0
 | | C281S glycylthricin complex | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCINE, N-formimidoyl fortimicin A synthase, ... | | 著者 | Wang, Y.L, Li, T.L. | | 登録日 | 2022-05-27 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.199 Å) | | 主引用文献 | N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry.
Nat Commun, 14, 2023
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7XYL
 | | E426Q-glycine-glycylthricin complex | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCINE, N-formimidoyl fortimicin A synthase, ... | | 著者 | Wang, Y.L, Li, T.L. | | 登録日 | 2022-06-01 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.099 Å) | | 主引用文献 | N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry.
Nat Commun, 14, 2023
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5CWZ
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7WAL
 | | Glutamyl-tRNA synthetase from Plasmodium falciparum (PfERS) in complex with Co | | 分子名称: | BETA-MERCAPTOETHANOL, CHLORIDE ION, COBALT (II) ION, ... | | 著者 | Sharma, V, Manickam, Y, Babbar, P, Sharma, A. | | 登録日 | 2021-12-14 | | 公開日 | 2022-12-21 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Structural characterization of glutamyl-tRNA synthetase (GluRS) from Plasmodium falciparum.
Mol.Biochem.Parasitol., 253, 2022
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7WAK
 | | Glutamyl-tRNA synthetase from Plasmodium falciparum (PfERS) in complex with ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Glutamyl-tRNA synthetase, ... | | 著者 | Sharma, V, Manickam, Y, Babbar, P, Sharma, A. | | 登録日 | 2021-12-14 | | 公開日 | 2022-12-21 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.782 Å) | | 主引用文献 | Structural characterization of glutamyl-tRNA synthetase (GluRS) from Plasmodium falciparum.
Mol.Biochem.Parasitol., 253, 2022
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7WAJ
 | | Glutamyl-tRNA synthetase from Plasmodium falciparum (PfERS) complexed with ATP and Co | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, BETA-MERCAPTOETHANOL, CHLORIDE ION, ... | | 著者 | Sharma, V, Manickam, Y, Babbar, P, Sharma, A. | | 登録日 | 2021-12-14 | | 公開日 | 2022-12-21 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.254 Å) | | 主引用文献 | Structural characterization of glutamyl-tRNA synthetase (GluRS) from Plasmodium falciparum.
Mol.Biochem.Parasitol., 253, 2022
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7WAO
 | | Glutamyl-tRNA synthetase from Plasmodium falciparum (PfERS) in complex with Mn | | 分子名称: | CHLORIDE ION, Glutamyl-tRNA synthetase, MANGANESE (II) ION | | 著者 | Sharma, V, Manickam, Y, Babbar, P, Sharma, A. | | 登録日 | 2021-12-14 | | 公開日 | 2022-12-21 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.582 Å) | | 主引用文献 | Structural characterization of glutamyl-tRNA synthetase (GluRS) from Plasmodium falciparum.
Mol.Biochem.Parasitol., 253, 2022
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7WAI
 | | Glutamyl-tRNA synthetase from Plasmodium falciparum (PfERS) | | 分子名称: | CHLORIDE ION, Glutamyl-tRNA synthetase | | 著者 | Sharma, V, Manickam, Y, Harlos, K, Sharma, A. | | 登録日 | 2021-12-14 | | 公開日 | 2022-12-21 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.105 Å) | | 主引用文献 | Structural characterization of glutamyl-tRNA synthetase (GluRS) from Plasmodium falciparum.
Mol.Biochem.Parasitol., 253, 2022
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7XMC
 | | Cryo-EM structure of Cytochrome bo3 from Escherichia coli, apo structure with DMSO | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, COPPER (II) ION, Cytochrome bo(3) ubiquinol oxidase subunit 1, ... | | 著者 | Nishida, Y, Shigematsu, H, Iwamoto, T, Takashima, S, Shintani, Y. | | 登録日 | 2022-04-25 | | 公開日 | 2022-12-21 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | | 主引用文献 | Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases.
Nat Commun, 13, 2022
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7XMD
 | | Cryo-EM structure of Cytochrome bo3 from Escherichia coli, the structure complexed with an allosteric inhibitor N4 | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, COPPER (II) ION, Cytochrome bo(3) ubiquinol oxidase subunit 1, ... | | 著者 | Nishida, Y, Shigematsu, H, Iwamoto, T, Takashima, S, Shintani, Y. | | 登録日 | 2022-04-25 | | 公開日 | 2022-12-21 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | | 主引用文献 | Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases.
Nat Commun, 13, 2022
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7XMA
 | | Crystal structure of Bovine heart cytochrome c oxidase, apo structure with DMSO | | 分子名称: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE, (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE, ... | | 著者 | Nishida, Y, Shinzawa-Itoh, K, Mizuno, N, Kumasaka, T, Yoshikawa, S, Tsukihara, T, Takashima, S, Shintani, Y. | | 登録日 | 2022-04-25 | | 公開日 | 2022-12-21 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases.
Nat Commun, 13, 2022
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7XMB
 | | Crystal structure of Bovine heart cytochrome c oxidase, the structure complexed with an allosteric inhibitor T113 | | 分子名称: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE, (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE, ... | | 著者 | Nishida, Y, Shinzawa-Itoh, K, Mizuno, N, Kumasaka, T, Yoshikawa, S, Tsukihara, T, Shintani, Y, Takashima, S. | | 登録日 | 2022-04-25 | | 公開日 | 2022-12-21 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases.
Nat Commun, 13, 2022
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4ZX3
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